NO932287L - 2'-deosky-2',2'-difluor(2,6,8-substituerte)purin-nukleosider med antiviralog anticanceraktivitet, og mellomprodukter - Google Patents

2'-deosky-2',2'-difluor(2,6,8-substituerte)purin-nukleosider med antiviralog anticanceraktivitet, og mellomprodukter

Info

Publication number
NO932287L
NO932287L NO932287A NO932287A NO932287L NO 932287 L NO932287 L NO 932287L NO 932287 A NO932287 A NO 932287A NO 932287 A NO932287 A NO 932287A NO 932287 L NO932287 L NO 932287L
Authority
NO
Norway
Prior art keywords
difluoro
intermediates
substituted
deosky
purine nucleosides
Prior art date
Application number
NO932287A
Other languages
English (en)
Other versions
NO932287D0 (no
Inventor
Gerald Burr Grindey
Cora Sue Grossman
Larry Wayne Hertel
Julian Stanley Kroln
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO932287D0 publication Critical patent/NO932287D0/no
Publication of NO932287L publication Critical patent/NO932287L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Det blir beskrevet 2-deoksy-2,2-difluor (2,6,8-substi- tuert) purin-nukleosider med formelen hvor Z er valgt fra gruppen bestående av Disse forbindelsene har anticancer- og antiviral aktivitet. Det blir dessuten beskrevet mellomprodukter for fremstilling av forbindelsene, og farmasøytiske produkter som inneholder forbindelsene.
NO932287A 1992-06-22 1993-06-21 2'-deosky-2',2'-difluor(2,6,8-substituerte)purin-nukleosider med antiviralog anticanceraktivitet, og mellomprodukter NO932287L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90230492A 1992-06-22 1992-06-22

Publications (2)

Publication Number Publication Date
NO932287D0 NO932287D0 (no) 1993-06-21
NO932287L true NO932287L (no) 1993-12-23

Family

ID=25415652

Family Applications (1)

Application Number Title Priority Date Filing Date
NO932287A NO932287L (no) 1992-06-22 1993-06-21 2'-deosky-2',2'-difluor(2,6,8-substituerte)purin-nukleosider med antiviralog anticanceraktivitet, og mellomprodukter

Country Status (14)

Country Link
EP (1) EP0576227A3 (no)
JP (1) JPH0656877A (no)
KR (1) KR940005656A (no)
CN (1) CN1084178A (no)
AU (1) AU4134793A (no)
BR (1) BR9302433A (no)
CA (1) CA2098876A1 (no)
CZ (1) CZ123293A3 (no)
FI (1) FI932868A (no)
HU (1) HUT64553A (no)
IL (1) IL106073A0 (no)
MX (1) MX9303709A (no)
NO (1) NO932287L (no)
PL (1) PL299412A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
AU2253297A (en) * 1996-01-23 1997-08-20 Regents Of The University Of Michigan, The Imidazo{1,2-a}pyridine c-nucleosides as antiviral agents
SK48199A3 (en) * 1996-10-16 2000-01-18 Icn Pharmaceuticals Purine l-nucleosides, analogs and uses thereof
TW466112B (en) * 1998-04-14 2001-12-01 Lilly Co Eli Novel use of 2'-deoxy-2',2'-difluorocytidine for immunosuppressive therapy and pharmaceutical composition comprising the same
WO2003062256A1 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
CN1293884C (zh) * 2002-10-29 2007-01-10 南京长澳医药科技有限公司 6－甲氧基双脱氧鸟苷在制备抗乙肝药物中的应用
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
AT502635A1 (de) * 2005-11-09 2007-05-15 Saischek Und Partner Meg Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung
JP5410295B2 (ja) * 2006-12-13 2014-02-05 ジボダン ネーデルランド サービシーズ ビー．ヴイ． カルボン酸およびプリン、ピリミジン、ヌクレオシドまたはヌクレオチドのフレーバー調節誘導体
CN101557725B (zh) * 2006-12-13 2013-09-18 奇华顿荷兰服务有限责任公司 羧酸和嘌呤、嘧啶、核苷或核苷酸的风味调节衍生物
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法
JP6983814B2 (ja) * 2016-12-14 2021-12-17 ヤマサ醤油株式会社 抗ウイルス活性を示すヌクレオシド誘導体
WO2018181102A1 (ja) * 2017-03-29 2018-10-04 ヤマサ醤油株式会社 ヌクレオシド誘導体又はその塩、及びそれを含む医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE92499T1 (de) * 1984-12-04 1993-08-15 Lilly Co Eli Tumorbehandlung bei saeugetieren.
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
US4914028A (en) * 1988-02-10 1990-04-03 Eli Lilly And Company Method of preparing beta-2',2'-difluoronucleosides
ES2075040T3 (es) * 1988-02-16 1995-10-01 Lilly Co Eli 2',3'-dideoxi-2',2'-difluoronucleosidos.

Also Published As

Publication number Publication date
CA2098876A1 (en) 1993-12-23
KR940005656A (ko) 1994-03-22
PL299412A1 (en) 1993-12-27
CN1084178A (zh) 1994-03-23
BR9302433A (pt) 1994-01-11
EP0576227A2 (en) 1993-12-29
JPH0656877A (ja) 1994-03-01
CZ123293A3 (en) 1994-03-16
MX9303709A (es) 1994-05-31
FI932868A0 (fi) 1993-06-21
IL106073A0 (en) 1993-10-20
HU9301821D0 (en) 1993-09-28
EP0576227A3 (en) 1994-02-09
NO932287D0 (no) 1993-06-21
FI932868A (fi) 1993-12-23
AU4134793A (en) 1993-12-23
HUT64553A (en) 1994-01-28

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