FI932868A - 2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter - Google Patents

2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter Download PDF

Info

Publication number
FI932868A
FI932868A FI932868A FI932868A FI932868A FI 932868 A FI932868 A FI 932868A FI 932868 A FI932868 A FI 932868A FI 932868 A FI932868 A FI 932868A FI 932868 A FI932868 A FI 932868A
Authority
FI
Finland
Prior art keywords
purinnukleosider
cancerhaemmande
difluor
deoxy
substitutes
Prior art date
Application number
FI932868A
Other languages
English (en)
Other versions
FI932868A0 (fi
Inventor
Gerald Burr Grindey
Cora Sue Grossman
Larry Wayne Hertel
Julian Stanley Kroin
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI932868A0 publication Critical patent/FI932868A0/fi
Publication of FI932868A publication Critical patent/FI932868A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI932868A 1992-06-22 1993-06-21 2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter FI932868A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90230492A 1992-06-22 1992-06-22

Publications (2)

Publication Number Publication Date
FI932868A0 FI932868A0 (fi) 1993-06-21
FI932868A true FI932868A (fi) 1993-12-23

Family

ID=25415652

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932868A FI932868A (fi) 1992-06-22 1993-06-21 2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter

Country Status (14)

Country Link
EP (1) EP0576227A3 (fi)
JP (1) JPH0656877A (fi)
KR (1) KR940005656A (fi)
CN (1) CN1084178A (fi)
AU (1) AU4134793A (fi)
BR (1) BR9302433A (fi)
CA (1) CA2098876A1 (fi)
CZ (1) CZ123293A3 (fi)
FI (1) FI932868A (fi)
HU (1) HUT64553A (fi)
IL (1) IL106073A0 (fi)
MX (1) MX9303709A (fi)
NO (1) NO932287L (fi)
PL (1) PL299412A1 (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
TR199801431T2 (xx) * 1996-01-23 1998-10-21 The Regents Of The University Of Michigan Antiviral aktif maddeler olarak de�i�tirilmi� benzimidazol n�kleosidler.
CZ126799A3 (cs) * 1996-10-16 1999-07-14 Icn Pharmaceuticals Purinové L-nukleosidy a jejich analogy a farmaceutické prostředky, které je obsahují
TW466112B (en) * 1998-04-14 2001-12-01 Lilly Co Eli Novel use of 2'-deoxy-2',2'-difluorocytidine for immunosuppressive therapy and pharmaceutical composition comprising the same
WO2003062256A1 (en) * 2002-01-17 2003-07-31 Ribapharm Inc. 2'-beta-modified-6-substituted adenosine analogs and their use as antiviral agents
CN1293884C (zh) * 2002-10-29 2007-01-10 南京长澳医药科技有限公司 6－甲氧基双脱氧鸟苷在制备抗乙肝药物中的应用
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
AT502635A1 (de) * 2005-11-09 2007-05-15 Saischek Und Partner Meg Neue 1,3-dithioverbindungen, verfahren zu deren herstellung und ihre verwendung
BRPI0719989B1 (pt) * 2006-12-13 2016-12-13 Givaudan Nederland Services Bv substâncias de modulação de sabor, composições aromatizantes e produtos compreendendo as mesmas, método de melhoramento do sabor de produtos, e processo de produção de preparação de sabor
EP2099316B1 (en) * 2006-12-13 2017-06-21 Givaudan S.A. Flavour modulating derivative of a carboxylic acid and a purine, pyrimidine, nucleoside or nucleotide
CN106317147B (zh) * 2015-07-06 2018-11-27 扬州硒瑞恩生物医药科技有限公司 核苷类化合物及其制备方法
JP6983814B2 (ja) * 2016-12-14 2021-12-17 ヤマサ醤油株式会社 抗ウイルス活性を示すヌクレオシド誘導体
WO2018181102A1 (ja) * 2017-03-29 2018-10-04 ヤマサ醤油株式会社 ヌクレオシド誘導体又はその塩、及びそれを含む医薬組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0184365B1 (en) * 1984-12-04 1993-08-04 Eli Lilly And Company Improvements in the treatment of tumors in mammals
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
US4914028A (en) * 1988-02-10 1990-04-03 Eli Lilly And Company Method of preparing beta-2',2'-difluoronucleosides
IL89258A0 (en) * 1988-02-16 1989-09-10 Lilly Co Eli 2',3'-dideoxy-2',2'-difluoro-nucleosides

Also Published As

Publication number Publication date
CZ123293A3 (en) 1994-03-16
BR9302433A (pt) 1994-01-11
EP0576227A2 (en) 1993-12-29
JPH0656877A (ja) 1994-03-01
CN1084178A (zh) 1994-03-23
IL106073A0 (en) 1993-10-20
NO932287D0 (no) 1993-06-21
KR940005656A (ko) 1994-03-22
EP0576227A3 (en) 1994-02-09
HUT64553A (en) 1994-01-28
CA2098876A1 (en) 1993-12-23
MX9303709A (es) 1994-05-31
NO932287L (no) 1993-12-23
HU9301821D0 (en) 1993-09-28
FI932868A0 (fi) 1993-06-21
AU4134793A (en) 1993-12-23
PL299412A1 (en) 1993-12-27

Similar Documents

Publication Publication Date Title
FI953489A (fi) 2,6-diaminopuriinijohdannaisia
DE68923387D1 (de) 2',3'-Dideoxy-2',2'-difluornucleoside.
FI945996A (fi) L-aspartyyli-D-alfa-Aminoalkanoyyli-(S)-N-alfa-Alkyylibentsyyliamidit, jotka ovat käyttökelpoisia keinotekoisina makeutusaineina
FR2654223B1 (fr) Protection d'objectif.
AT397656B (de) (6,7-substituierte-8-alkoxy-1-cyclopropyl-1,4-
FI954598A (fi) Radiofarmaseuttisea formulaatioita, joissa on ei-stanno-pelkistimiä
FI932868A (fi) 2'-deoxi-2'2'-difluor(2,6,8-substituerade) purinnukleosider med virus-och cancerhaemmande aktivitet, samt mellanprodukter
FI924012A0 (fi) Korvoeverdragsmaskin med foerbaettrat spiralformningsmunstycke.
DE3888530D1 (de) 3'-Azido-2',3'-dideoxynucleosid-5'-phosphonate.
FI932516A (fi) Styrkonsol, i synnerhet foer motorfordon
NO932842L (no) 1,4-benzodioksanderivater
DE59010722D1 (de) 2,4-Dimethyl-6-s-alkylphenole
FI931451A0 (fi) 7-oxo-7h-pyrido(1,2,3-de)(1,4)bensoxazin-6-karboxylsyror och -estrar
DE59308564D1 (de) 2,4-Dialkyl-6-sec-alkylphenole
FI890587A0 (fi) Reaktorkammare i en reaktor med fluidiserad baedd.
FI900932A0 (fi) Minnesdosa foer anvaendning i samband med tv-spelmaskin.
FI950101A0 (fi) 4-oksa-1-atsabisyklo 3,2,0 -7heptanoni-johdannaiset kasvainten vastaisina aineina
ES1022839Y (es) Bragas monouso.
FI935130A0 (fi) Raelsbund vagn med skjuttak, saerskilt foer biltransport
NO943791D0 (no) 1,2-dihydro-2-okso-3-metylsulfonylaminometylpyridin
ES1022892Y (es) Pupitre armable de uso infantil.
FR2693103B1 (fr) Meuble de stomatologue.
ES1022234Y (es) "corta-puros de bolsillo"
ES1022829Y (es) Pupitre de uso infantil.
LV10616A (lv) Aizvietoti ciklopropilamino-1,3,5-triazini

Legal Events

Date Code Title Description
FD Application lapsed