HK1197187A1 - 抗體及使用方法 - Google Patents

抗體及使用方法

Info

Publication number
HK1197187A1
HK1197187A1 HK14110783.4A HK14110783A HK1197187A1 HK 1197187 A1 HK1197187 A1 HK 1197187A1 HK 14110783 A HK14110783 A HK 14110783A HK 1197187 A1 HK1197187 A1 HK 1197187A1
Authority
HK
Hong Kong
Prior art keywords
lrp5
methods
antibodies
lrp5 antibodies
use lrp5
Prior art date
Application number
HK14110783.4A
Other languages
English (en)
Inventor
葉蔚藍
杰里米．布賴恩特．伯頓
吳岩
塞西莉亞．秋
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of HK1197187A1 publication Critical patent/HK1197187A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK14110783.4A 2012-01-18 2014-10-28 抗體及使用方法 HK1197187A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261588100P 2012-01-18 2012-01-18
PCT/US2013/022045 WO2013109819A1 (en) 2012-01-18 2013-01-18 Anti-lrp5 antibodies and methods of use

Publications (1)

Publication Number Publication Date
HK1197187A1 true HK1197187A1 (zh) 2015-01-09

Family

ID=47604271

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14110783.4A HK1197187A1 (zh) 2012-01-18 2014-10-28 抗體及使用方法

Country Status (25)

Country Link
US (4) US9200072B2 (zh)
EP (1) EP2804629A1 (zh)
JP (1) JP6242813B2 (zh)
KR (1) KR20140116490A (zh)
CN (1) CN104066449B (zh)
AR (1) AR089752A1 (zh)
AU (1) AU2013209707A1 (zh)
BR (1) BR112014017518A2 (zh)
CA (1) CA2862422A1 (zh)
CL (1) CL2014001888A1 (zh)
CO (1) CO7000747A2 (zh)
CR (1) CR20140382A (zh)
EA (1) EA028202B1 (zh)
HK (1) HK1197187A1 (zh)
IL (1) IL233317A0 (zh)
IN (1) IN2014DN05885A (zh)
MA (1) MA35898B1 (zh)
MX (1) MX2014008157A (zh)
NZ (1) NZ626520A (zh)
PE (1) PE20141561A1 (zh)
PH (1) PH12014501605A1 (zh)
SG (2) SG10201601747XA (zh)
TW (1) TW201335187A (zh)
WO (1) WO2013109819A1 (zh)
ZA (1) ZA201404675B (zh)

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AU2009291747B2 (en) * 2008-09-10 2016-05-26 Genentech, Inc. Methods for inhibiting ocular angiogenesis
JP5861469B2 (ja) * 2012-01-23 2016-02-16 日本電気硝子株式会社 ガラス管の清浄切断装置と清浄切断方法
MX2017000363A (es) 2014-07-11 2017-04-27 Genentech Inc Inhibicion de la via de notch.
US11142577B2 (en) 2014-09-12 2021-10-12 The Board Of Trustees Of The Leland Stanford Junior University WNT signaling agonist molecules
US11219694B2 (en) * 2015-09-24 2022-01-11 The University Of North Carolina At Chapel Hill Methods and compositions for reducing metastases
CN106367517A (zh) * 2016-09-28 2017-02-01 湖北工业大学 一种低密度脂蛋白受体相关蛋白5基因突变检测的试剂及应用
CN110891593A (zh) * 2017-05-05 2020-03-17 瑞特诺解决方案有限责任公司 基因的norrin诱导表达及其治疗疾病的用途
MA48760A (fr) 2017-05-31 2020-04-08 Boehringer Ingelheim Int Polypeptides ayant un effet antagoniste sur la signalisation wnt dans des cellules tumorales
CA3085782A1 (en) 2017-12-19 2019-06-27 Surrozen, Inc. Wnt surrogate molecules and uses thereof
CA3085785A1 (en) * 2017-12-19 2019-06-27 Surrozen, Inc. Anti-lrp5/6 antibodies and methods of use
MX2022001947A (es) * 2019-08-14 2022-06-14 Modmab Therapeutics Inc Anticuerpos que se unen a las proteinas lrp5 y metodos de uso.
CN115956089A (zh) 2020-05-04 2023-04-11 加利福尼亚大学董事会 抑制性抗enpp1抗体
CN111909935B (zh) * 2020-07-17 2022-11-15 武汉纽福斯生物科技有限公司 重组人卷曲蛋白受体4(fzd4)的表达载体及其应用
KR102536092B1 (ko) * 2020-09-29 2023-05-24 조선대학교산학협력단 Lrp5 발현 또는 활성 억제제를 포함하는 허혈성 심장질환의 예방 또는 치료용 약학적 조성물
WO2023250402A2 (en) * 2022-06-22 2023-12-28 Antlera Therapeutics Inc. Tetravalent fzd and wnt co-receptor binding antibody molecules and uses thereof

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US20190010228A1 (en) 2019-01-10
IL233317A0 (en) 2014-08-31
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AR089752A1 (es) 2014-09-17
JP6242813B2 (ja) 2017-12-06
KR20140116490A (ko) 2014-10-02
CR20140382A (es) 2014-10-07
EA201491357A1 (ru) 2014-11-28
BR112014017518A8 (pt) 2017-07-04
CN104066449B (zh) 2018-04-27
CN104066449A (zh) 2014-09-24
SG11201404198TA (en) 2014-08-28
US9522954B2 (en) 2016-12-20
MA35898B1 (fr) 2014-12-01
EP2804629A1 (en) 2014-11-26
BR112014017518A2 (pt) 2018-09-04
AU2013209707A1 (en) 2014-07-24
ZA201404675B (en) 2016-11-30
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TW201335187A (zh) 2013-09-01
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US20170166636A1 (en) 2017-06-15
EA028202B1 (ru) 2017-10-31
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CA2862422A1 (en) 2013-07-25
US20130183320A1 (en) 2013-07-18

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