SG10201608813PA - Quinazoline derivatives as raf kinase modulators and methods of use thereof - Google Patents
Quinazoline derivatives as raf kinase modulators and methods of use thereofInfo
- Publication number
- SG10201608813PA SG10201608813PA SG10201608813PA SG10201608813PA SG10201608813PA SG 10201608813P A SG10201608813P A SG 10201608813PA SG 10201608813P A SG10201608813P A SG 10201608813PA SG 10201608813P A SG10201608813P A SG 10201608813PA SG 10201608813P A SG10201608813P A SG 10201608813PA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- raf kinase
- quinazoline derivatives
- kinase modulators
- modulators
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/93—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6976308P | 2008-03-17 | 2008-03-17 | |
US11050808P | 2008-10-31 | 2008-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201608813PA true SG10201608813PA (en) | 2016-12-29 |
Family
ID=40852165
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201608813PA SG10201608813PA (en) | 2008-03-17 | 2009-03-17 | Quinazoline derivatives as raf kinase modulators and methods of use thereof |
SG2013046388A SG191678A1 (en) | 2008-03-17 | 2009-03-17 | Quinazoline derivatives as raf kinase modulators and methods of use thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2013046388A SG191678A1 (en) | 2008-03-17 | 2009-03-17 | Quinazoline derivatives as raf kinase modulators and methods of use thereof |
Country Status (23)
Country | Link |
---|---|
US (5) | US8618289B2 (en) |
EP (3) | EP3147281A1 (en) |
JP (1) | JP5542793B2 (en) |
KR (2) | KR101713501B1 (en) |
CN (2) | CN102026985B (en) |
AU (1) | AU2009226136B2 (en) |
BR (1) | BRPI0906186A2 (en) |
CA (2) | CA2718123C (en) |
DK (2) | DK2947072T3 (en) |
EA (1) | EA019350B1 (en) |
ES (2) | ES2610989T3 (en) |
HK (2) | HK1151525A1 (en) |
HU (2) | HUE032873T2 (en) |
IL (1) | IL207793A (en) |
MX (1) | MX2010010172A (en) |
MY (1) | MY161576A (en) |
NZ (1) | NZ587907A (en) |
PL (2) | PL2947072T3 (en) |
PT (2) | PT2947072T (en) |
SG (2) | SG10201608813PA (en) |
SI (2) | SI2947072T1 (en) |
WO (1) | WO2009117080A1 (en) |
ZA (1) | ZA201006524B (en) |
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