HK1170258A1 - 細胞的擴增 - Google Patents

細胞的擴增

Info

Publication number
HK1170258A1
HK1170258A1 HK12110647.2A HK12110647A HK1170258A1 HK 1170258 A1 HK1170258 A1 HK 1170258A1 HK 12110647 A HK12110647 A HK 12110647A HK 1170258 A1 HK1170258 A1 HK 1170258A1
Authority
HK
Hong Kong
Prior art keywords
expansion
cells
Prior art date
Application number
HK12110647.2A
Other languages
English (en)
Inventor
Evren Alici
Original Assignee
細胞維護北歐製藥公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 細胞維護北歐製藥公司 filed Critical 細胞維護北歐製藥公司
Publication of HK1170258A1 publication Critical patent/HK1170258A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0646—Natural killers cells [NK], NKT cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2302—Interleukin-2 (IL-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1164—NK cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
HK12110647.2A 2009-03-26 2012-10-25 細胞的擴增 HK1170258A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16359009P 2009-03-26 2009-03-26
PCT/SE2010/050333 WO2010110734A1 (en) 2009-03-26 2010-03-25 Expansion of nk cells

Publications (1)

Publication Number Publication Date
HK1170258A1 true HK1170258A1 (zh) 2013-02-22

Family

ID=42781254

Family Applications (1)

Application Number Title Priority Date Filing Date
HK12110647.2A HK1170258A1 (zh) 2009-03-26 2012-10-25 細胞的擴增

Country Status (11)

Country Link
US (1) US8877182B2 (zh)
EP (1) EP2411507B1 (zh)
JP (3) JP2012521215A (zh)
KR (1) KR101881520B1 (zh)
CN (1) CN102428173B (zh)
DK (1) DK2411507T3 (zh)
ES (1) ES2763169T3 (zh)
HK (1) HK1170258A1 (zh)
PL (1) PL2411507T3 (zh)
PT (1) PT2411507T (zh)
WO (1) WO2010110734A1 (zh)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2203176T1 (sl) 2007-09-28 2015-04-30 Anthrogenesis Corporation Tumorska supresija z uporabo humanega perfuzata placente in intermediarnih naravnih celic ubijalk, pridobljenih iz humane placente
KR20210063457A (ko) 2010-07-13 2021-06-01 안트로제네시스 코포레이션 천연 킬러 세포의 생성 방법
JP5572863B2 (ja) 2011-06-24 2014-08-20 国立大学法人九州大学 Ｎｋ細胞の増幅方法
KR101644984B1 (ko) * 2011-12-22 2016-08-12 재단법인 목암생명과학연구소 자연살해세포의 제조방법, 이러한 방법에 의해 제조된 자연살해세포 및 이를 포함하는 종양 및 감염성 질환 치료용 조성물
KR101525199B1 (ko) * 2012-09-13 2015-06-04 (주)케이셀바이오 100㎖ 이하 말초혈액으로부터 ｎｋ세포의 대량 증식 방법
CN102994449A (zh) * 2012-12-13 2013-03-27 上海柯莱逊生物技术有限公司 一种体外扩增nk细胞的方法
EP2948544A4 (en) 2013-01-28 2016-08-03 St Jude Childrens Res Hospital CHIMERIC RECEPTOR WITH NKG2D SPECIFICITY FOR CELL THERAPY AGAINST CANCER AND INFECTION DISEASES
EP2953635A4 (en) 2013-02-05 2016-10-26 Anthrogenesis Corp NATURAL KILLER CELLS FROM PLAZENTA
WO2014155572A1 (ja) * 2013-03-27 2014-10-02 株式会社日本バイオセラピー研究所 Nk細胞強化型血液製剤の製造方法
WO2014183066A2 (en) 2013-05-10 2014-11-13 Whitehead Institute For Biomedical Research Protein modification of living cells using sortase
WO2015125113A1 (en) * 2014-02-21 2015-08-27 Dr. Reddy's Laboratories Limited Method of culturing high cell density pbmc's
CN105002139B (zh) * 2014-04-25 2019-02-01 中国医学科学院肿瘤医院 一种cd3+cd8+cd56+t细胞亚型促进nk细胞增殖的方法
ES2839089T3 (es) 2014-05-15 2021-07-05 Nat Univ Singapore Linfocitos citolíticos naturales modificados y usos de los mismos
CN104357390B (zh) * 2014-10-15 2017-07-07 恒瑞源正（深圳）生物科技有限公司 同时扩增cd3+cd56+cik细胞和cd3‑cd56+nk细胞的方法
KR101697473B1 (ko) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 T 세포를 이용한 자연살해세포의 배양방법
WO2017070237A1 (en) * 2015-10-19 2017-04-27 University Of Maryland, Baltimore Methods for generating engineered human primary blood dendritic cell lines
CN105624109B (zh) * 2016-02-26 2019-07-12 广州赛莱拉干细胞科技股份有限公司 一种使用生物反应器培养nkt细胞的方法
CN107779434A (zh) * 2016-08-30 2018-03-09 天津市康婷生物工程有限公司 高效扩增人外周血nk细胞的实验方法
WO2018148462A1 (en) 2017-02-09 2018-08-16 Indapta Therapeutics, Inc. Engineered natural killer (nk) cells and compositions and methods thereof
BR112019020001A2 (pt) 2017-03-27 2020-04-28 Nat Univ Singapore linhagens celulares estimuladoras para expansão ex vivo e ativação de células exterminadoras naturais
US11365236B2 (en) 2017-03-27 2022-06-21 Nkarta, Inc. Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy
CN107541491A (zh) * 2017-10-12 2018-01-05 广州金晟生物科技有限公司 一种nk细胞体外培养方法
KR102265437B1 (ko) 2017-11-24 2021-06-15 의료법인 성광의료재단 Nk 배양용 조성물 및 이를 이용하여 nk 세포를 배양하는 방법
CN108060130B (zh) * 2017-12-29 2018-12-07 广州沙艾生物科技有限公司 控制培养箱适于免疫细胞的诱导扩增的方法
CN108192868B (zh) * 2017-12-29 2018-12-07 广州沙艾生物科技有限公司 免疫细胞的诱导扩增方法
IL276365B2 (en) 2018-02-01 2023-10-01 Nkmax Co Ltd A method for the production of natural killer cells and a preparation for cancer treatment
US20230181635A1 (en) * 2018-03-13 2023-06-15 Fundación Para La Investigación Biomédica Del Hospital Universitario La Paz Anti-cxcr4 antibody combined with activated and expanded natural killer cells for cancer immunotherapy
KR102232321B1 (ko) * 2018-03-23 2021-03-26 주식회사 녹십자랩셀 자연살해세포의 제조방법
WO2019182392A1 (ko) * 2018-03-23 2019-09-26 주식회사 녹십자랩셀 자연살해세포의 제조방법
GB201807050D0 (en) 2018-04-30 2018-06-13 Cellprotect Nordic Pharmaceuticals Ab Medical uses
KR102069704B1 (ko) * 2018-05-16 2020-01-23 고려대학교 산학협력단 Hdac 억제제를 이용한 사람 유래 자연살해세포의 확장 배양법
CN112469817B (zh) * 2018-05-31 2023-11-07 高丽大学校产学协力团 通过使用igfbp2对人源性自然杀伤细胞的扩增和培养
CN110628715B (zh) * 2018-06-21 2022-11-25 精准生技股份有限公司 体外扩增自然杀手细胞及自然杀手t细胞的方法及其医药组成物
JP2022511735A (ja) * 2018-11-21 2022-02-01 インダプタ セラピューティクス インコーポレイテッド ナチュラルキラー（ｎｋ）細胞サブセットの増大のための方法ならびに関連する組成物および方法
SG11202109057XA (en) 2019-03-05 2021-09-29 Nkarta Inc Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
JP2022525928A (ja) * 2019-03-21 2022-05-20 ガミダ セル リミテッド 併用療法における移植に適したｎｋ細胞画分の増殖及び増殖ｎｋ細胞画分の使用
US11453862B2 (en) 2019-07-08 2022-09-27 Immunitybio, Inc. Mononuclear cell derived NK cells
WO2021006875A1 (en) * 2019-07-08 2021-01-14 Nantkwest, Inc. Mononuclear cell derived nk cells
EP4096688A1 (en) 2020-01-28 2022-12-07 Sorrento Therapeutics, Inc. Natural killer cells for treatment of coronavirus infection
EP4263600A1 (en) 2020-12-18 2023-10-25 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
EP4277638A1 (en) * 2021-01-12 2023-11-22 Hadasit Medical Research Services&Development Ltd. Improved adoptive cell transfer therapy for cancer
GB202115389D0 (en) 2021-10-26 2021-12-08 XNK Therapeutics AB Methods
WO2023081813A1 (en) 2021-11-05 2023-05-11 St. Jude Children's Research Hospital, Inc. Zip cytokine receptors
WO2023240182A1 (en) 2022-06-08 2023-12-14 St. Jude Children's Research Hospital, Inc. Disruption of kdm4a in t cells to enhance immunotherapy
WO2024059787A1 (en) 2022-09-16 2024-03-21 St. Jude Children's Research Hospital, Inc. Disruption of asxl1 in t cells to enhance immunotherapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2391434A1 (en) * 1999-11-24 2001-05-31 Ernest G. Hope Anti-angiogenic cellular agent for cancer therapy
US20030119185A1 (en) * 2000-02-24 2003-06-26 Xcyte Therapies, Inc. Activation and expansion of cells
KR20030032961A (ko) * 2000-06-06 2003-04-26 기린 비루 가부시키가이샤 내츄럴 킬러 ｔ 세포의 증폭 방법
US20030068306A1 (en) * 2001-09-14 2003-04-10 Dilber Mehmet Sirac Medium
MXPA06014784A (es) * 2004-06-18 2007-04-25 Genentech Inc Metodos para utilizar agonistas del receptor apo-2l y actividadores de celulas nk.
US20090196850A1 (en) * 2005-01-06 2009-08-06 Novo Nordisk A/S Anti-Kir Combination Treatments and Methods
JP4953403B2 (ja) * 2007-11-05 2012-06-13 恒雄 倉持 がん免疫療法用細胞の製造方法
US20090123442A1 (en) * 2007-11-09 2009-05-14 Avaris Ab Expanded nk cells
KR20090127974A (ko) 2008-06-10 2009-12-15 주식회사 엔케이바이오 자기활성화 림프구 배양용 배지 조성물

Also Published As

Publication number Publication date
US8877182B2 (en) 2014-11-04
US20120258085A1 (en) 2012-10-11
JP2012521215A (ja) 2012-09-13
KR101881520B1 (ko) 2018-07-24
CN102428173A (zh) 2012-04-25
JP2018046840A (ja) 2018-03-29
KR20110132618A (ko) 2011-12-08
EP2411507A4 (en) 2013-06-19
DK2411507T3 (da) 2020-01-06
WO2010110734A1 (en) 2010-09-30
JP6574823B2 (ja) 2019-09-11
PL2411507T3 (pl) 2020-07-13
CN102428173B (zh) 2014-07-30
PT2411507T (pt) 2020-01-09
EP2411507A1 (en) 2012-02-01
ES2763169T3 (es) 2020-05-27
EP2411507B1 (en) 2019-09-25
JP2016105713A (ja) 2016-06-16

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