HK1209738A1 - 稠合雜環化合物、其製備方法、藥物組合物和用途 - Google Patents
稠合雜環化合物、其製備方法、藥物組合物和用途Info
- Publication number
- HK1209738A1 HK1209738A1 HK15110572.8A HK15110572A HK1209738A1 HK 1209738 A1 HK1209738 A1 HK 1209738A1 HK 15110572 A HK15110572 A HK 15110572A HK 1209738 A1 HK1209738 A1 HK 1209738A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- preparation
- pharmaceutical composition
- heterocyclic compound
- method therefor
- fused heterocyclic
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310485200 | 2013-10-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1209738A1 true HK1209738A1 (zh) | 2016-04-08 |
Family
ID=52827649
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK15110572.8A HK1209738A1 (zh) | 2013-10-16 | 2015-10-27 | 稠合雜環化合物、其製備方法、藥物組合物和用途 |
Country Status (15)
Country | Link |
---|---|
US (1) | US9656996B2 (zh) |
EP (1) | EP3059238B1 (zh) |
JP (1) | JP6139789B2 (zh) |
KR (1) | KR101982912B1 (zh) |
CN (3) | CN106831722B (zh) |
AU (1) | AU2014336775B2 (zh) |
CA (1) | CA2926596C (zh) |
HK (1) | HK1209738A1 (zh) |
IL (1) | IL245112B (zh) |
MX (1) | MX2016004964A (zh) |
NZ (1) | NZ718487A (zh) |
RU (1) | RU2663999C2 (zh) |
SG (1) | SG11201602446VA (zh) |
TW (1) | TWI631115B (zh) |
WO (1) | WO2015055071A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9656996B2 (en) | 2013-10-16 | 2017-05-23 | Shanghai Yingli Pharmaceutical Co., Ltd. | Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10765681B2 (en) | 2016-02-05 | 2020-09-08 | Academia Sinica | Purine compounds possessing anticancer activity |
KR102472453B1 (ko) * | 2016-06-16 | 2022-11-29 | 얀센 파마슈티카 엔.브이. | Pi3k 베타 저해제로서의 이환식 피리딘, 피라진, 및 피리미딘 유도체 |
KR20190133729A (ko) | 2017-03-29 | 2019-12-03 | 얀센 파마슈티카 엔.브이. | Pi3k-베타 억제제로서 퀴녹살린 및 피리도피라진 유도체 |
WO2019168874A1 (en) | 2018-02-27 | 2019-09-06 | The Research Foundation For The State University Of New York | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
MX2021003576A (es) | 2018-09-27 | 2021-05-28 | Shanghai Yingli Pharm Co Ltd | Forma cristalina de un compuesto de morfolino quinazolina, metodo de preparacion del mismo y uso del mismo. |
EP3912978B1 (en) * | 2019-01-16 | 2023-02-15 | Shanghai Yingli Pharmaceutical Co. Ltd. | Preparation method for morpholinquinazoline compound and midbody thereof |
CN111848598A (zh) * | 2019-04-26 | 2020-10-30 | 健艾仕生物医药有限公司 | 一种含杂环的化合物、其应用及含其的组合物 |
CN111943938A (zh) * | 2019-05-17 | 2020-11-17 | 上海再极医药科技有限公司 | 一种a2a腺苷受体拮抗剂的合成方法 |
CN113444073B (zh) * | 2020-03-26 | 2024-01-05 | 上海璎黎药业有限公司 | 吗啉基喹唑啉类化合物的晶型ⅲ、其制备方法及应用 |
CN115120732A (zh) * | 2021-03-26 | 2022-09-30 | 上海璎黎药业有限公司 | 一种喹唑啉化合物的药物组合物及其制备方法 |
CN115120596A (zh) * | 2021-03-26 | 2022-09-30 | 上海璎黎药业有限公司 | 一种喹唑啉化合物及药物组合物的应用 |
CN115252620A (zh) * | 2021-04-30 | 2022-11-01 | 上海璎黎药业有限公司 | 一种喹唑啉化合物及药物组合物的应用 |
KR20240024848A (ko) * | 2021-05-24 | 2024-02-26 | 상하이 잉리 파마슈티컬 컴퍼니 리미티드 | 질소 함유 헤테로고리 화합물, 이의 제조 방법 및 이의 응용 |
WO2023030437A1 (zh) * | 2021-09-01 | 2023-03-09 | 江苏恒瑞医药股份有限公司 | 一种pi3k抑制剂与btk抑制剂在制备治疗淋巴瘤的药物中的用途 |
WO2024041519A1 (zh) * | 2022-08-24 | 2024-02-29 | 上海璎黎药业有限公司 | 一种吗啉基喹唑啉类化合物、其药物组合物及应用 |
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MY141144A (en) | 2000-03-02 | 2010-03-15 | Smithkline Beecham Corp | 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
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WO2001083456A1 (fr) * | 2000-04-27 | 2001-11-08 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'heteroaryle condenses |
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- 2014-09-19 KR KR1020167012161A patent/KR101982912B1/ko active IP Right Grant
- 2014-09-19 CN CN201710045757.6A patent/CN106831722B/zh active Active
- 2014-09-19 US US15/029,882 patent/US9656996B2/en active Active
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- 2014-09-19 CN CN201710044794.5A patent/CN106831721B/zh active Active
- 2014-09-19 RU RU2016115934A patent/RU2663999C2/ru active
- 2014-09-19 AU AU2014336775A patent/AU2014336775B2/en active Active
- 2014-09-19 EP EP14853907.5A patent/EP3059238B1/en active Active
- 2014-09-19 WO PCT/CN2014/086914 patent/WO2015055071A1/zh active Application Filing
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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US9656996B2 (en) | 2013-10-16 | 2017-05-23 | Shanghai Yingli Pharmaceutical Co., Ltd. | Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof |
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Publication number | Publication date |
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CN106831721B (zh) | 2019-10-22 |
IL245112A0 (en) | 2016-06-30 |
IL245112B (en) | 2020-10-29 |
JP2016533372A (ja) | 2016-10-27 |
RU2016115934A (ru) | 2017-11-20 |
CN106831722A (zh) | 2017-06-13 |
NZ718487A (en) | 2020-01-31 |
EP3059238A1 (en) | 2016-08-24 |
CN104557872A (zh) | 2015-04-29 |
AU2014336775B2 (en) | 2018-04-05 |
TW201518288A (zh) | 2015-05-16 |
JP6139789B2 (ja) | 2017-05-31 |
SG11201602446VA (en) | 2016-05-30 |
EP3059238A4 (en) | 2017-04-12 |
RU2663999C2 (ru) | 2018-08-14 |
TWI631115B (zh) | 2018-08-01 |
US20160244432A1 (en) | 2016-08-25 |
KR20160062170A (ko) | 2016-06-01 |
CA2926596A1 (en) | 2015-04-23 |
CN104557872B (zh) | 2017-05-24 |
CA2926596C (en) | 2020-07-14 |
CN106831722B (zh) | 2019-08-30 |
KR101982912B1 (ko) | 2019-09-10 |
WO2015055071A1 (zh) | 2015-04-23 |
EP3059238B1 (en) | 2020-05-27 |
CN106831721A (zh) | 2017-06-13 |
MX2016004964A (es) | 2016-07-11 |
US9656996B2 (en) | 2017-05-23 |
AU2014336775A1 (en) | 2016-04-21 |
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