HK1221951A1 - 有关1-乙基-7-(2-甲基-6-(1H-1，2，4-三唑-3-基)吡啶-3-基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1H)-酮的药物制剂、程序、固体形式和使用方法 - Google Patents

有关1-乙基-7-(2-甲基-6-(1H-1，2，4-三唑-3-基)吡啶-3-基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1H)-酮的药物制剂、程序、固体形式和使用方法 Download PDF

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Publication number
HK1221951A1
HK1221951A1 HK16109682.6A HK16109682A HK1221951A1 HK 1221951 A1 HK1221951 A1 HK 1221951A1 HK 16109682 A HK16109682 A HK 16109682A HK 1221951 A1 HK1221951 A1 HK 1221951A1
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Hong Kong
Prior art keywords
dihydropyrazino
pyrazin
triazol
pyridin
ethyl
Prior art date
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HK16109682.6A
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English (en)
Chinese (zh)
Inventor
阿尼爾．門諾
阿尼尔．门诺
達爾尚．
达尔尚．K．帕瑞克
．帕瑞克
多拉．维斯基
多拉．維斯基
马修．迈克尔．克雷莱茵
馬修．邁克爾．克雷萊茵
内森．波尔森
內森．波爾森
托马斯．李
托馬斯．李
李英
珍．徐
梁晓章
梁曉章
威廉．威-华．莱昂
威廉．威-華．萊昂
本杰明．科恩
Original Assignee
西格诺药品有限公司
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Publication of HK1221951A1 publication Critical patent/HK1221951A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK16109682.6A 2013-04-17 2014-04-16 有关1-乙基-7-(2-甲基-6-(1H-1，2，4-三唑-3-基)吡啶-3-基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1H)-酮的药物制剂、程序、固体形式和使用方法 HK1221951A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361813064P 2013-04-17 2013-04-17
US61/813,064 2013-04-17
US201361911201P 2013-12-03 2013-12-03
US61/911,201 2013-12-03
PCT/US2014/034301 WO2014172423A1 (en) 2013-04-17 2014-04-16 Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

Publications (1)

Publication Number Publication Date
HK1221951A1 true HK1221951A1 (zh) 2017-06-16

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HK16109682.6A HK1221951A1 (zh) 2013-04-17 2014-04-16 有关1-乙基-7-(2-甲基-6-(1H-1，2，4-三唑-3-基)吡啶-3-基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1H)-酮的药物制剂、程序、固体形式和使用方法

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US (3) US9359364B2 (enExample)
EP (2) EP3549940A1 (enExample)
JP (2) JP2016516815A (enExample)
KR (2) KR102459285B1 (enExample)
CN (2) CN105324381A (enExample)
AU (1) AU2014254050B2 (enExample)
BR (1) BR112015026300A2 (enExample)
CA (1) CA2909629C (enExample)
CL (1) CL2015003068A1 (enExample)
CR (1) CR20150577A (enExample)
EA (2) EA037683B1 (enExample)
ES (1) ES2744198T3 (enExample)
HK (1) HK1221951A1 (enExample)
IL (1) IL242102B (enExample)
MX (2) MX380236B (enExample)
NI (1) NI201500152A (enExample)
NZ (2) NZ629230A (enExample)
PE (1) PE20160041A1 (enExample)
PH (2) PH12015502394A1 (enExample)
SA (1) SA515370014B1 (enExample)
SG (1) SG11201508527VA (enExample)
TW (1) TW201527300A (enExample)
WO (1) WO2014172423A1 (enExample)
ZA (1) ZA201507737B (enExample)

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EA037683B1 (ru) * 2013-04-17 2021-04-29 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Фармацевтические составы, способы, твердые формы и способы применения, относящиеся к 1-этил-7-(2-метил-6-(1h-1,2,4-триазол-3-ил)пиридин-3-ил)-3,4-дигидропиразино[2,3-b] пиразин-2(1h)-ону
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KR102221029B1 (ko) 2013-04-17 2021-02-26 시그날 파마소티칼 엘엘씨 디하이드로피라지노-피라진을 사용한 암의 치료
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