HK1165954A1 - Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors - Google Patents
Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitorsInfo
- Publication number
- HK1165954A1 HK1165954A1 HK12106517.7A HK12106517A HK1165954A1 HK 1165954 A1 HK1165954 A1 HK 1165954A1 HK 12106517 A HK12106517 A HK 12106517A HK 1165954 A1 HK1165954 A1 HK 1165954A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- nitrogen
- heterocyclic compounds
- fused heterocyclic
- beta amyloid
- containing fused
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15569709P | 2009-02-26 | 2009-02-26 | |
| JP2009043337 | 2009-02-26 | ||
| PCT/JP2010/053368 WO2010098487A1 (en) | 2009-02-26 | 2010-02-24 | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1165954A1 true HK1165954A1 (en) | 2012-10-12 |
Family
ID=42331601
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12106517.7A HK1165954A1 (en) | 2009-02-26 | 2012-07-04 | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8754100B2 (ru) |
| EP (2) | EP2401276B1 (ru) |
| JP (1) | JP2012519152A (ru) |
| KR (1) | KR20110122746A (ru) |
| CN (1) | CN102333777B (ru) |
| AR (1) | AR075606A1 (ru) |
| AU (1) | AU2010218714A1 (ru) |
| CA (1) | CA2753696A1 (ru) |
| HK (1) | HK1165954A1 (ru) |
| IL (1) | IL214780A (ru) |
| MX (1) | MX2011008501A (ru) |
| NZ (1) | NZ594776A (ru) |
| PE (1) | PE20120172A1 (ru) |
| RU (1) | RU2515976C2 (ru) |
| SG (1) | SG173710A1 (ru) |
| TW (1) | TW201035101A (ru) |
| WO (1) | WO2010098487A1 (ru) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| CA2713716A1 (en) | 2008-02-22 | 2009-08-27 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| WO2010040661A1 (en) | 2008-10-09 | 2010-04-15 | F. Hoffmann-La Roche Ag | Modulators for amyloid beta |
| EP2355817A1 (en) | 2008-11-10 | 2011-08-17 | F. Hoffmann-La Roche AG | Heterocyclic gamma secretase modulators |
| CA3017886A1 (en) | 2008-11-19 | 2010-05-27 | Envivo Pharmaceuticals, Inc. | Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof |
| JP5576403B2 (ja) | 2009-02-06 | 2014-08-20 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | γ分泌酵素調節物質としての新規置換二環複素環化合物 |
| CN102439005B (zh) | 2009-05-07 | 2015-07-22 | 杨森制药公司 | 作为γ-分泌酶调节剂的取代的吲唑和氮杂-吲唑衍生物 |
| MX2011011972A (es) * | 2009-05-11 | 2011-12-08 | Envivo Pharmaceuticals Inc | Tratamiento de trastornos cognitivos con determinados receptores de acido nicotinico alfa-7 en combinacion con inhibidores de acetilcolinesterasa. |
| US20120142672A1 (en) * | 2009-07-13 | 2012-06-07 | Tatsuki Koike | Heterocyclic compound and use thereof |
| BR112012000915A2 (pt) | 2009-07-15 | 2019-09-24 | Janssen Pharmaceuticals Inc | derivados de triazol e imidazol substituídos como moduladores de gama secretase. |
| US9145399B2 (en) | 2010-01-15 | 2015-09-29 | Janssen Pharmaceuticals, Inc. | Substituted bicyclic triazole derivatives as gamma secretase modulators |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| DK3029039T3 (en) | 2010-05-17 | 2017-12-04 | Forum Pharmaceuticals Inc | PHARMACEUTICAL FORMS CONTAINING CRYSTALLINIC FORMS OF (R) -7-CHLOR-N- (QUINUCLIDIN-3-YL) BENZO (B) THIOPHEN-2-CARBOXAMIDE HYDROCHLORIDE MONOHYDRATE |
| JP6069661B2 (ja) | 2010-06-24 | 2017-02-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 種々のアミロイドβペプチドアロフォームレベルの調節における組成物及びその使用 |
| CA2809779A1 (en) | 2010-09-02 | 2012-03-08 | Takeda Pharmaceutical Company Limited | Fused triazoles for the treatment or prophylaxis of mild cognitive impairment |
| AU2012230348A1 (en) | 2011-03-24 | 2013-08-29 | Cellzome Limited | Novel substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators |
| WO2013005354A1 (ja) * | 2011-07-01 | 2013-01-10 | 武田薬品工業株式会社 | 複素環化合物 |
| KR101913135B1 (ko) * | 2011-07-15 | 2018-10-30 | 얀센 파마슈티칼즈, 인코포레이티드 | 감마 세크레타제 조절 인자로서의 신규의 치환 인돌 유도체 |
| WO2013106328A1 (en) * | 2012-01-09 | 2013-07-18 | Envivo Pharmaceuticals, Inc. | Tetrasubstituted benzenes for treatment of early onset alzheimer's disease |
| WO2013169646A1 (en) | 2012-05-08 | 2013-11-14 | Envivo Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| NZ702611A (en) | 2012-05-16 | 2016-10-28 | Cellzome Ltd | Substituted 3, 4 - dihydro - 2h - pyrido [1, 2 -a] pyrazine - 1, 6 - dione derivatives useful for the treatment of (inter alia) alzheimer’s disease |
| EP2687528A1 (en) * | 2012-07-17 | 2014-01-22 | Ares Trading S.A. | Fused triazole derivatives as gamma secretase modulators |
| EP2953949B1 (en) | 2012-12-20 | 2016-09-28 | Janssen Pharmaceutica NV | Novel tricyclic 3,4-dihydro-2h-pyrido[1,2-a]pyrazine-1,6-dione derivatives as gamma secretase modulators |
| JP6283691B2 (ja) | 2013-01-17 | 2018-02-21 | ヤンセン ファーマシューティカ エヌ．ベー． | γセクレターゼ調節剤としての新規な置換ピリド−ピペラジノン誘導体 |
| US9938263B2 (en) | 2013-03-12 | 2018-04-10 | The General Hospital Corporation | Gamma-secretase modulators |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| CN103910781B (zh) * | 2014-03-18 | 2016-02-17 | 重庆大学 | 一种Aβ聚集抑制剂 |
| WO2016070107A1 (en) | 2014-10-31 | 2016-05-06 | The General Hospital Corporation | Potent gamma-secretase modulators |
| EP3031458A1 (en) | 2014-12-09 | 2016-06-15 | Iproteos S.L. | Use of 1-[(2-phenylcycloprop-1-yl)carbonyl]-2-[(1,3-thiazolidin-3-yl)carbonyl]perhydroindole in the treatment of schizophrenia-associated cognitive deficits |
| TWI696617B (zh) * | 2015-04-28 | 2020-06-21 | 大陸商上海復尚慧創醫藥研究有限公司 | 特定蛋白質激酶抑制劑 |
| PL3846903T3 (pl) * | 2018-09-03 | 2024-05-06 | F. Hoffmann-La Roche Ag | Bicykliczne pochodne heteroarylowe |
| CN110642689B (zh) * | 2019-09-05 | 2022-06-24 | 南通大学 | 一种3,6-二溴-2-甲基苯甲醛及其化学合成方法 |
| CN112661639A (zh) * | 2020-12-07 | 2021-04-16 | 浙江工业大学 | 一种4-乙酰丁酸酯类化合物合成方法 |
| CN116621846B (zh) * | 2023-07-24 | 2023-10-17 | 华润医药研究院（深圳）有限公司 | 双环杂环及三环杂环类化合物及其制备方法和医药用途 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA54393C2 (ru) * | 1995-04-21 | 2003-03-17 | Н'Юросерч А/С | Соединения бензимидазола, фармацевтические композиции, содержащие эти соединения и способ лечения чувствительных к положительной модуляции гамк-рецепторных комплексов расстройств цнс |
| IL131618A0 (en) * | 1997-04-16 | 2001-01-28 | Abbott Lab | 5,7-Disubstituted aminopyrido [2,3-D] pyrimidine compounds and their use as adenosine kinase inhibitors |
| US7244739B2 (en) * | 2003-05-14 | 2007-07-17 | Torreypines Therapeutics, Inc. | Compounds and uses thereof in modulating amyloid beta |
| KR100966749B1 (ko) | 2004-05-26 | 2010-06-30 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신나미드 화합물 |
| MY144960A (en) | 2005-11-24 | 2011-11-30 | Eisai R&D Man Co Ltd | Morpholine type cinnamide compound |
| TWI370130B (en) | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| GEP20115139B (en) | 2006-03-09 | 2011-01-10 | Eisai R&D Man Co Ltd | Polycyclic cinnamide derivative |
| JP2009184924A (ja) | 2006-05-31 | 2009-08-20 | Eisai R & D Management Co Ltd | 生物学的試薬用化合物 |
| TW200848054A (en) | 2007-02-28 | 2008-12-16 | Eisai R&D Man Co Ltd | Two cyclic oxomorpholine derivatives |
| AR068121A1 (es) | 2007-08-31 | 2009-11-04 | Eisai R&D Man Co Ltd | Compuestos multiciclicos para tratar enfermedades neurodegenerativas |
| US7935815B2 (en) | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| EP2229381A1 (en) | 2007-12-06 | 2010-09-22 | Schering Corporation | Gamma secretase modulators |
| WO2010025197A1 (en) | 2008-08-27 | 2010-03-04 | Eisai R&D Management Co., Ltd. | Process for preparing certain cinnamide compounds |
| JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
| PL2401270T3 (pl) | 2009-02-26 | 2014-03-31 | Glaxo Group Ltd | Pochodne pirazolu stosowane jako antagoniści receptora CCR4 |
| BRPI1007883A2 (pt) | 2009-02-26 | 2016-02-23 | Eisai R&D Man Co Ltd | sal, e, cristal. |
| JP2012051806A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | イミダゾリルピラジン誘導体 |
| MY153941A (en) | 2009-02-26 | 2015-04-15 | Boehringer Ingelheim Int | Compounds as bradykinin b1 antagonists |
| BR112012000915A2 (pt) | 2009-07-15 | 2019-09-24 | Janssen Pharmaceuticals Inc | derivados de triazol e imidazol substituídos como moduladores de gama secretase. |
| WO2011031984A2 (en) | 2009-09-11 | 2011-03-17 | Simplisse, Inc. | Nipple shield |
-
2010
- 2010-02-24 KR KR1020117022134A patent/KR20110122746A/ko not_active Application Discontinuation
- 2010-02-24 EP EP10708824.7A patent/EP2401276B1/en active Active
- 2010-02-24 EP EP13162886.9A patent/EP2615090A1/en not_active Withdrawn
- 2010-02-24 NZ NZ594776A patent/NZ594776A/xx not_active IP Right Cessation
- 2010-02-24 AU AU2010218714A patent/AU2010218714A1/en not_active Abandoned
- 2010-02-24 TW TW099105284A patent/TW201035101A/zh unknown
- 2010-02-24 SG SG2011058864A patent/SG173710A1/en unknown
- 2010-02-24 CN CN201080009288.9A patent/CN102333777B/zh not_active Expired - Fee Related
- 2010-02-24 JP JP2011536639A patent/JP2012519152A/ja not_active Ceased
- 2010-02-24 RU RU2011139132/04A patent/RU2515976C2/ru not_active IP Right Cessation
- 2010-02-24 US US13/138,504 patent/US8754100B2/en not_active Expired - Fee Related
- 2010-02-24 MX MX2011008501A patent/MX2011008501A/es active IP Right Grant
- 2010-02-24 CA CA2753696A patent/CA2753696A1/en not_active Abandoned
- 2010-02-24 WO PCT/JP2010/053368 patent/WO2010098487A1/en active Application Filing
- 2010-02-24 PE PE2011001502A patent/PE20120172A1/es not_active Application Discontinuation
- 2010-02-25 AR ARP100100548A patent/AR075606A1/es not_active Application Discontinuation
-
2011
- 2011-08-22 IL IL214780A patent/IL214780A/en not_active IP Right Cessation
-
2012
- 2012-07-04 HK HK12106517.7A patent/HK1165954A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN102333777B (zh) | 2014-06-25 |
| CN102333777A (zh) | 2012-01-25 |
| RU2515976C2 (ru) | 2014-05-20 |
| EP2615090A1 (en) | 2013-07-17 |
| KR20110122746A (ko) | 2011-11-10 |
| US20120053171A1 (en) | 2012-03-01 |
| TW201035101A (en) | 2010-10-01 |
| US8754100B2 (en) | 2014-06-17 |
| EP2401276A1 (en) | 2012-01-04 |
| AR075606A1 (es) | 2011-04-20 |
| MX2011008501A (es) | 2011-09-01 |
| JP2012519152A (ja) | 2012-08-23 |
| EP2401276B1 (en) | 2013-06-05 |
| AU2010218714A1 (en) | 2011-09-08 |
| PE20120172A1 (es) | 2012-03-08 |
| CA2753696A1 (en) | 2010-09-02 |
| WO2010098487A1 (en) | 2010-09-02 |
| RU2011139132A (ru) | 2013-04-20 |
| IL214780A0 (en) | 2011-11-30 |
| IL214780A (en) | 2014-06-30 |
| SG173710A1 (en) | 2011-09-29 |
| NZ594776A (en) | 2013-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1165954A1 (en) | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors | |
| AR121612A2 (es) | Inhibidores de glucosilceramida sintasa | |
| TN2011000400A1 (en) | Inhibitors of beta-secretase | |
| MY177250A (en) | Novel nicotinamide derivative or salt thereof | |
| TN2012000125A1 (en) | Substituted carbamoylmethylamino acetic acid derivatives as novel nep inhibitors | |
| CU20110217A7 (es) | Derivados amino-propiónicos sustituidos como inhibidores de neprilisina | |
| MX2013005533A (es) | Derivados de acido amino-bisfenil-pentanoico sustituidos como inhibidores de nep. | |
| EA201490807A1 (ru) | Новые замещенные имидазопиримидины как модуляторы рецептора gpbar1 | |
| EA201071370A1 (ru) | Серосодержащее гетероциклическое производное, обладающее активностью ингибитора бета-секретазы | |
| MY148703A (en) | Polycyclic cinnamide derivatives | |
| WO2008108378A3 (en) | Bicyclic oxomorpholine derivative | |
| EA200900924A1 (ru) | Циклизованные производные как ингибиторы eg-5 | |
| AR084011A1 (es) | Compuestos nitrogenados heterociclicos utiles para el tratamiento de infecciones por el virus sincitial respiratorio (rsv), proceso para prepararlos y composiciones farmaceuticas que los contienen | |
| NO20091858L (no) | Hydrobenzamid derivater som inhibitorer av HSP90 | |
| IN2014MN01521A (ru) | ||
| EA201170722A1 (ru) | Лактамы в качестве ингибиторов бета-секретазы | |
| ECSP11011196A (es) | Derivados de piperidina | |
| MX343077B (es) | Nuevo derivado de octahidrotienoquinolina, composicion farmaceutica que comprende el derivado, y uso de los mismos. | |
| UA111950C2 (uk) | Гетероциклічні сполуки для лікування або профілактики розладів, викликаних зниженою нейротрансмісією серотоніну, норепінефрину або допаміну | |
| MX2012007836A (es) | Derivados de acido carboxilico heterociclicos que comprenden un anillo de oxazolopirimidina 2,5-sustituida. | |
| MX2012007834A (es) | Derivados de acido carboxilico que comprenden un anillo de oxazolopirimidina 2,5-sustituido. | |
| MX2010009876A (es) | Nuevo proceso para la preparacion de derivados de acido ciclohexanocarboxilico por medio del derivado de ciclohexanocarboxamida correspondiente. | |
| PE20140239A1 (es) | Derivados de 1,4-oxazepano | |
| MX345264B (es) | Derivado de azol. | |
| EA201591487A1 (ru) | Производные замещенной бисфенилбутановой кислоты в качестве ингибиторов nep с улучшенной in vivo эффективностью |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20170224 |