HK1244512A1 - 突变型smoothened及其使用方法 - Google Patents

突变型smoothened及其使用方法 Download PDF

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Publication number
HK1244512A1
HK1244512A1 HK18103171.5A HK18103171A HK1244512A1 HK 1244512 A1 HK1244512 A1 HK 1244512A1 HK 18103171 A HK18103171 A HK 18103171A HK 1244512 A1 HK1244512 A1 HK 1244512A1
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Hong Kong
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amino acid
smo
antibody
cell
protein
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HK18103171.5A
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English (en)
Chinese (zh)
Inventor
弗德里克．J．德萨万格
弗德里克．J．德薩萬格
罗伯特．L．约奇
格里特．J．P．戴克赫拉夫
羅伯特．L．約奇
海莉．夏普
妮可．巴吉特．塞甘
Original Assignee
健泰科生物技术公司
柯瑞斯公司
法国国家卫生及研究医学协会
Université Paris Cité
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Publication of HK1244512A1 publication Critical patent/HK1244512A1/zh

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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/5759—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds localised on the membrane of tumour or cancer cells
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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HK18103171.5A 2015-02-04 2016-02-04 突变型smoothened及其使用方法 HK1244512A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562112074P 2015-02-04 2015-02-04
US62/112,074 2015-02-04
PCT/US2016/016614 WO2016126972A1 (en) 2015-02-04 2016-02-04 Mutant smoothened and methods of using the same

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HK1244512A1 true HK1244512A1 (zh) 2018-08-10

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US (1) US10330683B2 (https=)
EP (1) EP3253784B1 (https=)
JP (1) JP2018512597A (https=)
CN (1) CN107636170A (https=)
AU (1) AU2016215227A1 (https=)
CA (1) CA2975875A1 (https=)
HK (1) HK1244512A1 (https=)
WO (1) WO2016126972A1 (https=)

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CN108645830A (zh) * 2018-05-15 2018-10-12 华中科技大学鄂州工业技术研究院 一种纳米荧光探针联合蛋白芯片寻找药物作用靶点的方法
CN110174363A (zh) * 2019-01-09 2019-08-27 北京九强生物技术股份有限公司 6-磷酸葡萄糖脱氢酶突变体及其在制备检测试剂中的用途
CN109887553B (zh) * 2019-01-29 2021-01-26 杭州纽安津生物科技有限公司 针对肿瘤靶向药物耐药位点的多肽疫苗及其设计方法
EP3924520A1 (en) * 2019-02-13 2021-12-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for selecting a cancer treatment in a subject suffering from cancer
CN111658628B (zh) * 2019-03-08 2022-03-01 中国科学院动物研究所 Gli2抑制剂的用途以及抑制gli2的化合物的筛选方法
CN116953228A (zh) * 2021-02-10 2023-10-27 广东菲鹏生物有限公司 一种鉴别结合突变型抗原的抗体的方法及试剂
CN115247191B (zh) * 2021-11-30 2025-03-28 南京启真基因工程有限公司 基因编辑系统及其在构建双基因突变的痣样基底细胞癌综合征猪核移植供体细胞中的应用
CN114464246B (zh) * 2022-01-19 2023-05-30 华中科技大学同济医学院附属协和医院 基于CovMutt框架检测与遗传性增加相关的突变的方法
CN115327134B (zh) * 2022-08-26 2025-03-18 复旦大学附属中山医院 Erbb2 s310f突变的抗体在制备诊断检测胆囊癌中的应用

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