HK1211605A1 - Methods for treating or preventing asthma by administering an il-4r antagonist il-4r - Google Patents

Methods for treating or preventing asthma by administering an il-4r antagonist il-4r

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Publication number
HK1211605A1
HK1211605A1 HK15112506.5A HK15112506A HK1211605A1 HK 1211605 A1 HK1211605 A1 HK 1211605A1 HK 15112506 A HK15112506 A HK 15112506A HK 1211605 A1 HK1211605 A1 HK 1211605A1
Authority
HK
Hong Kong
Prior art keywords
antagonist
administering
treating
methods
preventing asthma
Prior art date
Application number
HK15112506.5A
Other languages
English (en)
Chinese (zh)
Inventor
Marius Ardeleanu
Namita Gandhi
Neil Graham
Stephane C Kirkesseli
Sudeep Kundu
Allen Radin
Ross E Rocklin
Steven Weinstein
Hamilton Jennifer Davidson
Jeffrey Ming
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50148186&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1211605(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of HK1211605A1 publication Critical patent/HK1211605A1/xx

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
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    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • C07K16/247IL-4
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    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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HK15112506.5A 2012-08-21 2015-12-18 Methods for treating or preventing asthma by administering an il-4r antagonist il-4r HK1211605A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261691625P 2012-08-21 2012-08-21
US201361758097P 2013-01-29 2013-01-29
US201361761279P 2013-02-06 2013-02-06
US201361783796P 2013-03-14 2013-03-14
US201361805797P 2013-03-27 2013-03-27
FR1356994 2013-07-16
PCT/US2013/055747 WO2014031610A1 (en) 2012-08-21 2013-08-20 Methods for treating or preventing asthma by administering an il-4r antagonist

Publications (1)

Publication Number Publication Date
HK1211605A1 true HK1211605A1 (en) 2016-05-27

Family

ID=50148186

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Application Number Title Priority Date Filing Date
HK15112506.5A HK1211605A1 (en) 2012-08-21 2015-12-18 Methods for treating or preventing asthma by administering an il-4r antagonist il-4r

Country Status (28)

Country Link
US (2) US9574004B2 (pt)
EP (4) EP4324479A3 (pt)
JP (3) JP6306588B2 (pt)
KR (4) KR102386304B1 (pt)
CN (2) CN104755495A (pt)
AR (1) AR092177A1 (pt)
AU (3) AU2013305945B2 (pt)
BR (1) BR112015003590A8 (pt)
CA (1) CA2882416A1 (pt)
DK (1) DK2888281T3 (pt)
ES (2) ES2900342T3 (pt)
HK (1) HK1211605A1 (pt)
HR (1) HRP20181963T1 (pt)
HU (1) HUE064945T2 (pt)
IL (2) IL293398A (pt)
IN (1) IN2015KN00414A (pt)
LT (1) LT2888281T (pt)
MX (1) MX371344B (pt)
NZ (3) NZ744109A (pt)
PL (3) PL4011915T3 (pt)
PT (2) PT3470432T (pt)
RS (1) RS58091B1 (pt)
RU (1) RU2690675C2 (pt)
SG (2) SG11201500889TA (pt)
SI (1) SI2888281T1 (pt)
TW (1) TWI656880B (pt)
UY (1) UY34984A (pt)
WO (1) WO2014031610A1 (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608693B2 (en) * 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
CN106267189B (zh) 2010-10-06 2021-02-26 瑞泽恩制药公司 含有抗白介素-4受体(il-4r)的抗体的稳定制剂
AR092177A1 (es) 2012-08-21 2015-03-25 Sanofi Sa Metodos para tratar o prevenir asma administrando un antagonista de il-4r
PT2888281T (pt) * 2012-08-21 2018-12-14 Regeneron Pharma Métodos para tratamento ou prevenção da asma por meio de administração de um antagonista de il-4r
TWI633891B (zh) 2013-06-04 2018-09-01 再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
KR20230066127A (ko) 2013-06-21 2023-05-12 사노피 바이오테크놀로지 Il-4r 길항제를 투여함에 의한 비용종증의 치료 방법
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
EP3725311A1 (en) 2014-02-10 2020-10-21 Respivant Sciences GmbH Methods for the treatment of lung diseases with mast cell stabilizers
US20150224077A1 (en) 2014-02-10 2015-08-13 Patara Pharma, LLC Methods for the Treatment of Systemic Disorders Treatable with Mast Cell Stabilizers, including Mast Cell Related Disorders
IL247290B (en) * 2014-02-21 2021-06-30 Sanofi Biotechnology Methods of treating or preventing asthma by adding an il-4r antagonist
MX2016010854A (es) * 2014-02-21 2017-01-05 Sanofi Biotechnology Metodos para el tratamiento o la prevencion del asma mediante la administracion de un antagonista de il-4r.
KR20160120735A (ko) 2014-02-28 2016-10-18 리제너론 파아마슈티컬스, 인크. Il-4r 길항제의 투여에 의한 피부 감염의 치료 방법
NO2785538T3 (pt) 2014-05-07 2018-08-04
MA40164A (fr) * 2014-06-27 2017-05-03 Sanofi Sa Anticorps bispécifiques anti-il4-il13
TWI745962B (zh) 2014-06-27 2021-11-11 法商賽諾菲公司 測定投予至人類個體之包括雙-v-區類抗體蛋白或其片段的劑量是否在人類個體中與il-4或il-13特異性結合之方法
KR20170081262A (ko) 2014-11-14 2017-07-11 사노피 바이오테크놀로지 Il-4r 길항제의 투여에 의한, 비용종을 동반한 만성 부비동염의 치료 방법
KR102457921B1 (ko) 2014-12-09 2022-10-25 리제너론 파마슈티칼스 인코포레이티드 인간화 분화 클러스터 274 유전자를 갖는 비인간 동물
US10265296B2 (en) 2015-08-07 2019-04-23 Respivant Sciences Gmbh Methods for the treatment of systemic disorders treatable with mast cell stabilizers, including mast cell related disorders
US10238625B2 (en) 2015-08-07 2019-03-26 Respivant Sciences Gmbh Methods for the treatment of mast cell related disorders with mast cell stabilizers
CN107474134B (zh) 2016-06-08 2021-07-27 苏州康乃德生物医药有限公司 用于结合白细胞介素4受体的抗体
US20180056018A1 (en) * 2016-08-31 2018-03-01 Cephalon, Inc. Inhalation Systems, Devices and Methods
JP2019528320A (ja) 2016-08-31 2019-10-10 レシュピファント サイエンシス ゲゼルシャフト ミット ベシュレンクター ハフトゥングRespivant Sciences Gmbh 特発性肺線維症による慢性咳の治療のためのクロモリン組成物
WO2018045130A1 (en) * 2016-09-01 2018-03-08 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an il-4r antagonist
EP3522983A4 (en) 2016-10-07 2020-06-03 Respivant Sciences GmbH CROMOLYNE-BASED COMPOSITIONS FOR THE TREATMENT OF PULMONARY FIBROSIS
CN110062765A (zh) * 2016-10-31 2019-07-26 维克特拉有限公司 包括il-13抗体的可吸入粉末组合物
CN110431240A (zh) 2017-04-13 2019-11-08 雷杰纳荣制药公司 在编码il33和il1rl1的基因中具有风险等位基因的患者的炎症性肺部疾病的治疗和抑制
MX2019012570A (es) 2017-04-21 2019-12-02 Kindred Biosciences Inc Molecula del receptor de interleucina 4/interleucina 13 para uso veterinario.
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
PT3515465T (pt) 2017-08-18 2024-03-04 Regeneron Pharma Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r
KR20200081429A (ko) * 2017-10-30 2020-07-07 사노피 바이오테크놀로지, 소시에떼 빠르 악씨옹 셍쁠리피에 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법
US20200397343A1 (en) * 2017-11-15 2020-12-24 Venkata Satya Suresh ATTILI A device and method to determine the mean/average control of asthma/copd over time and compliance to treatment
US11292847B2 (en) 2018-05-13 2022-04-05 Regeneron Pharmaceuticals, Inc. Methods for treating atopic dermatitis by administering an IL-4R inhibitor
BR112021002989A2 (pt) 2018-08-24 2021-05-11 Jiangsu Hengrui Medicine Co., Ltd. anticorpo para ligação de il-4r de humano, fragmento para ligação de antígeno e uso médico do mesmo
CN110872349A (zh) * 2018-09-04 2020-03-10 三生国健药业(上海)股份有限公司 结合人il-4r的抗体、其制备方法和用途
WO2020074005A1 (en) 2018-10-12 2020-04-16 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric genes
CN111514292B (zh) 2018-12-25 2023-06-20 江苏荃信生物医药股份有限公司 抗人白介素4受体α单克隆抗体的制药用途
US20230295312A1 (en) * 2018-12-27 2023-09-21 Akeso Biopharma, Inc Antibody against human il-4ra and use thereof
SG11202109003QA (en) * 2019-03-06 2021-09-29 Regeneron Pharma Il-4/il-13 pathway inhibitors for enhanced efficacy in treating cancer
CA3132587A1 (en) 2019-03-21 2020-09-24 Regeneron Pharmaceuticals, Inc. Combination of il-4/il-13 pathway inhibitors and plasma cell ablation for treating allergy
BR112021021195A2 (pt) * 2019-05-01 2022-03-03 Regeneron Pharma Métodos para tratamento ou prevenção da asma pela administração de um antagonista de il-33
CN111592597B (zh) * 2019-05-29 2022-04-26 山东博安生物技术股份有限公司 白介素4受体(il-4r)结合蛋白及其用途
EP3999114A1 (en) * 2019-07-16 2022-05-25 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
CA3147068A1 (en) 2019-08-05 2021-02-11 Regeneron Pharmaceuticals, Inc. Methods for treating allergy and enhancing allergen-specific immunotherapy by administering an il-4r antagonist
EP3992974A1 (en) 2020-11-02 2022-05-04 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
WO2021119028A1 (en) 2019-12-09 2021-06-17 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
CA3169959A1 (en) 2020-02-21 2021-08-26 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pharmaceutical composition containing anti-il-4r antibody and use thereof
CN113527485A (zh) * 2020-04-17 2021-10-22 上海麦济生物技术有限公司 抗人白细胞介素-4受体α抗体及其制备方法和应用
CN114957472B (zh) * 2020-06-22 2023-10-31 南京融捷康生物科技有限公司 抗IL-4Rα的单域抗体以及应用和药物
CN116583539A (zh) 2020-12-22 2023-08-11 江苏恒瑞医药股份有限公司 抗il-4r抗体或其抗原结合片段的复合物及医药用途

Family Cites Families (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1356994A (fr) 1963-02-08 1964-04-03 Objets décoratifs et procédé pour leur fabrication
GB8808015D0 (en) 1988-04-06 1988-05-05 Ritter M A Chemical compounds
WO1990005183A1 (en) 1988-10-31 1990-05-17 Immunex Corporation Interleukin-4 receptors
JPH06510750A (ja) 1991-05-03 1994-12-01 セラジェン インク 炎症性関節炎治療を目的としてインタ−ロイキン受容体を標的にした分子
JP3315427B2 (ja) 1992-03-05 2002-08-19 大日本除蟲菊株式会社 皮膚炎治療剤
US5714146A (en) 1992-08-26 1998-02-03 Board Of Regents Of The University Of Washington IL-4 bone therapy
EP0604693A1 (en) 1992-12-29 1994-07-06 Schering-Plough Monoclonal antibodies against the human interleukin-4 receptor and hybridomas producing the same
RU2162711C2 (ru) 1993-09-07 2001-02-10 Смитклайн Бичам Корпорейшн Рекомбинантные il4-антитела, используемые для лечения нарушений, связанных с действием il4
CA2343052A1 (en) 1998-09-18 2000-03-30 Dynavax Technologies Corporation Methods of treating ige-associated disorders and compositions for use therein
US6927044B2 (en) 1998-09-25 2005-08-09 Regeneron Pharmaceuticals, Inc. IL-1 receptor based cytokine traps
EP1283851B1 (en) 2000-05-26 2012-03-28 Immunex Corporation Use of il-4r antibodies and compositions thereof
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
DE60130466T2 (de) 2000-07-26 2008-06-12 Hououdou Co. Ltd. Antipruritische zusammensetzungen und die wundheilung fördernde zusammensetzungen
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
ES2239203T3 (es) 2001-01-31 2005-09-16 Pfizer Products Inc. Derivados nicotinamida y sus mimeticos como inhibidores de isozimas pde4.
US8178098B2 (en) 2001-04-03 2012-05-15 National Jewish Health Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies
US20030103938A1 (en) 2001-05-09 2003-06-05 Alk-Abello A/S Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio
BR0117009A (pt) 2001-05-11 2004-04-20 Novartis Ag Composiçoes para utilização no tratamento de distúrbios associados a ige
DE60233519D1 (de) 2001-05-23 2009-10-08 Duotol Ab Unterdrückung von allergischen reaktionen durch transkutane verabreichung von allergenen zusammen mit oder fusioniert mit toxinuntereinheiten oder deren fragmenten
EP2990394A1 (en) 2001-11-30 2016-03-02 Biogen MA Inc. Antibodies against monocyte chemotactic proteins
PT1527100E (pt) 2002-03-29 2009-08-25 Schering Corp Anticorpos monoclonais humanos para interleucina-5 e métodos e composições compreendendo os mesmos
MXPA05005528A (es) 2002-11-26 2006-04-05 Alk Abello As Producto farmaceutico de alergeno.
DK2000481T3 (en) 2003-02-01 2016-06-06 Tanox Inc High affinity anti-human IgE antibodies
US7923209B2 (en) 2003-03-14 2011-04-12 Anergis, S.A. Allergen peptide fragments and use thereof
WO2005032399A2 (en) 2003-05-30 2005-04-14 The Regents Of The University Of California Il4 receptor antagonists for horse, dog and cat
CN1856325A (zh) * 2003-09-23 2006-11-01 Pdl生物制药股份有限公司 用抗il-2受体的抗体治疗呼吸道疾病
UA93653C2 (ru) 2003-11-07 2011-03-10 Иммунекс Корпорейшн Выделенное антитело, kotopoe специфически связывается c человеческим рецептором il-4 (il-4r)
AU2004309373A1 (en) 2003-12-22 2005-07-14 Amgen Inc. Methods for identifying functional antibodies
DE602005006758D1 (de) 2004-02-27 2008-06-26 Regeneron Pharma Il-4/il-13-spezifische polypetide und deren therapeutische verwendung
US20090098142A1 (en) 2004-06-09 2009-04-16 Kasaian Marion T Methods and compositions for treating and monitoring treatment of IL-13-associated disorders
TWI307630B (en) 2004-07-01 2009-03-21 Glaxo Group Ltd Immunoglobulins
JP5234445B2 (ja) 2004-10-05 2013-07-10 源一郎 杣 薬剤
WO2006083390A2 (en) 2004-12-07 2006-08-10 Children's Hospital Medical Center Eotaxin-3 in eosinophilic esophagitis
TW200902555A (en) 2005-01-03 2009-01-16 Hoffmann La Roche Antibodies against IL-13 receptor alpha 1 and uses thereof
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
CN101578298A (zh) 2006-01-24 2009-11-11 杜门蒂斯有限公司 结合il-4和/或il-13的配体
ES2398076T3 (es) 2006-06-02 2013-03-13 Regeneron Pharmaceuticals, Inc. Anticuerpos de alta afinidad contra el receptor de IL-6 humano
CN101517011B (zh) 2006-07-21 2013-01-16 巴斯福公司 含铁氧体的合成云母基珠光颜料
JP4221018B2 (ja) 2006-08-31 2009-02-12 トヨタ自動車株式会社 頭部保護エアバッグ装置
LT2769992T (lt) 2006-10-02 2021-04-12 Regeneron Pharmaceuticals, Inc. Didelio afiniškumo žmogaus antikūnai, atpažįstantys žmogaus il-4 receptorių
US7608693B2 (en) 2006-10-02 2009-10-27 Regeneron Pharmaceuticals, Inc. High affinity human antibodies to human IL-4 receptor
US20100144646A1 (en) 2006-11-03 2010-06-10 Blake Paterson Method of diagnosing and treating asthma
EP2022507A1 (en) 2007-08-07 2009-02-11 Universität Hamburg Antibody compositions specific for lgE, lgG4 and lgA epitopes as tools for the design of hypoallergenic molecules for specific immunotherapy
US20090062168A1 (en) 2007-08-27 2009-03-05 Joseph Timar Process for making a two-cycle gasoline engine lubricant
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
WO2009061819A1 (en) 2007-11-05 2009-05-14 The Regents Of The University Of Colorado Minimally-invasive measurement of esophageal inflammation
US8092804B2 (en) 2007-12-21 2012-01-10 Medimmune Limited Binding members for interleukin-4 receptor alpha (IL-4Rα)-173
JP5571567B2 (ja) 2007-12-21 2014-08-13 メディミューン リミテッド インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー
JP2011518128A (ja) 2008-04-02 2011-06-23 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 腫瘍、炎症性障害および免疫障害の治療のためのil−4受容体に対する結合剤
DE202008006598U1 (de) 2008-04-11 2008-10-02 Alk-Abelló A/S Allergie-Impfstoff-Formulierung zur mucosalen Verabreichung
US20090264392A1 (en) 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
US20110301046A1 (en) 2008-12-01 2011-12-08 Children's Hospital Medical Center Methods of Determining Efficacy of Glucocorticoid Treatment of Eosinophilic Esophagitis
EP2414520A2 (en) 2009-03-31 2012-02-08 Altair Therapeutics, Inc. Methods of modulating an immune response to a viral infection
US8497528B2 (en) 2010-05-06 2013-07-30 Taiwan Semiconductor Manufacturing Company, Ltd. Method for fabricating a strained structure
CN102596237A (zh) 2009-09-07 2012-07-18 Dbv技术公司 治疗嗜酸细胞性食管炎的方法
EP2547964B1 (en) 2010-03-16 2016-04-13 Airsonett AB Treatment of asthma, allergic rhinitis and improvement of quality of sleep by temperature controlled laminar airflow treatment
WO2011159821A1 (en) 2010-06-16 2011-12-22 Bruce Chandler May Use of levocetirizine and montelukast in the treatment of influenza, common cold and inflammation
US20120164080A1 (en) 2010-06-24 2012-06-28 Meritage Pharma, Inc. Methods of treatment for esophageal inflammation
CN106267189B (zh) 2010-10-06 2021-02-26 瑞泽恩制药公司 含有抗白介素-4受体(il-4r)的抗体的稳定制剂
UA111731C2 (uk) 2010-10-06 2016-06-10 Рідженерон Фармасьютікалз, Інк. Стабілізована композиція, яка містить антитіло до рецептора інтерлейкіну-4 (іl-4r), варіанти
MX2013004212A (es) * 2010-10-15 2013-09-02 Medimmune Ltd Terapias para mejorar la funcion pulmonar.
WO2012094643A2 (en) 2011-01-06 2012-07-12 Children's Hospital Medical Center Esophageal cytokine expression profiles in eosinophilic esophagitis
US20130052190A1 (en) 2011-02-22 2013-02-28 Oxagen Limited CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions
US9928344B2 (en) 2011-06-21 2018-03-27 Children's Hospital Medical Center Diagnostic methods of eosinophilic esophagitis
KR20130011821A (ko) 2011-07-22 2013-01-30 삼성전자주식회사 거래 관련 서비스 제공 방법 및 그 장치
WO2013051928A1 (en) 2011-10-06 2013-04-11 N.V. Nutricia Treatment of eosinophilic esophagitis
JP2014533246A (ja) 2011-11-01 2014-12-11 メディミューン,エルエルシー 喘息の急性増悪の頻度および重症度を低下させる方法
WO2013088109A1 (en) 2011-12-16 2013-06-20 Oxagen Limited Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
EP2677838B1 (en) 2012-06-18 2017-12-06 Whirlpool Corporation Microwave heating apparatus
AR092177A1 (es) 2012-08-21 2015-03-25 Sanofi Sa Metodos para tratar o prevenir asma administrando un antagonista de il-4r
NZ630178A (en) 2012-09-07 2017-06-30 Regeneron Pharma Methods for treating atopic dermatitis by administering an il-4r antagonist
CN103674979B (zh) 2012-09-19 2016-12-21 同方威视技术股份有限公司 一种行李物品ct安检系统及其探测器装置
US10132809B2 (en) 2012-10-10 2018-11-20 Rhote Island Hospital Differential expression of protein markers for the diagnosis and treatment of eosinophilic esophagitis
JO3532B1 (ar) 2013-03-13 2020-07-05 Regeneron Pharma الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
TWI633891B (zh) 2013-06-04 2018-09-01 再生元醫藥公司 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法
KR20230066127A (ko) 2013-06-21 2023-05-12 사노피 바이오테크놀로지 Il-4r 길항제를 투여함에 의한 비용종증의 치료 방법
TWI634900B (zh) 2013-07-11 2018-09-11 再生元醫藥公司 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法
MX2016010854A (es) 2014-02-21 2017-01-05 Sanofi Biotechnology Metodos para el tratamiento o la prevencion del asma mediante la administracion de un antagonista de il-4r.
KR20160120735A (ko) 2014-02-28 2016-10-18 리제너론 파아마슈티컬스, 인크. Il-4r 길항제의 투여에 의한 피부 감염의 치료 방법
KR20170081262A (ko) 2014-11-14 2017-07-11 사노피 바이오테크놀로지 Il-4r 길항제의 투여에 의한, 비용종을 동반한 만성 부비동염의 치료 방법
US10314904B2 (en) 2016-02-19 2019-06-11 Regeneron Pharmaceuticals, Inc. Methods for enhancing efficacy of a vaccine by administering an IL-4R antagonist
WO2018045130A1 (en) 2016-09-01 2018-03-08 Regeneron Pharmaceuticals, Inc. Methods for preventing or treating allergy by administering an il-4r antagonist
TWI784988B (zh) 2016-12-01 2022-12-01 美商再生元醫藥公司 治療發炎症狀的方法
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
PT3515465T (pt) 2017-08-18 2024-03-04 Regeneron Pharma Métodos para o tratamento de uma dermatite atópica grave mediante a administração de um inibidor de il-4r
KR20200081429A (ko) 2017-10-30 2020-07-07 사노피 바이오테크놀로지, 소시에떼 빠르 악씨옹 셍쁠리피에 Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법
CN112513293A (zh) 2018-05-22 2021-03-16 阿尔卡贝洛股份公司 通过免疫治疗来治疗特应性疾病的生物标志物方法
KR102330596B1 (ko) 2018-11-09 2021-11-26 아주대학교산학협력단 인간 il-4 수용체 알파에 대한 고친화도 인간 항체 및 이의 용도
BR112021021195A2 (pt) 2019-05-01 2022-03-03 Regeneron Pharma Métodos para tratamento ou prevenção da asma pela administração de um antagonista de il-33
EP3999114A1 (en) 2019-07-16 2022-05-25 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4r antagonist
WO2021119028A1 (en) 2019-12-09 2021-06-17 Sanofi Biotechnology Methods for treating digitally-identified il-4/il-13 related disorders
BR112023004020A2 (pt) 2020-10-05 2023-04-25 Sanofi Biotechnology Métodos para tratamento de asma em indivíduos pediátricos através da administração de um antagonista de il-4r
US20230146317A1 (en) 2021-07-26 2023-05-11 Sanofi Biotechnology Methods for treating chronic spontaneous urticaria by administering an il-4r antagonist
WO2023069976A1 (en) 2021-10-20 2023-04-27 Sanofi Biotechnology Methods for treating prurigo nodularis by administering an il-4r antagonist

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