HK1243459A1 - 從經基因改造的微生物生產黏康酸 - Google Patents

從經基因改造的微生物生產黏康酸

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Publication number
HK1243459A1
HK1243459A1 HK18102984.4A HK18102984A HK1243459A1 HK 1243459 A1 HK1243459 A1 HK 1243459A1 HK 18102984 A HK18102984 A HK 18102984A HK 1243459 A1 HK1243459 A1 HK 1243459A1
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HK
Hong Kong
Prior art keywords
production
genetically engineered
muconic acid
engineered microorganisms
microorganisms
Prior art date
Application number
HK18102984.4A
Other languages
English (en)
Inventor
R Rogers Yocum
Wei Gong
Sudhanshu Dole
Ryan Sillers
Meghal Gandhi
Janice G Pero
Original Assignee
Pttgc Innovation America Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pttgc Innovation America Corp filed Critical Pttgc Innovation America Corp
Publication of HK1243459A1 publication Critical patent/HK1243459A1/zh

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
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    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245Escherichia (G)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0012Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0069Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1022Transferases (2.) transferring aldehyde or ketonic groups (2.2)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1085Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/88Lyases (4.)
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    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44Polycarboxylic acids
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    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01025Shikimate dehydrogenase (1.1.1.25)
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    • C12Y205/00Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/010543-Deoxy-7-phosphoheptulonate synthase (2.5.1.54)
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    • C12YENZYMES
    • C12Y402/00Carbon-oxygen lyases (4.2)
    • C12Y402/01Hydro-lyases (4.2.1)
    • C12Y402/011183-Dehydroshikimate dehydratase (4.2.1.118)

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK18102984.4A 2012-01-30 2018-03-01 從經基因改造的微生物生產黏康酸 HK1243459A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261632777P 2012-01-30 2012-01-30

Publications (1)

Publication Number Publication Date
HK1243459A1 true HK1243459A1 (zh) 2018-07-13

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Country Status (11)

Country Link
US (2) US20150044755A1 (zh)
EP (2) EP3312267B1 (zh)
JP (3) JP2015504688A (zh)
KR (1) KR102092422B1 (zh)
CN (2) CN107177540A (zh)
BR (1) BR112014017686A2 (zh)
CA (1) CA2862051A1 (zh)
ES (1) ES2663445T3 (zh)
HK (1) HK1243459A1 (zh)
MY (1) MY172307A (zh)
WO (1) WO2013116244A1 (zh)

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SG10202008244TA (en) 2016-03-02 2020-10-29 Ptt Global Chemical Public Co Ltd Improved muconic acid production from genetically engineered microorganisms
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CN108314712A (zh) * 2017-01-16 2018-07-24 中国科学院微生物研究所 L-苏氨酸转运蛋白ThrF及其编码基因与应用
CN108314713A (zh) * 2017-01-16 2018-07-24 中国科学院微生物研究所 L-苏氨酸转运蛋白ThrG及其编码基因与应用
JP2020513790A (ja) 2017-02-06 2020-05-21 ザイマージェン インコーポレイテッド 発酵によりチラミンを生成させるための遺伝子操作型生合成経路
CN106947727B (zh) * 2017-02-20 2019-08-16 波顿(上海)生物技术有限公司 一种基因工程菌及其构建方法与生产香兰素的方法
US11708590B2 (en) 2017-07-18 2023-07-25 Arizona Board Of Regents On Behalf Of Arizona State University Synthetic metabolic funneling for biochemical production
KR102003911B1 (ko) * 2018-02-23 2019-07-25 씨제이제일제당 주식회사 마이코스포린 유사 아미노산을 생산하는 미생물 및 이를 이용한 마이코스포린 유사 아미노산의 생산방법
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CN111662892B (zh) * 2020-07-29 2022-07-01 上海市农业科学院 β-酮己二酸代谢相关三个基因的结构优化与应用
CN112266892B (zh) * 2020-10-21 2021-10-08 中国科学院天津工业生物技术研究所 AroG的突变体及其在产氨基酸基因工程菌中的应用
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Also Published As

Publication number Publication date
ES2663445T3 (es) 2018-04-12
CN104220587A (zh) 2014-12-17
WO2013116244A1 (en) 2013-08-08
BR112014017686A2 (pt) 2017-06-27
US20190345437A1 (en) 2019-11-14
JP2019195330A (ja) 2019-11-14
EP2809771A1 (en) 2014-12-10
EP2809771B1 (en) 2017-12-27
KR20140131939A (ko) 2014-11-14
US20150044755A1 (en) 2015-02-12
JP2017184746A (ja) 2017-10-12
EP3312267A1 (en) 2018-04-25
MY172307A (en) 2019-11-21
CN107177540A (zh) 2017-09-19
CA2862051A1 (en) 2013-08-08
EP3312267B1 (en) 2020-03-11
JP2015504688A (ja) 2015-02-16
KR102092422B1 (ko) 2020-03-24
EP2809771A4 (en) 2016-01-27

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