HK1250131A1 - 表達嵌合主要組織相容性複合物(mhc)ii類分子的基因修飾小鼠 - Google Patents

表達嵌合主要組織相容性複合物(mhc)ii類分子的基因修飾小鼠

Info

Publication number
HK1250131A1
HK1250131A1 HK18109591.4A HK18109591A HK1250131A1 HK 1250131 A1 HK1250131 A1 HK 1250131A1 HK 18109591 A HK18109591 A HK 18109591A HK 1250131 A1 HK1250131 A1 HK 1250131A1
Authority
HK
Hong Kong
Prior art keywords
mhc
molecules
genetically modified
major histocompatibility
histocompatibility complex
Prior art date
Application number
HK18109591.4A
Other languages
English (en)
Inventor
L‧麥克唐納
A‧J‧莫菲
N‧圖
C‧古雷爾
V‧沃羅寧那
S‧史蒂文斯
Original Assignee
瑞澤恩制藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 瑞澤恩制藥公司 filed Critical 瑞澤恩制藥公司
Publication of HK1250131A1 publication Critical patent/HK1250131A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK18109591.4A 2011-10-28 2018-07-24 表達嵌合主要組織相容性複合物(mhc)ii類分子的基因修飾小鼠 HK1250131A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161552584P 2011-10-28 2011-10-28

Publications (1)

Publication Number Publication Date
HK1250131A1 true HK1250131A1 (zh) 2018-11-30

Family

ID=47430036

Family Applications (2)

Application Number Title Priority Date Filing Date
HK14110588.1A HK1196999A1 (zh) 2011-10-28 2014-10-23 表達嵌合主要組織相容性複合物 類分子的轉基因小鼠
HK18109591.4A HK1250131A1 (zh) 2011-10-28 2018-07-24 表達嵌合主要組織相容性複合物(mhc)ii類分子的基因修飾小鼠

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK14110588.1A HK1196999A1 (zh) 2011-10-28 2014-10-23 表達嵌合主要組織相容性複合物 類分子的轉基因小鼠

Country Status (25)

Country Link
US (6) US8847005B2 (zh)
EP (4) EP3272214B1 (zh)
JP (2) JP6285361B2 (zh)
KR (2) KR101926442B1 (zh)
CN (3) CN108401986B (zh)
AU (4) AU2012327205B2 (zh)
BR (1) BR112014009941B1 (zh)
CA (1) CA2852962C (zh)
CY (2) CY1119283T1 (zh)
DK (3) DK3272214T3 (zh)
ES (3) ES2640241T3 (zh)
HK (2) HK1196999A1 (zh)
HR (3) HRP20220616T1 (zh)
HU (2) HUE048511T2 (zh)
IL (3) IL231895B (zh)
IN (1) IN2014CN03892A (zh)
LT (3) LT3272214T (zh)
MX (1) MX355726B (zh)
PL (3) PL2770822T3 (zh)
PT (3) PT2770822T (zh)
RS (3) RS56330B1 (zh)
RU (1) RU2660564C2 (zh)
SG (3) SG10201510056SA (zh)
SI (3) SI3590332T1 (zh)
WO (1) WO2013063340A1 (zh)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008054865A2 (en) 2006-04-26 2008-05-08 L-3 Communications Security And Detection Systems, Inc. Multi-source surveillance systems
US9043996B2 (en) 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
EP2818478B1 (en) 2011-10-28 2017-02-01 Regeneron Pharmaceuticals, Inc. Humanized IL-6 and IL-6 receptor
CA2852962C (en) 2011-10-28 2022-05-03 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
KR102579405B1 (ko) 2013-02-20 2023-09-18 리제너론 파아마슈티컬스, 인크. 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스
KR102211267B1 (ko) * 2013-02-22 2021-02-04 리제너론 파아마슈티컬스, 인크. 사람화된 주요 조직적합성 복합체를 발현하는 마우스
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
EP2967015B9 (en) 2013-03-11 2023-08-09 Regeneron Pharmaceuticals, Inc. Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules
LT3175706T (lt) 2013-09-23 2019-02-25 Regeneron Pharmaceuticals, Inc. Gyvūnai, išskyrus žmogų, turintys humanizuotą signalą reguliuojančio baltymo geną
ES2613379T3 (es) * 2013-10-15 2017-05-24 Regeneron Pharmaceuticals, Inc. Animales con IL-15 humanizada
KR102223264B1 (ko) 2014-04-08 2021-03-09 리제너론 파아마슈티컬스, 인크. 인간화된 Fc-감마 수용체를 갖는 비-인간 동물
NO2785538T3 (zh) 2014-05-07 2018-08-04
MX2016016903A (es) * 2014-06-19 2017-03-27 Regeneron Pharma Animales no humanos que tienen un gen de muerte celular programada 1 humanizado.
CA2959428A1 (en) 2014-09-19 2016-03-24 Regeneron Pharmaceuticals, Inc. Chimeric antigen receptors
SI3223605T1 (sl) 2014-11-24 2021-03-31 Regeneron Pharmaceuticals, Inc. Nehumane živali, ki izražajo humaniziran CD3 kompleks
NZ731471A (en) 2014-12-05 2021-12-24 Regeneron Pharma Non-human animals having a humanized cluster of differentiation 47 gene
MX2017012829A (es) 2015-04-06 2018-02-23 Regeneron Pharma Respuestas inmunitarias mediadas por células t humanizadas en animales no humanos.
MX2018005389A (es) 2015-11-20 2018-09-05 Regeneron Pharma Animales no humanos que tienen un gen 3 de activacion linfocitaria humanizado.
CN108779159B (zh) * 2016-02-04 2022-12-30 瑞泽恩制药公司 具有经改造的angptl8基因的非人动物
US10070632B2 (en) 2016-02-29 2018-09-11 Regeneron Pharmaceuticals, Inc. Rodents having a humanized TMPRSS gene
CN113907043B (zh) 2016-06-03 2023-08-01 瑞泽恩制药公司 表达外源末端脱氧核苷酸转移酶的非人动物
SG11202002456WA (en) 2017-11-30 2020-04-29 Regeneron Pharma Non-human animals comprising a humanized trkb locus
WO2019190922A1 (en) 2018-03-24 2019-10-03 Regeneron Pharmaceuticals, Inc. Genetically modified non-human animals for generating therapeutic antibodies against peptide-mhc complexes, methods of making and uses thereof
AU2019242586A1 (en) 2018-03-26 2020-10-01 Regeneron Pharmaceuticals, Inc. Humanized rodents for testing therapeutic agents
WO2020018511A1 (en) 2018-07-16 2020-01-23 Regeneron Pharmaceuticals, Inc. Non-human animal models of ditra disease and uses thereof
WO2021081156A1 (en) * 2019-10-22 2021-04-29 The Trustees Of Columbia University In The City Of New York Transgenic swine, methods of making and uses thereof, and methods of making human immune system mice
AU2020395122A1 (en) 2019-12-02 2022-06-09 Regeneron Pharmaceuticals, Inc. Peptide-MHC II protein constructs and uses thereof
AU2022249328A1 (en) 2021-03-31 2023-09-21 Regeneron Pharmaceuticals, Inc. Genetically modified mice comprising humanized cellular immune system components with improved diversity of tcrβ repertoire
WO2023240109A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Multispecific molecules for modulating t-cell activity, and uses thereof
WO2023240124A1 (en) 2022-06-07 2023-12-14 Regeneron Pharmaceuticals, Inc. Pseudotyped viral particles for targeting tcr-expressing cells
WO2024064860A1 (en) 2022-09-22 2024-03-28 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing components of human cellular immune system

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574205A (en) 1989-07-25 1996-11-12 Cell Genesys Homologous recombination for universal donor cells and chimeric mammalian hosts
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
ATE423195T1 (de) 1989-07-25 2009-03-15 Cell Genesys Inc Homologe rekombination für universelle donorzellen und chimerische säugetierzellen
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
GB9100481D0 (en) 1991-01-10 1991-02-20 Inst Nat Sante Rech Med Genetically engineered mice
AU2661692A (en) 1991-09-19 1993-04-27 President And Fellows Of Harvard College Transgenic mhc class i and class ii antigen-deficient mammals
WO1994006908A1 (en) 1992-09-11 1994-03-31 The Regents Of The University Of California Transgenic non-human animals having targeted lymphocyte transduction genes
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
GB9315303D0 (en) 1993-07-23 1993-09-08 Zeneca Ltd Polypeptide
US5965787A (en) 1995-08-31 1999-10-12 Mayo Foundation For Medical Education And Research HLA-DRBI peptides with specific binding affinity for HLA-DQ molecules: prevention and treatment of rheumatoid arthritis
US6002066A (en) 1996-01-16 1999-12-14 Ortho Pharmaceutical Corp. H2-M modified transgenic mice
WO1997032603A1 (en) 1996-03-05 1997-09-12 The Scripps Research Institute Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens
CA2616914C (en) 1996-12-03 2012-05-29 Abgenix, Inc. Egfr-binding antibody
WO1999014236A1 (en) 1997-09-16 1999-03-25 Oregon Health Sciences University Recombinant mhc molecules useful for manipulation of antigen-specific t-cells
US6372955B1 (en) 1998-02-17 2002-04-16 Ortho Mcneil Pharmaceutical, Inc. Methods for Producing B cells and antibodies from H2-O modified transgenic mice
CN1161614C (zh) * 1998-03-30 2004-08-11 研究发展基金会 用促肾上腺皮质素释放因子受体-1缺陷型小鼠鉴定促效剂和拮抗剂的方法
AU1023401A (en) 1999-10-12 2001-04-23 Institut Pasteur Design of a polyepitopic construct for the induction of hla-a2.1 restricted hiv 1 specific ctl responses using hhd mice
US7067308B1 (en) * 2000-03-28 2006-06-27 Bioagri Corporation Vector for genetically modifying non-human animals
WO2002000933A2 (en) 2000-06-23 2002-01-03 Interleukin Genetics, Inc. Screening assays for identifying modulators of the inflammatory or immune responses
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US7105348B2 (en) 2000-10-31 2006-09-12 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
JPWO2002047474A1 (ja) 2000-12-13 2004-04-15 住友製薬株式会社 Ｈｌａ−ａ２４発現トランスジェニック動物及びその利用
DK1409646T3 (da) 2000-12-19 2012-08-06 Altor Bioscience Corp Transgene dyr omfattende et humaniseret immunsystem
FR2827302B1 (fr) 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
US20040072262A1 (en) 2002-10-11 2004-04-15 Montero-Julian Felix A. Methods and systems for detecting MHC class I binding peptides
US7663017B2 (en) 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
DE10347710B4 (de) * 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Rekombinante Impfstoffe und deren Verwendung
JP4857450B2 (ja) 2004-03-09 2012-01-18 財団法人名古屋産業科学研究所 ヒト関節リウマチの病態を再現するトランスジェニック非ヒト哺乳動物
DK2767161T3 (en) 2004-10-19 2018-05-07 Regeneron Pharma Method of generating an animal homozygous for genetic modification
EP1878342A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses
EP1878798A1 (en) 2006-07-13 2008-01-16 Institut Pasteur Method of producing a multichimeric mouse and applications to study the immunopathogenesis of human tissue-specific pathologies
HU0700534D0 (en) * 2006-11-24 2007-10-29 Mezoegazdasagi Biotechnologiai Transgenic animal with enhanced immune response and method for the preparation thereof
RU2448979C2 (ru) 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
TWI476280B (zh) 2008-03-07 2015-03-11 Regeneron Pharma 來自二倍體宿主胚胎注射之ｅｓ－細胞衍生的老鼠
US20090328240A1 (en) 2008-06-24 2009-12-31 Sing George L Genetically modified mice as predictors of immune response
HUE055817T2 (hu) 2009-07-08 2021-12-28 Kymab Ltd Állatmodellek és terápiás molekulák
CN101695587B (zh) * 2009-10-21 2012-08-29 上海中山医疗科技发展公司 一种基因修饰及调控的内皮祖细胞捕获支架的制备方法
EP2593551B1 (en) 2010-07-15 2016-09-14 Technion Research & Development Foundation Ltd. Isolated high affinity entities with t-cell receptor like specificity towards native complexes of mhc class ii and glutamic acid decarboxylase (gad) autoantigenic peptides
US9557323B2 (en) 2010-09-24 2017-01-31 The United States Of America As Represented By The Secretary Of The Navy Humanized transgenic mouse model
US9043996B2 (en) 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
CA2852962C (en) 2011-10-28 2022-05-03 Regeneron Pharmaceuticals, Inc. Genetically modified mice expressing chimeric major histocompatibility complex (mhc) ii molecules
KR102579405B1 (ko) 2013-02-20 2023-09-18 리제너론 파아마슈티컬스, 인크. 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
KR102211267B1 (ko) 2013-02-22 2021-02-04 리제너론 파아마슈티컬스, 인크. 사람화된 주요 조직적합성 복합체를 발현하는 마우스
EP2967015B9 (en) 2013-03-11 2023-08-09 Regeneron Pharmaceuticals, Inc. Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules
MX2017012829A (es) 2015-04-06 2018-02-23 Regeneron Pharma Respuestas inmunitarias mediadas por células t humanizadas en animales no humanos.

Also Published As

Publication number Publication date
US20150040253A1 (en) 2015-02-05
IL243565A (en) 2017-10-31
CA2852962C (en) 2022-05-03
DK3272214T3 (da) 2020-03-02
NZ623146A (en) 2016-06-24
PL2770822T3 (pl) 2017-11-30
BR112014009941B1 (pt) 2022-11-29
KR102113108B1 (ko) 2020-05-20
HRP20200305T1 (hr) 2020-06-12
SI3590332T1 (sl) 2022-07-29
SI3272214T1 (sl) 2020-04-30
AU2021200438A1 (en) 2021-02-25
HUE034374T2 (en) 2018-02-28
IL231895B (en) 2018-07-31
CA2852962A1 (en) 2013-05-02
MX2014004896A (es) 2014-09-12
RS59997B1 (sr) 2020-04-30
SI2770822T1 (sl) 2017-10-30
AU2016202317B2 (en) 2017-11-30
US20190239496A1 (en) 2019-08-08
AU2021200438B2 (en) 2023-11-02
AU2012327205B2 (en) 2016-01-14
LT2770822T (lt) 2017-10-10
DK2770822T3 (en) 2017-09-25
KR20180132970A (ko) 2018-12-12
KR101926442B1 (ko) 2018-12-12
EP3590332A1 (en) 2020-01-08
CN108707608A (zh) 2018-10-26
HRP20220616T1 (hr) 2022-06-24
CN104039133A (zh) 2014-09-10
EP3590332B1 (en) 2022-02-23
US20170135329A1 (en) 2017-05-18
EP3272214A1 (en) 2018-01-24
CN108401986A (zh) 2018-08-17
AU2018201402C1 (en) 2021-05-06
PL3590332T3 (pl) 2022-06-13
ES2774488T3 (es) 2020-07-21
US10986822B2 (en) 2021-04-27
ES2640241T3 (es) 2017-11-02
JP2014532411A (ja) 2014-12-08
PT3272214T (pt) 2020-03-04
LT3272214T (lt) 2020-03-10
RU2018115251A3 (zh) 2021-09-07
CN104039133B (zh) 2018-05-04
CY1119283T1 (el) 2018-02-14
US20190239497A1 (en) 2019-08-08
RU2014116577A (ru) 2015-12-10
AU2016202317A1 (en) 2016-05-05
IL231895A0 (en) 2014-05-28
JP6652529B2 (ja) 2020-02-26
AU2018201402B2 (en) 2020-10-22
RS56330B1 (sr) 2017-12-29
US8847005B2 (en) 2014-09-30
SG10201510056SA (en) 2016-01-28
US20210195878A1 (en) 2021-07-01
CN108401986B (zh) 2021-09-21
IL260209A (en) 2018-07-31
CY1122700T1 (el) 2021-03-12
EP4052572A1 (en) 2022-09-07
EP2770822B1 (en) 2017-06-14
PT2770822T (pt) 2017-09-18
NZ717130A (en) 2018-07-27
WO2013063340A1 (en) 2013-05-02
IN2014CN03892A (zh) 2015-10-16
LT3590332T (lt) 2022-08-10
US10219493B2 (en) 2019-03-05
US20130111616A1 (en) 2013-05-02
DK3590332T3 (da) 2022-05-23
MX355726B (es) 2018-04-27
SG11201400938UA (en) 2014-04-28
PT3590332T (pt) 2022-05-27
HUE048511T2 (hu) 2020-07-28
EP2770822B9 (en) 2019-12-11
AU2018201402A1 (en) 2018-03-15
HK1196999A1 (zh) 2015-01-02
SG10201909638UA (en) 2019-11-28
US9585373B2 (en) 2017-03-07
RS63220B1 (sr) 2022-06-30
RU2660564C2 (ru) 2018-07-06
KR20140089558A (ko) 2014-07-15
HRP20171327T1 (hr) 2017-11-03
US11219195B2 (en) 2022-01-11
JP6285361B2 (ja) 2018-02-28
RU2018115251A (ru) 2019-03-04
PL3272214T3 (pl) 2020-06-29
IL260209B (en) 2019-12-31
EP3272214B1 (en) 2019-11-27
EP2770822A1 (en) 2014-09-03
ES2914374T3 (es) 2022-06-10
JP2018019700A (ja) 2018-02-08
BR112014009941A2 (pt) 2020-12-22
AU2012327205A1 (en) 2013-05-23

Similar Documents

Publication Publication Date Title
HK1250131A1 (zh) 表達嵌合主要組織相容性複合物(mhc)ii類分子的基因修飾小鼠
IL261239B (en) Mice with mhc genetic changes
HRP20181626T1 (hr) Genetski modificirani miševi receptora t-stanice (tcr-miševi)
HK1212859A1 (zh) 表達嵌合的主要組織相容性複合物 類分子的轉基因小鼠
HK1213144A1 (zh) 表達嵌合主要組織相容性複合物 類分子的基因修飾小鼠