DK291390A - Terapeutiske anvendelser af 2',5'-oligoadenylatderivater - Google Patents

Terapeutiske anvendelser af 2',5'-oligoadenylatderivater Download PDF

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Publication number
DK291390A
DK291390A DK291390A DK291390A DK291390A DK 291390 A DK291390 A DK 291390A DK 291390 A DK291390 A DK 291390A DK 291390 A DK291390 A DK 291390A DK 291390 A DK291390 A DK 291390A
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DK
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Prior art keywords
therapeutic applications
oligoadenylate
derivatives
analogs
oligoadenylate derivatives
Prior art date
Application number
DK291390A
Other languages
English (en)
Other versions
DK291390D0 (da
DK174025B1 (da
Inventor
Robert J Suhadolnik
Wolfgang Pfleiderer
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Publication of DK291390A publication Critical patent/DK291390A/da
Publication of DK291390D0 publication Critical patent/DK291390D0/da
Application granted granted Critical
Publication of DK174025B1 publication Critical patent/DK174025B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK199002913A 1988-06-09 1990-12-07 Anvendelse af visse 2',5'-oligoadenylatanaloger til fremstilling af et lægemiddel mod retrovirusinfektioner, hidtil ukendte blandt en sådan type forbindelser, også til anvendelse ved behandling af en retrovirusinfektion, samt anvendelse af ........ DK174025B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20465988A 1988-06-09 1988-06-09
US20465988 1988-06-09
PCT/US1989/002284 WO1989012380A2 (en) 1988-06-09 1989-05-24 Therapeutic uses of 2',5'-oligoadenylate derivatives
US8902284 1989-05-24

Publications (3)

Publication Number Publication Date
DK291390A true DK291390A (da) 1990-12-07
DK291390D0 DK291390D0 (da) 1990-12-07
DK174025B1 DK174025B1 (da) 2002-04-29

Family

ID=22758878

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199002913A DK174025B1 (da) 1988-06-09 1990-12-07 Anvendelse af visse 2',5'-oligoadenylatanaloger til fremstilling af et lægemiddel mod retrovirusinfektioner, hidtil ukendte blandt en sådan type forbindelser, også til anvendelse ved behandling af en retrovirusinfektion, samt anvendelse af ........

Country Status (14)

Country Link
EP (2) EP0716856B1 (da)
JP (1) JP2947580B2 (da)
KR (1) KR0141684B1 (da)
CN (1) CN1107508C (da)
AT (2) ATE141796T1 (da)
AU (1) AU637975B2 (da)
CA (1) CA1335356C (da)
DE (2) DE68927055T2 (da)
DK (1) DK174025B1 (da)
ES (1) ES2016464A6 (da)
IL (1) IL90499A (da)
NZ (1) NZ229422A (da)
PT (1) PT90816B (da)
WO (1) WO1989012380A2 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550111A (en) * 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
PH30703A (en) * 1990-06-21 1997-09-16 Patrick T Prendergast Administering particular compounds against variousparasites, mycoplasmas, other indications and otheer indications and other infections.
US5594121A (en) * 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
AU6632094A (en) * 1993-04-19 1994-11-08 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
US6362171B1 (en) 1997-06-12 2002-03-26 Temple University-Of The Commonwealth System Of Higher Education Aminoaklanoyl-linked conjugates of 2′,5′-oligoadenylate and antiviral uses thereof
WO1998056385A1 (en) 1997-06-12 1998-12-17 Temple University - Of The Commonwealth System Of Higher Education Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof
AU5429000A (en) * 1999-06-25 2001-01-31 Sankyo Company Limited Novel bicyclonucleoside derivatives
TWI347948B (en) 2002-11-19 2011-09-01 Sankyo Co Novel 2',5'-oligoadenylic acid compositions
GB201019043D0 (en) 2010-11-10 2010-12-22 Protea Biopharma N V Use of 2',5'-oligoadenylate derivative compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210746A (en) * 1978-08-10 1980-07-01 National Research Development Corporation Nucleotide inhibitor of protein synthesis
US4464359A (en) * 1981-04-10 1984-08-07 Research Corporation (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
US4539313A (en) * 1981-04-10 1985-09-03 Research Corporation (2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof
US4824941A (en) * 1983-03-10 1989-04-25 Julian Gordon Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
US4859768A (en) * 1984-07-11 1989-08-22 Temple University Of The Commonwealth System Of Higher Education Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof
US4654326A (en) * 1984-07-12 1987-03-31 Yair Devash Inhibition of plant viruses with oligonucleotides

Also Published As

Publication number Publication date
EP0420872B1 (en) 1996-08-28
AU3740389A (en) 1990-01-12
DE68927055T2 (de) 1997-04-10
NZ229422A (en) 1992-12-23
JPH03504970A (ja) 1991-10-31
KR0141684B1 (ko) 1998-06-01
WO1989012380A3 (en) 1990-06-28
CA1335356C (en) 1995-04-25
EP0420872A4 (en) 1992-10-21
KR900701279A (ko) 1990-12-01
DK291390D0 (da) 1990-12-07
WO1989012380A2 (en) 1989-12-28
DK174025B1 (da) 2002-04-29
EP0716856B1 (en) 2001-08-29
AU637975B2 (en) 1993-06-17
PT90816A (pt) 1989-12-29
EP0420872A1 (en) 1991-04-10
DE68929321T2 (de) 2002-05-08
IL90499A0 (en) 1990-01-18
CN1040321A (zh) 1990-03-14
IL90499A (en) 1994-05-30
ES2016464A6 (es) 1990-11-01
EP0716856A2 (en) 1996-06-19
DE68927055D1 (de) 1996-10-02
DE68929321D1 (de) 2001-10-04
CN1107508C (zh) 2003-05-07
ATE204752T1 (de) 2001-09-15
EP0716856A3 (en) 1996-10-30
PT90816B (pt) 1994-11-30
JP2947580B2 (ja) 1999-09-13
ATE141796T1 (de) 1996-09-15

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B1 Patent granted (law 1993)
PBP Patent lapsed

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