JPS6422853A - Nucleoside analog - Google Patents
Nucleoside analogInfo
- Publication number
- JPS6422853A JPS6422853A JP17723487A JP17723487A JPS6422853A JP S6422853 A JPS6422853 A JP S6422853A JP 17723487 A JP17723487 A JP 17723487A JP 17723487 A JP17723487 A JP 17723487A JP S6422853 A JPS6422853 A JP S6422853A
- Authority
- JP
- Japan
- Prior art keywords
- adenine
- amino
- compound
- formula
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyridine Compounds (AREA)
Abstract
NEW MATERIAL:A compound of the formula (B is residue of nucleic acid base). EXAMPLE:9-[2,3-Dideoxy-4a-(hydroxymethyl)-2-cyclopentene-1a-yl]adenine. USE:Antitumor agent, antiviral or agrochemicals. PREPARATION:For example, in the preparation of adenosine, the reaction of 5-amino-4,6-dichloropyrimidine with cis-4-amino-2-cyclopentanemethanol gives a diaminopyrimidine derivative, then ethyl orthoformate is used to form the purine skeleton, further the chlorine atom in the 6-position of the purine ring is treated with ammonia to convert into adenine to give the compound of the formula.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17723487A JPS6422853A (en) | 1987-07-17 | 1987-07-17 | Nucleoside analog |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17723487A JPS6422853A (en) | 1987-07-17 | 1987-07-17 | Nucleoside analog |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS6422853A true JPS6422853A (en) | 1989-01-25 |
Family
ID=16027498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP17723487A Pending JPS6422853A (en) | 1987-07-17 | 1987-07-17 | Nucleoside analog |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS6422853A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0349242A2 (en) * | 1988-06-27 | 1990-01-03 | The Wellcome Foundation Limited | Therapeutic nucleosides |
WO1991015490A1 (en) * | 1990-04-06 | 1991-10-17 | Glaxo Inc. | Synthesis of purine substituted cyclopentene derivatives |
WO1991015489A1 (en) * | 1990-04-06 | 1991-10-17 | Glaxo Inc. | Process for the synthesis of cyclopentene derivatives |
US5922694A (en) * | 1988-01-20 | 1999-07-13 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
JP2008515962A (en) * | 2004-10-12 | 2008-05-15 | グレンマーク・ファーマシューティカルズ・エスエー | Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and processes for preparing them |
-
1987
- 1987-07-17 JP JP17723487A patent/JPS6422853A/en active Pending
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922694A (en) * | 1988-01-20 | 1999-07-13 | Regents Of The University Of Minnesota | Optically-active isomers of dideoxycarbocyclic nucleosides |
US5962684A (en) * | 1988-01-20 | 1999-10-05 | Regents Of The University Of Minnesota | Method of preparation of dideoxycarbocyclic nucleosides |
US6072053A (en) * | 1988-01-20 | 2000-06-06 | Univ Minnesota | Dideoxycarbocyclic nucleosides |
EP0349242A2 (en) * | 1988-06-27 | 1990-01-03 | The Wellcome Foundation Limited | Therapeutic nucleosides |
US5034394A (en) * | 1988-06-27 | 1991-07-23 | Burroughs Wellcome Co. | Therapeutic nucleosides |
US5049671A (en) * | 1988-06-27 | 1991-09-17 | Burroughs Wellcome Co. | 6-substituted purine carbocyclic nucleosides |
WO1991015490A1 (en) * | 1990-04-06 | 1991-10-17 | Glaxo Inc. | Synthesis of purine substituted cyclopentene derivatives |
WO1991015489A1 (en) * | 1990-04-06 | 1991-10-17 | Glaxo Inc. | Process for the synthesis of cyclopentene derivatives |
US5126452A (en) * | 1990-04-06 | 1992-06-30 | Glaxo Inc. | Synthesis of purine substituted cyclopentene derivatives |
US5144034A (en) * | 1990-04-06 | 1992-09-01 | Glaxo Inc. | Process for the synthesis of cyclopentene derivatives of purines |
JP2008515962A (en) * | 2004-10-12 | 2008-05-15 | グレンマーク・ファーマシューティカルズ・エスエー | Novel dipeptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and processes for preparing them |
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