HK1142926A1 - Differentiation of human embryonic stem cells - Google Patents
Differentiation of human embryonic stem cellsInfo
- Publication number
- HK1142926A1 HK1142926A1 HK10109459.3A HK10109459A HK1142926A1 HK 1142926 A1 HK1142926 A1 HK 1142926A1 HK 10109459 A HK10109459 A HK 10109459A HK 1142926 A1 HK1142926 A1 HK 1142926A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- differentiation
- stem cells
- embryonic stem
- human embryonic
- human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0678—Stem cells; Progenitor cells; Precursor cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/119—Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/415—Wnt; Frizzeled
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77931107A | 2007-07-18 | 2007-07-18 | |
PCT/US2008/070418 WO2009012428A2 (en) | 2007-07-18 | 2008-07-18 | Differentiation of human embryonic stem cells |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1142926A1 true HK1142926A1 (en) | 2010-12-17 |
Family
ID=40260391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10109459.3A HK1142926A1 (en) | 2007-07-18 | 2010-10-04 | Differentiation of human embryonic stem cells |
Country Status (15)
Country | Link |
---|---|
US (1) | US20100255580A1 (xx) |
EP (3) | EP2562248B1 (xx) |
JP (1) | JP5738591B2 (xx) |
KR (1) | KR101555824B1 (xx) |
CN (2) | CN101861386A (xx) |
BR (1) | BRPI0814425A2 (xx) |
CA (1) | CA2693156C (xx) |
DK (1) | DK2562248T3 (xx) |
ES (1) | ES2537578T3 (xx) |
HK (1) | HK1142926A1 (xx) |
MX (1) | MX2010000746A (xx) |
PL (1) | PL2185695T3 (xx) |
RU (1) | RU2465323C2 (xx) |
WO (1) | WO2009012428A2 (xx) |
ZA (1) | ZA201001158B (xx) |
Families Citing this family (88)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8017395B2 (en) | 2004-12-17 | 2011-09-13 | Lifescan, Inc. | Seeding cells on porous supports |
US9074189B2 (en) | 2005-06-08 | 2015-07-07 | Janssen Biotech, Inc. | Cellular therapy for ocular degeneration |
US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
US9080145B2 (en) | 2007-07-01 | 2015-07-14 | Lifescan Corporation | Single pluripotent stem cell culture |
BRPI0814894A2 (pt) | 2007-07-31 | 2014-10-21 | Lifescan Inc | Diferenciação de células-tronco embrionárias de ser humano. |
CN101878298B (zh) | 2007-11-27 | 2017-08-15 | 生命扫描有限公司 | 人胚胎干细胞的分化 |
SG154367A1 (en) * | 2008-01-31 | 2009-08-28 | Es Cell Int Pte Ltd | Method of differentiating stem cells |
CA2715878C (en) | 2008-02-21 | 2017-06-13 | Centocor Ortho Biotech Inc. | Methods, surface modified plates and compositions for cell attachment, cultivation and detachment |
US7939322B2 (en) * | 2008-04-24 | 2011-05-10 | Centocor Ortho Biotech Inc. | Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm |
US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
PL2310492T3 (pl) | 2008-06-30 | 2015-12-31 | Janssen Biotech Inc | Różnocowanie pluripotencjalnych komórek macierzystych |
CN102333862B (zh) * | 2008-10-31 | 2018-04-27 | 詹森生物科技公司 | 人胚胎干细胞向胰腺内分泌谱系的分化 |
MX2011004565A (es) | 2008-10-31 | 2011-07-28 | Centocor Ortho Biotech Inc | Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico. |
AU2009316580B2 (en) | 2008-11-20 | 2016-04-14 | Janssen Biotech, Inc. | Pluripotent stem cell culture on micro-carriers |
CA2744227C (en) | 2008-11-20 | 2018-10-02 | Centocor Ortho Biotech Inc. | Methods and compositions for cell attachment and cultivation on planar substrates |
US8268621B2 (en) * | 2008-12-03 | 2012-09-18 | International Stem Cell Corporation | Methods of deriving definitive endoderm cells from pluripotent parthenogenetic stem cells |
ES2948761T3 (es) * | 2009-02-03 | 2023-09-18 | Koninklijke Nederlandse Akademie Van Wetenschappen | Combinaciones de inhibidores de la replicación del virus de la influenza |
EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
WO2010136583A2 (en) * | 2009-05-29 | 2010-12-02 | Novo Nordisk A/S | INDUCED DERIVATION OF SPECIFIC ENDODERM FROM hPS CELL-DERIVED DEFINITIVE ENDODERM |
MX348077B (es) | 2009-07-20 | 2017-05-25 | Janssen Biotech Inc | Diferenciacion de celulas madre embrionarias humanas. |
AU2010276440B2 (en) | 2009-07-20 | 2014-07-03 | Janssen Biotech Inc. | Differentiation of human embryonic stem cells |
RU2540016C2 (ru) | 2009-07-20 | 2015-01-27 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека |
SG10201408552YA (en) | 2009-12-23 | 2015-02-27 | Janssen Biotech Inc | Differentiation of human embryonic stem cells |
CN102712902B (zh) | 2009-12-23 | 2019-01-08 | 詹森生物科技公司 | 人胚胎干细胞的分化 |
CA2785966C (en) * | 2009-12-29 | 2020-10-27 | Takeda Pharmaceutical Company Limited | Method for manufacturing pancreatic-hormone-producing cells |
AU2011223900A1 (en) | 2010-03-01 | 2012-09-13 | Janssen Biotech, Inc. | Methods for purifying cells derived from pluripotent stem cells |
EP2550355B1 (en) | 2010-03-22 | 2016-11-16 | Takara Bio Europe AB | Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of wnt-signalling pathway |
AU2011250912A1 (en) | 2010-05-12 | 2012-11-22 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
AU2011290123B2 (en) * | 2010-08-09 | 2016-11-10 | Takeda Pharmaceutical Company Limited | Method of producing pancreatic hormone-producing cells |
GB201014169D0 (en) * | 2010-08-25 | 2010-10-06 | Cambridge Entpr Ltd | In vitro hepatic differentiation |
WO2012030538A2 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells |
BR112013004514A2 (pt) | 2010-08-31 | 2016-06-07 | Janssen Biotech Inc | diferenciação das células-tronco embrionárias humanas |
WO2012030540A2 (en) | 2010-08-31 | 2012-03-08 | Janssen Biotech, Inc. | Differentiation of pluripotent stem cells |
US9404087B2 (en) | 2010-12-15 | 2016-08-02 | Kadimastem Ltd. | Insulin producing cells derived from pluripotent stem cells |
WO2012175633A1 (en) | 2011-06-21 | 2012-12-27 | Novo Nordisk A/S | Efficient induction of definitive endoderm from pluripotent stem cells |
JP2014519854A (ja) | 2011-06-23 | 2014-08-21 | ザ チルドレンズ ホスピタル オブ フィラデルフィア | ヒト多能性幹細胞から生じる自己複製する内胚葉前駆細胞株とその使用方法 |
SG10201608914WA (en) | 2011-12-22 | 2016-12-29 | Janssen Biotech Inc | Differentiation of human embryonic stem cells into single hormonal insulin positive cells |
RU2482870C1 (ru) * | 2012-02-27 | 2013-05-27 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Средство, индуцирующее дифференцировку стволовых кроветворных клеток в тромбоциты |
JP6383292B2 (ja) | 2012-03-07 | 2018-08-29 | ヤンセン バイオテツク,インコーポレーテツド | 多能性幹細胞の増殖及び維持のための明確な培地 |
CN102608323A (zh) * | 2012-03-26 | 2012-07-25 | 西北农林科技大学 | 一种基于哺乳动物囊胚的分子免疫检测的胚胎质量分析方法 |
RU2668814C2 (ru) * | 2012-05-07 | 2018-10-02 | Янссен Байотек, Инк. | Способы продуцирования клеток дефинитивной энтодермы и панкреатической энтодермы |
RU2018108851A (ru) * | 2012-06-08 | 2019-02-26 | Янссен Байотек, Инк. | Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки |
US9175263B2 (en) * | 2012-08-22 | 2015-11-03 | Biotime, Inc. | Methods and compositions for targeting progenitor cell lines |
JP6470687B2 (ja) | 2012-09-03 | 2019-02-13 | ノヴォ ノルディスク アー/エス | 小分子を用いた多能性幹細胞からの膵臓内胚葉の作製 |
GB201216796D0 (en) * | 2012-09-20 | 2012-11-07 | Cambridge Entpr Ltd | In vitro pancreatic differentiation |
SG10201709338RA (en) * | 2012-12-31 | 2017-12-28 | Janssen Biotech Inc | Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells |
CN105705634A (zh) | 2012-12-31 | 2016-06-22 | 詹森生物科技公司 | 用于分化成胰腺内分泌细胞的人多能细胞的悬浮和群集 |
ES2942484T3 (es) | 2012-12-31 | 2023-06-01 | Janssen Biotech Inc | Diferenciación de células madre embrionarias humanas en células endocrinas pancreáticas usando reguladores de HB9 |
US10370644B2 (en) | 2012-12-31 | 2019-08-06 | Janssen Biotech, Inc. | Method for making human pluripotent suspension cultures and cells derived therefrom |
WO2014127219A1 (en) * | 2013-02-14 | 2014-08-21 | The Cleveland Clinic Foundation | Methods for induction of cell fates from pluripotent cells |
CN105431522B (zh) | 2013-03-14 | 2021-08-03 | 加利福尼亚大学董事会 | 内侧神经节隆起前体细胞的体外产生 |
US8859286B2 (en) * | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
CN103194424A (zh) * | 2013-03-28 | 2013-07-10 | 于涛 | 一种诱导胚胎干细胞为胰腺组织样细胞的方法 |
EP3888640A1 (en) | 2013-06-05 | 2021-10-06 | AgeX Therapeutics, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
MX2015017103A (es) | 2013-06-11 | 2016-11-07 | Harvard College | Celulas beta derivadas de células madre ( sc-beta ) y composiciones y métodos para generarlas. |
EP2896688A1 (en) * | 2014-01-20 | 2015-07-22 | Centre National de la Recherche Scientifique (CNRS) | A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide |
US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
CA2949056A1 (en) | 2014-05-16 | 2015-11-19 | Janssen Biotech, Inc. | Use of small molecules to enhance mafa expression in pancreatic endocrine cells |
US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
RU2579997C2 (ru) * | 2014-07-24 | 2016-04-10 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт фармакологии имени Е.Д. Гольдберга" Сибирского отделения Российской академии медицинских наук | СПОСОБ ИНДУКЦИИ НАПРАВЛЕННОЙ ДИФФЕРЕНЦИРОВКИ МУЛЬТИПОТЕНТНЫХ ПРОГЕНИТОРНЫХ КЛЕТОК ПОДЖЕЛУДОЧНОЙ ЖЕЛЕЗЫ В ИНСУЛИН-ПРОДУЦИРУЮЩИЕ β-КЛЕТКИ ПРИ САХАРНОМ ДИАБЕТЕ |
US10253298B2 (en) | 2014-12-18 | 2019-04-09 | President And Fellows Of Harvard College | Methods for generating stem cell-derived beta cells and methods of use thereof |
WO2016100898A1 (en) | 2014-12-18 | 2016-06-23 | President And Fellows Of Harvard College | Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof |
US10190096B2 (en) | 2014-12-18 | 2019-01-29 | President And Fellows Of Harvard College | Methods for generating stem cell-derived β cells and uses thereof |
CN104694462B (zh) * | 2015-03-17 | 2018-02-13 | 奥思达干细胞有限公司 | 一种胚胎干细胞定向诱导分化为肝细胞的方法 |
JP6954711B2 (ja) | 2015-04-24 | 2021-10-27 | ユニバーシティ オブ コペンハーゲン | 真正膵臓前駆細胞の単離 |
EP3344264B1 (en) * | 2015-09-03 | 2023-03-15 | The Brigham and Women's Hospital, Inc. | Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease |
MA45479A (fr) | 2016-04-14 | 2019-02-20 | Janssen Biotech Inc | Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
CA2983845C (en) | 2017-10-26 | 2024-01-30 | University Of Copenhagen | Generation of glucose-responsive beta cells |
KR20200087201A (ko) | 2017-11-15 | 2020-07-20 | 셈마 테라퓨틱스, 인크. | 섬세포 제조 조성물 및 사용 방법 |
WO2019182157A1 (ja) | 2018-03-19 | 2019-09-26 | 国立大学法人京都大学 | ハイドロゲルカプセル |
BR112020021802A2 (pt) | 2018-04-23 | 2021-02-23 | Kyoto University | métodos para produzir uma população de células produtoras de insulina ou uma população de células beta pancreáticas e para diminuir o número ou inibir a proliferação de células positivas para ki67, e, população de células progenitoras pancreáticas ou células em um estágio posterior de diferenciação |
EP3831931A4 (en) | 2018-08-03 | 2022-05-18 | Kyoto University | CELL PRODUCTION PROCESS |
EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | ISLE DIFFERENTIATION DERIVED FROM STEM CELLS |
US20210353686A1 (en) | 2018-09-19 | 2021-11-18 | Takeda Pharmaceutical Company Limited | Insulin-producing cells |
CN109749986B (zh) * | 2019-03-13 | 2021-04-02 | 武汉大学 | 一种由人多能干细胞分化获得胰腺前体细胞及胰岛β细胞的方法 |
KR20210151903A (ko) | 2019-04-10 | 2021-12-14 | 오리즈루 세라퓨틱스 가부시키가이샤 | 생체 조직형 구조체의 제조 방법 |
WO2020243665A1 (en) | 2019-05-31 | 2020-12-03 | W. L. Gore & Associates, Inc. | A biocompatible membrane composite |
JP2022535239A (ja) | 2019-05-31 | 2022-08-05 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | 生体適合性メンブレン複合体 |
AU2020282355B2 (en) | 2019-05-31 | 2023-11-02 | Viacyte, Inc. | A biocompatible membrane composite |
CA3139292A1 (en) | 2019-05-31 | 2020-12-03 | Timothy M. BRUHN | Cell encapsulation devices with controlled oxygen diffusion distances |
WO2021079874A1 (ja) | 2019-10-21 | 2021-04-29 | 武田薬品工業株式会社 | 増殖抑制剤 |
JPWO2021241668A1 (xx) | 2020-05-28 | 2021-12-02 | ||
CN116391028A (zh) | 2020-11-20 | 2023-07-04 | 千纸鹤治疗公司 | 促熟剂 |
TW202246489A (zh) | 2021-02-09 | 2022-12-01 | 日商千紙鶴治療公司 | 成熟化劑 |
US20230236171A1 (en) * | 2021-12-14 | 2023-07-27 | California Institute Of Technology | Methods, culture medias and devices for generating embryos in vitro from stem cells |
US20240101957A1 (en) * | 2022-09-02 | 2024-03-28 | California Institute Of Technology | Methods and compositions for generating embryos in vitro from pluripotent stem cells |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4557264A (en) | 1984-04-09 | 1985-12-10 | Ethicon Inc. | Surgical filament from polypropylene blended with polyethylene |
US5863531A (en) | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
US5804178A (en) | 1986-11-20 | 1998-09-08 | Massachusetts Institute Of Technology | Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue |
CA1340581C (en) | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
US5567612A (en) | 1986-11-20 | 1996-10-22 | Massachusetts Institute Of Technology | Genitourinary cell-matrix structure for implantation into a human and a method of making |
GB9206861D0 (en) | 1992-03-28 | 1992-05-13 | Univ Manchester | Wound healing and treatment of fibrotic disorders |
US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
AU1197699A (en) | 1997-10-23 | 1999-05-10 | Geron Corporation | Methods and materials for the growth of primate-derived primordial stem cells |
ZA9811898B (en) | 1997-12-29 | 2000-06-28 | Ortho Mcneil Pharm Inc | Anti-Inflammatory Compounds. |
MY132496A (en) | 1998-05-11 | 2007-10-31 | Vertex Pharma | Inhibitors of p38 |
US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
US6413556B1 (en) | 1999-01-08 | 2002-07-02 | Sky High, Llc | Aqueous anti-apoptotic compositions |
US6306424B1 (en) | 1999-06-30 | 2001-10-23 | Ethicon, Inc. | Foam composite for the repair or regeneration of tissue |
US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
US7005252B1 (en) | 2000-03-09 | 2006-02-28 | Wisconsin Alumni Research Foundation | Serum free cultivation of primate embryonic stem cells |
US7439064B2 (en) | 2000-03-09 | 2008-10-21 | Wicell Research Institute, Inc. | Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium |
JP4524072B2 (ja) | 2000-10-23 | 2010-08-11 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規化合物 |
US6599323B2 (en) | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
US6656488B2 (en) | 2001-04-11 | 2003-12-02 | Ethicon Endo-Surgery, Inc. | Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering |
US6626950B2 (en) | 2001-06-28 | 2003-09-30 | Ethicon, Inc. | Composite scaffold with post anchor for the repair and regeneration of tissue |
GB0117583D0 (en) | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
CA2470539C (en) | 2001-12-07 | 2011-10-04 | Geron Corporation | Islet cells from human embryonic stem cells |
US20060003446A1 (en) | 2002-05-17 | 2006-01-05 | Gordon Keller | Mesoderm and definitive endoderm cell populations |
US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
US7144999B2 (en) | 2002-11-23 | 2006-12-05 | Isis Pharmaceuticals, Inc. | Modulation of hypoxia-inducible factor 1 alpha expression |
WO2004081172A2 (en) * | 2003-03-12 | 2004-09-23 | Reliance Life Sciences Pvt. Ltd. | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells |
ITRM20030395A1 (it) | 2003-08-12 | 2005-02-13 | Istituto Naz Per Le Malattie Infettive Lazz | Terreno di coltura per il mantenimento, la proliferazione e il differenziamento di cellule di mammifero. |
US20050266554A1 (en) | 2004-04-27 | 2005-12-01 | D Amour Kevin A | PDX1 expressing endoderm |
US20050233446A1 (en) | 2003-12-31 | 2005-10-20 | Parsons Xuejun H | Defined media for stem cell culture |
CN1950498A (zh) | 2004-03-10 | 2007-04-18 | 加利福尼亚大学董事会 | 培养胚胎干细胞的组合物和方法 |
AU2005272078B2 (en) * | 2004-07-09 | 2011-04-14 | Viacyte, Inc. | Methods for identifying factors for differentiating definitive endoderm |
KR20070083559A (ko) | 2004-08-13 | 2007-08-24 | 더 유니버시티 오브 죠지아 리서치 파운데이션, 인코포레이티드 | 인간 배아 줄기세포에서의 자가재생 및 분화를 위한 조성물및 방법 |
EP1957636B1 (en) * | 2005-10-27 | 2018-07-04 | Viacyte, Inc. | Pdx1-expressing dorsal and ventral foregut endoderm |
DK2650360T3 (da) * | 2006-03-02 | 2019-10-07 | Viacyte Inc | Endokrine prekursorceller, pancreatiske hormon udtrykkende celler og fremgangsmåder til fremstilling |
EP3527658A1 (en) * | 2006-04-28 | 2019-08-21 | Lifescan, Inc. | Differentiation of human embryonic stem cells |
AU2008211103B2 (en) * | 2007-01-30 | 2014-05-08 | University Of Georgia Research Foundation, Inc. | Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (MMC) |
-
2008
- 2008-07-18 KR KR1020107003550A patent/KR101555824B1/ko active IP Right Grant
- 2008-07-18 EP EP12172814.1A patent/EP2562248B1/en active Active
- 2008-07-18 EP EP08796270.0A patent/EP2185695B1/en active Active
- 2008-07-18 CA CA2693156A patent/CA2693156C/en active Active
- 2008-07-18 WO PCT/US2008/070418 patent/WO2009012428A2/en active Application Filing
- 2008-07-18 CN CN200880107548A patent/CN101861386A/zh active Pending
- 2008-07-18 JP JP2010517176A patent/JP5738591B2/ja active Active
- 2008-07-18 CN CN201510368989.6A patent/CN105176919A/zh active Pending
- 2008-07-18 MX MX2010000746A patent/MX2010000746A/es active IP Right Grant
- 2008-07-18 PL PL08796270T patent/PL2185695T3/pl unknown
- 2008-07-18 RU RU2010105690/10A patent/RU2465323C2/ru active
- 2008-07-18 DK DK12172814.1T patent/DK2562248T3/da active
- 2008-07-18 EP EP21178371.7A patent/EP3957716A1/en active Pending
- 2008-07-18 BR BRPI0814425-7A2A patent/BRPI0814425A2/pt not_active IP Right Cessation
- 2008-07-18 ES ES08796270.0T patent/ES2537578T3/es active Active
- 2008-07-18 US US12/669,289 patent/US20100255580A1/en not_active Abandoned
-
2010
- 2010-02-17 ZA ZA2010/01158A patent/ZA201001158B/en unknown
- 2010-10-04 HK HK10109459.3A patent/HK1142926A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2010105690A (ru) | 2011-08-27 |
ZA201001158B (en) | 2011-04-28 |
EP2185695A2 (en) | 2010-05-19 |
KR101555824B1 (ko) | 2015-09-25 |
CA2693156C (en) | 2018-03-06 |
JP2010533500A (ja) | 2010-10-28 |
EP3957716A1 (en) | 2022-02-23 |
RU2465323C2 (ru) | 2012-10-27 |
EP2562248B1 (en) | 2021-06-09 |
ES2537578T3 (es) | 2015-06-09 |
CN101861386A (zh) | 2010-10-13 |
US20100255580A1 (en) | 2010-10-07 |
BRPI0814425A2 (pt) | 2014-10-21 |
EP2185695B1 (en) | 2015-02-25 |
WO2009012428A3 (en) | 2009-04-02 |
WO2009012428A2 (en) | 2009-01-22 |
MX2010000746A (es) | 2010-07-05 |
CA2693156A1 (en) | 2009-01-22 |
DK2562248T3 (da) | 2021-08-23 |
EP2562248A1 (en) | 2013-02-27 |
CN105176919A (zh) | 2015-12-23 |
KR20100042649A (ko) | 2010-04-26 |
JP5738591B2 (ja) | 2015-06-24 |
PL2185695T3 (pl) | 2015-08-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1142926A1 (en) | Differentiation of human embryonic stem cells | |
AU2016202260A1 (en) | Differentiation of human embryonic stem cells | |
GB2485112B (en) | Differentiation of human embryonic stem cells | |
ZA201205487B (en) | Differentiation of human embryonic stem cells | |
ZA201205488B (en) | Differentiation of human embryonic stem cells | |
ZA201201220B (en) | Differentiation of human embryonic stem cells | |
ZA201201219B (en) | Differentiation of human embryonic stem cells | |
GB2441718B (en) | Differentiation of human embryonic stem cells to cardiomyocyte-lineage cells | |
HK1216905A1 (zh) | 多能幹細胞的分化 | |
ZA201209383B (en) | Differentiation of human embryonic stem cells | |
SG10201506852VA (en) | Differentiation of human embryonic stem cells | |
GB2447191B (en) | Direct differentiation of cardiomyocytes from human embryonic stem cells | |
GB2458863B (en) | Improved culture of stem cells | |
BRPI0814894A2 (pt) | Diferenciação de células-tronco embrionárias de ser humano. | |
SG138570A1 (en) | Growth of embryonic stem cells | |
SG10201506855RA (en) | Differentiation of human embryonic stem cells | |
GB0622394D0 (en) | Differentiation of pluripotent cells | |
AU2007903225A0 (en) | Differentiation of human embryonic stem cells | |
GB0805670D0 (en) | Increasing the plasticity of stem cells |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20190723 |