ES2089974A1 - Utilizacion de los derivados de 1-(4-)4-aril (o heteroaril)-1-piperazinil)-butil)-1-h-azol para la preparacion de medicamentos destinados al tratamiento de los trastornos de la secrecion gastrica. - Google Patents

Utilizacion de los derivados de 1-(4-)4-aril (o heteroaril)-1-piperazinil)-butil)-1-h-azol para la preparacion de medicamentos destinados al tratamiento de los trastornos de la secrecion gastrica.

Info

Publication number
ES2089974A1
ES2089974A1 ES09402417A ES9402417A ES2089974A1 ES 2089974 A1 ES2089974 A1 ES 2089974A1 ES 09402417 A ES09402417 A ES 09402417A ES 9402417 A ES9402417 A ES 9402417A ES 2089974 A1 ES2089974 A1 ES 2089974A1
Authority
ES
Spain
Prior art keywords
heteroaryl
aryl
treatment
medicaments
disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09402417A
Other languages
English (en)
Other versions
ES2089974B1 (es
Inventor
Constansa Jordi Frigola
Vidal Ramon Merce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Publication of ES2089974A1 publication Critical patent/ES2089974A1/es
Application granted granted Critical
Publication of ES2089974B1 publication Critical patent/ES2089974B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

UTILIZACION DE LOS DERIVADOS DE 1-(4-[4-ARIL(O HETEROARIL)-1-PIPERAZINIL]-BUTIL)-1-HAZOL, PARA LA PREPARACION DE MEDICAMENTOS DESTINADOS AL TRATAMIENTO DE LOS TRANSTORNOS DE LA SECRECION GASTRICA. LA PRESENTE INVENCION CONCIERNE LA UTILIZACION DE LOS DERIVADOS DE 1-(4-[4-ARIL(O HETEROARIL)-1-PIPERAZINIL]-BUTIL)-1-HAZOL, ASI COMO DE SUS SALES FISIOLOGICAMENTE ACEPTABLES, PARA LA FABRICACION DE MEDICAMENTOS DESTINADOS AL TRATAMIENTO DE LOS TRASTORNOS ASOCIADOS A LA SECRECION GASTRICA.
ES09402417A 1993-11-25 1994-11-24 Utilizacion de los derivados de 1-(4-)4-aril (o heteroaril)-1-piperazinil)-butil)-1-h-azol para la preparacion de medicamentos destinados al tratamiento de los trastornos de la secrecion gastrica. Expired - Lifetime ES2089974B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9314102A FR2712808B1 (fr) 1993-11-25 1993-11-25 Utilisation des dérivés de 1-{4-[4-aryl(ou hétéroaryl)-1-pipérazinyl]-butyl}-1-H-azole pour la préparation de médicaments destinés au traitement des troubles de la sécrétion gastrique .

Publications (2)

Publication Number Publication Date
ES2089974A1 true ES2089974A1 (es) 1996-10-01
ES2089974B1 ES2089974B1 (es) 1997-03-16

Family

ID=9453220

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09402417A Expired - Lifetime ES2089974B1 (es) 1993-11-25 1994-11-24 Utilizacion de los derivados de 1-(4-)4-aril (o heteroaril)-1-piperazinil)-butil)-1-h-azol para la preparacion de medicamentos destinados al tratamiento de los trastornos de la secrecion gastrica.

Country Status (10)

Country Link
US (1) US5532234A (es)
EP (1) EP0655248B1 (es)
JP (1) JPH07242626A (es)
AT (1) ATE184485T1 (es)
AU (1) AU674458B2 (es)
CA (1) CA2136661A1 (es)
DE (1) DE69420679D1 (es)
ES (1) ES2089974B1 (es)
FR (1) FR2712808B1 (es)
ZA (1) ZA949332B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2149691A1 (es) * 1997-06-02 2000-11-01 Esteve Labor Dr 2-4-[4-(4,5-dicloro-2metilimidazol-1-il)butil]-1-piperacinil -5-fluoropirimidina, su preparacion y su utilizacion terapeutica.

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681956A (en) * 1990-12-28 1997-10-28 Neurogen Corporation 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands
US5712392A (en) 1990-12-28 1998-01-27 Neurogen Corporation Certain 4-piperidine- and piperazinoalkyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands
WO1997003058A1 (fr) * 1995-07-07 1997-01-30 Taisho Pharmaceutical Co., Ltd. Derives de 4-alkylthiazoline
US6166205A (en) * 1998-09-02 2000-12-26 Neurogen Corporation 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
JP2002542155A (ja) * 1999-03-03 2002-12-10 メルク エンド カムパニー インコーポレーテッド プレニル蛋白トランスフェラーゼの阻害剤
AU8125501A (en) 2000-08-14 2002-02-25 Ortho Mcneil Pharm Inc Substituted pyrazoles
MXPA03001420A (es) 2000-08-14 2004-01-26 Johnson & Johnson Pirazoles sustituidos.
MXPA03001422A (es) 2000-08-14 2004-01-26 Johnson & Johnson Pirazoles substituidos.
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
AU2001288714A1 (en) 2000-09-06 2002-03-22 Ortho-Mcneil Pharmaceutical, Inc. A method for treating allergies
GB2435827A (en) * 2006-03-09 2007-09-12 Del Dr Esteve S A Spain Lab Use of substituted piperazine compounds for the treatment of food related disorders
EP2924032B1 (en) * 2012-11-26 2019-03-06 Shenyang Haiwang Biotechnology Co., Ltd Benzo five-membered nitrogen heterocyclic piperidine or piperazine derivatives and preparation methods and pharmaceutical compositions thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0455510A2 (en) * 1990-05-04 1991-11-06 Eli Lilly And Company Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2672052B1 (fr) * 1991-01-28 1995-05-24 Esteve Labor Dr Derives d'aryl (ou heteroaryl)-piperazinyl-alkyl-azoles, leur preparation et leur application en tant que medicaments.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0455510A2 (en) * 1990-05-04 1991-11-06 Eli Lilly And Company Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COSTALL, B. y col. "Profile of Action of a Novel 5-Hydroxytryptamine 1A Receptor Ligand E-4424 to Inhibit Aversive Behavior in the Mouse, Rat and Marmoset" The J. of Pharmacology and Experimental Therapeutics. 1992, Vol. 262, N‘ 1, pßginas 90-98 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2149691A1 (es) * 1997-06-02 2000-11-01 Esteve Labor Dr 2-4-[4-(4,5-dicloro-2metilimidazol-1-il)butil]-1-piperacinil -5-fluoropirimidina, su preparacion y su utilizacion terapeutica.

Also Published As

Publication number Publication date
AU7900794A (en) 1995-06-01
EP0655248A1 (fr) 1995-05-31
US5532234A (en) 1996-07-02
JPH07242626A (ja) 1995-09-19
ES2089974B1 (es) 1997-03-16
ZA949332B (en) 1995-11-14
FR2712808A1 (fr) 1995-06-02
ATE184485T1 (de) 1999-10-15
EP0655248B1 (fr) 1999-09-15
CA2136661A1 (fr) 1995-05-26
FR2712808B1 (fr) 1996-02-16
DE69420679D1 (de) 1999-10-21
AU674458B2 (en) 1996-12-19

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