HK35597A - New phospholipid derivatives of nucleosides their preparation and their use as antiviral drugs - Google Patents

New phospholipid derivatives of nucleosides their preparation and their use as antiviral drugs

Info

Publication number
HK35597A
HK35597A HK35597A HK35597A HK35597A HK 35597 A HK35597 A HK 35597A HK 35597 A HK35597 A HK 35597A HK 35597 A HK35597 A HK 35597A HK 35597 A HK35597 A HK 35597A
Authority
HK
Hong Kong
Prior art keywords
preparation
nucleosides
antiviral drugs
phospholipid derivatives
new phospholipid
Prior art date
Application number
HK35597A
Other languages
English (en)
Inventor
Harald Zilch
Herbert Leinert
Alfred Mertens
Dieter Herrmann
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25896049&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK35597(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of HK35597A publication Critical patent/HK35597A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK35597A 1990-08-20 1997-03-20 New phospholipid derivatives of nucleosides their preparation and their use as antiviral drugs HK35597A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4026265A DE4026265A1 (de) 1990-08-20 1990-08-20 Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
PCT/EP1991/001541 WO1992003462A1 (fr) 1990-08-20 1991-08-14 Nouveaux derives phospholipidiques de nucleosides, leur production et leur utilisation comme medicaments antiviraux
US08/661,038 US5756711A (en) 1990-08-20 1996-06-10 Phospholipid derivatives of nucleosides and their use as anti-viral medicaments

Publications (1)

Publication Number Publication Date
HK35597A true HK35597A (en) 1997-03-27

Family

ID=25896049

Family Applications (1)

Application Number Title Priority Date Filing Date
HK35597A HK35597A (en) 1990-08-20 1997-03-20 New phospholipid derivatives of nucleosides their preparation and their use as antiviral drugs

Country Status (15)

Country Link
US (1) US5756711A (fr)
EP (1) EP0545966B1 (fr)
CN (1) CN1032258C (fr)
AT (1) ATE114316T1 (fr)
CA (1) CA2090024C (fr)
DE (2) DE4026265A1 (fr)
DK (1) DK0545966T3 (fr)
ES (1) ES2066461T3 (fr)
FI (1) FI104176B (fr)
HK (1) HK35597A (fr)
IE (1) IE64374B1 (fr)
NO (1) NO179710C (fr)
PT (1) PT98720B (fr)
SK (1) SK281826B6 (fr)
WO (1) WO1992003462A1 (fr)

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US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
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DE4204032A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
US6080734A (en) * 1992-08-08 2000-06-27 Roche Diagnostic Gmbh Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents
DE4226279A1 (de) * 1992-08-08 1994-02-10 Boehringer Mannheim Gmbh Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
DE69431596D1 (de) * 1993-06-10 2002-11-28 Wake Forest University Winston (phospho)lipide zum bekämpfen einer hepatitis b-infektion
KR0125779B1 (ko) * 1993-12-04 1997-12-19 김승호 뉴클레오시드 화합물 및 이의 제조방법
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US7135584B2 (en) 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
US5962437A (en) 1994-08-29 1999-10-05 Wake Forest University Lipid analogs for treating viral infections
NZ295682A (en) * 1994-11-12 1999-09-29 Roche Diagnostics Gmbh Change Lipid cleavage enzyme complex and use in diagnostic testing to identify compounds that act as a ligand or substrate of the complex
DE19505168A1 (de) * 1995-02-16 1996-08-22 Boehringer Mannheim Gmbh Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel
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DE19547022A1 (de) * 1995-12-15 1997-06-19 Boehringer Mannheim Gmbh Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
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US9512125B2 (en) * 2004-11-19 2016-12-06 The Regents Of The University Of California Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
WO2006066074A2 (fr) * 2004-12-16 2006-06-22 The Regents Of The University Of California Medicaments destines au poumon
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WO2009046448A1 (fr) * 2007-10-04 2009-04-09 Intellikine, Inc. Entités chimiques et leurs utilisations thérapeutiques
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EP2240452B1 (fr) 2008-01-04 2019-05-29 Intellikine, LLC Dérivés de 1h-pyrazolo[3,4-d]pyrimidin-4-amine en tant que modulateurs de kinase pi3, leurs compositions et utilisations
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US8476431B2 (en) 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
JP5789252B2 (ja) 2009-05-07 2015-10-07 インテリカイン， エルエルシー 複素環式化合物およびその使用
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Also Published As

Publication number Publication date
CN1032258C (zh) 1996-07-10
DE59103595D1 (de) 1995-01-05
ATE114316T1 (de) 1994-12-15
SK281826B6 (sk) 2001-08-06
NO179710C (no) 1996-12-04
DE4026265A1 (de) 1992-02-27
DK0545966T3 (da) 1995-05-08
PT98720B (pt) 1999-02-26
CA2090024A1 (fr) 1992-02-21
IE912930A1 (en) 1992-02-26
CN1059149A (zh) 1992-03-04
AU8325191A (en) 1992-03-17
CA2090024C (fr) 2000-05-02
NO930587L (no) 1993-02-19
IE64374B1 (en) 1995-07-26
NO179710B (no) 1996-08-26
FI104176B1 (fi) 1999-11-30
PT98720A (pt) 1992-07-31
FI104176B (fi) 1999-11-30
FI930753A0 (fi) 1993-02-19
SK9293A3 (en) 1993-07-07
AU654670B2 (en) 1994-11-17
ES2066461T3 (es) 1995-03-01
FI930753A (fi) 1993-02-19
EP0545966A1 (fr) 1993-06-16
US5756711A (en) 1998-05-26
EP0545966B1 (fr) 1994-11-23
NO930587D0 (no) 1993-02-19
WO1992003462A1 (fr) 1992-03-05

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090814