HK1213144A1 - 表達嵌合主要組織相容性複合物 類分子的基因修飾小鼠 - Google Patents

表達嵌合主要組織相容性複合物 類分子的基因修飾小鼠

Info

Publication number
HK1213144A1
HK1213144A1 HK16101130.1A HK16101130A HK1213144A1 HK 1213144 A1 HK1213144 A1 HK 1213144A1 HK 16101130 A HK16101130 A HK 16101130A HK 1213144 A1 HK1213144 A1 HK 1213144A1
Authority
HK
Hong Kong
Prior art keywords
mhc
molecules
class
transgenic mice
major histocompatibility
Prior art date
Application number
HK16101130.1A
Other languages
English (en)
Inventor
‧麥克唐納
‧莫菲
‧圖
‧古雷爾
‧沃羅寧那
‧史蒂文斯
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50543313&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1213144(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/793,935 external-priority patent/US9043996B2/en
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of HK1213144A1 publication Critical patent/HK1213144A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Environmental Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Eye Examination Apparatus (AREA)
HK16101130.1A 2013-03-11 2016-02-01 表達嵌合主要組織相容性複合物 類分子的基因修飾小鼠 HK1213144A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/793,935 US9043996B2 (en) 2011-10-28 2013-03-11 Genetically modified major histocompatibility complex animals
PCT/US2014/023068 WO2014164638A1 (en) 2013-03-11 2014-03-11 Transgenic mice expressing chimeric major histocompatibility comples (mhc) class ii molecules

Publications (1)

Publication Number Publication Date
HK1213144A1 true HK1213144A1 (zh) 2016-06-30

Family

ID=50543313

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101130.1A HK1213144A1 (zh) 2013-03-11 2016-02-01 表達嵌合主要組織相容性複合物 類分子的基因修飾小鼠

Country Status (9)

Country Link
EP (2) EP2967015B9 (zh)
JP (1) JP6456350B2 (zh)
KR (1) KR102309653B1 (zh)
CN (2) CN108464278B (zh)
AU (1) AU2014249148B2 (zh)
CA (1) CA2903025A1 (zh)
ES (1) ES2948808T3 (zh)
HK (1) HK1213144A1 (zh)
WO (1) WO2014164638A1 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9043996B2 (en) 2011-10-28 2015-06-02 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex animals
KR101926442B1 (ko) 2011-10-28 2018-12-12 리제너론 파아마슈티컬스, 인크. 키메라 주요 조직적합성 복합체 （ｍｈｃ） ｉｉ 분자들을 발현하는 유전자 변형된 마우스
KR102313047B1 (ko) 2013-02-20 2021-10-19 리제너론 파아마슈티컬스, 인크. 사람화된 ｔ-세포 보조-수용체를 발현하는 마우스
US20150342163A1 (en) 2013-02-22 2015-12-03 Regeneron Pharmaceuticals, Inc. Genetically modified major histocompatibility complex mice
CN105164154B (zh) 2013-02-22 2019-06-07 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠
CN104560944A (zh) * 2014-12-24 2015-04-29 张华� 一种hla-dqbi完全基因剔除实验小鼠模型的建立方法
AU2016246698B2 (en) 2015-04-06 2022-06-02 Regeneron Pharmaceuticals, Inc. Humanized T cell mediated immune responses in non-human animals
KR102327343B1 (ko) 2015-09-07 2021-11-17 주식회사 만도 아이들 스톱 제어 장치 및 방법
US20230072216A1 (en) * 2020-01-10 2023-03-09 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric mhc protein complex
CN113999873B (zh) * 2021-12-31 2022-05-20 北京市疾病预防控制中心 一种基因修饰的非人动物的构建方法及其应用

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US7713739B1 (en) * 2000-11-17 2010-05-11 Novartis Vaccines And Diagnostics, Inc. Microparticle-based transfection and activation of dendritic cells
US6596541B2 (en) * 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6586251B2 (en) 2000-10-31 2003-07-01 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
FR2827302B1 (fr) * 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
US7663017B2 (en) * 2003-07-30 2010-02-16 Institut Pasteur Transgenic mice having a human major histocompatability complex (MHC) phenotype, experimental uses and applications
DE10347710B4 (de) * 2003-10-14 2006-03-30 Johannes-Gutenberg-Universität Mainz Rekombinante Impfstoffe und deren Verwendung
ES2463476T3 (es) 2004-10-19 2014-05-28 Regeneron Pharmaceuticals, Inc. Método para generar un ratón homocigótico para una modificación genética
AU2006218454B2 (en) * 2005-03-03 2011-11-17 Immunomedics, Inc. Humanized L243 antibodies
UA101142C2 (ru) * 2006-03-17 2013-03-11 Байоджэн Айдэк Ма Инк. Способ разработки антитела
PT2121920E (pt) * 2007-03-01 2011-10-03 Symphogen As Método de clonagem de anticorpos cognatos
JP2010523117A (ja) * 2007-04-07 2010-07-15 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ 体細胞の再プログラミング
JP5213962B2 (ja) * 2007-11-01 2013-06-19 エフ．ホフマン−ラ ロシュ アーゲー 四重トランスジェニック非ヒト動物
CN103865997B (zh) * 2008-02-21 2015-11-11 国立大学法人爱媛大学 高血压易感基因组的鉴定
WO2009114400A1 (en) 2008-03-07 2009-09-17 Regeneron Pharmaceuticals, Inc. Es cell-derived mice from diploid host embryo injection
LT2708559T (lt) * 2008-04-11 2018-06-11 Chugai Seiyaku Kabushiki Kaisha Antigeną surišanti molekulė, galinti pakartotinai prisijungti prie dviejų ar daugiau antigeno molekulių
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CN101812458A (zh) * 2010-02-05 2010-08-25 中国水产科学研究院南海水产研究所 军曹鱼MHC-Ⅱα基因序列
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EP2534257B1 (en) * 2010-02-12 2017-09-27 Oncomed Pharmaceuticals, Inc. Methods for identifying and isolating cells expressing a polypeptide
AU2011225716A1 (en) * 2010-03-11 2012-09-27 Pfizer Inc. Antibodies with pH dependent antigen binding
JP2013538555A (ja) * 2010-07-15 2013-10-17 テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド Ｍｈｃクラスｉｉとグルタミン酸デカルボキシラーゼ（ｇａｄ）自己抗原性ペプチドとの天然型複合体に対するｔ細胞受容体様特異性を有する単離された高親和性実体
KR101926442B1 (ko) 2011-10-28 2018-12-12 리제너론 파아마슈티컬스, 인크. 키메라 주요 조직적합성 복합체 （ｍｈｃ） ｉｉ 분자들을 발현하는 유전자 변형된 마우스
CN105164154B (zh) * 2013-02-22 2019-06-07 瑞泽恩制药公司 表达人源化主要组织相容性复合物的小鼠

Also Published As

Publication number Publication date
ES2948808T3 (es) 2023-09-19
JP6456350B2 (ja) 2019-01-23
AU2014249148A1 (en) 2015-09-24
CN105208855A (zh) 2015-12-30
EP2967015B9 (en) 2023-08-09
EP4249507A3 (en) 2023-12-27
KR20150126410A (ko) 2015-11-11
AU2014249148B2 (en) 2020-04-02
EP4249507A2 (en) 2023-09-27
WO2014164638A1 (en) 2014-10-09
EP2967015C0 (en) 2023-06-07
CA2903025A1 (en) 2014-10-09
EP2967015B1 (en) 2023-06-07
EP2967015A1 (en) 2016-01-20
KR102309653B1 (ko) 2021-10-08
CN108464278B (zh) 2021-05-04
CN108464278A (zh) 2018-08-31
JP2016510997A (ja) 2016-04-14
CN105208855B (zh) 2018-04-27

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