FI932868A0 - 2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter - Google Patents

2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter

Info

Publication number
FI932868A0
FI932868A0 FI932868A FI932868A FI932868A0 FI 932868 A0 FI932868 A0 FI 932868A0 FI 932868 A FI932868 A FI 932868A FI 932868 A FI932868 A FI 932868A FI 932868 A0 FI932868 A0 FI 932868A0
Authority
FI
Finland
Prior art keywords
deoxy
difluoro
viral
substituted
product
Prior art date
Application number
FI932868A
Other languages
English (en)
Other versions
FI932868A (fi
Inventor
Gerald Burr Grindey
Cora Sue Grossman
Larry Wayne Hertel
Julian Stanley Kroin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI932868A0 publication Critical patent/FI932868A0/fi
Publication of FI932868A publication Critical patent/FI932868A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI932868A 1992-06-22 1993-06-21 2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter FI932868A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90230492A 1992-06-22 1992-06-22

Publications (2)

Publication Number Publication Date
FI932868A0 true FI932868A0 (fi) 1993-06-21
FI932868A FI932868A (fi) 1993-12-23

Family

ID=25415652

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932868A FI932868A (fi) 1992-06-22 1993-06-21 2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter

Country Status (14)

Country Link
EP (1) EP0576227A3 (fi)
JP (1) JPH0656877A (fi)
KR (1) KR940005656A (fi)
CN (1) CN1084178A (fi)
AU (1) AU4134793A (fi)
BR (1) BR9302433A (fi)
CA (1) CA2098876A1 (fi)
CZ (1) CZ123293A3 (fi)
FI (1) FI932868A (fi)
HU (1) HUT64553A (fi)
IL (1) IL106073A0 (fi)
MX (1) MX9303709A (fi)
NO (1) NO932287L (fi)
PL (1) PL299412A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
WO1997027205A1 (en) * 1996-01-23 1997-07-31 The Regents Of The University Of Michigan Imidazo[1,2-a]pyridine c-nucleosides as antiviral agents
CN1233254A (zh) * 1996-10-16 1999-10-27 Icn药品公司 嘌呤l－核苷、其类似物及其用途
TW466112B (en) * 1998-04-14 2001-12-01 Lilly Co Eli Novel use of 2'-deoxy-2',2'-difluorocytidine for immunosuppressive therapy and pharmaceutical composition comprising the same
WO2003062256A1 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
CN1293884C (zh) * 2002-10-29 2007-01-10 南京长澳医药科技有限公司 6－甲氧基双脱氧鸟苷在制备抗乙肝药物中的应用
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
AT502635A1 (de) * 2005-11-09 2007-05-15 Saischek Und Partner Meg Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung
CN101557725B (zh) * 2006-12-13 2013-09-18 奇华顿荷兰服务有限责任公司 羧酸和嘌呤、嘧啶、核苷或核苷酸的风味调节衍生物
MX2009005879A (es) 2006-12-13 2009-09-09 Givaudan Nederland Services B Derivado modulador del sabor de un acido carboxilico y una purina, pirimidina, nucleosido o nucleotido.
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法
WO2018110643A1 (ja) * 2016-12-14 2018-06-21 ヤマサ醤油株式会社 抗ウイルス活性を示すヌクレオシド誘導体
JP7084591B2 (ja) * 2017-03-29 2022-06-15 ヤマサ醤油株式会社 ヌクレオシド誘導体又はその塩、及びそれを含む医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587500T2 (de) * 1984-12-04 1993-12-16 Lilly Co Eli Tumorbehandlung bei Säugetieren.
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
US4914028A (en) * 1988-02-10 1990-04-03 Eli Lilly And Company Method of preparing beta-2',2'-difluoronucleosides
ES2075040T3 (es) * 1988-02-16 1995-10-01 Lilly Co Eli 2',3'-dideoxi-2',2'-difluoronucleosidos.

Also Published As

Publication number Publication date
PL299412A1 (en) 1993-12-27
IL106073A0 (en) 1993-10-20
FI932868A (fi) 1993-12-23
CN1084178A (zh) 1994-03-23
HU9301821D0 (en) 1993-09-28
NO932287L (no) 1993-12-23
EP0576227A3 (en) 1994-02-09
MX9303709A (es) 1994-05-31
CA2098876A1 (en) 1993-12-23
JPH0656877A (ja) 1994-03-01
AU4134793A (en) 1993-12-23
BR9302433A (pt) 1994-01-11
EP0576227A2 (en) 1993-12-29
CZ123293A3 (en) 1994-03-16
NO932287D0 (no) 1993-06-21
KR940005656A (ko) 1994-03-22
HUT64553A (en) 1994-01-28

Similar Documents

Publication Publication Date Title
DE3780581D1 (de) Antiviralen phosphonomethoxyalkylen-purin- und -pyrimidin-derivate.
ATE126060T1 (de) Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
AU6972187A (en) Carbocyclic purine nucleosides, their production and use
ATE113603T1 (de) Antivirale nukleoside.
FI932870A0 (fi) 2'-deoxi-2'2'-difluor-(4-substituerad pyrimidin)nukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter
DE3852682D1 (de) Therapeutische Nucleoside.
FI932868A0 (fi) 2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter
NZ227663A (en) Purine nucleoside analogues, pyrimidine derivatives and pharmaceutical compositions
IE900275L (en) Antivirals and methods of increasing the antiviral activity¹of azt
EP0409227A3 (en) Pyrimidine and purine nucleosides, their preparation and use as medicaments
CA2102782A1 (en) 2-fluoro-2-substituted adeninyl arabinosides as anti-cancer agents
IT8422739A0 (it) Derivati nucleosidici e purinici 8-sostituiti.
DK630589D0 (da) 2',3'-dideoxypurinnucleosid/purinnucleosid-phosphorylase-inhibitor-sammensaetning
AU6868187A (en) Carbocyclic purine nucleosides
DE68914750D1 (de) Therapeutische Nucleoside.
DE3664257D1 (en) Antiviral nucleosides
PT876146E (pt) Analogos de nucleosidos em terapia de combinacao de infeccoes por herpes simplex
ZA861933B (en) Antiviral nucleosides
KR900700498A (ko) 항종양 6-술펜아미드, 6-술핀아미드 및 6-술폰아미드퓨린, 퓨린 뉴클레오시드, 퓨린 뉴클레오티드 및 관련 화합물
GB9506644D0 (en) Preparation of nucleoside analogues
Hatfield (2-hydroxyethoxy) methyl nucleoside analogues.
ATE104675T1 (de) Therapeutische nucleoside.
IT8821190A0 (it) Derivati purinici aventi attivita' antivirale.
EP0544668A4 (en) 6-HALO- AND 2-AMINO-6-HALO-PURINE 2 ', 3'-DIDESOXY NUCLEOSIDES AND THEIR USE AS ANTIVIRAL AGENTS.
ATE49002T1 (de) N6-substituierte adenosine.

Legal Events

Date Code Title Description
FD Application lapsed