EA200100681A1 - Антигистаминные спиро-соединения - Google Patents
Антигистаминные спиро-соединенияInfo
- Publication number
- EA200100681A1 EA200100681A1 EA200100681A EA200100681A EA200100681A1 EA 200100681 A1 EA200100681 A1 EA 200100681A1 EA 200100681 A EA200100681 A EA 200100681A EA 200100681 A EA200100681 A EA 200100681A EA 200100681 A1 EA200100681 A1 EA 200100681A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- hydrogen
- alkyloxycarbonyl
- het
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Dental Preparations (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к соединениям формулы (I), к их пролекарствам, N-оксидам, солям присоединения, четвертичным аминам или их стереохимически изомерным формам, где Rпредставляет собой водород, Cалкил, галоген, формил, карбоксил, Cалкилоксикарбонил, Cалкилкарбонил, N(RR) C(=O)-, N(RR)C(=O)N(R)-, этенил, замещенный карбоксилом или Cалкилоксикарбонилом, или Cалкил, замещенный гидрокси, карбоксилом, Cалкилокси, Cалкилоксикарбонилом, N(RR)C(=O)-, Cалкил-C(=O)N(R)-, Cалкил-S(=O)N(R)- или N (RR)C(=O)N(R)-, где каждый Rи каждый Rнезависимо представляют собой водород или Cалкил, и Rпредставляет собой водород или гидрокси; Rпредставляет собой водород, Cалкил, гидрокси-Cалкил, Cалкилокси-Cалкил, N(RR)C(=O)-, арил или галоген; n равно 1 или 2; -A-B- представляет двухвалентный радикал формулы -Y-CH=CH-, -CH=CH-Y-, или -CH=CH-CH=CH-, где каждый атом водорода может быть независимо замещен R, где Rпредставляет собой Cалкил, галоген, гидрокси, Cалкилокси, этенил, замещенный карбоксилом или Cалкилоксикарбонилом, гидрокси-Cалкилом, формилом, карбоксилом или гидроксикарбонил-Cалкилом, и каждый Y независимо представляет собой двухвалентный радикал формулы -O-, -S-или -NR-, где Rпредставляет собой водород, Cалкил или Cалкилкарбонил; Z представляет собой двухвалентный радикал формулы -(CH), -CH=CH-, -CH-CHOH-, -CH-O-, -CH-C(=O) или -CH-C(-NOH)-, при условии, что двухвалентные радикалы присоединены к азоту имидазольного кольца через их -CH-фрагменты; и где p равно 1, 2, 3 или 4; L представляет собой водород; Cалкил; Cалкенил; Cалкилкарбонил; Cалкилоксикарбонил; Cалкил, замещенный гидрокси, карбоксилом, Cалкилокси, Cалкилоксикарбонилом, арилом, арилокси, циано или RHN-, где Rпредставляет собой водород, Cалкил, Cалкилоксикарбонил, Cалкилкарбонил; или L представляет радикал формулы -Alk-Y-Het, -Alk-NH-CO-Hetили -Alk-Hetгде Alk представляет Cалкандиил; Y представляет O, S или NH; Het, Hetи Hetкаждый представляет
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98204347 | 1998-12-19 | ||
| PCT/EP1999/010176 WO2000037470A1 (en) | 1998-12-19 | 1999-12-15 | Antihistaminic spiro compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200100681A1 true EA200100681A1 (ru) | 2001-12-24 |
| EA004500B1 EA004500B1 (ru) | 2004-04-29 |
Family
ID=8234498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100681A EA004500B1 (ru) | 1998-12-19 | 1999-12-15 | Антигистаминные спиросоединения |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US7148214B1 (ru) |
| EP (1) | EP1144411B1 (ru) |
| JP (1) | JP4601175B2 (ru) |
| KR (1) | KR100598725B1 (ru) |
| CN (1) | CN1258533C (ru) |
| AR (1) | AR021888A1 (ru) |
| AT (1) | ATE294178T1 (ru) |
| AU (1) | AU764820C (ru) |
| BG (1) | BG65133B1 (ru) |
| BR (1) | BR9916371A (ru) |
| CA (1) | CA2355939C (ru) |
| CO (1) | CO5140116A1 (ru) |
| CZ (1) | CZ301953B6 (ru) |
| DE (1) | DE69925036T2 (ru) |
| DK (1) | DK1144411T3 (ru) |
| EA (1) | EA004500B1 (ru) |
| EE (1) | EE04917B1 (ru) |
| EG (1) | EG24605A (ru) |
| ES (1) | ES2242443T3 (ru) |
| HK (1) | HK1043128B (ru) |
| HR (1) | HRP20010453B1 (ru) |
| HU (1) | HU229406B1 (ru) |
| ID (1) | ID29268A (ru) |
| IL (1) | IL143767A0 (ru) |
| MY (1) | MY129663A (ru) |
| NO (1) | NO318891B1 (ru) |
| NZ (1) | NZ512870A (ru) |
| PL (1) | PL196262B1 (ru) |
| PT (1) | PT1144411E (ru) |
| SA (1) | SA00210113B1 (ru) |
| SI (1) | SI1144411T1 (ru) |
| SK (1) | SK286158B6 (ru) |
| TR (1) | TR200101711T2 (ru) |
| TW (1) | TWI250981B (ru) |
| UA (1) | UA74537C2 (ru) |
| WO (1) | WO2000037470A1 (ru) |
| ZA (1) | ZA200104977B (ru) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0213325A (pt) | 2001-10-15 | 2004-10-13 | Janssen Pharmaceutica Nv | Derivados de 4-fenil-4-[1h-imidazol-2-il]-piperidina substituìda para a redução de dano isquêmico |
| AU2002346994B2 (en) * | 2001-10-15 | 2007-09-06 | Janssen Pharmaceutica N.V. | Novel substituted 4-phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives and their use as selective non-peptide delta opioid agonists |
| EP1765052A4 (en) * | 2004-05-11 | 2012-06-20 | George E Alliss | TRIMMER |
| DE602005014124D1 (de) * | 2004-09-07 | 2009-06-04 | Banyu Pharma Co Ltd | Carbamoylsubstituiertes spiro-derivat |
| DK2285808T3 (da) | 2008-04-29 | 2014-02-03 | Novartis Ag | Spiroindolderivater til behandling af parasitsygdomme |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX2021012208A (es) | 2013-10-04 | 2023-01-19 | Infinity Pharmaceuticals Inc | Compuestos heterocíclicos y usos de los mismos. |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| MX2016012021A (es) | 2014-03-19 | 2017-04-13 | Infinity Pharmaceuticals Inc | Compuestos heterociclicos para utilizarlos en el tratamiento de trastornos mediados por pi3k-gamma. |
| AU2015308350B2 (en) | 2014-08-29 | 2020-03-05 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3350183A1 (en) | 2015-09-14 | 2018-07-25 | Infinity Pharmaceuticals, Inc. | Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same |
| WO2017088080A1 (es) | 2015-11-25 | 2017-06-01 | Natural Response S.A. | Método para la obtención de saponinas a partir de plantas |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| KR20240052354A (ko) | 2022-10-14 | 2024-04-23 | 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. | 여과 장치 |
| KR20240052355A (ko) | 2022-10-14 | 2024-04-23 | 지이 일렉트리컬 엔지니어링 컴퍼니., 리미티드. | 여과 장치용 커버 |
| CN117624052B (zh) * | 2024-01-26 | 2024-04-12 | 四川益能康生环保科技有限公司 | 一种用于捕集二氧化碳的离子液体及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464380A (en) | 1983-05-25 | 1984-08-07 | Pfizer Inc. | Imidazolidinedione derivatives |
| PH30434A (en) | 1989-04-07 | 1997-05-09 | Janssen Pharmaceutica Nv | Hydroxyalkylfuranyl derivatives |
| ATE124045T1 (de) * | 1990-10-10 | 1995-07-15 | Schering Corp | Substituierte imidazobenzazepine und imidazopyridoazepine. |
| IL101850A (en) * | 1991-06-13 | 1996-01-31 | Janssen Pharmaceutica Nv | History 11-) 4-Pipridinyl (-Imidazo] B-1, 2 [] 3 [Benzazepine, their preparation and pharmaceutical preparations containing them |
| IL101851A (en) * | 1991-06-13 | 1996-05-14 | Janssen Pharmaceutica Nv | History 01 -) 4 - Pipridinyl - and Pipridinylidene (- Imidazo] A-1,2 [Pirolo, Thiano or Purano (] 3,2 [Azpin, their preparation and pharmaceutical preparations containing them and composition |
| US5106844A (en) * | 1991-09-10 | 1992-04-21 | Sterling Drug Inc. | Imidazo[2,2-b][3]benzazepine and pyrimido[2,1-b][3]benzazepine antiarrhythmic agents |
| TW382017B (en) * | 1995-12-27 | 2000-02-11 | Janssen Pharmaceutica Nv | 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives |
-
1999
- 1999-12-15 BR BR9916371-3A patent/BR9916371A/pt not_active Application Discontinuation
- 1999-12-15 UA UA2001064351A patent/UA74537C2/ru unknown
- 1999-12-15 AT AT99964625T patent/ATE294178T1/de active
- 1999-12-15 CN CNB998147052A patent/CN1258533C/zh not_active Expired - Lifetime
- 1999-12-15 ID IDW00200101298A patent/ID29268A/id unknown
- 1999-12-15 JP JP2000589540A patent/JP4601175B2/ja not_active Expired - Lifetime
- 1999-12-15 PT PT99964625T patent/PT1144411E/pt unknown
- 1999-12-15 TR TR2001/01711T patent/TR200101711T2/xx unknown
- 1999-12-15 ES ES99964625T patent/ES2242443T3/es not_active Expired - Lifetime
- 1999-12-15 DK DK99964625T patent/DK1144411T3/da active
- 1999-12-15 DE DE69925036T patent/DE69925036T2/de not_active Expired - Lifetime
- 1999-12-15 PL PL348295A patent/PL196262B1/pl unknown
- 1999-12-15 SK SK814-2001A patent/SK286158B6/sk not_active IP Right Cessation
- 1999-12-15 NZ NZ512870A patent/NZ512870A/en not_active IP Right Cessation
- 1999-12-15 IL IL14376799A patent/IL143767A0/xx not_active IP Right Cessation
- 1999-12-15 SI SI9930798T patent/SI1144411T1/xx unknown
- 1999-12-15 KR KR1020017005016A patent/KR100598725B1/ko active IP Right Grant
- 1999-12-15 US US09/868,535 patent/US7148214B1/en not_active Expired - Lifetime
- 1999-12-15 CZ CZ20012069A patent/CZ301953B6/cs not_active IP Right Cessation
- 1999-12-15 EP EP99964625A patent/EP1144411B1/en not_active Expired - Lifetime
- 1999-12-15 EE EEP200100328A patent/EE04917B1/xx unknown
- 1999-12-15 CA CA2355939A patent/CA2355939C/en not_active Expired - Lifetime
- 1999-12-15 EA EA200100681A patent/EA004500B1/ru not_active IP Right Cessation
- 1999-12-15 WO PCT/EP1999/010176 patent/WO2000037470A1/en active IP Right Grant
- 1999-12-15 HU HU0104779A patent/HU229406B1/hu unknown
- 1999-12-15 AU AU30412/00A patent/AU764820C/en not_active Expired
- 1999-12-17 MY MYPI99005537A patent/MY129663A/en unknown
- 1999-12-17 TW TW088122194A patent/TWI250981B/zh not_active IP Right Cessation
- 1999-12-17 CO CO99079021A patent/CO5140116A1/es unknown
- 1999-12-17 AR ARP990106513A patent/AR021888A1/es active IP Right Grant
- 1999-12-18 EG EG162699A patent/EG24605A/xx active
-
2000
- 2000-05-21 SA SA00210113A patent/SA00210113B1/ar unknown
-
2001
- 2001-05-29 BG BG105546A patent/BG65133B1/bg unknown
- 2001-06-01 NO NO20012710A patent/NO318891B1/no not_active IP Right Cessation
- 2001-06-15 HR HR20010453A patent/HRP20010453B1/xx not_active IP Right Cessation
- 2001-06-18 ZA ZA200104977A patent/ZA200104977B/en unknown
-
2002
- 2002-07-03 HK HK02104999.1A patent/HK1043128B/zh unknown
-
2004
- 2004-07-26 US US10/898,844 patent/US7087595B2/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |