HK1150601A1 - Pyridin-2-yl derivatives as immunomodulating agents - Google Patents

Pyridin-2-yl derivatives as immunomodulating agents

Info

Publication number
HK1150601A1
HK1150601A1 HK11104636.9A HK11104636A HK1150601A1 HK 1150601 A1 HK1150601 A1 HK 1150601A1 HK 11104636 A HK11104636 A HK 11104636A HK 1150601 A1 HK1150601 A1 HK 1150601A1
Authority
HK
Hong Kong
Prior art keywords
pyridin
derivatives
immunomodulating agents
immunomodulating
agents
Prior art date
Application number
HK11104636.9A
Other languages
English (en)
Inventor
Martin Bolli
Cyrille Lescop
Boris Mathys
Claus Mueller
Oliver Nayler
Beat Steiner
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40584746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1150601(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of HK1150601A1 publication Critical patent/HK1150601A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
HK11104636.9A 2008-03-07 2011-05-11 Pyridin-2-yl derivatives as immunomodulating agents HK1150601A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB2008050848 2008-03-07
PCT/IB2009/050749 WO2009109872A1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents

Publications (1)

Publication Number Publication Date
HK1150601A1 true HK1150601A1 (en) 2012-01-06

Family

ID=40584746

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11104636.9A HK1150601A1 (en) 2008-03-07 2011-05-11 Pyridin-2-yl derivatives as immunomodulating agents

Country Status (27)

Country Link
US (1) US8575200B2 (zh)
EP (1) EP2252609B1 (zh)
JP (1) JP5435745B2 (zh)
KR (1) KR101615779B1 (zh)
CN (1) CN102015695B (zh)
AR (1) AR070858A1 (zh)
AU (1) AU2009220861B2 (zh)
BR (1) BRPI0909055A2 (zh)
CA (1) CA2715437C (zh)
CL (1) CL2009000532A1 (zh)
CY (1) CY1114096T1 (zh)
DK (1) DK2252609T3 (zh)
ES (1) ES2414533T3 (zh)
HK (1) HK1150601A1 (zh)
HR (1) HRP20130641T1 (zh)
IL (1) IL207972A (zh)
MA (1) MA32173B1 (zh)
MX (1) MX2010009644A (zh)
MY (1) MY183039A (zh)
NZ (1) NZ588438A (zh)
PL (1) PL2252609T3 (zh)
PT (1) PT2252609E (zh)
RU (1) RU2494099C2 (zh)
SI (1) SI2252609T1 (zh)
TW (1) TWI444377B (zh)
WO (1) WO2009109872A1 (zh)
ZA (1) ZA201007136B (zh)

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* Cited by examiner, † Cited by third party
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KR101470659B1 (ko) * 2006-09-07 2014-12-08 액테리온 파마슈티칼 리미티드 면역조절제로서 피리딘-4-일 유도체
EP2069335B1 (en) * 2006-09-08 2012-12-26 Actelion Pharmaceuticals Ltd. Pyridin-3-yl derivatives as immunomodulating agents
US8044076B2 (en) * 2006-09-21 2011-10-25 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
JP2010521450A (ja) * 2007-03-16 2010-06-24 アクテリオン ファーマシューティカルズ リミテッド Ｓ１ｐ１／ｅｄｇ１受容体アゴニストとしてのアミノ−ピリジン誘導体
SI2195311T1 (sl) * 2007-08-17 2011-07-29 Actelion Pharmaceuticals Ltd Derivati piridina kot modulatorji receptorja s1p1/edg1
WO2009057079A2 (en) * 2007-11-01 2009-05-07 Actelion Pharmaceuticals Ltd Novel pyrimidine derivatives
CN102471328B (zh) 2009-07-16 2015-04-01 埃科特莱茵药品有限公司 吡啶-4-基衍生物
WO2011128018A1 (en) * 2010-04-15 2011-10-20 Merck Patent Gmbh Process for the preparation of hydroquinones
SG191742A1 (en) 2011-01-19 2013-08-30 Actelion Pharmaceuticals Ltd 2-methoxy-pyridin-4-yl derivatives
PT2970236T (pt) * 2013-03-15 2017-11-30 Idorsia Pharmaceuticals Ltd Derivados de piridin-4-ilo
EP3298008B1 (en) 2015-05-20 2019-11-20 Idorsia Pharmaceuticals Ltd Crystalline form of the compound (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol

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CA2051494C (en) 1990-09-20 2006-03-14 Robert J. Dinerstein 1-aryl-3-pyridinyl-2-propene-1-ones as calcium uptake inhibitors
DE4429465A1 (de) 1994-08-19 1996-02-22 Bayer Ag Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
JP2003034684A (ja) * 2001-06-29 2003-02-07 Biofor Inc 新規な種類の抗真菌剤
US7199142B2 (en) * 2002-06-17 2007-04-03 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl) benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl) pyrrolidine-3-carboxylates as edg receptor agonists
DE10237883A1 (de) 2002-08-19 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
AU2003279915A1 (en) * 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
CA2539438A1 (en) * 2003-10-01 2005-04-14 Merck And Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
EP1697333A4 (en) * 2003-12-17 2009-07-08 Merck & Co Inc 3,4-DISUSBSTITUTED PROPANOIC CARBOXYLATES AS S1P RECEPTOR AGONISTS (EDG)
US8039674B2 (en) * 2004-06-23 2011-10-18 Ono Pharmaceutical Co., Ltd. Compound having S1P receptor binding potency and use thereof
WO2006010379A1 (en) * 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
EP2371811B1 (en) * 2004-12-13 2014-10-08 Ono Pharmaceutical Co., Ltd. Azetidinecarboxylic acid derivative and medicinal use thereof
SI1863787T1 (sl) * 2005-03-23 2011-10-28 Actelion Pharmaceuticals Ltd Hidrogenirani benzo(c)tiofenski derivati kot imunomodulatorji
US7605269B2 (en) * 2005-03-23 2009-10-20 Actelion Pharmaceuticals Ltd. Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
BRPI0609665A2 (pt) * 2005-03-23 2010-04-20 Actelion Pharmaceuticals Ltd composto, composição farmacêutica, e, uso de um composto
EP1874772A1 (en) * 2005-04-05 2008-01-09 Pharmacopeia, Inc. Purine and imidazopyridine derivatives for immunosuppression
JPWO2006115188A1 (ja) 2005-04-22 2008-12-18 第一三共株式会社 ヘテロ環化合物
RU2007147940A (ru) * 2005-06-08 2009-07-20 Новартис АГ (CH) Полициклические оксадиазолы или изоксазолы и их применение в качестве лигандов s1p рецептора
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AR057894A1 (es) * 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
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TWI408139B (zh) * 2006-09-07 2013-09-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
KR101470659B1 (ko) * 2006-09-07 2014-12-08 액테리온 파마슈티칼 리미티드 면역조절제로서 피리딘-4-일 유도체
EP2069335B1 (en) * 2006-09-08 2012-12-26 Actelion Pharmaceuticals Ltd. Pyridin-3-yl derivatives as immunomodulating agents
US8044076B2 (en) * 2006-09-21 2011-10-25 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
WO2008037476A1 (en) * 2006-09-29 2008-04-03 Novartis Ag Oxadiazole derivatives with anti-inflammatory and immunosuppressive properties
JP2008120794A (ja) 2006-10-16 2008-05-29 Daiichi Sankyo Co Ltd ヘテロ環化合物を含有する医薬組成物
BRPI0720043A2 (pt) * 2006-12-15 2014-01-07 Abbott Lab Composto oxadiazol
JP2010521450A (ja) * 2007-03-16 2010-06-24 アクテリオン ファーマシューティカルズ リミテッド Ｓ１ｐ１／ｅｄｇ１受容体アゴニストとしてのアミノ−ピリジン誘導体
SI2195311T1 (sl) * 2007-08-17 2011-07-29 Actelion Pharmaceuticals Ltd Derivati piridina kot modulatorji receptorja s1p1/edg1
WO2009057079A2 (en) * 2007-11-01 2009-05-07 Actelion Pharmaceuticals Ltd Novel pyrimidine derivatives
MX2010005889A (es) * 2007-12-10 2010-06-22 Actelion Pharmaceuticals Ltd Derivados de tiofeno como agonistas de s1p1/edg1.
JP5411877B2 (ja) * 2008-03-06 2014-02-12 アクテリオン ファーマシューティカルズ リミテッド ピリジン化合物
JP2011513385A (ja) * 2008-03-06 2011-04-28 アクテリオン ファーマシューティカルズ リミテッド 新規なピリミジン−ピリジン誘導体
AU2009220893A1 (en) * 2008-03-07 2009-09-11 Actelion Pharmaceuticals Ltd Novel aminomethyl benzene derivatives
CN102471328B (zh) * 2009-07-16 2015-04-01 埃科特莱茵药品有限公司 吡啶-4-基衍生物

Also Published As

Publication number Publication date
TWI444377B (zh) 2014-07-11
ZA201007136B (en) 2014-03-26
RU2494099C2 (ru) 2013-09-27
TW200940532A (en) 2009-10-01
IL207972A0 (en) 2010-12-30
EP2252609A1 (en) 2010-11-24
ES2414533T3 (es) 2013-07-19
DK2252609T3 (da) 2013-06-24
NZ588438A (en) 2012-05-25
MY183039A (en) 2021-02-08
MA32173B1 (fr) 2011-03-01
CA2715437C (en) 2016-05-24
CN102015695B (zh) 2014-08-27
EP2252609B1 (en) 2013-04-17
RU2010140854A (ru) 2012-04-20
AU2009220861A1 (en) 2009-09-11
SI2252609T1 (sl) 2013-07-31
IL207972A (en) 2016-03-31
BRPI0909055A2 (pt) 2019-02-26
CA2715437A1 (en) 2009-09-11
CN102015695A (zh) 2011-04-13
JP2011513381A (ja) 2011-04-28
WO2009109872A1 (en) 2009-09-11
HRP20130641T1 (en) 2013-08-31
US8575200B2 (en) 2013-11-05
MX2010009644A (es) 2010-09-22
AU2009220861B2 (en) 2014-05-29
AR070858A1 (es) 2010-05-12
PT2252609E (pt) 2013-06-24
US20100331372A1 (en) 2010-12-30
KR101615779B1 (ko) 2016-04-26
JP5435745B2 (ja) 2014-03-05
CL2009000532A1 (es) 2010-04-09
CY1114096T1 (el) 2016-07-27
PL2252609T3 (pl) 2013-09-30
KR20100137493A (ko) 2010-12-30

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190225