HK1213294A1 - 穩定的非多腺苷酸化 的產生 - Google Patents
穩定的非多腺苷酸化 的產生Info
- Publication number
- HK1213294A1 HK1213294A1 HK16101305.0A HK16101305A HK1213294A1 HK 1213294 A1 HK1213294 A1 HK 1213294A1 HK 16101305 A HK16101305 A HK 16101305A HK 1213294 A1 HK1213294 A1 HK 1213294A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- production
- stable non
- polyadenylated rnas
- rnas rna
- rna
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/15—Nucleic acids forming more than 2 strands, e.g. TFOs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3519—Fusion with another nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261714697P | 2012-10-16 | 2012-10-16 | |
US201261716764P | 2012-10-22 | 2012-10-22 | |
US201261739153P | 2012-12-19 | 2012-12-19 | |
PCT/US2013/065239 WO2014062801A1 (en) | 2012-10-16 | 2013-10-16 | Production of stable non-polyadenylated rnas |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1213294A1 true HK1213294A1 (zh) | 2016-06-30 |
Family
ID=50488728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16101305.0A HK1213294A1 (zh) | 2012-10-16 | 2016-02-04 | 穩定的非多腺苷酸化 的產生 |
Country Status (11)
Country | Link |
---|---|
US (2) | US9717749B2 (zh) |
EP (1) | EP2909321A4 (zh) |
JP (1) | JP2015536647A (zh) |
KR (1) | KR20150070307A (zh) |
CN (1) | CN104955951A (zh) |
AU (1) | AU2013331351A1 (zh) |
CA (1) | CA2888215A1 (zh) |
HK (1) | HK1213294A1 (zh) |
IL (1) | IL238256A0 (zh) |
MX (1) | MX2015004853A (zh) |
WO (1) | WO2014062801A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2015004853A (es) | 2012-10-16 | 2015-12-09 | Massachusetts Inst Technology | Produccion de acidos ribonucleicos no poliadenilados estables. |
CA2964796C (en) * | 2014-10-17 | 2022-01-11 | The Penn State Research Foundation | Methods and compositions for multiplex rna guided genome editing and other rna technologies |
US12019066B2 (en) * | 2016-05-16 | 2024-06-25 | Biomadison, Inc. | Assay with synaptobrevin based moiety |
SG11201908043UA (en) * | 2017-03-02 | 2019-09-27 | Meiragtx Uk Ii Limited | Regulation of gene expression by aptamer-modulated rnase p cleavage |
US10378070B2 (en) * | 2017-09-07 | 2019-08-13 | Kyoto University | Vector and gene introduction agent for monitoring and visualizing cell differentiation using expression of micro RNA as indicator and monitoring and visualizing method using thereof |
CN112236153A (zh) | 2018-04-05 | 2021-01-15 | 阿兹特拉公司 | 用重组微生物治疗皮肤疾病的方法和组合物 |
AU2020260154A1 (en) * | 2019-04-17 | 2021-11-11 | The Trustees Of The University Of Pennsylvania | Triple helix terminator for efficient RNA trans-splicing |
CN112790125B (zh) * | 2021-01-22 | 2022-09-06 | 中国科学院水生生物研究所 | 一种玉兔百褶裙泰狮金鱼的创制方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5824497A (en) * | 1995-02-10 | 1998-10-20 | Mcmaster University | High efficiency translation of mRNA molecules |
US6242187B1 (en) * | 1996-01-29 | 2001-06-05 | Virologic, Inc. | Compositions and methods for determining anti-viral drug susceptibility and resistance and anti-viral drug screening |
SG181564A1 (en) | 2009-12-07 | 2012-07-30 | Katalin Kariko | Rna preparations comprising purified modified rna for reprogramming cells |
US8853377B2 (en) | 2010-11-30 | 2014-10-07 | Shire Human Genetic Therapies, Inc. | mRNA for use in treatment of human genetic diseases |
EP3460064B8 (en) * | 2011-04-03 | 2024-03-20 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Efficient protein expression in vivo using modified rna (mod-rna) |
MX2015004853A (es) | 2012-10-16 | 2015-12-09 | Massachusetts Inst Technology | Produccion de acidos ribonucleicos no poliadenilados estables. |
-
2013
- 2013-10-16 MX MX2015004853A patent/MX2015004853A/es unknown
- 2013-10-16 CN CN201380060191.4A patent/CN104955951A/zh active Pending
- 2013-10-16 JP JP2015537026A patent/JP2015536647A/ja active Pending
- 2013-10-16 EP EP13847465.5A patent/EP2909321A4/en not_active Withdrawn
- 2013-10-16 AU AU2013331351A patent/AU2013331351A1/en not_active Abandoned
- 2013-10-16 US US14/436,228 patent/US9717749B2/en active Active
- 2013-10-16 CA CA2888215A patent/CA2888215A1/en not_active Abandoned
- 2013-10-16 WO PCT/US2013/065239 patent/WO2014062801A1/en active Application Filing
- 2013-10-16 KR KR1020157012583A patent/KR20150070307A/ko not_active Application Discontinuation
-
2015
- 2015-04-13 IL IL238256A patent/IL238256A0/en unknown
-
2016
- 2016-02-04 HK HK16101305.0A patent/HK1213294A1/zh unknown
-
2017
- 2017-07-31 US US15/664,017 patent/US10946035B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2014062801A1 (en) | 2014-04-24 |
US20180140625A1 (en) | 2018-05-24 |
US20150315574A1 (en) | 2015-11-05 |
US10946035B2 (en) | 2021-03-16 |
CA2888215A1 (en) | 2014-04-24 |
EP2909321A4 (en) | 2016-06-22 |
US9717749B2 (en) | 2017-08-01 |
MX2015004853A (es) | 2015-12-09 |
EP2909321A1 (en) | 2015-08-26 |
JP2015536647A (ja) | 2015-12-24 |
CN104955951A (zh) | 2015-09-30 |
KR20150070307A (ko) | 2015-06-24 |
AU2013331351A1 (en) | 2015-04-30 |
IL238256A0 (en) | 2015-06-30 |
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