SG11201807544WA - Improved muconic acid production from genetically engineered microorganisms - Google Patents
Improved muconic acid production from genetically engineered microorganismsInfo
- Publication number
- SG11201807544WA SG11201807544WA SG11201807544WA SG11201807544WA SG11201807544WA SG 11201807544W A SG11201807544W A SG 11201807544WA SG 11201807544W A SG11201807544W A SG 11201807544WA SG 11201807544W A SG11201807544W A SG 11201807544WA SG 11201807544W A SG11201807544W A SG 11201807544WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- muconic acid
- acid
- pct
- street
- Prior art date
Links
- TXXHDPDFNKHHGW-UHFFFAOYSA-N muconic acid Chemical compound OC(=O)C=CC=CC(O)=O TXXHDPDFNKHHGW-UHFFFAOYSA-N 0.000 title abstract 9
- TXXHDPDFNKHHGW-CCAGOZQPSA-N Muconic acid Natural products OC(=O)\C=C/C=C\C(O)=O TXXHDPDFNKHHGW-CCAGOZQPSA-N 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 244000005700 microbiome Species 0.000 title abstract 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 abstract 4
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 abstract 4
- 101150040872 aroE gene Proteins 0.000 abstract 2
- YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 229940074391 gallic acid Drugs 0.000 abstract 2
- 235000004515 gallic acid Nutrition 0.000 abstract 2
- 101150046211 pobA gene Proteins 0.000 abstract 2
- 229940079877 pyrogallol Drugs 0.000 abstract 2
- PJWIPEXIFFQAQZ-PUFIMZNGSA-N 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonic acid Chemical compound OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@H](O)CC(=O)C(O)=O PJWIPEXIFFQAQZ-PUFIMZNGSA-N 0.000 abstract 1
- 101100163490 Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) aroA1 gene Proteins 0.000 abstract 1
- 101100392078 Caenorhabditis elegans cat-4 gene Proteins 0.000 abstract 1
- 101100435903 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) aroG gene Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 229920000057 Mannan Polymers 0.000 abstract 1
- 101100435931 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) aroK gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 101150037081 aroA gene Proteins 0.000 abstract 1
- 101150042732 aroC gene Proteins 0.000 abstract 1
- 101150102858 aroD gene Proteins 0.000 abstract 1
- 101150019536 aroF gene Proteins 0.000 abstract 1
- 101150018055 aroH gene Proteins 0.000 abstract 1
- 101150083869 aroK gene Proteins 0.000 abstract 1
- 101150007004 aroL gene Proteins 0.000 abstract 1
- 101150108612 aroQ gene Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 239000002420 orchard Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- TXXHDPDFNKHHGW-ZPUQHVIOSA-N trans,trans-muconic acid Chemical compound OC(=O)\C=C\C=C\C(O)=O TXXHDPDFNKHHGW-ZPUQHVIOSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
- C12Y113/11—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of two atoms of oxygen (1.13.11)
- C12Y113/11001—Catechol 1,2-dioxygenase (1.13.11.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
- C12Y202/01—Transketolases and transaldolases (2.2.1)
- C12Y202/01001—Transketolase (2.2.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
- C12Y205/01054—3-Deoxy-7-phosphoheptulonate synthase (2.5.1.54)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01063—Protocatechuate decarboxylase (4.1.1.63)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/01—Hydro-lyases (4.2.1)
- C12Y402/01118—3-Dehydroshikimate dehydratase (4.2.1.118)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
- C12Y402/03004—3-Dehydroquinate synthase (4.2.3.4)
Abstract
FigurearoG, aroF, aroH Quinnic Acid 14— Tyr-Phe-Trp pobA PCA DAHP pobA Gallic Acid aroY Pyrogallol rr aroD DHS 4 Leaky aroE SHK rr aroK, aroL S3P CHA 4, aroY Catechol 4, cat4 ccMuA 4 , lsomerase ttMuA Gallic Acid 4, aro) . Pyrogallol aroZ W O 20 17 / 15 18 11 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/151811 Al 8 September 2017 (08.09.2017) WIPO I PCT 11111111111111 0 111011111111111 010 11111 III 011111111 H 01111111 011 (51) International Patent Classification: C12N 1/21 (2006.01) C12P 7/44 (2006.01) C12N 15/09 (2006.01) C12N 15/60 (2006.01) C12N 15/52 (2006.01) (21) International Application Number: PCT/US2017/020263 (22) International Filing Date: 1 March 2017 (01.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/302,558 2 March 2016 (02.03.2016) US (71) Applicant: MYRIANT CORPORATION [US/US]; 42 Cummings Park, Woburn, MA 01801 (US). (72) Inventors: SILLERS, Ryan; 17 Forest Circle, Winchester, MA 01890 (US). SPENCER, Michelle; 82 Oak Hill Street, Pepperell, MA 01463 (US). YOCUM, R., Rogers; 4 Orchard Street, Lexington, MA 02420 (US). HER- MANN, Theron; 151 Warren Street, Arlington, MA 02474 (US). (74) Agent: MANNAN, Ramasamy, Mannar; Myriant Cor- poration, 42 Cummings Park, Woburn, MA 01801 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). [Continued on next page] (54) Title: IMPROVED MUCONIC ACID PRODUCTION FROM GENETICALLY ENGINEERED MICROORGANISMS (57) : The subject of this inven- tion is improvements in the yield and titer of biological production of muconic acid by fermentation. Increased activity of one or more enzymes involved in the muconic acid pathway leads to increased production of muconic acid. WO 2017/151811 Al 1#1101M011111 11111111ME3011111111111111111111111111111111111 Published: with international search report (Art. 2 1 (3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) — with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662302558P | 2016-03-02 | 2016-03-02 | |
| PCT/US2017/020263 WO2017151811A1 (en) | 2016-03-02 | 2017-03-01 | Improved muconic acid production from genetically engineered microorganisms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201807544WA true SG11201807544WA (en) | 2018-09-27 |
Family
ID=59744431
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202008244TA SG10202008244TA (en) | 2016-03-02 | 2017-03-01 | Improved muconic acid production from genetically engineered microorganisms |
| SG11201807544WA SG11201807544WA (en) | 2016-03-02 | 2017-03-01 | Improved muconic acid production from genetically engineered microorganisms |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202008244TA SG10202008244TA (en) | 2016-03-02 | 2017-03-01 | Improved muconic acid production from genetically engineered microorganisms |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20200181658A1 (en) |
| EP (1) | EP3423563B1 (en) |
| JP (1) | JP7437116B2 (en) |
| KR (2) | KR20240005196A (en) |
| CN (1) | CN109415684B (en) |
| ES (1) | ES2947938T3 (en) |
| SG (2) | SG10202008244TA (en) |
| WO (1) | WO2017151811A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11518975B2 (en) | 2018-04-30 | 2022-12-06 | Alliance For Sustainable Energy, Llc | Engineered microorganisms for the production of intermediates and final products |
| JP2021524230A (en) * | 2018-05-15 | 2021-09-13 | デューク ユニバーシティ | Systems and methods for genetic engineering of Akkermansia species |
| WO2020080467A1 (en) * | 2018-10-17 | 2020-04-23 | 国立大学法人弘前大学 | Muconic acid-producing transformed microorganism and use thereof |
| CN112300972B (en) * | 2019-08-02 | 2023-06-30 | 南京理工大学 | Genetically engineered bacterium for producing mucofuroic acid by using lignin as raw material |
| CN112300973B (en) * | 2019-08-02 | 2022-06-24 | 南京理工大学 | Rhodococcus gene editing method using phenylalanyl-tRNA synthetase gene mutant as reverse screening marker |
| CN111004761A (en) * | 2019-12-02 | 2020-04-14 | 天津科技大学 | L-tyrosine gene engineering bacterium, method for producing L-tyrosine by using same and application thereof |
| WO2021110993A1 (en) * | 2019-12-04 | 2021-06-10 | Synbionik Gmbh | An efficient shuttle vector system for the expression of heterologous and homologous proteins for the genus zymomonas |
| CN112266892B (en) * | 2020-10-21 | 2021-10-08 | 中国科学院天津工业生物技术研究所 | AroG mutant and application thereof in producing amino acid genetic engineering bacteria |
| CN112961878B (en) * | 2021-03-08 | 2023-04-25 | 昆明理工大学 | Application of lactobacillus plantarum gene in folic acid biological generation |
| CN114540396A (en) * | 2022-02-24 | 2022-05-27 | 天津大学 | Construction method of glucose metabolic pathway in Shewanella strain |
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| US4588688A (en) | 1981-07-27 | 1986-05-13 | Celanese Corporation | Process for the production of muconic acid |
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| JPS6090771A (en) | 1983-10-26 | 1985-05-21 | Tokyo Electric Co Ltd | Ink dot printer |
| US4833078A (en) | 1984-06-22 | 1989-05-23 | Celgene Corporation | Semi-continuous fermentation process for aromatic hydrocarbon bioconversion |
| US4968612A (en) | 1984-07-27 | 1990-11-06 | Celgene Corporation | Continuous fermentation process for aromatic hydrocarbon bioconversion |
| JPS61247392A (en) | 1985-02-04 | 1986-11-04 | エンジニツクス インコ−ポレ−テツド | Recombined microorganism capable of simultaneously producingtwo or more amino acids |
| US4753883A (en) | 1986-05-07 | 1988-06-28 | Biotechnica International, Inc. | Enzyme deregulation |
| US5168056A (en) | 1991-02-08 | 1992-12-01 | Purdue Research Foundation | Enhanced production of common aromatic pathway compounds |
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| US5487987A (en) | 1993-09-16 | 1996-01-30 | Purdue Research Foundation | Synthesis of adipic acid from biomass-derived carbon sources |
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| US6210937B1 (en) | 1997-04-22 | 2001-04-03 | Bechtel Bwxt Idaho, Llc | Development of genetically engineered bacteria for production of selected aromatic compounds |
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| WO2005030949A1 (en) | 2003-09-24 | 2005-04-07 | Board Of Trustees Operating Michigan State University | Methods and materials for the production of shikimic acid |
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| CA2620468A1 (en) | 2005-08-18 | 2007-02-22 | Basf Aktiengesellschaft | Microorganisms with increased efficiency for methionine synthesis |
| WO2010148049A2 (en) | 2009-06-16 | 2010-12-23 | Draths Corporation | Preparation of trans, trans muconic acid and trans, trans muconates |
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| CA2786405C (en) | 2010-01-08 | 2019-04-02 | Amyris, Inc. | Methods for producing isomers of muconic acid and muconate salts |
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| JP6204912B2 (en) | 2011-07-22 | 2017-09-27 | ミリアント・コーポレイションＭｙｒｉａｎｔ Ｃｏｒｐｏｒａｔｉｏｎ | Organic acid fermentation of glycerol |
| EP3312267B1 (en) | 2012-01-30 | 2020-03-11 | PTT Global Chemical Public Company Limited | Production of muconic acid from genetically engineered microorganisms |
| BR112015005416A2 (en) * | 2012-09-14 | 2017-08-08 | Myriant Corp | organic acid production by low ph fermentation |
| CN103667166A (en) * | 2012-09-21 | 2014-03-26 | 天津工业生物技术研究所 | Escherichia coli for producing adipic acid precursor namely cis,cis-muconic acid and application of escherichia coli |
| CN104099284B (en) * | 2014-07-01 | 2018-12-04 | 江南大学 | One plant using glucose as the colibacillus engineering of substrate synthesis muconic acid |
| US10017792B2 (en) | 2014-07-18 | 2018-07-10 | Alliance For Sustainable Energy, Llc | Biomass conversion to fuels and chemicals |
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2017
- 2017-03-01 EP EP17760744.7A patent/EP3423563B1/en active Active
- 2017-03-01 JP JP2018545971A patent/JP7437116B2/en active Active
- 2017-03-01 US US16/081,504 patent/US20200181658A1/en not_active Abandoned
- 2017-03-01 CN CN201780026997.XA patent/CN109415684B/en active Active
- 2017-03-01 WO PCT/US2017/020263 patent/WO2017151811A1/en active Application Filing
- 2017-03-01 ES ES17760744T patent/ES2947938T3/en active Active
- 2017-03-01 SG SG10202008244TA patent/SG10202008244TA/en unknown
- 2017-03-01 KR KR1020237044654A patent/KR20240005196A/en active Application Filing
- 2017-03-01 KR KR1020187028248A patent/KR20190003939A/en not_active IP Right Cessation
- 2017-03-01 SG SG11201807544WA patent/SG11201807544WA/en unknown
-
2021
- 2021-05-21 US US17/326,643 patent/US11685938B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| SG10202008244TA (en) | 2020-10-29 |
| JP2019506886A (en) | 2019-03-14 |
| EP3423563B1 (en) | 2023-05-24 |
| EP3423563A4 (en) | 2019-10-16 |
| KR20190003939A (en) | 2019-01-10 |
| KR20240005196A (en) | 2024-01-11 |
| ES2947938T3 (en) | 2023-08-24 |
| CN109415684A (en) | 2019-03-01 |
| US11685938B2 (en) | 2023-06-27 |
| CN109415684B (en) | 2022-06-07 |
| JP7437116B2 (en) | 2024-02-22 |
| EP3423563A1 (en) | 2019-01-09 |
| US20210277429A1 (en) | 2021-09-09 |
| WO2017151811A1 (en) | 2017-09-08 |
| US20200181658A1 (en) | 2020-06-11 |
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