ATE204752T1 - Therapeutische anwendungen von 2',5'- oligoadenylat-derivaten - Google Patents
Therapeutische anwendungen von 2',5'- oligoadenylat-derivatenInfo
- Publication number
- ATE204752T1 ATE204752T1 AT96101815T AT96101815T ATE204752T1 AT E204752 T1 ATE204752 T1 AT E204752T1 AT 96101815 T AT96101815 T AT 96101815T AT 96101815 T AT96101815 T AT 96101815T AT E204752 T1 ATE204752 T1 AT E204752T1
- Authority
- AT
- Austria
- Prior art keywords
- therapeutic uses
- oligoadenylate
- derivatives
- analogs
- oligoadenylate derivatives
- Prior art date
Links
- SIIZPVYVXNXXQG-KGXOGWRBSA-N [(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-4-[[(3s,4r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methyl [(2r,4r,5r)-2-(6-aminopurin-9-yl)-4-hydroxy-5-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate Chemical class C1=NC2=C(N)N=CN=C2N1[C@@H]1O[C@H](COP(O)(=O)OC2[C@@H](O[C@H](COP(O)(O)=O)[C@H]2O)N2C3=NC=NC(N)=C3N=C2)[C@@H](O)[C@H]1OP(O)(=O)OCC([C@@H](O)[C@H]1O)OC1N1C(N=CN=C2N)=C2N=C1 SIIZPVYVXNXXQG-KGXOGWRBSA-N 0.000 title abstract 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000824 D-ribofuranosyl group Chemical group [H]OC([H])([H])[C@@]1([H])OC([H])(*)[C@]([H])(O[H])[C@]1([H])O[H] 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical group 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical group N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Botany (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20465988A | 1988-06-09 | 1988-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE204752T1 true ATE204752T1 (de) | 2001-09-15 |
Family
ID=22758878
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89906575T ATE141796T1 (de) | 1988-06-09 | 1989-05-24 | 2',5'-oligoadenylat-derivate zur verwendung als heilmittel |
| AT96101815T ATE204752T1 (de) | 1988-06-09 | 1989-05-24 | Therapeutische anwendungen von 2',5'- oligoadenylat-derivaten |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89906575T ATE141796T1 (de) | 1988-06-09 | 1989-05-24 | 2',5'-oligoadenylat-derivate zur verwendung als heilmittel |
Country Status (14)
| Country | Link |
|---|---|
| EP (2) | EP0716856B1 (de) |
| JP (1) | JP2947580B2 (de) |
| KR (1) | KR0141684B1 (de) |
| CN (1) | CN1107508C (de) |
| AT (2) | ATE141796T1 (de) |
| AU (1) | AU637975B2 (de) |
| CA (1) | CA1335356C (de) |
| DE (2) | DE68929321T2 (de) |
| DK (1) | DK174025B1 (de) |
| ES (1) | ES2016464A6 (de) |
| IL (1) | IL90499A (de) |
| NZ (1) | NZ229422A (de) |
| PT (1) | PT90816B (de) |
| WO (1) | WO1989012380A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550111A (en) * | 1984-07-11 | 1996-08-27 | Temple University-Of The Commonwealth System Of Higher Education | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof |
| IE882585L (en) * | 1988-08-25 | 1990-02-25 | Prendergast Patrick T | Viral treatment system |
| PH30703A (en) * | 1990-06-21 | 1997-09-16 | Patrick T Prendergast | Administering particular compounds against variousparasites, mycoplasmas, other indications and otheer indications and other infections. |
| US5594121A (en) * | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| AU6632094A (en) * | 1993-04-19 | 1994-11-08 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| US6281201B1 (en) | 1997-06-12 | 2001-08-28 | Temple University- Of The Commonwealth System Of Higher Education | Base-modified derivatives of 2′,5′-oligoadenylate and antiviral uses thereof |
| AU7710398A (en) | 1997-06-12 | 1998-12-30 | Temple University - Of The Commonwealth System Of Higher Education | Aminoaklanoyl-linked conjugates of 2',5'-oligoadenylate and antiviral uses thereof |
| WO2001000641A1 (fr) * | 1999-06-25 | 2001-01-04 | Sankyo Company, Limited | Nouveaux dérivés de bicyclonucléoside |
| TWI347948B (en) | 2002-11-19 | 2011-09-01 | Sankyo Co | Novel 2',5'-oligoadenylic acid compositions |
| GB201019043D0 (en) | 2010-11-10 | 2010-12-22 | Protea Biopharma N V | Use of 2',5'-oligoadenylate derivative compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210746A (en) * | 1978-08-10 | 1980-07-01 | National Research Development Corporation | Nucleotide inhibitor of protein synthesis |
| US4464359A (en) * | 1981-04-10 | 1984-08-07 | Research Corporation | (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof |
| US4539313A (en) | 1981-04-10 | 1985-09-03 | Research Corporation | (2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof |
| US4824941A (en) * | 1983-03-10 | 1989-04-25 | Julian Gordon | Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems |
| US4859768A (en) * | 1984-07-11 | 1989-08-22 | Temple University Of The Commonwealth System Of Higher Education | Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof |
| US4654326A (en) * | 1984-07-12 | 1987-03-31 | Yair Devash | Inhibition of plant viruses with oligonucleotides |
-
1989
- 1989-05-24 AT AT89906575T patent/ATE141796T1/de not_active IP Right Cessation
- 1989-05-24 EP EP96101815A patent/EP0716856B1/de not_active Expired - Lifetime
- 1989-05-24 DE DE68929321T patent/DE68929321T2/de not_active Expired - Fee Related
- 1989-05-24 EP EP89906575A patent/EP0420872B1/de not_active Expired - Lifetime
- 1989-05-24 WO PCT/US1989/002284 patent/WO1989012380A2/en not_active Ceased
- 1989-05-24 AU AU37403/89A patent/AU637975B2/en not_active Ceased
- 1989-05-24 DE DE68927055T patent/DE68927055T2/de not_active Expired - Fee Related
- 1989-05-24 KR KR1019900700257A patent/KR0141684B1/ko not_active Expired - Fee Related
- 1989-05-24 JP JP1506395A patent/JP2947580B2/ja not_active Expired - Fee Related
- 1989-05-24 AT AT96101815T patent/ATE204752T1/de not_active IP Right Cessation
- 1989-06-01 IL IL9049989A patent/IL90499A/en not_active IP Right Cessation
- 1989-06-08 ES ES8901996A patent/ES2016464A6/es not_active Expired - Lifetime
- 1989-06-09 CA CA000602302A patent/CA1335356C/en not_active Expired - Fee Related
- 1989-06-09 PT PT90816A patent/PT90816B/pt not_active IP Right Cessation
- 1989-06-09 CN CN89106235A patent/CN1107508C/zh not_active Expired - Fee Related
- 1989-10-06 NZ NZ229422A patent/NZ229422A/xx unknown
-
1990
- 1990-12-07 DK DK199002913A patent/DK174025B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR0141684B1 (ko) | 1998-06-01 |
| IL90499A0 (en) | 1990-01-18 |
| EP0716856B1 (de) | 2001-08-29 |
| CA1335356C (en) | 1995-04-25 |
| PT90816B (pt) | 1994-11-30 |
| IL90499A (en) | 1994-05-30 |
| ES2016464A6 (es) | 1990-11-01 |
| PT90816A (pt) | 1989-12-29 |
| DE68929321D1 (de) | 2001-10-04 |
| NZ229422A (en) | 1992-12-23 |
| EP0716856A2 (de) | 1996-06-19 |
| EP0716856A3 (de) | 1996-10-30 |
| AU637975B2 (en) | 1993-06-17 |
| EP0420872A1 (de) | 1991-04-10 |
| JPH03504970A (ja) | 1991-10-31 |
| EP0420872B1 (de) | 1996-08-28 |
| CN1040321A (zh) | 1990-03-14 |
| EP0420872A4 (en) | 1992-10-21 |
| DE68927055T2 (de) | 1997-04-10 |
| DK174025B1 (da) | 2002-04-29 |
| WO1989012380A2 (en) | 1989-12-28 |
| JP2947580B2 (ja) | 1999-09-13 |
| AU3740389A (en) | 1990-01-12 |
| DE68927055D1 (de) | 1996-10-02 |
| CN1107508C (zh) | 2003-05-07 |
| ATE141796T1 (de) | 1996-09-15 |
| DK291390A (da) | 1990-12-07 |
| DE68929321T2 (de) | 2002-05-08 |
| KR900701279A (ko) | 1990-12-01 |
| DK291390D0 (da) | 1990-12-07 |
| WO1989012380A3 (en) | 1990-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |