HK1211040A1 - New albumin binding compositions, methods and uses - Google Patents
New albumin binding compositions, methods and usesInfo
- Publication number
- HK1211040A1 HK1211040A1 HK15111838.6A HK15111838A HK1211040A1 HK 1211040 A1 HK1211040 A1 HK 1211040A1 HK 15111838 A HK15111838 A HK 15111838A HK 1211040 A1 HK1211040 A1 HK 1211040A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- methods
- albumin binding
- binding compositions
- new albumin
- new
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title 1
- 108010088751 Albumins Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96261807P | 2007-07-31 | 2007-07-31 | |
EP07113533 | 2007-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1211040A1 true HK1211040A1 (en) | 2016-05-13 |
Family
ID=40057660
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15111838.6A HK1211040A1 (en) | 2007-07-31 | 2015-12-02 | New albumin binding compositions, methods and uses |
Country Status (11)
Country | Link |
---|---|
US (2) | US8937153B2 (hr) |
EP (2) | EP2190863B1 (hr) |
JP (1) | JP5718638B2 (hr) |
CN (2) | CN104710518A (hr) |
AU (1) | AU2008281913B2 (hr) |
CA (1) | CA2694139C (hr) |
DE (1) | DE08786222T1 (hr) |
DK (1) | DK2190863T3 (hr) |
ES (1) | ES2346178T3 (hr) |
HK (1) | HK1211040A1 (hr) |
WO (1) | WO2009016043A2 (hr) |
Families Citing this family (68)
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CN104710518A (zh) * | 2007-07-31 | 2015-06-17 | 阿菲博迪公司 | 新白蛋白结合组合物、方法及应用 |
ES2548030T3 (es) * | 2009-06-01 | 2015-10-13 | Medimmune, Llc | Moléculas con semividas prolongadas y usos de las mismas |
WO2011110515A1 (en) * | 2010-03-08 | 2011-09-15 | Affibody Ab | Immunoglobulin g fc region binding polypeptide |
MX2012012383A (es) * | 2010-04-30 | 2012-11-30 | Sanwa Kagaku Kenkyusho Co | Peptido para mejorar la bioestabilidad de una sustancia bioactica y sustancia bioactiva que tiene bioestabilidad mejorada. |
CN110437320B (zh) * | 2010-07-09 | 2023-10-20 | 阿菲博迪公司 | 多肽 |
CA2807127C (en) * | 2010-08-02 | 2019-02-12 | Leslie S. Johnson | Covalent diabodies and uses thereof |
EA201390450A1 (ru) | 2010-09-28 | 2013-07-30 | Амилин Фармасьютикалс, Ллк. | Полипептиды с увеличенной продолжительностью действия |
BR112013007388B1 (pt) * | 2010-09-28 | 2022-01-04 | Amylin Pharmaceuticals, Llc | Polipeptídeo tendo domínio de ligação de albumina e leptina, seu uso no tratamento de doenças, bem como composição farmacêutica que o compreende |
KR20140032356A (ko) | 2010-11-26 | 2014-03-14 | 몰리큘라 파트너스 아게 | 설계된 안키린 반복 단백질에 대한 개선된 n-말단 캡핑 모듈 |
WO2012162068A2 (en) * | 2011-05-21 | 2012-11-29 | Macrogenics, Inc. | Deimmunized serum-binding domains and their use for extending serum half-life |
JP6006309B2 (ja) * | 2011-07-08 | 2016-10-12 | アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals,Llc | 作用持続期間が増大し、免疫原性が減少した操作されたポリペプチド |
US20140256621A1 (en) * | 2011-07-08 | 2014-09-11 | Astrazeneca Pharmaceuticals Lp | Engineered poypeptides having enhanced duration of action and reduced immunogenicity |
SI2817329T1 (sl) | 2012-02-20 | 2019-04-30 | Swedish Orphan Biovitrum Ab (Publ) | Polipeptidi, ki se vežejo na človeški komplement c5 |
JP2020033372A (ja) * | 2012-03-28 | 2020-03-05 | アフィボディ・アーベー | 経口投与 |
KR20210075191A (ko) | 2012-03-28 | 2021-06-22 | 애피바디 에이비 | 경구투여 |
US20150133373A1 (en) * | 2012-03-28 | 2015-05-14 | Amylin Pharmaceuticals, Llc | Transmucosal delivery of engineered polypeptides |
EP2855509B1 (en) | 2012-05-25 | 2018-05-02 | Janssen Biotech, Inc. | Non-natural consensus albumin binding domains |
CN111763247A (zh) * | 2012-09-25 | 2020-10-13 | 阿菲博迪公司 | 白蛋白结合多肽 |
CN104768976B (zh) | 2012-10-05 | 2020-09-22 | 阿菲博迪公司 | Her3结合多肽 |
ES2639099T3 (es) * | 2012-10-25 | 2017-10-25 | Affibody Ab | Polipéptido de unión a albúmina |
WO2014064238A1 (en) * | 2012-10-25 | 2014-05-01 | Affibody Ab | Method for the separation of proteins containing an albumin-binding |
WO2014076179A1 (en) | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
US9255262B2 (en) | 2013-03-06 | 2016-02-09 | Vision Global Holdings Ltd. | Albumin-binding arginine deminase and the use thereof |
USRE48805E1 (en) | 2013-03-06 | 2021-11-02 | Vision Global Holdings Ltd. | Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein |
BR112015021681A2 (pt) | 2013-03-14 | 2017-11-14 | Daiichi Sankyo Co Ltd | proteínas de ligação para pcsk9 |
CA2902789A1 (en) | 2013-03-14 | 2014-09-18 | The Governing Council Of The University Of Toronto | Scaffolded peptidic libraries and methods of making and screening the same |
BR112015021730A2 (pt) | 2013-03-15 | 2017-08-29 | Affibody Ab | POLIPEPTÍDEO DE LIGAÇÃO AO FcRn, PROTEÍNA DE FUSÃO OU CONJUGADO, POLINUCLEOTÍDEO QUE CODIFICA UM POLIPEPTÍDEO, COMPOSIÇÃO, POLIPEPTÍDEO DE LIGAÇÃO AO FcRn, PROTEÍNA DE FUSÃO OU CONJUGADO E POLIPEPTÍDEO DE LIGAÇÃO AO FcRn, PROTEÍNA DE FUSÃO, CONJUGADO OU COMPOSIÇÃO PARA USO |
CA2908198A1 (en) | 2013-04-18 | 2014-10-23 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
JP2016528879A (ja) | 2013-06-17 | 2016-09-23 | アルモ・バイオサイエンシーズ・インコーポレイテッド | タンパク質の同一性および安定性を評価する方法 |
EP3811961A1 (en) | 2013-08-28 | 2021-04-28 | IPC Research, LLC | Stable polypeptides binding to human complement c5 |
EP3039033B1 (en) | 2013-08-28 | 2019-06-19 | Affibody AB | Binding polypeptides having a mutated scaffold |
US10010588B2 (en) | 2013-08-30 | 2018-07-03 | Armo Biosciences, Inc. | Methods of using pegylated interleukin-10 for treating hyperlipidemia |
WO2015070060A1 (en) | 2013-11-11 | 2015-05-14 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
US10167322B2 (en) | 2013-12-20 | 2019-01-01 | Affibody Ab | Engineered albumin binding polypeptide |
US10293043B2 (en) | 2014-06-02 | 2019-05-21 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
CA2953827A1 (en) | 2014-07-30 | 2016-02-04 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
LT3193930T (lt) | 2014-09-17 | 2019-10-25 | Affibody Ab | Nauji polipeptidai |
JP2017536098A (ja) | 2014-10-14 | 2017-12-07 | アルモ・バイオサイエンシーズ・インコーポレイテッド | インターロイキン−15組成物及びその使用 |
US10143726B2 (en) | 2014-10-22 | 2018-12-04 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
EP3212226B1 (en) | 2014-10-31 | 2020-03-18 | NGM Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
NZ732978A (en) | 2015-01-12 | 2022-01-28 | Affibody Ab | Il-17a-binding polypeptides |
WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
EP3291828A4 (en) | 2015-05-06 | 2018-10-03 | Alborz Mahdavi | Glucose responsive insulins |
US20160361415A1 (en) | 2015-05-28 | 2016-12-15 | Armo Biosciences, Inc. | Methods of Using Interleukin-10 for Treating Diseases and Disorders |
EA037478B1 (ru) | 2015-08-04 | 2021-04-01 | Дьюк Юниверсити | Генетически кодируемые внутренне неупорядоченные полимеры-"невидимки" для доставки и способы их применения |
AU2016312510A1 (en) | 2015-08-25 | 2018-03-08 | Armo Biosciences, Inc. | Methods of using Interleukin-10 for treating diseases and disorders |
US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
CN107022031A (zh) * | 2016-01-29 | 2017-08-08 | 中国人民解放军军事医学科学院微生物流行病研究所 | 融合蛋白HSA1-Vβ1及其应用 |
US11467156B2 (en) | 2016-06-01 | 2022-10-11 | Duke University | Nonfouling biosensors |
CN107952080A (zh) * | 2016-10-14 | 2018-04-24 | 中国科学院过程工程研究所 | 一种肿瘤靶向多肽-药物偶联衍生物、其制备方法及应用 |
WO2018132732A1 (en) | 2017-01-12 | 2018-07-19 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
WO2018213320A1 (en) | 2017-05-15 | 2018-11-22 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
JP2020530453A (ja) * | 2017-08-09 | 2020-10-22 | マサチューセッツ インスティテュート オブ テクノロジー | アルブミン結合ペプチド結合体及びその方法 |
WO2019071150A1 (en) * | 2017-10-06 | 2019-04-11 | University Of Utah Research Foundation | FUSION PROTEIN FOR TARGETED THERAPY OF AUTOIMMUNE DISEASE |
US20200239575A1 (en) * | 2017-10-06 | 2020-07-30 | University Of Utah Research Foundation | A fusion protein for targeted therapy of autoimmune disease |
US11505576B2 (en) | 2018-03-13 | 2022-11-22 | Affibody Ab | Polypeptides based on a scaffold |
US11649275B2 (en) | 2018-08-02 | 2023-05-16 | Duke University | Dual agonist fusion proteins |
US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
EP3785726A1 (en) | 2019-09-02 | 2021-03-03 | Biotest AG | Factor viii protein with increased half-life |
JP2022546525A (ja) | 2019-09-02 | 2022-11-04 | ビオテスト・アクチエンゲゼルシャフト | 延長された半減期を有する第viii因子タンパク質 |
WO2021089695A1 (en) | 2019-11-05 | 2021-05-14 | Affibody Ab | Polypeptides |
US20230190881A1 (en) | 2020-02-17 | 2023-06-22 | Biotest Ag | Subcutaneous administration of factor viii |
WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
EP4263589A1 (en) | 2020-12-21 | 2023-10-25 | Affibody AB | New polypeptide |
EP4291251A1 (en) | 2021-02-15 | 2023-12-20 | Affibody AB | New her2-binding polypeptide |
AR128475A1 (es) | 2022-02-08 | 2024-05-15 | Affibody Ab | Polipéptidos y proteínas de fusión con afinidad de unión por tslp |
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SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
FR2718452B1 (fr) * | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
FR2726471B1 (fr) * | 1994-11-07 | 1997-01-31 | Pf Medicament | Procede pour ameliorer l'immunogenicite d'un compose immunogene ou d'un haptene et application a la preparation de vaccins |
DE19742706B4 (de) * | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
GB9823071D0 (en) * | 1998-10-21 | 1998-12-16 | Affibody Technology Ab | A method |
GB9911287D0 (en) * | 1999-05-14 | 1999-07-14 | Affibody Technology Sweden Ab | Self-assembling protein structures |
US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
ATE422369T1 (de) | 1999-12-24 | 2009-02-15 | Genentech Inc | Verfahren und zusammensetzungen zur verlängerung der entsorgungshalbwertszeit von biowirksamen verbindungen |
CN1169827C (zh) | 2001-08-07 | 2004-10-06 | 沈阳三生制药股份有限公司 | 一种增强多肽在体内稳定性药物的生产方法及其应用 |
WO2003029462A1 (en) * | 2001-09-27 | 2003-04-10 | Pieris Proteolab Ag | Muteins of human neutrophil gelatinase-associated lipocalin and related proteins |
US7118915B2 (en) * | 2001-09-27 | 2006-10-10 | Pieris Proteolab Ag | Muteins of apolipoprotein D |
SE0400274D0 (sv) * | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
JP5634008B2 (ja) | 2004-04-06 | 2014-12-03 | アフィボディ・アーベー | 新規の使用および方法 |
EP2899277A1 (en) | 2004-11-26 | 2015-07-29 | Pieris AG | Compound with affinity for the cytotoxic T lymphocyte-associated antigen (CTLA-4) |
CN104710518A (zh) * | 2007-07-31 | 2015-06-17 | 阿菲博迪公司 | 新白蛋白结合组合物、方法及应用 |
JP5960598B2 (ja) * | 2009-11-04 | 2016-08-02 | アフィボディ・アーベー | Her3結合ポリペプチド |
-
2008
- 2008-07-17 CN CN201510071238.8A patent/CN104710518A/zh active Pending
- 2008-07-17 DK DK08786222.3T patent/DK2190863T3/da active
- 2008-07-17 DE DE08786222T patent/DE08786222T1/de active Pending
- 2008-07-17 EP EP08786222.3A patent/EP2190863B1/en active Active
- 2008-07-17 CN CN200880101168.4A patent/CN101765608B/zh active Active
- 2008-07-17 CA CA2694139A patent/CA2694139C/en active Active
- 2008-07-17 US US12/452,731 patent/US8937153B2/en active Active
- 2008-07-17 AU AU2008281913A patent/AU2008281913B2/en active Active
- 2008-07-17 ES ES08786222.3T patent/ES2346178T3/es active Active
- 2008-07-17 JP JP2010518606A patent/JP5718638B2/ja active Active
- 2008-07-17 WO PCT/EP2008/059389 patent/WO2009016043A2/en active Application Filing
- 2008-07-17 EP EP12176805.5A patent/EP2546261A3/en not_active Withdrawn
-
2014
- 2014-11-24 US US14/551,931 patent/US10118949B2/en active Active
-
2015
- 2015-12-02 HK HK15111838.6A patent/HK1211040A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP2546261A3 (en) | 2013-08-14 |
CN101765608A (zh) | 2010-06-30 |
WO2009016043A3 (en) | 2009-06-04 |
WO2009016043A2 (en) | 2009-02-05 |
AU2008281913B2 (en) | 2013-11-07 |
JP5718638B2 (ja) | 2015-05-13 |
US8937153B2 (en) | 2015-01-20 |
US10118949B2 (en) | 2018-11-06 |
DE08786222T1 (de) | 2010-11-25 |
CN104710518A (zh) | 2015-06-17 |
US20100273979A1 (en) | 2010-10-28 |
ES2346178T3 (es) | 2015-11-02 |
CA2694139C (en) | 2018-06-05 |
US20150158916A1 (en) | 2015-06-11 |
EP2546261A2 (en) | 2013-01-16 |
CN101765608B (zh) | 2015-03-11 |
DK2190863T3 (en) | 2015-11-30 |
JP2010534486A (ja) | 2010-11-11 |
CA2694139A1 (en) | 2009-02-05 |
ES2346178T1 (es) | 2010-10-13 |
AU2008281913A1 (en) | 2009-02-05 |
EP2190863B1 (en) | 2015-09-02 |
EP2190863A2 (en) | 2010-06-02 |
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