HRP20000027B1 - Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds - Google Patents

Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds

Info

Publication number
HRP20000027B1
HRP20000027B1 HR20000027A HRP20000027A HRP20000027B1 HR P20000027 B1 HRP20000027 B1 HR P20000027B1 HR 20000027 A HR20000027 A HR 20000027A HR P20000027 A HRP20000027 A HR P20000027A HR P20000027 B1 HRP20000027 B1 HR P20000027B1
Authority
HR
Croatia
Prior art keywords
compounds
alkoxyfuranoneamine
derivatives
preparation
compounds obtained
Prior art date
Application number
HR20000027A
Other languages
English (en)
Inventor
Bouchet Raphael
Brion Francis
Colladant Colette
Lagouardat Jacques
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of HRP20000027A2 publication Critical patent/HRP20000027A2/hr
Publication of HRP20000027B1 publication Critical patent/HRP20000027B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Abstract

Spojevi, naznačeni time, što imaju formule (IVa),(IVb), (IVc) ili (IVd) ispod: gdje R1 je alkilna skupina koja sadržava od 1 do 4 ugljikova atoma ili fenilalkilna skupina koja sadržava od 7 do 11 ugljikovih atoma, kao i njihove adicijske soli s kiselinama. Patent sadrži još 18 patentnih zahtjeva.
HR20000027A 1997-07-15 2000-01-14 Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds HRP20000027B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9708932A FR2766188B1 (fr) 1997-07-15 1997-07-15 Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
PCT/FR1998/001480 WO1999003852A1 (fr) 1997-07-15 1998-07-09 Procede de preparation de derives amines d'alkyloxyfuranone, composes issus de ce procede et utilisation de ces composes

Publications (2)

Publication Number Publication Date
HRP20000027A2 HRP20000027A2 (en) 2000-10-31
HRP20000027B1 true HRP20000027B1 (en) 2006-07-31

Family

ID=9509210

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000027A HRP20000027B1 (en) 1997-07-15 2000-01-14 Process for the preparation of alkoxyfuranoneamine derivatives, compounds obtained by this process, and the use of these compounds

Country Status (34)

Country Link
US (1) US6235899B1 (hr)
EP (1) EP0998470B1 (hr)
JP (1) JP4450987B2 (hr)
KR (1) KR100519691B1 (hr)
CN (1) CN100363355C (hr)
AP (1) AP1071A (hr)
AR (1) AR015924A1 (hr)
AT (1) ATE239713T1 (hr)
AU (1) AU744272B2 (hr)
BG (1) BG64050B1 (hr)
BR (1) BR9810896A (hr)
CA (1) CA2296742C (hr)
CZ (1) CZ295312B6 (hr)
DE (1) DE69814395T2 (hr)
DK (1) DK0998470T3 (hr)
EA (1) EA002883B1 (hr)
EE (1) EE03873B1 (hr)
ES (1) ES2197489T3 (hr)
FR (1) FR2766188B1 (hr)
HR (1) HRP20000027B1 (hr)
HU (1) HU230148B1 (hr)
ID (1) ID23784A (hr)
IL (1) IL134031A (hr)
ME (1) ME01708B (hr)
NO (1) NO324508B1 (hr)
NZ (1) NZ502338A (hr)
PL (1) PL200820B1 (hr)
PT (1) PT998470E (hr)
RS (1) RS49832B (hr)
SK (1) SK284168B6 (hr)
TR (1) TR200000117T2 (hr)
UA (1) UA66364C2 (hr)
WO (1) WO1999003852A1 (hr)
ZA (1) ZA986203B (hr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053056B2 (en) 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
SK15592002A3 (sk) * 2000-04-24 2003-04-01 Vertex Pharmaceuticals Incorporated Spôsob a medziprodukty na prípravu substituovaných acetálov kyseliny aspartovej
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) * 2000-09-20 2003-11-19 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸誘導体の製造方法
JPWO2002055478A1 (ja) * 2001-01-16 2004-05-13 鐘淵化学工業株式会社 光学活性アミノラクトン誘導体の製造法およびその中間体
AR047981A1 (es) 2004-02-27 2006-03-15 Vertex Pharma Inhibidores de caspasa y sus usos correspondientes
KR101135765B1 (ko) 2004-03-12 2012-04-23 버텍스 파마슈티칼스 인코포레이티드 아스파르트산 아세탈 카스파아제 억제제의 제조를 위한방법 및 중간체

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme

Also Published As

Publication number Publication date
IL134031A (en) 2004-06-01
BG104073A (en) 2001-05-31
ME01708B (me) 2008-08-07
WO1999003852A1 (fr) 1999-01-28
CN1269795A (zh) 2000-10-11
JP4450987B2 (ja) 2010-04-14
CA2296742C (fr) 2009-12-08
PT998470E (pt) 2003-09-30
CA2296742A1 (fr) 1999-01-28
CZ295312B6 (cs) 2005-07-13
CN100363355C (zh) 2008-01-23
PL200820B1 (pl) 2009-02-27
CZ200065A3 (cs) 2000-07-12
YU1500A (sh) 2002-10-18
DE69814395T2 (de) 2003-12-11
NO20000182L (no) 2000-03-07
AU744272B2 (en) 2002-02-21
US6235899B1 (en) 2001-05-22
HUP0003857A2 (hu) 2001-04-28
ATE239713T1 (de) 2003-05-15
SK284168B6 (sk) 2004-10-05
UA66364C2 (uk) 2004-05-17
KR20010021834A (ko) 2001-03-15
AR015924A1 (es) 2001-05-30
EP0998470B1 (fr) 2003-05-07
EE03873B1 (et) 2002-10-15
DK0998470T3 (da) 2003-09-01
TR200000117T2 (tr) 2000-07-21
DE69814395D1 (de) 2003-06-12
ID23784A (id) 2000-05-11
HU230148B1 (hu) 2015-09-28
EE200000024A (et) 2000-10-16
AU8633398A (en) 1999-02-10
HRP20000027A2 (en) 2000-10-31
FR2766188A1 (fr) 1999-01-22
NZ502338A (en) 2001-09-28
NO324508B1 (no) 2007-11-05
EA200000127A1 (ru) 2000-08-28
FR2766188B1 (fr) 2000-02-11
BR9810896A (pt) 2000-09-26
RS49832B (sr) 2008-08-07
EA002883B1 (ru) 2002-10-31
EP0998470A1 (fr) 2000-05-10
NO20000182D0 (no) 2000-01-14
AP1071A (en) 2002-05-20
JP2001510191A (ja) 2001-07-31
SK302000A3 (en) 2000-11-07
HUP0003857A3 (en) 2002-08-28
KR100519691B1 (ko) 2005-10-13
AP2000001732A0 (en) 2000-03-31
ZA986203B (en) 1999-08-18
ES2197489T3 (es) 2004-01-01
BG64050B1 (bg) 2003-11-28
IL134031A0 (en) 2001-04-30
PL338035A1 (en) 2000-09-25

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
PPPP Transfer of rights

Owner name: AVENTIS PHARMA S.A., FR

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20170626

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20180709