IL90499A - Pharmaceutical preparations containing analog (2, (5-oligoadnyl) - Google Patents

Pharmaceutical preparations containing analog (2, (5-oligoadnyl)

Info

Publication number
IL90499A
IL90499A IL9049989A IL9049989A IL90499A IL 90499 A IL90499 A IL 90499A IL 9049989 A IL9049989 A IL 9049989A IL 9049989 A IL9049989 A IL 9049989A IL 90499 A IL90499 A IL 90499A
Authority
IL
Israel
Prior art keywords
adenylyl
compound
composition according
deoxyadenylyl
deoxyadenosine
Prior art date
Application number
IL9049989A
Other languages
English (en)
Hebrew (he)
Other versions
IL90499A0 (en
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Priority to IL10670989A priority Critical patent/IL106709A/en
Publication of IL90499A0 publication Critical patent/IL90499A0/xx
Priority to IL106709A priority patent/IL106709A0/xx
Publication of IL90499A publication Critical patent/IL90499A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IL9049989A 1988-06-09 1989-06-01 Pharmaceutical preparations containing analog (2, (5-oligoadnyl) IL90499A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL10670989A IL106709A (en) 1988-06-09 1989-06-01 Antiviral preparations containing viruses containing 2,5-oligoadnylates
IL106709A IL106709A0 (en) 1988-06-09 1993-08-16 Therapeutic uses of 2',5'-oligoadenylates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20465988A 1988-06-09 1988-06-09

Publications (2)

Publication Number Publication Date
IL90499A0 IL90499A0 (en) 1990-01-18
IL90499A true IL90499A (en) 1994-05-30

Family

ID=22758878

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9049989A IL90499A (en) 1988-06-09 1989-06-01 Pharmaceutical preparations containing analog (2, (5-oligoadnyl)

Country Status (14)

Country Link
EP (2) EP0716856B1 (de)
JP (1) JP2947580B2 (de)
KR (1) KR0141684B1 (de)
CN (1) CN1107508C (de)
AT (2) ATE141796T1 (de)
AU (1) AU637975B2 (de)
CA (1) CA1335356C (de)
DE (2) DE68927055T2 (de)
DK (1) DK174025B1 (de)
ES (1) ES2016464A6 (de)
IL (1) IL90499A (de)
NZ (1) NZ229422A (de)
PT (1) PT90816B (de)
WO (1) WO1989012380A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550111A (en) * 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
IE882585L (en) * 1988-08-25 1990-02-25 Prendergast Patrick T Viral treatment system
AU7920491A (en) * 1990-06-21 1992-01-02 Patrick T. Prendergast Administering particular compounds against various parasites, mycoplasmas, other indications and other infections
US5594121A (en) * 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
EP0695306A1 (de) * 1993-04-19 1996-02-07 Gilead Sciences, Inc. Erhoehte bildung von tripel-und doppel-helix mit modifizierte purine enthaltenden oligomeren
WO1998056384A1 (en) 1997-06-12 1998-12-17 Temple University - Of The Commonwealth System Of Higher Education Aminoaklanoyl-linked conjugates of 2',5'-oligoadenylate and antiviral uses thereof
US6281201B1 (en) 1997-06-12 2001-08-28 Temple University- Of The Commonwealth System Of Higher Education Base-modified derivatives of 2′,5′-oligoadenylate and antiviral uses thereof
AU5429000A (en) * 1999-06-25 2001-01-31 Sankyo Company Limited Novel bicyclonucleoside derivatives
TWI347948B (en) * 2002-11-19 2011-09-01 Sankyo Co Novel 2',5'-oligoadenylic acid compositions
GB201019043D0 (en) 2010-11-10 2010-12-22 Protea Biopharma N V Use of 2',5'-oligoadenylate derivative compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4210746A (en) * 1978-08-10 1980-07-01 National Research Development Corporation Nucleotide inhibitor of protein synthesis
US4539313A (en) * 1981-04-10 1985-09-03 Research Corporation (2'-5')-Oligo (3'-deoxyandenylate) and derivatives thereof
US4464359A (en) * 1981-04-10 1984-08-07 Research Corporation (2'-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
US4824941A (en) * 1983-03-10 1989-04-25 Julian Gordon Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5'-oligonucleotides in biological systems
US4859768A (en) * 1984-07-11 1989-08-22 Temple University Of The Commonwealth System Of Higher Education Derivatives of 2', 5'-oligoadenylate and antiviral uses thereof
US4654326A (en) * 1984-07-12 1987-03-31 Yair Devash Inhibition of plant viruses with oligonucleotides

Also Published As

Publication number Publication date
NZ229422A (en) 1992-12-23
EP0716856A3 (de) 1996-10-30
JPH03504970A (ja) 1991-10-31
CN1107508C (zh) 2003-05-07
PT90816A (pt) 1989-12-29
DK174025B1 (da) 2002-04-29
AU637975B2 (en) 1993-06-17
DE68929321D1 (de) 2001-10-04
EP0420872A1 (de) 1991-04-10
CN1040321A (zh) 1990-03-14
DE68927055D1 (de) 1996-10-02
EP0716856A2 (de) 1996-06-19
JP2947580B2 (ja) 1999-09-13
PT90816B (pt) 1994-11-30
EP0420872A4 (en) 1992-10-21
KR0141684B1 (ko) 1998-06-01
WO1989012380A3 (en) 1990-06-28
DE68929321T2 (de) 2002-05-08
WO1989012380A2 (en) 1989-12-28
IL90499A0 (en) 1990-01-18
ATE204752T1 (de) 2001-09-15
EP0716856B1 (de) 2001-08-29
DK291390A (da) 1990-12-07
CA1335356C (en) 1995-04-25
DK291390D0 (da) 1990-12-07
KR900701279A (ko) 1990-12-01
DE68927055T2 (de) 1997-04-10
EP0420872B1 (de) 1996-08-28
AU3740389A (en) 1990-01-12
ATE141796T1 (de) 1996-09-15
ES2016464A6 (es) 1990-11-01

Similar Documents

Publication Publication Date Title
US5550111A (en) Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
US5643889A (en) Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
EP0694559B1 (de) 2'-5'-Phosphorothioat-Oligoadenylate und deren antivirale Verwendungen
US5700785A (en) 3'-deoxy or 3'-O-substituted-2',5'-oligoadenylates as antiviral agents
CA1335356C (en) Therapeutic uses of 2',5'-oligoadenylates
WO1998056385A1 (en) Base-modified derivatives of 2',5'-oligoadenylate and antiviral uses thereof
EP0777485B1 (de) 2',5'-phosphorthioat/phosphodiester-oligoadenylate und ihre antiviralen verwendungen
EP0630249B1 (de) Antivirale 2',5'-oligoadenylatderivate mit doppelter wirkung und ihre verwendungen
IL106709A (en) Antiviral preparations containing viruses containing 2,5-oligoadnylates
NZ240169A (en) The use of 2',5'-olioadenylates to treat virus infections
IE83348B1 (en) Therapeutic uses of 2',5'-oligoadenylate derivatives
WO1998056384A1 (en) Aminoaklanoyl-linked conjugates of 2',5'-oligoadenylate and antiviral uses thereof

Legal Events

Date Code Title Description
KB Patent renewed
RH1 Patent not in force