BR0011835A - Polimorfos de cloreto de (2-benzidril-1-azabiciclo [2,2,2] Èct-3-il)-(5-isopropil-2-metoxibenzil) amÈnio cristalino como antagonistas de receptor nk-1 - Google Patents
Polimorfos de cloreto de (2-benzidril-1-azabiciclo [2,2,2] Èct-3-il)-(5-isopropil-2-metoxibenzil) amÈnio cristalino como antagonistas de receptor nk-1Info
- Publication number
- BR0011835A BR0011835A BR0011835-4A BR0011835A BR0011835A BR 0011835 A BR0011835 A BR 0011835A BR 0011835 A BR0011835 A BR 0011835A BR 0011835 A BR0011835 A BR 0011835A
- Authority
- BR
- Brazil
- Prior art keywords
- èct
- benzhydryl
- polymorphs
- methoxybenzyl
- isopropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Patente de Invenção: "POLIMORFOS DE CLORETO DE (2-BENZIDRIL-1-AZABICICLO [2,2,2] ÈCT-3-IL)-(5-ISOPROPIL-2-METOXIBENZIL) AMÈNIO CRISTALINO COMO ANTAGONISTAS DE RECEPTOR NK-1". Duas formas polimórficas cristalinas de dihidrato de dicloridrato de (2-benzidril-1-azo-biciclo[2,2,2]oct-3-il)-(5-isopropil-2-metoxibenzil)-a mina são a Forma I e a Forma II. A composição farmacêutica contendo pelo menos um desses polimorfos possui uma estabilidade vantajosa para formulação para tratar a êmese em pacientes recebendo quimioterapia. A administração desta composição farmacêutica é oral convencional preferencialmente por comprimidos ou cápsulas ou intravenosa. Um método de fabricação das Forma I e II também é revelado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14023399P | 1999-06-22 | 1999-06-22 | |
PCT/IB2000/000756 WO2000078759A1 (en) | 1999-06-22 | 2000-06-06 | Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0011835A true BR0011835A (pt) | 2002-03-05 |
Family
ID=22490317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0011835-4A BR0011835A (pt) | 1999-06-22 | 2000-06-06 | Polimorfos de cloreto de (2-benzidril-1-azabiciclo [2,2,2] Èct-3-il)-(5-isopropil-2-metoxibenzil) amÈnio cristalino como antagonistas de receptor nk-1 |
Country Status (35)
Country | Link |
---|---|
US (1) | US6262067B1 (pt) |
EP (1) | EP1187834A1 (pt) |
JP (1) | JP2003502425A (pt) |
KR (1) | KR20020030280A (pt) |
CN (1) | CN1390216A (pt) |
AP (1) | AP2001002367A0 (pt) |
AR (1) | AR024411A1 (pt) |
AU (1) | AU767336B2 (pt) |
BG (1) | BG106205A (pt) |
BR (1) | BR0011835A (pt) |
CA (1) | CA2375265A1 (pt) |
CO (1) | CO5190663A1 (pt) |
CZ (1) | CZ20014458A3 (pt) |
DZ (1) | DZ3055A1 (pt) |
EA (1) | EA004264B1 (pt) |
EC (1) | ECSP003538A (pt) |
EE (1) | EE200100698A (pt) |
HR (1) | HRP20010920A2 (pt) |
HU (1) | HUP0201694A3 (pt) |
IL (1) | IL146410A0 (pt) |
IS (1) | IS6161A (pt) |
MA (1) | MA26744A1 (pt) |
MX (1) | MXPA02000033A (pt) |
NO (1) | NO20016187L (pt) |
NZ (1) | NZ515348A (pt) |
OA (1) | OA11952A (pt) |
PA (1) | PA8496701A1 (pt) |
PE (1) | PE20010322A1 (pt) |
PL (1) | PL352899A1 (pt) |
SK (1) | SK18672001A3 (pt) |
TN (1) | TNSN00137A1 (pt) |
TR (1) | TR200103688T2 (pt) |
UY (1) | UY26211A1 (pt) |
WO (1) | WO2000078759A1 (pt) |
ZA (1) | ZA200110387B (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6387925B1 (en) * | 1999-06-01 | 2002-05-14 | Pfizer Inc. | Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions |
US7683071B2 (en) * | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
US6939873B2 (en) | 2000-07-26 | 2005-09-06 | Taro Pharmaceuticals Industries Limited | Non-sedating barbituric acid derivatives |
US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
AU2002334103A1 (en) * | 2002-10-04 | 2004-04-23 | Merck Sharp And Dohme Limited | Azabicyclic spiroether derivatives as receptor antagonists |
DE60324703D1 (de) | 2002-12-11 | 2008-12-24 | Taro Pharma Ind | Barbitursäure derivaten. |
EP1781624A4 (en) * | 2004-07-02 | 2010-06-23 | Taro Pharma Ind | PROCESS FOR THE PREPARATION OF 1-METHOXYMETHYL-5,5-DIPHENYLBARBITURIC ACID |
WO2008066704A2 (en) * | 2006-11-14 | 2008-06-05 | Taro Pharmaceuticals North America, Inc. | Method of improving bioavailability for non-sedating barbiturates |
UA102128C2 (en) * | 2008-12-05 | 2013-06-10 | Х. Луннбек А/С | Nalmefene hydrochloride dihydrate |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
DE122006000066I2 (de) * | 1991-05-31 | 2007-12-06 | Pfizer | Chinuclidinderivate |
AU676489B2 (en) * | 1992-11-12 | 1997-03-13 | Pfizer Inc. | Quinuclidine derivative as substance P antagonist |
US5393762A (en) * | 1993-06-04 | 1995-02-28 | Pfizer Inc. | Pharmaceutical agents for treatment of emesis |
-
2000
- 2000-05-04 US US09/564,528 patent/US6262067B1/en not_active Expired - Fee Related
- 2000-06-06 NZ NZ515348A patent/NZ515348A/en unknown
- 2000-06-06 EE EEP200100698A patent/EE200100698A/xx unknown
- 2000-06-06 CZ CZ20014458A patent/CZ20014458A3/cs unknown
- 2000-06-06 SK SK1867-2001A patent/SK18672001A3/sk unknown
- 2000-06-06 BR BR0011835-4A patent/BR0011835A/pt not_active IP Right Cessation
- 2000-06-06 IL IL14641000A patent/IL146410A0/xx unknown
- 2000-06-06 PA PA20008496701A patent/PA8496701A1/es unknown
- 2000-06-06 HU HU0201694A patent/HUP0201694A3/hu unknown
- 2000-06-06 PL PL00352899A patent/PL352899A1/xx not_active Application Discontinuation
- 2000-06-06 MX MXPA02000033A patent/MXPA02000033A/es unknown
- 2000-06-06 AU AU47745/00A patent/AU767336B2/en not_active Ceased
- 2000-06-06 CN CN00809305A patent/CN1390216A/zh active Pending
- 2000-06-06 KR KR1020017016407A patent/KR20020030280A/ko not_active Application Discontinuation
- 2000-06-06 AP APAP/P/2001/002367A patent/AP2001002367A0/en unknown
- 2000-06-06 WO PCT/IB2000/000756 patent/WO2000078759A1/en not_active Application Discontinuation
- 2000-06-06 JP JP2001504925A patent/JP2003502425A/ja active Pending
- 2000-06-06 OA OA1200100314A patent/OA11952A/en unknown
- 2000-06-06 EP EP00929745A patent/EP1187834A1/en not_active Withdrawn
- 2000-06-06 EA EA200101179A patent/EA004264B1/ru not_active IP Right Cessation
- 2000-06-06 CA CA002375265A patent/CA2375265A1/en not_active Abandoned
- 2000-06-06 TR TR2001/03688T patent/TR200103688T2/xx unknown
- 2000-06-13 CO CO00043885A patent/CO5190663A1/es not_active Application Discontinuation
- 2000-06-20 AR ARP000103053A patent/AR024411A1/es not_active Application Discontinuation
- 2000-06-20 UY UY26211A patent/UY26211A1/es not_active Application Discontinuation
- 2000-06-20 PE PE2000000613A patent/PE20010322A1/es not_active Application Discontinuation
- 2000-06-21 DZ DZ000113A patent/DZ3055A1/xx active
- 2000-06-21 TN TNTNSN00137A patent/TNSN00137A1/fr unknown
- 2000-06-21 MA MA26007A patent/MA26744A1/fr unknown
- 2000-06-22 EC EC2000003538A patent/ECSP003538A/es unknown
-
2001
- 2001-11-13 IS IS6161A patent/IS6161A/is unknown
- 2001-12-10 BG BG106205A patent/BG106205A/bg unknown
- 2001-12-11 HR HR20010920A patent/HRP20010920A2/hr not_active Application Discontinuation
- 2001-12-18 NO NO20016187A patent/NO20016187L/no not_active Application Discontinuation
- 2001-12-19 ZA ZA200110387A patent/ZA200110387B/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008. |