HK1207120A1 - Improved harvest operations for recombinant proteins - Google Patents

Improved harvest operations for recombinant proteins

Info

Publication number
HK1207120A1
HK1207120A1 HK15107689.4A HK15107689A HK1207120A1 HK 1207120 A1 HK1207120 A1 HK 1207120A1 HK 15107689 A HK15107689 A HK 15107689A HK 1207120 A1 HK1207120 A1 HK 1207120A1
Authority
HK
Hong Kong
Prior art keywords
recombinant proteins
harvest operations
improved harvest
improved
operations
Prior art date
Application number
HK15107689.4A
Other languages
English (en)
Chinese (zh)
Inventor
Michael W Laird
John Richard St
Jane V Gunson
Kim Kaleas
Deepa Nadarajah
Rachel Adams
Bradley R Snedecor
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1207120A1 publication Critical patent/HK1207120A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/40Means for regulation, monitoring, measurement or control, e.g. flow regulation of pressure
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK15107689.4A 2012-03-27 2015-08-10 Improved harvest operations for recombinant proteins HK1207120A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261616297P 2012-03-27 2012-03-27
PCT/US2013/031383 WO2013148249A1 (en) 2012-03-27 2013-03-14 Improved harvest operations for recombinant proteins

Publications (1)

Publication Number Publication Date
HK1207120A1 true HK1207120A1 (en) 2016-01-22

Family

ID=48040433

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15107689.4A HK1207120A1 (en) 2012-03-27 2015-08-10 Improved harvest operations for recombinant proteins

Country Status (21)

Country Link
US (8) US20140080180A1 (ru)
EP (1) EP2831261B1 (ru)
JP (4) JP6225162B2 (ru)
KR (2) KR102096678B1 (ru)
CN (2) CN104350156B (ru)
AR (2) AR090340A1 (ru)
AU (3) AU2013240280A1 (ru)
BR (1) BR112014023176B1 (ru)
CA (2) CA2866753C (ru)
ES (1) ES2654424T3 (ru)
HK (1) HK1207120A1 (ru)
HR (1) HRP20171966T1 (ru)
IL (1) IL234377B (ru)
MX (3) MX365947B (ru)
MY (1) MY171729A (ru)
PL (1) PL2831261T3 (ru)
RU (2) RU2636353C2 (ru)
SG (4) SG10202007206WA (ru)
SI (1) SI2831261T1 (ru)
WO (1) WO2013148249A1 (ru)
ZA (1) ZA201406434B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109496237A (zh) 2016-06-10 2019-03-19 隆扎有限公司 用于稳定化蛋白质的方法
WO2018085769A1 (en) * 2016-11-07 2018-05-11 Seattle Genetics, Inc. Distribution of engineered-cysteine caps
WO2019191133A1 (en) * 2018-03-27 2019-10-03 Bristol-Myers Squibb Company Real-time monitoring of protein concentration using ultraviolet signal
CN109725088B (zh) * 2019-03-16 2021-05-18 丁立平 一种测定豆芽中2-萘甲酸及其衍生物的气相色谱-质谱联用法
CN110305903B (zh) * 2019-07-31 2021-10-01 江苏璟泽生物医药有限公司 重组人促卵泡激素及其制备方法
CN113155776A (zh) * 2021-04-29 2021-07-23 华东交通大学 一种柑桔最佳采收期预测方法
FR3146146A1 (fr) 2023-02-24 2024-08-30 Bgene Genetics Production d’acide 1-4-dihydroxy-2-naphtoïque par Escherichia coli

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2036891B (en) 1978-12-05 1983-05-05 Windsor Smith C Change speed gear
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
ZA811368B (en) 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5672347A (en) 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
WO1987002671A1 (en) 1985-11-01 1987-05-07 International Genetic Engineering, Inc. Modular assembly of antibody genes, antibodies prepared thereby and use
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
EP0420937B1 (en) 1988-06-21 1994-11-09 Genentech, Inc. Therapeutic compositions for the treatment of myocardial infarction
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE122006000006I2 (de) 1991-08-14 2011-06-16 Genentech Inc Veränderte Immunglobuline für spezifische FC-Epsilon Rezeptoren
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
ES2112431T3 (es) 1992-08-21 1998-04-01 Genentech Inc Procedimiento para el tratamiento de un trastorno mediado por lfa-1.
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
DE69405251T2 (de) 1993-12-10 1998-02-05 Genentech Inc Methoden zur diagnose von allergie und prüfung anti-allergischer therapeutika
DE69501817T2 (de) 1994-01-18 1998-09-10 Genentech Inc Verfahren zur behandlung von parasitären infektionen unter verwendung von ige-antagonisten
JP3780315B2 (ja) 1994-03-03 2006-05-31 ジェネンテク・インコーポレイテッド 炎症性疾患の処置のための抗il−8モノクローナル抗体
US5639635A (en) 1994-11-03 1997-06-17 Genentech, Inc. Process for bacterial production of polypeptides
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
WO1996040210A1 (en) 1995-06-07 1996-12-19 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth of tumors
WO1997026912A2 (en) 1996-01-23 1997-07-31 Genentech, Inc. Anti-cd18 antibodies for use against stroke
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
WO1998023761A1 (en) 1996-11-27 1998-06-04 Genentech, Inc. HUMANIZED ANTI-CD11a ANTIBODIES
DE122007000021I1 (de) 1997-04-07 2007-05-24 Genentech Inc Anti-vefg Antibodies
DE69838249T3 (de) 1997-05-15 2012-01-19 Genentech, Inc. Anti-apo-2 antikörper
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
NZ518477A (en) 1999-10-29 2004-10-29 Genentech Inc Isolated anti-prostate stem cell antigen (PSCA) antibodies that internalise upon binding to PSCA on a mammalian cell, including a PSCA-expressing tumour cell, in vivo
US6946271B2 (en) * 2000-09-20 2005-09-20 Degussa Ag Nucleotide sequences which code for the menE gene
US6979556B2 (en) 2000-12-14 2005-12-27 Genentech, Inc. Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes
BRPI0316779B1 (pt) 2002-12-16 2020-04-28 Genentech Inc anticorpo humanizado que liga cd20 humano, composição, artigo manufaturado, método de indução da apoptose, método de tratamento de câncer cd20 positivo, métodos de tratamento de doenças autoimunes, ácidos nucléicos isolados, vetores de expressão, células hospedeiras, método para a produção de um anticorpo 2h7 humanizado, polipeptídeo isolado, formulação líquida, método de tratamento de artrite reumatóide (ra) e anticorpos de ligação de cd20 humanizados
JP4579158B2 (ja) * 2003-03-26 2010-11-10 明治乳業株式会社 1,4−ジヒドロキシ−2−ナフトエ酸の安定化方法
WO2005017162A2 (en) * 2003-08-13 2005-02-24 Sandoz Ag Expression vectors, transformed host cells and fermentation process for the production of recombinant polypeptides
AU2005212237B2 (en) * 2004-02-04 2009-06-11 Merck Sharp & Dohme Llc Process for large scale production of plasmid DNA by E. coli fermentation
US7361764B2 (en) * 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
CN101115832A (zh) * 2004-11-26 2008-01-30 协和发酵工业株式会社 工业上有用的微生物
ES2536852T3 (es) * 2006-05-05 2015-05-28 Gangagen, Inc. Actividades antimicrobianas derivadas de fagos
JP5305615B2 (ja) * 2006-06-05 2013-10-02 株式会社Adeka メナキノンの新規生合成経路に関与するタンパク質の遺伝子群を利用したメナキノンの製造方法
ZA200900229B (en) * 2006-07-14 2010-04-28 Genentech Inc Refolding of recombinant proteins
DE17196350T1 (de) * 2007-07-09 2018-12-27 Genentech, Inc. Verhindern der disulfid-bindungsreduktion während der rekombinanten herstellung von polypeptiden
CN101665798B (zh) * 2008-09-06 2012-11-21 浙江我武生物科技股份有限公司 一种制备重组人血清白蛋白与干扰素α融合蛋白的方法
CN101503470A (zh) * 2008-09-27 2009-08-12 上海交通大学 rhDSL重组蛋白及其制备方法
JP2010088387A (ja) * 2008-10-10 2010-04-22 Waseda Univ 放線菌内で目的タンパク質を誘導発現可能なプロモーター

Also Published As

Publication number Publication date
MY171729A (en) 2019-10-25
CN104350156A (zh) 2015-02-11
HRP20171966T1 (hr) 2018-02-09
US20240158825A1 (en) 2024-05-16
US9765379B2 (en) 2017-09-19
AU2017202484A1 (en) 2017-05-04
ES2654424T3 (es) 2018-02-13
MX2019007032A (es) 2019-08-16
RU2636353C2 (ru) 2017-11-22
US20200199639A1 (en) 2020-06-25
ZA201406434B (en) 2017-08-30
SG10202007206WA (en) 2020-08-28
RU2017139267A (ru) 2019-02-12
SG10201912877SA (en) 2020-02-27
WO2013148249A1 (en) 2013-10-03
BR112014023176B1 (pt) 2021-09-28
PL2831261T3 (pl) 2018-04-30
US20210171997A1 (en) 2021-06-10
BR112014023176A2 (pt) 2017-06-20
US20140080180A1 (en) 2014-03-20
CA3086730A1 (en) 2013-10-03
AR116615A2 (es) 2021-05-26
AU2017202484B2 (en) 2019-06-13
MX2018007677A (es) 2020-11-12
KR102096678B1 (ko) 2020-04-02
US20150225760A1 (en) 2015-08-13
JP2019141049A (ja) 2019-08-29
AU2019226192A1 (en) 2019-09-26
KR20140148392A (ko) 2014-12-31
CA2866753C (en) 2020-09-22
IL234377B (en) 2021-01-31
JP6225162B2 (ja) 2017-11-01
SI2831261T1 (en) 2018-01-31
US20180291411A1 (en) 2018-10-11
CN104350156B (zh) 2019-04-02
KR20200037425A (ko) 2020-04-08
AU2013240280A1 (en) 2014-10-16
CA2866753A1 (en) 2013-10-03
EP2831261A1 (en) 2015-02-04
EP2831261B1 (en) 2017-10-18
US20160130624A1 (en) 2016-05-12
JP2018046825A (ja) 2018-03-29
SG10201508420VA (en) 2015-11-27
JP2015512259A (ja) 2015-04-27
SG11201406112TA (en) 2014-10-30
MX365947B (es) 2019-06-19
MX2014011558A (es) 2014-11-14
US20230069966A1 (en) 2023-03-09
AR090340A1 (es) 2014-11-05
CN109880867A (zh) 2019-06-14
RU2014137554A (ru) 2016-05-20
JP2020202849A (ja) 2020-12-24

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