HK4792A - Pyridine derivatives and their production - Google Patents

Pyridine derivatives and their production Download PDF

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Publication number
HK4792A
HK4792A HK47/92A HK4792A HK4792A HK 4792 A HK4792 A HK 4792A HK 47/92 A HK47/92 A HK 47/92A HK 4792 A HK4792 A HK 4792A HK 4792 A HK4792 A HK 4792A
Authority
HK
Hong Kong
Prior art keywords
compound
methyl
reaction
compound according
compounds
Prior art date
Application number
HK47/92A
Other languages
German (de)
English (en)
Inventor
Akira Nohara
Yoshitaka Maki
Original Assignee
Takeda Pharmaceutical Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15916456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK4792(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Company Limited filed Critical Takeda Pharmaceutical Company Limited
Publication of HK4792A publication Critical patent/HK4792A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/68—One oxygen atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Claims (11)

1. Composé de formule (I) dans laquelle R1 est l'hydrogène, un groupe méthoxy ou trifluorométhyle, R2 et R3, indépendamment l'un de l'autre, sont l'hydrogène ou le méthyle, R4 est un groupe alkyle fluoré en C1-4 et n représente le chiffre 0 ou 1, et un sel pharmacologiquement acceptable de ce composé.
2. Composé selon la revendication 1, dans lequel R1 est l'hydrogène.
3. Composé selon la revendication 1 ou 2, dans lequel R2 est le méthyle.
4. Composé selon l'une quelconque des revendications 1 à 3, dans lequel R3 est l'hydrogène.
5. Composé selon l'une quelconque des revendications 1 à 4, dans lequel R4 est un groupe alkyle fluoré en C1-2.
6. Composé selon la revendication 1, qui est le 2-(3-méthyl-4-(2,2,2-trifluoroéthoxy)-pyrid-2-yl)méthyl- sulfinylbenzimidazole.
7. Composé selon la revendication 1, qui est le 2-(3-méthyl-4-(2,2,3,3,3-pentafluoropropoxy)-pyrid-2-yl)méthylsulfinylbenzimidazole.
8. Composé selon la revendication 1, qui est le 2-(3-méthyl-4-(2,2,3,3-tétrafluoropropoxy)-pyrid-2-yl]-méthylsulfinylbenzimidazole.
9. Procédé de préparation d'un dérivé de pyridine selon la revendication 1, caractérisé en ce que l'on fait réagir un composé de formule (II) dans laquelle R1 a la même signification qu'indiqué à la revendication 1, avec un composé de formule (III) dans laquelle R2, R3 et R4 ont la même signification qu'indiqué à la revendication 1 et l'un de X1 et X2 est SH et l'autre est un groupe qui peut être éliminé, et s'il s'avère nécessaire, ou soumet le produit réactionnel à une oxydation.
10. Procédé selon la revendication 9, dans lequel X1 est SH et X2 est un I1 est SH et X2 est un halogène.
11. Composition pharmaceutique pour la prévention ou le traitement thérapeutique d'ulcères du tractus digestif, qui comprend, comme substance active, une quantité efficace d'un comosé ou de son sel, tels que défini à la revendication 1, et un véhicule, excipient ou diluant, pharmacologiquement acceptable pour celui-ci.
HK47/92A 1984-08-16 1992-01-16 Pyridine derivatives and their production HK4792A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59171069A JPS6150978A (ja) 1984-08-16 1984-08-16 ピリジン誘導体およびその製造法

Publications (1)

Publication Number Publication Date
HK4792A true HK4792A (en) 1992-01-17

Family

ID=15916456

Family Applications (1)

Application Number Title Priority Date Filing Date
HK47/92A HK4792A (en) 1984-08-16 1992-01-16 Pyridine derivatives and their production

Country Status (23)

Country Link
US (2) US4628098A (fr)
EP (1) EP0174726B1 (fr)
JP (1) JPS6150978A (fr)
KR (1) KR920002128B1 (fr)
AU (1) AU570130B2 (fr)
BG (1) BG60415B2 (fr)
CA (1) CA1255314A (fr)
DE (3) DE19975020I2 (fr)
DK (1) DK171340B1 (fr)
ES (1) ES8607288A1 (fr)
GE (1) GEP19960313B (fr)
GR (1) GR851981B (fr)
HK (1) HK4792A (fr)
HU (1) HU195210B (fr)
IE (1) IE58363B1 (fr)
MX (1) MX9203043A (fr)
NL (1) NL930109I2 (fr)
NO (2) NO163131C (fr)
PH (1) PH20946A (fr)
SG (1) SG103291G (fr)
SU (1) SU1507211A3 (fr)
UA (1) UA7140A1 (fr)
ZA (1) ZA856117B (fr)

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US4689333A (en) 1987-08-25
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