HK1216100A1 - 在用於治療癌症疾病中作為 激酶調節劑的 -二甲氧基喹唑啉- -基氧基 苯基 -三氟- -甲基丙烷- -基 異惡唑- -基 - Google Patents
在用於治療癌症疾病中作為 激酶調節劑的 -二甲氧基喹唑啉- -基氧基 苯基 -三氟- -甲基丙烷- -基 異惡唑- -基Info
- Publication number
- HK1216100A1 HK1216100A1 HK16104063.6A HK16104063A HK1216100A1 HK 1216100 A1 HK1216100 A1 HK 1216100A1 HK 16104063 A HK16104063 A HK 16104063A HK 1216100 A1 HK1216100 A1 HK 1216100A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- raf
- dimethoxyquinazolin
- methylpropan
- isoxazol
- yloxy
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
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- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
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- Oncology (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6976308P | 2008-03-17 | 2008-03-17 | |
US11050808P | 2008-10-31 | 2008-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1216100A1 true HK1216100A1 (zh) | 2016-10-14 |
Family
ID=40852165
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11105522.3A HK1151525A1 (zh) | 2008-03-17 | 2011-06-01 | 作為 激酶調節劑的喹唑啉衍生物及其使用方法 |
HK16104063.6A HK1216100A1 (zh) | 2008-03-17 | 2016-04-08 | 在用於治療癌症疾病中作為 激酶調節劑的 -二甲氧基喹唑啉- -基氧基 苯基 -三氟- -甲基丙烷- -基 異惡唑- -基 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11105522.3A HK1151525A1 (zh) | 2008-03-17 | 2011-06-01 | 作為 激酶調節劑的喹唑啉衍生物及其使用方法 |
Country Status (23)
Country | Link |
---|---|
US (5) | US8618289B2 (zh) |
EP (3) | EP2947072B1 (zh) |
JP (1) | JP5542793B2 (zh) |
KR (2) | KR101601997B1 (zh) |
CN (2) | CN102026985B (zh) |
AU (1) | AU2009226136B2 (zh) |
BR (1) | BRPI0906186A2 (zh) |
CA (2) | CA2718123C (zh) |
DK (2) | DK2268623T3 (zh) |
EA (1) | EA019350B1 (zh) |
ES (2) | ES2547406T3 (zh) |
HK (2) | HK1151525A1 (zh) |
HU (2) | HUE025197T2 (zh) |
IL (1) | IL207793A (zh) |
MX (1) | MX2010010172A (zh) |
MY (1) | MY161576A (zh) |
NZ (1) | NZ587907A (zh) |
PL (2) | PL2268623T3 (zh) |
PT (2) | PT2947072T (zh) |
SG (2) | SG191678A1 (zh) |
SI (2) | SI2268623T1 (zh) |
WO (1) | WO2009117080A1 (zh) |
ZA (1) | ZA201006524B (zh) |
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BRPI0908268A2 (pt) * | 2008-02-29 | 2018-10-30 | Array Biopharma Inc | compostos do inibidor de raf e seus métodos de uso |
JP2011513330A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | Raf阻害化合物およびその使用方法 |
JP2011513329A (ja) * | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | RAF阻害化合物として使用されるイミダゾ[4,5−b]ピリジン誘導体 |
SI2268623T1 (sl) | 2008-03-17 | 2016-01-29 | Ambit Biosciences Corporation | Derivati kinazolina kot modulatorji raf-kinaze in postopki uporabe le-teh |
CA2752265A1 (en) * | 2009-02-17 | 2010-08-26 | Boehringer Ingelheim International Gmbh | Pyrimido [5,4-d] pyrimidine derivatives for the inhibition of tyrosine kinases |
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EP2496584B1 (en) * | 2009-11-05 | 2016-09-21 | Ambit Biosciences Corporation | Process for the preparation of imidazo[2,1-b][1,3]benzothiazole derivatives |
JP5787977B2 (ja) | 2010-04-08 | 2015-09-30 | レスピバート・リミテツド | P38mapキナーゼ阻害剤 |
US8933228B2 (en) | 2010-06-17 | 2015-01-13 | Respivert, Ltd. | Respiratory formulations and compounds for use therein |
NZ618795A (en) | 2011-05-13 | 2015-07-31 | Array Biopharma Inc | Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors |
CA2846574C (en) | 2011-08-26 | 2020-07-07 | Neupharma, Inc. | Quinoxaline sulfonamide derivates for use as kinase inhibitors |
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MY167798A (en) | 2011-10-03 | 2018-09-26 | Respivert Ltd | 1-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p38 map kinase inhibitors |
EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
TWI562989B (en) | 2011-11-14 | 2016-12-21 | Ignyta Inc | Uracil derivatives as axl and c-met kinase inhibitors |
WO2013112950A2 (en) | 2012-01-25 | 2013-08-01 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
EP2626073A1 (en) * | 2012-02-13 | 2013-08-14 | Harmonic Pharma | Compound for use in the prevention and/or treatment of a neurogenerative disease or a disease involving an activation of phosphodiesterase-4 (PDE4) |
GB201214750D0 (en) | 2012-08-17 | 2012-10-03 | Respivert Ltd | Compounds |
US20150225369A1 (en) * | 2012-08-29 | 2015-08-13 | Merck Patent Gmbh | Ddr2 inhibitors for the treatment of osteoarthritis |
EP2897618B1 (en) | 2012-09-24 | 2021-11-17 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
CN103102315B (zh) * | 2012-11-01 | 2016-01-20 | 云南大学 | 一种喹唑啉类芳基脲及其制备方法和用途 |
US9725421B2 (en) | 2012-11-12 | 2017-08-08 | Neupharma, Inc. | Substituted quinoxalines as B-raf kinase inhibitors |
WO2014076484A1 (en) | 2012-11-16 | 2014-05-22 | Respivert Limited | Kinase inhibitors |
WO2014127335A1 (en) * | 2013-02-15 | 2014-08-21 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
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