HRP20010453B1 - Antihistaminic spiro compounds - Google Patents
Antihistaminic spiro compoundsInfo
- Publication number
- HRP20010453B1 HRP20010453B1 HR20010453A HRP20010453A HRP20010453B1 HR P20010453 B1 HRP20010453 B1 HR P20010453B1 HR 20010453 A HR20010453 A HR 20010453A HR P20010453 A HRP20010453 A HR P20010453A HR P20010453 B1 HRP20010453 B1 HR P20010453B1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- hydroxy
- hydrogen
- alkyloxycarbonyl
- substituted
- Prior art date
Links
- 230000001387 anti-histamine Effects 0.000 title 1
- 239000000739 antihistaminic agent Substances 0.000 title 1
- 150000003413 spiro compounds Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
- -1 hydroxy, carboxyl Chemical group 0.000 abstract 8
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 abstract 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 abstract 1
- 125000001113 thiadiazolyl group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Dental Preparations (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98204347 | 1998-12-19 | ||
| PCT/EP1999/010176 WO2000037470A1 (en) | 1998-12-19 | 1999-12-15 | Antihistaminic spiro compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20010453A2 HRP20010453A2 (en) | 2002-06-30 |
| HRP20010453B1 true HRP20010453B1 (en) | 2010-07-31 |
Family
ID=8234498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010453A HRP20010453B1 (en) | 1998-12-19 | 2001-06-15 | Antihistaminic spiro compounds |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US7148214B1 (pt) |
| EP (1) | EP1144411B1 (pt) |
| JP (1) | JP4601175B2 (pt) |
| KR (1) | KR100598725B1 (pt) |
| CN (1) | CN1258533C (pt) |
| AR (1) | AR021888A1 (pt) |
| AT (1) | ATE294178T1 (pt) |
| AU (1) | AU764820C (pt) |
| BG (1) | BG65133B1 (pt) |
| BR (1) | BR9916371A (pt) |
| CA (1) | CA2355939C (pt) |
| CO (1) | CO5140116A1 (pt) |
| CZ (1) | CZ301953B6 (pt) |
| DE (1) | DE69925036T2 (pt) |
| DK (1) | DK1144411T3 (pt) |
| EA (1) | EA004500B1 (pt) |
| EE (1) | EE04917B1 (pt) |
| EG (1) | EG24605A (pt) |
| ES (1) | ES2242443T3 (pt) |
| HK (1) | HK1043128B (pt) |
| HR (1) | HRP20010453B1 (pt) |
| HU (1) | HU229406B1 (pt) |
| ID (1) | ID29268A (pt) |
| IL (1) | IL143767A0 (pt) |
| MY (1) | MY129663A (pt) |
| NO (1) | NO318891B1 (pt) |
| NZ (1) | NZ512870A (pt) |
| PL (1) | PL196262B1 (pt) |
| PT (1) | PT1144411E (pt) |
| SA (1) | SA00210113B1 (pt) |
| SI (1) | SI1144411T1 (pt) |
| SK (1) | SK286158B6 (pt) |
| TR (1) | TR200101711T2 (pt) |
| TW (1) | TWI250981B (pt) |
| UA (1) | UA74537C2 (pt) |
| WO (1) | WO2000037470A1 (pt) |
| ZA (1) | ZA200104977B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA76224C2 (en) * | 2001-10-15 | 2006-07-17 | Janssen Pharmaceutica Nv | Substituted 4-phenyl 4-[1h-imidazol-2-yl]-piperidine derivatives and use thereof as selective non-peptide delta-opioid agonists |
| PL370371A1 (en) | 2001-10-15 | 2005-05-16 | Janssen Pharmaceutica N.V. | Substituted 4-phenyl-4-(1h-imidazol-2-yl)-piperidine derivatives for reducing ischaemic damage |
| WO2005110685A2 (en) * | 2004-05-11 | 2005-11-24 | Alliss George E | Vegetation trimmer apparatus |
| EP1795527B1 (en) * | 2004-09-07 | 2009-04-22 | Banyu Pharmaceutical Co., Ltd. | Carbamoyl-substituted spiro derivative |
| CA2719365C (en) | 2008-04-29 | 2017-03-07 | Novartis Ag | Spiro-indole derivatives for the treatment of parasitic diseases |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2015051241A1 (en) | 2013-10-04 | 2015-04-09 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| ES2900806T3 (es) | 2013-10-04 | 2022-03-18 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos y usos de los mismos |
| JP6701088B2 (ja) | 2014-03-19 | 2020-05-27 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | Ｐｉ３ｋ−ガンマ媒介障害の治療で使用するための複素環式化合物 |
| CA2959208C (en) | 2014-08-29 | 2023-09-19 | Tes Pharma S.R.L. | Pyrimidine derivatives and their use as inhibitors of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| US10160761B2 (en) | 2015-09-14 | 2018-12-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinones, and process of making, composition comprising, and methods of using the same |
| WO2017088080A1 (es) | 2015-11-25 | 2017-06-01 | Natural Response S.A. | Método para la obtención de saponinas a partir de plantas |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| KR20240052354A (ko) | 2022-10-14 | 2024-04-23 | 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. | 여과 장치 |
| KR20240052355A (ko) | 2022-10-14 | 2024-04-23 | 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. | 여과 장치용 커버 |
| CN117624052B (zh) * | 2024-01-26 | 2024-04-12 | 四川益能康生环保科技有限公司 | 一种用于捕集二氧化碳的离子液体及其制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0393738A1 (en) * | 1989-04-07 | 1990-10-24 | Janssen Pharmaceutica N.V. | Hydroxyalkylfuranyl derivatives |
| EP0518434A1 (en) * | 1991-06-13 | 1992-12-16 | Janssen Pharmaceutica N.V. | Imidazo(1,2-a)(pyrrolo, thieno or furano)(3,2-d)azepine derivatives, compositions and methods of use |
| WO1997024356A1 (en) * | 1995-12-27 | 1997-07-10 | Janssen Pharmaceutica N.V. | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464380A (en) | 1983-05-25 | 1984-08-07 | Pfizer Inc. | Imidazolidinedione derivatives |
| JPH089616B2 (ja) * | 1990-10-10 | 1996-01-31 | シェリング・コーポレーション | 置換されたイミダゾベンズアゼピン類およびイミダゾピリドアゼピン類 |
| IL101850A (en) * | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
| US5106844A (en) * | 1991-09-10 | 1992-04-21 | Sterling Drug Inc. | Imidazo[2,2-b][3]benzazepine and pyrimido[2,1-b][3]benzazepine antiarrhythmic agents |
-
1999
- 1999-12-15 JP JP2000589540A patent/JP4601175B2/ja not_active Expired - Lifetime
- 1999-12-15 SI SI9930798T patent/SI1144411T1/xx unknown
- 1999-12-15 KR KR1020017005016A patent/KR100598725B1/ko active IP Right Grant
- 1999-12-15 AT AT99964625T patent/ATE294178T1/de active
- 1999-12-15 AU AU30412/00A patent/AU764820C/en not_active Expired
- 1999-12-15 ID IDW00200101298A patent/ID29268A/id unknown
- 1999-12-15 DK DK99964625T patent/DK1144411T3/da active
- 1999-12-15 HU HU0104779A patent/HU229406B1/hu unknown
- 1999-12-15 UA UA2001064351A patent/UA74537C2/uk unknown
- 1999-12-15 PL PL348295A patent/PL196262B1/pl unknown
- 1999-12-15 CN CNB998147052A patent/CN1258533C/zh not_active Expired - Lifetime
- 1999-12-15 EE EEP200100328A patent/EE04917B1/xx unknown
- 1999-12-15 BR BR9916371-3A patent/BR9916371A/pt not_active Application Discontinuation
- 1999-12-15 IL IL14376799A patent/IL143767A0/xx not_active IP Right Cessation
- 1999-12-15 US US09/868,535 patent/US7148214B1/en not_active Expired - Lifetime
- 1999-12-15 EA EA200100681A patent/EA004500B1/ru not_active IP Right Cessation
- 1999-12-15 PT PT99964625T patent/PT1144411E/pt unknown
- 1999-12-15 SK SK814-2001A patent/SK286158B6/sk not_active IP Right Cessation
- 1999-12-15 CZ CZ20012069A patent/CZ301953B6/cs not_active IP Right Cessation
- 1999-12-15 TR TR2001/01711T patent/TR200101711T2/xx unknown
- 1999-12-15 EP EP99964625A patent/EP1144411B1/en not_active Expired - Lifetime
- 1999-12-15 CA CA2355939A patent/CA2355939C/en not_active Expired - Lifetime
- 1999-12-15 ES ES99964625T patent/ES2242443T3/es not_active Expired - Lifetime
- 1999-12-15 NZ NZ512870A patent/NZ512870A/en not_active IP Right Cessation
- 1999-12-15 WO PCT/EP1999/010176 patent/WO2000037470A1/en active IP Right Grant
- 1999-12-15 DE DE69925036T patent/DE69925036T2/de not_active Expired - Lifetime
- 1999-12-17 MY MYPI99005537A patent/MY129663A/en unknown
- 1999-12-17 TW TW088122194A patent/TWI250981B/zh not_active IP Right Cessation
- 1999-12-17 AR ARP990106513A patent/AR021888A1/es active IP Right Grant
- 1999-12-17 CO CO99079021A patent/CO5140116A1/es unknown
- 1999-12-18 EG EG162699A patent/EG24605A/xx active
-
2000
- 2000-05-21 SA SA00210113A patent/SA00210113B1/ar unknown
-
2001
- 2001-05-29 BG BG105546A patent/BG65133B1/bg unknown
- 2001-06-01 NO NO20012710A patent/NO318891B1/no not_active IP Right Cessation
- 2001-06-15 HR HR20010453A patent/HRP20010453B1/xx not_active IP Right Cessation
- 2001-06-18 ZA ZA200104977A patent/ZA200104977B/en unknown
-
2002
- 2002-07-03 HK HK02104999.1A patent/HK1043128B/zh unknown
-
2004
- 2004-07-26 US US10/898,844 patent/US7087595B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0393738A1 (en) * | 1989-04-07 | 1990-10-24 | Janssen Pharmaceutica N.V. | Hydroxyalkylfuranyl derivatives |
| EP0518434A1 (en) * | 1991-06-13 | 1992-12-16 | Janssen Pharmaceutica N.V. | Imidazo(1,2-a)(pyrrolo, thieno or furano)(3,2-d)azepine derivatives, compositions and methods of use |
| WO1997024356A1 (en) * | 1995-12-27 | 1997-07-10 | Janssen Pharmaceutica N.V. | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
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