ES2066461T3 - Nuevos derivados fosfolipidicos de nucleosidos, su preparacion, asi como su utilizacion como medicamentos antiviricos. - Google Patents

Nuevos derivados fosfolipidicos de nucleosidos, su preparacion, asi como su utilizacion como medicamentos antiviricos.

Info

Publication number
ES2066461T3
ES2066461T3 ES91914553T ES91914553T ES2066461T3 ES 2066461 T3 ES2066461 T3 ES 2066461T3 ES 91914553 T ES91914553 T ES 91914553T ES 91914553 T ES91914553 T ES 91914553T ES 2066461 T3 ES2066461 T3 ES 2066461T3
Authority
ES
Spain
Prior art keywords
preparation
well
antiviric
phospholipidic
nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91914553T
Other languages
English (en)
Inventor
Harald Zilch
Herbert Leinert
Alfred Mertens
Dieter Herrmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25896049&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2066461(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of ES2066461T3 publication Critical patent/ES2066461T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

COMPUESTOS DE LA FORMULA (I), DONDE R1 Y R2 SON UNA CADENA C8 C15 2 Y A ES UN RESTO NUCLEOTIDO, METODO PARA SU PREPARACION Y MEDICAMENTOS DE ACCION ANTIVIRAL QUE CONTIENEN ESTOS COMPUESTOS.
ES91914553T 1990-08-20 1991-08-14 Nuevos derivados fosfolipidicos de nucleosidos, su preparacion, asi como su utilizacion como medicamentos antiviricos. Expired - Lifetime ES2066461T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4026265A DE4026265A1 (de) 1990-08-20 1990-08-20 Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
US08/661,038 US5756711A (en) 1990-08-20 1996-06-10 Phospholipid derivatives of nucleosides and their use as anti-viral medicaments

Publications (1)

Publication Number Publication Date
ES2066461T3 true ES2066461T3 (es) 1995-03-01

Family

ID=25896049

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91914553T Expired - Lifetime ES2066461T3 (es) 1990-08-20 1991-08-14 Nuevos derivados fosfolipidicos de nucleosidos, su preparacion, asi como su utilizacion como medicamentos antiviricos.

Country Status (15)

Country Link
US (1) US5756711A (es)
EP (1) EP0545966B1 (es)
CN (1) CN1032258C (es)
AT (1) ATE114316T1 (es)
CA (1) CA2090024C (es)
DE (2) DE4026265A1 (es)
DK (1) DK0545966T3 (es)
ES (1) ES2066461T3 (es)
FI (1) FI104176B1 (es)
HK (1) HK35597A (es)
IE (1) IE64374B1 (es)
NO (1) NO179710C (es)
PT (1) PT98720B (es)
SK (1) SK281826B6 (es)
WO (1) WO1992003462A1 (es)

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US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
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DE4204032A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue liponucleotide, deren herstellunmg sowie deren verwendung als antivirale arzneimittel
DE4204031A1 (de) * 1992-02-12 1993-08-19 Boehringer Mannheim Gmbh Neue lipidphosphonsaeure-nucleosid-konjugate sowie deren verwendung als antivirale arzneimittel
US6080734A (en) * 1992-08-08 2000-06-27 Roche Diagnostic Gmbh Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents
DE4226279A1 (de) * 1992-08-08 1994-02-10 Boehringer Mannheim Gmbh Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
AU7044894A (en) * 1993-06-10 1995-01-03 University Of North Carolina At Chapel Hill, The (phospho)lipids for combatting hepatitis b virus infection
KR0125779B1 (ko) * 1993-12-04 1997-12-19 김승호 뉴클레오시드 화합물 및 이의 제조방법
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
US5962437A (en) 1994-08-29 1999-10-05 Wake Forest University Lipid analogs for treating viral infections
US7135584B2 (en) 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
ES2239761T3 (es) * 1994-11-12 2005-10-01 Heidelberg Pharma Gmbh Complejo de enzima que desdobla lipidos.
DE19505168A1 (de) * 1995-02-16 1996-08-22 Boehringer Mannheim Gmbh Spezifische Lipidkonjugate von Nucleosid-Diphosphonaten und deren Verwendung als Arzneimittel
TW343975B (en) * 1995-12-15 1998-11-01 Boehringer Mannheim Gmbh New phospholipid derivatives of phosphonocarboxylic acids, the production thereof as well as their use as antiviral pharmaceutical agents
DE19547022A1 (de) * 1995-12-15 1997-06-19 Boehringer Mannheim Gmbh Kovalente Lipid-Phosphonocarbonsäure-Konjugate, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
DE19602757A1 (de) 1996-01-26 1997-07-31 Boehringer Mannheim Gmbh Feste Instant-Release-Darreichungsformen und Verfahren zu ihrer Herstellung
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WO2006068760A2 (en) * 2004-11-19 2006-06-29 The Regents Of The University Of California Anti-inflammatory pyrazolopyrimidines
ES2401285T3 (es) * 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
AU2005321239B2 (en) 2004-12-30 2009-02-12 Medivir Ab Compounds useful in the treatment of HIV
EP2842559A3 (en) 2005-04-08 2015-03-18 Chimerix, Inc. Compounds, compositions and methods for the treatment of viral infections and other medical disorders
US8642577B2 (en) 2005-04-08 2014-02-04 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
NO324263B1 (no) 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US7585868B2 (en) * 2006-04-04 2009-09-08 The Regents Of The University Of California Substituted pyrazolo[3,4-D]pyrimidines as kinase antagonists
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US7378401B2 (en) 2006-07-14 2008-05-27 Heidelberg Pharma Gmbh Use of Fosfluridine Tidoxil (FT) for the treatment of intraepithelial proliferative diseases
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US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
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Also Published As

Publication number Publication date
FI104176B (fi) 1999-11-30
WO1992003462A1 (de) 1992-03-05
PT98720A (pt) 1992-07-31
SK9293A3 (en) 1993-07-07
NO179710C (no) 1996-12-04
AU654670B2 (en) 1994-11-17
FI930753A0 (fi) 1993-02-19
CN1032258C (zh) 1996-07-10
SK281826B6 (sk) 2001-08-06
PT98720B (pt) 1999-02-26
ATE114316T1 (de) 1994-12-15
FI930753A (fi) 1993-02-19
DK0545966T3 (da) 1995-05-08
IE64374B1 (en) 1995-07-26
CN1059149A (zh) 1992-03-04
HK35597A (en) 1997-03-27
CA2090024C (en) 2000-05-02
AU8325191A (en) 1992-03-17
FI104176B1 (fi) 1999-11-30
DE4026265A1 (de) 1992-02-27
IE912930A1 (en) 1992-02-26
DE59103595D1 (de) 1995-01-05
EP0545966A1 (de) 1993-06-16
NO930587D0 (no) 1993-02-19
EP0545966B1 (de) 1994-11-23
NO930587L (no) 1993-02-19
CA2090024A1 (en) 1992-02-21
US5756711A (en) 1998-05-26
NO179710B (no) 1996-08-26

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