BR112014017686A2 - produção de ácido mucônico a partir de micro-organismos geneticamente engenheirados - Google Patents
produção de ácido mucônico a partir de micro-organismos geneticamente engenheiradosInfo
- Publication number
- BR112014017686A2 BR112014017686A2 BR112014017686A BR112014017686A BR112014017686A2 BR 112014017686 A2 BR112014017686 A2 BR 112014017686A2 BR 112014017686 A BR112014017686 A BR 112014017686A BR 112014017686 A BR112014017686 A BR 112014017686A BR 112014017686 A2 BR112014017686 A2 BR 112014017686A2
- Authority
- BR
- Brazil
- Prior art keywords
- genetically engineered
- muconic acid
- present
- producing
- renewable
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
- C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01025—Shikimate dehydrogenase (1.1.1.25)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01054—3-Deoxy-7-phosphoheptulonate synthase (2.5.1.54)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01118—3-Dehydroshikimate dehydratase (4.2.1.118)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
abstract (0230) this present invention is in the field of producing renewable chemical feedstocks using biocatalysts that have been genetically engineered to increase their ability to convert renewable carbon resources into useful compounds. more specifically, the present invention provides a process for producing muconic acid form renewable carbon resources using a genetically modified organism. tradução do resumo resumo patente de invenção: "produção de ácido mucônico a partir de micro-organismos geneticamente engenheirados". a presente invenção está no campo de produção de matérias-primas químicas renováveis usando biocatalisadores que foram geneticamente engenheirados para aumentar sua habilidade em converter fontes de carbono renováveis em compostos úteis. mais especificamente, a presente invenção provê um processo para a produção de ácido mucônico a partir de fontes de carbono renováveis usando um organismo geneticamente modificado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261632777P | 2012-01-30 | 2012-01-30 | |
PCT/US2013/023690 WO2013116244A1 (en) | 2012-01-30 | 2013-01-29 | Production of muconic acid from genetically engineered microorganisms |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014017686A2 true BR112014017686A2 (pt) | 2017-06-27 |
Family
ID=48905760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014017686A BR112014017686A2 (pt) | 2012-01-30 | 2013-01-29 | produção de ácido mucônico a partir de micro-organismos geneticamente engenheirados |
Country Status (11)
Country | Link |
---|---|
US (2) | US20150044755A1 (pt) |
EP (2) | EP3312267B1 (pt) |
JP (3) | JP2015504688A (pt) |
KR (1) | KR102092422B1 (pt) |
CN (2) | CN107177540A (pt) |
BR (1) | BR112014017686A2 (pt) |
CA (1) | CA2862051A1 (pt) |
ES (1) | ES2663445T3 (pt) |
HK (1) | HK1243459A1 (pt) |
MY (1) | MY172307A (pt) |
WO (1) | WO2013116244A1 (pt) |
Families Citing this family (20)
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US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
KR102064475B1 (ko) * | 2014-04-17 | 2020-01-10 | (주)에스티알바이오텍 | 뮤코닉산 생산용 미생물 및 그 제조방법 |
WO2016036748A1 (en) * | 2014-09-03 | 2016-03-10 | Coffa Gianguido | Production of cis, cis-muconic acid from carbonaceous material |
WO2016207403A1 (en) | 2015-06-24 | 2016-12-29 | Deinove | Method of producing muconic acid |
KR20190003939A (ko) * | 2016-03-02 | 2019-01-10 | 피티티지씨 이노베이션 아메리카 코포레이션 | 유전자 조작된 미생물로부터 개선된 뮤콘산 생산 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
CN108314713A (zh) * | 2017-01-16 | 2018-07-24 | 中国科学院微生物研究所 | L-苏氨酸转运蛋白ThrG及其编码基因与应用 |
CN108314712A (zh) * | 2017-01-16 | 2018-07-24 | 中国科学院微生物研究所 | L-苏氨酸转运蛋白ThrF及其编码基因与应用 |
CA3052635A1 (en) | 2017-02-06 | 2018-11-08 | Zymergen Inc. | Engineered biosynthetic pathways for production of tyramine by fermentation |
CN106947727B (zh) * | 2017-02-20 | 2019-08-16 | 波顿(上海)生物技术有限公司 | 一种基因工程菌及其构建方法与生产香兰素的方法 |
US11708590B2 (en) | 2017-07-18 | 2023-07-25 | Arizona Board Of Regents On Behalf Of Arizona State University | Synthetic metabolic funneling for biochemical production |
KR102003911B1 (ko) * | 2018-02-23 | 2019-07-25 | 씨제이제일제당 주식회사 | 마이코스포린 유사 아미노산을 생산하는 미생물 및 이를 이용한 마이코스포린 유사 아미노산의 생산방법 |
US20220228178A1 (en) | 2019-05-10 | 2022-07-21 | Toray Industries, Inc. | Genetically modified microorganism for producing 3-hydroxyhexanedioic acid, (e)-hex-2-enedioic acid and/or hexanedioic acid, and production method for said chemicals |
JPWO2020230718A1 (pt) * | 2019-05-10 | 2020-11-19 | ||
CN110184288A (zh) * | 2019-05-28 | 2019-08-30 | 南京趣酶生物科技有限公司 | 没食子酸和原儿茶酸的制备方法及其反应催化剂的制备方法 |
CN111662892B (zh) * | 2020-07-29 | 2022-07-01 | 上海市农业科学院 | β-酮己二酸代谢相关三个基因的结构优化与应用 |
CN112266892B (zh) * | 2020-10-21 | 2021-10-08 | 中国科学院天津工业生物技术研究所 | AroG的突变体及其在产氨基酸基因工程菌中的应用 |
EP4245844A1 (en) | 2020-11-11 | 2023-09-20 | Toray Industries, Inc. | Genetically modified microorganism for producing 3-hydroxyadipic acid and/or ?-hydromuconic acid, and method for producing chemical product |
CN117004547B (zh) * | 2023-09-27 | 2023-12-22 | 北京化工大学 | 一种以葡萄糖为底物从头合成顺,顺-粘康酸的基因工程菌及其应用 |
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2013
- 2013-01-29 ES ES13743123.5T patent/ES2663445T3/es active Active
- 2013-01-29 BR BR112014017686A patent/BR112014017686A2/pt not_active Application Discontinuation
- 2013-01-29 WO PCT/US2013/023690 patent/WO2013116244A1/en active Application Filing
- 2013-01-29 MY MYPI2014002156A patent/MY172307A/en unknown
- 2013-01-29 JP JP2014554943A patent/JP2015504688A/ja active Pending
- 2013-01-29 CN CN201710442475.XA patent/CN107177540A/zh active Pending
- 2013-01-29 EP EP17001811.3A patent/EP3312267B1/en active Active
- 2013-01-29 EP EP13743123.5A patent/EP2809771B1/en active Active
- 2013-01-29 CA CA2862051A patent/CA2862051A1/en not_active Abandoned
- 2013-01-29 CN CN201380017560.1A patent/CN104220587A/zh active Pending
- 2013-01-29 KR KR1020147024229A patent/KR102092422B1/ko active IP Right Grant
- 2013-01-29 US US14/375,071 patent/US20150044755A1/en not_active Abandoned
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2017
- 2017-05-17 JP JP2017097925A patent/JP2017184746A/ja active Pending
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2018
- 2018-03-01 HK HK18102984.4A patent/HK1243459A1/zh unknown
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2019
- 2019-06-04 JP JP2019104585A patent/JP2019195330A/ja active Pending
- 2019-07-10 US US16/508,048 patent/US20190345437A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2809771B1 (en) | 2017-12-27 |
CN107177540A (zh) | 2017-09-19 |
KR20140131939A (ko) | 2014-11-14 |
JP2019195330A (ja) | 2019-11-14 |
EP3312267A1 (en) | 2018-04-25 |
EP2809771A1 (en) | 2014-12-10 |
CN104220587A (zh) | 2014-12-17 |
JP2015504688A (ja) | 2015-02-16 |
US20150044755A1 (en) | 2015-02-12 |
CA2862051A1 (en) | 2013-08-08 |
EP2809771A4 (en) | 2016-01-27 |
MY172307A (en) | 2019-11-21 |
KR102092422B1 (ko) | 2020-03-24 |
ES2663445T3 (es) | 2018-04-12 |
HK1243459A1 (zh) | 2018-07-13 |
JP2017184746A (ja) | 2017-10-12 |
US20190345437A1 (en) | 2019-11-14 |
EP3312267B1 (en) | 2020-03-11 |
WO2013116244A1 (en) | 2013-08-08 |
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