US2554736A
(en)
|
|
1951-05-29 |
|
Tertiary aminoalkyl-iminodibenzyls |
US532248A
(en)
|
|
1895-01-08 |
|
powell |
US3282942A
(en)
|
|
1966-11-01 |
|
Substituted cycloalkanoindoles |
US2868818A
(en)
|
1953-12-15 |
1959-01-13 |
Merck & Co Inc |
Alpha methyl phenylalanines
|
US3046283A
(en)
|
1957-08-19 |
1962-07-24 |
Merck & Co Inc |
10-(omega-aminoalkylidene)-thioxanthenes
|
NL110232C
(he)
|
1958-12-06 |
|
|
|
US3409640A
(en)
|
1959-07-22 |
1968-11-05 |
Schering Corp |
5-(3'-dimethylamino-2'-methyl-propyl)dibenzocycloheptenes
|
NL256049A
(he)
|
1959-09-22 |
|
|
|
NL274885A
(he)
|
1960-09-16 |
|
|
|
US3454554A
(en)
|
1960-10-14 |
1969-07-08 |
Colgate Palmolive Co |
Aminoalkyliminodibenzyl compounds
|
FR1332145A
(he)
|
1961-06-08 |
1963-12-16 |
|
|
US3158648A
(en)
|
1962-04-09 |
1964-11-24 |
Merck & Co Inc |
Direct resolution of alpha-methyl-3, 4-dihydroxyphenylalanine
|
US3202660A
(en)
|
1961-10-09 |
1965-08-24 |
Boehringer Sohn Ingelheim |
Process for the preparation of 3-arylamino-1, 3-diazacycloalkenes
|
NL127069C
(he)
|
1961-10-10 |
|
|
|
CH426833A
(de)
|
1962-03-27 |
1966-12-31 |
Dumex Ltd As |
Verfahren zur Herstellung des N-Oxyds des N-(3-Dimethylamino-propyl)-iminodibenzyls oder seiner Salze
|
US3205264A
(en)
|
1962-06-15 |
1965-09-07 |
Merck & Co Inc |
Process for the preparation of 10, 11-dihydro-5-(gamma-methyl-and dimethyl-amino propylidene)-5h-dibenzo[a, d] cycloheptene
|
US3244748A
(en)
|
1962-07-03 |
1966-04-05 |
Merck & Co Inc |
5h-dibenzo [a, d] cycloheptenes
|
US3271451A
(en)
|
1962-07-03 |
1966-09-06 |
Merck & Co Inc |
Process for preparing 5-(3-methylaminopropyl)-5h-dibenzo [a, d] cycloheptenes
|
US3922305A
(en)
|
1962-08-09 |
1975-11-25 |
Merck & Co Inc |
Chemical compounds
|
NL130095C
(he)
|
1962-08-31 |
|
|
|
US3310553A
(en)
|
1962-09-25 |
1967-03-21 |
Pfizer & Co C |
Alkylated thioxathenesulfonamides
|
GB991651A
(en)
|
1963-02-20 |
1965-05-12 |
Dumex Ltd As |
Dibenzocycloheptadiene derivatives
|
US3389139A
(en)
|
1963-06-14 |
1968-06-18 |
Wander Ag Dr A |
6-homopiperazino and piperazinomorphanthridines
|
FR88751E
(he)
|
1963-07-09 |
1967-06-07 |
|
|
US3981917A
(en)
|
1963-07-25 |
1976-09-21 |
Merck & Co., Inc. |
Chemical compounds
|
US3978121A
(en)
|
1963-07-25 |
1976-08-31 |
Merck & Co., Inc. |
5H Dibenzo[a,d]cycloheptene derivatives
|
US3963778A
(en)
|
1965-11-10 |
1976-06-15 |
Bayer Aktiengesellschaft |
Basic oximes and their preparation
|
US3505321A
(en)
|
1965-11-24 |
1970-04-07 |
Bayer Ag |
Basically substituted oximes of 5h-dibenzo-(a,d)10,11-dihydro-cycloheptenylidene and their preparation
|
NL129434C
(he)
|
1966-03-12 |
|
|
|
GB1192812A
(en)
|
1966-05-20 |
1970-05-20 |
American Cyanamid Co |
2-Chloro-11-(1-Piperazinyl)Dibenz[b,f]-[1,4]Oxazepine, Non-Toxic Acid Addition Salts thereof, and Therapeutic Compositions containing said Oxazepine or Salts
|
FR1532301A
(fr)
|
1967-01-18 |
1968-07-12 |
Rhone Poulenc Sa |
Nouveaux dérivés de la dibenzazépine et leur préparation
|
US3539573A
(en)
|
1967-03-22 |
1970-11-10 |
Jean Schmutz |
11-basic substituted dibenzodiazepines and dibenzothiazepines
|
GB1177525A
(en)
|
1967-04-13 |
1970-01-14 |
Leo Ab |
New Heterocyclic Aminoketones of Therapeutic Interest
|
CH479559A
(de)
|
1967-09-26 |
1969-10-15 |
Wander Ag Dr A |
Verfahren zur Herstellung von Acylguanidinen
|
US3892777A
(en)
|
1968-05-01 |
1975-07-01 |
Hoffmann La Roche |
Substituted benzylethylenedicarbamates
|
US3758528A
(en)
|
1970-03-13 |
1973-09-11 |
Science Union & Cie |
Tricyclic compounds
|
US4017542A
(en)
|
1971-02-23 |
1977-04-12 |
Ciba-Geigy Corporation |
9-(2-Hydroxy-3-amino-propyl)-9,10-dihydro-9,10-ethano-anthracenes and salts thereof
|
US4045580A
(en)
|
1971-02-23 |
1977-08-30 |
Ciba-Geigy Corporation |
Pharmaceutical preparation using 9-(2-hydroxy-3-amino-propyl)-9,10-dihydro-9,10-ethano-anthracenes as antidepressants
|
US4250094A
(en)
|
1971-04-28 |
1981-02-10 |
The Upjohn Company |
1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
|
US4029792A
(en)
|
1972-02-29 |
1977-06-14 |
Pfizer Inc. |
(2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
|
BE795970A
(fr)
|
1972-02-29 |
1973-08-27 |
Pfizer |
Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
|
JPS5229318B2
(he)
|
1972-03-30 |
1977-08-01 |
|
|
CH570401A5
(he)
|
1972-05-09 |
1975-12-15 |
Wander Ag Dr A |
|
GB1422263A
(en)
|
1973-01-30 |
1976-01-21 |
Ferrosan As |
4-phenyl-piperidine compounds
|
US4020096A
(en)
|
1974-02-01 |
1977-04-26 |
Merck & Co., Inc. |
10,11,Dihydro-N-alkoxycarbonyl-10,10,11,11-tetrafluoro-5H-dibenzo[a,d]cycloheptene-5-methylamines
|
US4193926A
(en)
|
1974-03-20 |
1980-03-18 |
Schering Aktiengesellschaft |
4-(Polyalkoxy phenyl)-2-pyrrolidones
|
US4097483A
(en)
|
1974-11-01 |
1978-06-27 |
Kyorin Pharmaceutical Co., Ltd. |
Pyrazolo 1,5-a!pyridines
|
US4017621A
(en)
|
1974-12-09 |
1977-04-12 |
Sumitomo Chemical Company, Limited |
2-Morpholinyl tricyclic dibenzazepine compounds
|
US3956296A
(en)
|
1974-12-11 |
1976-05-11 |
A. H. Robins Company, Incorporated |
1-Substituted-4-benzylpiperidines
|
US4358620A
(en)
|
1974-12-13 |
1982-11-09 |
Sumitomo Chemical Company, Limited |
9-Formyl-9,10-dihydro-9,10-methanoanthracene
|
GB1508669A
(en)
|
1974-12-13 |
1978-04-26 |
Sumitomo Chemical Co |
Methanoanthracene derivative and a process for the preparation thereof
|
NL189199C
(nl)
|
1975-04-05 |
1993-02-01 |
Akzo Nv |
Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
|
US4048223A
(en)
|
1975-04-11 |
1977-09-13 |
Merck & Co., Inc. |
3-Dimethylsulfamoyl-5-[amino(alkyl or alkylidene)]-5H-dibenzo [a,d]cycloheptenes
|
US4014335A
(en)
|
1975-04-21 |
1977-03-29 |
Alza Corporation |
Ocular drug delivery device
|
JPS527972A
(en)
|
1975-07-07 |
1977-01-21 |
Sumitomo Chem Co Ltd |
Process for preparing novel morpholine derivatives
|
FR2319333A1
(fr)
|
1975-07-28 |
1977-02-25 |
Roussel Uclaf |
Nouveaux derives du 7-amino 6,7-dihydro/5h/ benzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments de ces produits
|
US4128641A
(en)
|
1975-07-31 |
1978-12-05 |
Hzi Research Center Inc. |
Tetracyclic psychotropic drug
|
GB1531278A
(en)
|
1975-12-15 |
1978-11-08 |
Shionogi & Co |
9,10-dihydro-9,10-methanoanthracene n-oxide derivatives and the production thereof
|
US4088647A
(en)
|
1976-02-04 |
1978-05-09 |
Glushkov Robert Georgievich |
Pyrazino (1,2,3-ab)-β-carboline derivatives and salts thereof and method of preparing same
|
NL7610942A
(nl)
|
1976-10-02 |
1978-04-04 |
Akzo Nv |
Werkwijze voor het bereiden van 1,4-diazepine derivaten.
|
US4256108A
(en)
|
1977-04-07 |
1981-03-17 |
Alza Corporation |
Microporous-semipermeable laminated osmotic system
|
US4160452A
(en)
|
1977-04-07 |
1979-07-10 |
Alza Corporation |
Osmotic system having laminated wall comprising semipermeable lamina and microporous lamina
|
IE46852B1
(en)
|
1977-06-10 |
1983-10-05 |
Otsuka Pharma Co Ltd |
Novel carbostyril derivatives
|
DE2727481A1
(de)
|
1977-06-18 |
1979-01-11 |
Basf Ag |
Dihydropyridazone und dihydropyridazone enthaltende therapeutische mittel
|
CA1114379A
(en)
|
1977-11-03 |
1981-12-15 |
Pfizer Corporation |
Piperidino-phthalazines
|
DE2907460A1
(de)
|
1978-03-07 |
1979-09-13 |
Sandoz Ag |
Neue resorbierbare galenische kompositionen
|
NL171194C
(nl)
|
1978-05-23 |
1983-02-16 |
Giesen Metaalgieterij |
Warmwater-ketel, bijvoorbeeld een centrale verwarmingsketel.
|
US4287175A
(en)
|
1978-06-22 |
1981-09-01 |
Merck & Co., Inc. |
Contact lens wetting agents
|
DE2837161A1
(de)
|
1978-08-25 |
1980-03-06 |
Thomae Gmbh Dr K |
Neue benzimidazole und deren verwendung
|
NL7809726A
(nl)
|
1978-09-26 |
1980-03-28 |
Akzo Nv |
Nieuwe tetracyclische verbindingen.
|
JPS6056143B2
(ja)
|
1979-08-02 |
1985-12-09 |
山之内製薬株式会社 |
アミジン誘導体ならびにその製造法
|
PH16099A
(en)
|
1979-03-06 |
1983-06-24 |
Yamanouchi Pharma Co Ltd |
Guanidinothiazole compounds,process for preparing them and medical composition containing them
|
US4285957A
(en)
|
1979-04-10 |
1981-08-25 |
Richardson-Merrell Inc. |
1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof
|
US4285958A
(en)
|
1979-04-10 |
1981-08-25 |
Richardson-Merrell Inc. |
1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
|
US4254130A
(en)
|
1979-04-10 |
1981-03-03 |
Richardson-Merrell Inc. |
Piperidine derivatives
|
US4254129A
(en)
|
1979-04-10 |
1981-03-03 |
Richardson-Merrell Inc. |
Piperidine derivatives
|
NZ193935A
(en)
|
1979-06-18 |
1985-05-31 |
Richardson Merrell Inc |
4-aroyl-imidazol-2-one derivatives;pharmaceutical compositions
|
NZ195564A
(en)
|
1979-11-26 |
1983-09-30 |
Sterling Drug Inc |
5-pyridinyl-2(1h)-pyridinones pharmaceutical compositions intermediate pyridine compounds
|
US4300557A
(en)
|
1980-01-07 |
1981-11-17 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Method for treating intraocular malignancies
|
US4512978A
(en)
*
|
1980-01-24 |
1985-04-23 |
Inwood Louis R |
Dermatological composition useful in the treatment of psoriasis
|
DE3009034A1
(de)
|
1980-03-08 |
1981-09-24 |
Basf Ag, 6700 Ludwigshafen |
10-substituierte 5-cyanmethylendibenzo (a,d) -cycloheptne
|
US4265874A
(en)
|
1980-04-25 |
1981-05-05 |
Alza Corporation |
Method of delivering drug with aid of effervescent activity generated in environment of use
|
US4394508A
(en)
|
1980-06-07 |
1983-07-19 |
Bristol-Myers Company |
Chemical compounds
|
US4316885A
(en)
|
1980-08-25 |
1982-02-23 |
Ayerst, Mckenna And Harrison, Inc. |
Acyl derivatives of rapamycin
|
EP0056782B1
(en)
|
1981-01-09 |
1984-08-01 |
Sandoz Ag |
Novel cyclosporins
|
US4513002A
(en)
|
1981-01-16 |
1985-04-23 |
Hoffmann-La Roche Inc. |
Cycloheptene derivatives
|
US4510309A
(en)
|
1981-03-03 |
1985-04-09 |
Bristol-Myers Company |
Histamine H2 -antagonists
|
US4877805A
(en)
|
1985-07-26 |
1989-10-31 |
Kligman Albert M |
Methods for treatment of sundamaged human skin with retinoids
|
JPS5851853A
(ja)
|
1981-09-18 |
1983-03-26 |
Kyowa Hakko Kogyo Co Ltd |
リン脂質混合物の処理法
|
PT75625B
(en)
|
1981-10-08 |
1985-12-09 |
Merck & Co Inc |
Process for preparing biosoluble ocular insert
|
US4517199A
(en)
|
1981-11-20 |
1985-05-14 |
Alcon Laboratories, Inc. |
Method for lowering intraocular pressure using phenylimino-imidazoles
|
US4486432A
(en)
|
1982-09-30 |
1984-12-04 |
Eli Lilly And Company |
Quinoxalinedione leukotriene release inhibitors
|
DE3241102A1
(de)
|
1982-11-06 |
1984-05-10 |
A. Nattermann & Cie GmbH, 5000 Köln |
Imidazolylalkylthienyl-tetrahydropyridazine und verfahren zu ihrer herstellung
|
FR2541680B1
(fr)
|
1983-02-24 |
1985-06-14 |
Rhone Poulenc Sante |
Nouveaux derives de l'amino-5 dithiole-1,2 one-3, leur preparation et les compositions medicinales qui les contiennent
|
JPS59167590A
(ja)
|
1983-03-14 |
1984-09-21 |
Kyorin Pharmaceut Co Ltd |
ピラゾロ〔1,5−a〕ピリジン誘導体、その製法及びそれを含有する治療剤
|
US4440933A
(en)
|
1983-03-16 |
1984-04-03 |
Bristol-Myers Company |
Process for preparing 1,2,5-thiadiazoles
|
US4569935A
(en)
*
|
1983-03-17 |
1986-02-11 |
University Of Tennessee Research Corp. |
Topical treatment of psoriasis with imidazole antibiotics
|
US5169637A
(en)
|
1983-03-24 |
1992-12-08 |
The Liposome Company, Inc. |
Stable plurilamellar vesicles
|
CA1237671A
(en)
|
1983-08-01 |
1988-06-07 |
Michael W. Fountain |
Enhancement of pharmaceutical activity
|
GB8321157D0
(en)
|
1983-08-05 |
1983-09-07 |
Fordonal Sa |
Piperidine derivatives
|
GB8400863D0
(en)
|
1984-01-13 |
1984-02-15 |
Smith Kline French Lab |
Chemical compounds
|
US4894366A
(en)
|
1984-12-03 |
1990-01-16 |
Fujisawa Pharmaceutical Company, Ltd. |
Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
|
US5639724A
(en)
|
1984-07-24 |
1997-06-17 |
Sandoz Ltd. |
Cyclosporin galenic forms
|
US4582822A
(en)
|
1984-10-09 |
1986-04-15 |
Eli Lilly And Company |
Antibiotic A80190, pharmaceutical compositions containing same and method of use
|
US5254562A
(en)
|
1984-12-03 |
1993-10-19 |
Fujisawa Pharmaceutical Company, Ltd. |
Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
|
GB8509276D0
(en)
|
1985-04-11 |
1985-05-15 |
Smith Kline French Lab |
Pyridine derivatives
|
US4824863A
(en)
|
1985-05-28 |
1989-04-25 |
Eli Lilly And Company |
Antibiotic A80438
|
US5409704A
(en)
|
1985-06-26 |
1995-04-25 |
The Liposome Company, Inc. |
Liposomes comprising aminoglycoside phosphates and methods of production and use
|
US4975282A
(en)
|
1985-06-26 |
1990-12-04 |
The Liposome Company, Inc. |
Multilamellar liposomes having improved trapping efficiencies
|
JPS625963A
(ja)
|
1985-07-02 |
1987-01-12 |
Mitsui Toatsu Chem Inc |
イソキノリン誘導体
|
US4655074A
(en)
|
1985-08-12 |
1987-04-07 |
The Babcock & Wilcox Company |
Self-zeroing pressure transmitter with automatic pressure manifold
|
FR2588189B1
(fr)
|
1985-10-03 |
1988-12-02 |
Merck Sharp & Dohme |
Composition pharmaceutique de type a transition de phase liquide-gel
|
PT83530B
(pt)
|
1985-10-17 |
1989-05-31 |
Smith Kline French Lab |
Processo de preparacao de derivados da piridona, em especial derivados fenilicos
|
US4650803A
(en)
|
1985-12-06 |
1987-03-17 |
University Of Kansas |
Prodrugs of rapamycin
|
US5023087A
(en)
|
1986-02-10 |
1991-06-11 |
Liposome Technology, Inc. |
Efficient method for preparation of prolonged release liposome-based drug delivery system
|
GB8607684D0
(en)
|
1986-03-27 |
1986-04-30 |
Ici America Inc |
Thiazepine compounds
|
US4742175A
(en)
|
1986-05-07 |
1988-05-03 |
Merrell Dow Pharmaceuticals Inc. |
Preparation of polymorphically pure terfenadine
|
IE60901B1
(en)
|
1986-08-21 |
1994-08-24 |
Vestar Inc |
Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
|
US5049388A
(en)
|
1986-11-06 |
1991-09-17 |
Research Development Foundation |
Small particle aerosol liposome and liposome-drug combinations for medical use
|
US4956388A
(en)
|
1986-12-22 |
1990-09-11 |
Eli Lilly And Company |
3-aryloxy-3-substituted propanamines
|
NZ222843A
(en)
|
1986-12-22 |
1989-10-27 |
Ortho Pharma Corp |
Benzoxazinyl- and benzothiazinyl-tetrahydropyridazinones and intermediates, and medicaments
|
US5272153A
(en)
|
1986-12-31 |
1993-12-21 |
Hoechst-Roussel Pharmaceuticals, Inc. |
Method of inhibiting the activity of leukocyte derived cytokines
|
US4965271A
(en)
|
1986-12-31 |
1990-10-23 |
Hoechst Roussel Pharmaceuticals, Inc. |
Method of inhibiting the activity of leukocyte derived cytokines
|
US5096906A
(en)
|
1986-12-31 |
1992-03-17 |
University Of Virginia Alumni Patents Foundation |
Method of inhibiting the activity of leukocyte derived cytokines
|
US5032582A
(en)
|
1987-02-27 |
1991-07-16 |
Liposome Technology, Inc. |
Method for treating fungal infections with amphotericin B/cholesterol sulfate composition
|
US4798823A
(en)
|
1987-06-03 |
1989-01-17 |
Merck & Co., Inc. |
New cyclosporin analogs with modified "C-9 amino acids"
|
JP2577049B2
(ja)
|
1987-06-04 |
1997-01-29 |
三共株式会社 |
シクロスポリン製剤
|
AU614965B2
(en)
|
1987-06-06 |
1991-09-19 |
Merck Patent Gesellschaft Mit Beschrankter Haftung |
Thiadiazinones
|
US4925849A
(en)
|
1987-06-15 |
1990-05-15 |
Fujisawa Pharmaceutical Company, Ltd. |
Pharmaceutically useful pyrazolopyridines
|
GB2206880B
(en)
|
1987-07-16 |
1991-04-24 |
Farmos Oy |
Optical isomers of an imidazole derivative
|
US5227467A
(en)
|
1987-08-03 |
1993-07-13 |
Merck & Co., Inc. |
Immunosuppressive fluorinated cyclosporin analogs
|
US4839342A
(en)
*
|
1987-09-03 |
1989-06-13 |
University Of Georgia Research Foundation, Inc. |
Method of increasing tear production by topical administration of cyclosporin
|
WO1989001772A1
(en)
*
|
1987-09-03 |
1989-03-09 |
University Of Georgia Research Foundation, Inc. |
Ocular cyclosporin composition
|
US4833138A
(en)
|
1987-10-23 |
1989-05-23 |
Washington University |
Phenothiazinealkaneamines for treatment of neurotoxic injury
|
EP0326307B1
(en)
|
1988-01-23 |
1994-08-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Novel pyridazinone derivatives and pharmaceutical preparations containing them
|
US5188826A
(en)
|
1988-02-08 |
1993-02-23 |
Insite Vision Incorporated |
Topical ophthalmic suspensions
|
JP2717687B2
(ja)
|
1988-02-13 |
1998-02-18 |
日本曹達株式会社 |
ピリダジノン誘導体及びその製造方法
|
US5238959A
(en)
|
1988-04-08 |
1993-08-24 |
Eli Lilly And Company |
3-phenyloxy-3-phenyl propanamines
|
US5314875A
(en)
|
1988-05-02 |
1994-05-24 |
Eli Lilly And Company |
Method for treating swine dysentery with the derivatives of the antibiotic A82810
|
US4994213A
(en)
|
1988-05-17 |
1991-02-19 |
Liposome Technology, Inc. |
Method of preparing lipid structures
|
GB2222770B
(en)
|
1988-09-16 |
1992-07-29 |
Sandoz Ltd |
Pharmaceutical compositions containing cyclosporins
|
US5342625A
(en)
|
1988-09-16 |
1994-08-30 |
Sandoz Ltd. |
Pharmaceutical compositions comprising cyclosporins
|
US6007840A
(en)
|
1988-09-16 |
1999-12-28 |
Novartis Ag |
Pharmaceutical compositions comprising cyclosporins
|
US4908372A
(en)
|
1988-10-13 |
1990-03-13 |
Merrell Dow Pharmaceuticals Inc. |
Antihistaminic piperidinyl benzimidazoles
|
GB8827820D0
(en)
|
1988-11-29 |
1988-12-29 |
Janssen Pharmaceutica Nv |
(1h-azol-1-ylmethyl)substituted quinoline derivatives
|
IL92351A
(he)
|
1988-11-29 |
1994-02-27 |
Allergan Inc Irvine |
תמיסות אופטימליות מימיות המכילות דותחמוצת כלור מיוצב ומלח אנאורגני
|
US5098443A
(en)
|
1989-03-23 |
1992-03-24 |
University Of Miami |
Method of implanting intraocular and intraorbital implantable devices for the controlled release of pharmacological agents
|
US5180721A
(en)
|
1989-05-22 |
1993-01-19 |
Allergan, Inc. |
Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
|
US5281591A
(en)
|
1989-05-22 |
1994-01-25 |
Allergan, Inc. |
Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
|
US5021410A
(en)
|
1989-05-22 |
1991-06-04 |
Allergan, Inc. |
Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
|
NZ234186A
(en)
|
1989-07-07 |
1991-10-25 |
Janssen Pharmaceutica Nv |
Imidazo quinazolin-one derivatives and pharmaceutical compositions
|
US5284826A
(en)
|
1989-07-24 |
1994-02-08 |
Sandoz Ltd. |
0-hydroxyethyl and acyloxyethyl derivatives of [ser]8 cyclosporins
|
US5194266A
(en)
|
1989-08-08 |
1993-03-16 |
Liposome Technology, Inc. |
Amphotericin B/cholesterol sulfate composition and method
|
US5231096A
(en)
|
1989-10-12 |
1993-07-27 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US5077292A
(en)
|
1989-10-12 |
1991-12-31 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
|
US5204347A
(en)
|
1989-10-12 |
1993-04-20 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines
|
US5198442A
(en)
|
1989-10-12 |
1993-03-30 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
|
US5112822A
(en)
|
1989-10-12 |
1992-05-12 |
Allergan, Inc. |
(2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
|
US5326763A
(en)
|
1989-10-12 |
1994-07-05 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US5356633A
(en)
|
1989-10-20 |
1994-10-18 |
Liposome Technology, Inc. |
Method of treatment of inflamed tissues
|
US5208228A
(en)
|
1989-11-13 |
1993-05-04 |
Merck & Co., Inc. |
Aminomacrolides and derivatives having immunosuppressive activity
|
US5215991A
(en)
|
1990-01-26 |
1993-06-01 |
Allergan, Inc. |
Combination of selective alpha-adrenergic agonists and Na+ /H+ ex
|
US5130441A
(en)
|
1990-02-06 |
1992-07-14 |
Allergan, Inc. |
Method for producing amino-2-imidazoline derivatives
|
US5237072A
(en)
|
1990-02-06 |
1993-08-17 |
Allergan, Inc. |
Method for producing amino-2-imidazoline derivatives
|
US5122511A
(en)
|
1990-02-27 |
1992-06-16 |
Merck & Co., Inc. |
Immunosuppressive cyclosporin analogs with modified amino acids at position-8
|
US4963561A
(en)
|
1990-02-28 |
1990-10-16 |
Sterling Drug Inc. |
Imidazopyridines, their preparation and use
|
US5252595A
(en)
|
1990-02-28 |
1993-10-12 |
Allergan, Inc. |
Method for reducing or maintaining intraocular pressure in the mammalian eye by administering pharmaceutical compositions containing 2-(2-alkylphenylamino)-oxazolines, 2-(2-alkylphenylamino)-thiazolines and 2-(2-alkylphenylamino)-imidazolines
|
US5124455A
(en)
|
1990-08-08 |
1992-06-23 |
American Home Products Corporation |
Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
|
US5091528A
(en)
|
1990-09-12 |
1992-02-25 |
Allergan, Inc. |
6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
|
PT98990A
(pt)
|
1990-09-19 |
1992-08-31 |
American Home Prod |
Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
|
US5143918A
(en)
|
1990-10-11 |
1992-09-01 |
Merck & Co., Inc. |
Halomacrolides and derivatives having immunosuppressive activity
|
DE4034218A1
(de)
|
1990-10-27 |
1992-04-30 |
Merck Patent Gmbh |
Verfahren zur herstellung von carebastin
|
US5141931A
(en)
|
1991-01-03 |
1992-08-25 |
Sterling Winthrop Inc. |
5-Quinolinylpyridinones, cardiotonic compositions and methods
|
US5378475A
(en)
|
1991-02-21 |
1995-01-03 |
University Of Kentucky Research Foundation |
Sustained release drug delivery devices
|
US5120842A
(en)
|
1991-04-01 |
1992-06-09 |
American Home Products Corporation |
Silyl ethers of rapamycin
|
US5100883A
(en)
|
1991-04-08 |
1992-03-31 |
American Home Products Corporation |
Fluorinated esters of rapamycin
|
US5118678A
(en)
|
1991-04-17 |
1992-06-02 |
American Home Products Corporation |
Carbamates of rapamycin
|
WO1992018104A1
(en)
|
1991-04-19 |
1992-10-29 |
Vestar, Inc. |
Pharmaceutical formulation and process
|
US5162334A
(en)
|
1991-05-13 |
1992-11-10 |
Merck & Co., Inc. |
Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
|
US5250678A
(en)
|
1991-05-13 |
1993-10-05 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
|
US5262533A
(en)
|
1991-05-13 |
1993-11-16 |
Merck & Co., Inc. |
Amino O-aryl macrolides having immunosuppressive activity
|
US5120727A
(en)
|
1991-05-29 |
1992-06-09 |
American Home Products Corporation |
Rapamycin dimers
|
US5120725A
(en)
|
1991-05-29 |
1992-06-09 |
American Home Products Corporation |
Bicyclic rapamycins
|
IL102236A0
(en)
|
1991-06-27 |
1993-01-14 |
Ltt Inst Co Ltd |
Topical preparations containing cyclosporin
|
US5202332A
(en)
|
1991-08-07 |
1993-04-13 |
American Home Products Corporation |
Rapamycin analog as immunosuppressant
|
US5169851A
(en)
|
1991-08-07 |
1992-12-08 |
American Home Products Corporation |
Rapamycin analog as immunosuppressants and antifungals
|
GB9216298D0
(en)
|
1991-08-15 |
1992-09-16 |
Ici Plc |
Piperidine derivatives
|
GB9216297D0
(en)
|
1991-08-15 |
1992-09-16 |
Ici Plc |
Therapeutic agents
|
US5512575A
(en)
|
1991-08-15 |
1996-04-30 |
Zeneca Limited |
Methanoanthraceneyl methyl piperidinyl compounds
|
US5189042A
(en)
|
1991-08-22 |
1993-02-23 |
Merck & Co. Inc. |
Fluoromacrolides having immunosuppressive activity
|
US5208241A
(en)
|
1991-09-09 |
1993-05-04 |
Merck & Co., Inc. |
N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
|
US5151413A
(en)
|
1991-11-06 |
1992-09-29 |
American Home Products Corporation |
Rapamycin acetals as immunosuppressant and antifungal agents
|
US5770592A
(en)
|
1991-11-22 |
1998-06-23 |
Alcon Laboratories, Inc. |
Prevention and treatment of ocular neovascularization using angiostatic steroids
|
US5278150A
(en)
|
1992-04-24 |
1994-01-11 |
Whitby Research, Inc. |
2-hydrazoadenosines and their utility for the treatmeat of vascular conditions
|
JP3631490B2
(ja)
*
|
1992-05-13 |
2005-03-23 |
ノバルティス ファーマ株式会社 |
シクロスポリン含有眼科用組成物
|
US5284840A
(en)
|
1992-06-12 |
1994-02-08 |
Merck & Co., Inc. |
Alkylidene macrolides having immunosuppressive activity
|
ES2284740T3
(es)
|
1992-08-03 |
2007-11-16 |
Sepracor Inc. |
Carboxilato de terfenadina y el tratamiento de la irritacion cutanea.
|
GR1002207B
(en)
|
1992-08-06 |
1996-03-27 |
Johnson & Johnson Consumer |
Skin care compositions containing imidazoles.
|
US5258389A
(en)
|
1992-11-09 |
1993-11-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives
|
US5552155A
(en)
|
1992-12-04 |
1996-09-03 |
The Liposome Company, Inc. |
Fusogenic lipsomes and methods for making and using same
|
MY113268A
(en)
|
1992-12-29 |
2002-01-31 |
Insite Vision Incorporated |
Plasticized bioerodible controlled delivery system
|
US5504091A
(en)
|
1993-04-23 |
1996-04-02 |
American Home Products Corporation |
Biotin esters of rapamycin
|
GB9301192D0
(en)
|
1993-06-09 |
1993-06-09 |
Trott Francis W |
Flower shaped mechanised table
|
HU226559B1
(en)
|
1993-06-24 |
2009-03-30 |
Amr Technology |
Process for the production of piperidine derivatives
|
US5965595A
(en)
|
1993-07-01 |
1999-10-12 |
The Procter & Gamble Company |
2-Imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
|
WO1995007267A1
(fr)
|
1993-09-10 |
1995-03-16 |
Eisai Co., Ltd. |
Compose de quinazoline
|
EP1285657A3
(en)
|
1993-10-13 |
2003-08-20 |
Allergan, Inc. |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US6323204B1
(en)
|
1993-10-13 |
2001-11-27 |
Allergan |
Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
|
US6022852A
(en)
|
1993-10-22 |
2000-02-08 |
Hexal Ag |
Pharmaceutical composition containing cyclosporin A
|
US5580892A
(en)
|
1993-10-22 |
1996-12-03 |
Allergan |
Method for using 2-(2-alkylphenylamino)-oxazolines as adrenergic agents
|
KR100327264B1
(ko)
|
1993-10-29 |
2002-07-02 |
요시히로 미와 |
인돌유도체,그의염및이를함유하는심질환치료제
|
US5574173A
(en)
|
1993-12-06 |
1996-11-12 |
Schering Corporation |
Tricyclic derivatives, compositions and methods of use
|
US5464840A
(en)
|
1993-12-06 |
1995-11-07 |
Schering Corporation |
Tricyclic derivatives, compositions and methods of use
|
US5578607A
(en)
|
1993-12-17 |
1996-11-26 |
The Procter & Gamble Company |
6-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
|
NZ333370A
(en)
|
1993-12-17 |
2001-03-30 |
Procter & Gamble |
6-(2-Imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
|
US5576437A
(en)
|
1993-12-17 |
1996-11-19 |
The Procter & Gamble Company |
7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
|
US6117871A
(en)
|
1993-12-17 |
2000-09-12 |
The Procter & Gamble Company |
6-(2-imidazolinylamino)quinoxaline compounds useful as alpha-2 adrenoceptor agonists
|
US5478858A
(en)
|
1993-12-17 |
1995-12-26 |
The Procter & Gamble Company |
5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
|
ATE194771T1
(de)
|
1993-12-17 |
2000-08-15 |
Procter & Gamble |
6-(2-imidazolinylamino) chinoxalin-verbindungen als alpha-2-adrenorezeptoragonisten
|
GB9401090D0
(en)
|
1994-01-21 |
1994-03-16 |
Glaxo Lab Sa |
Chemical compounds
|
GB9514465D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Chemical compounds
|
AU677513B2
(en)
|
1994-02-08 |
1997-04-24 |
Alcon Laboratories, Inc. |
Novel process for preparation of clonidine derivatives
|
CH687062A5
(de)
|
1994-02-14 |
1996-09-13 |
Cerbios Pharma Sa |
Konzentrierte Injektionsloesung von Alkalimetallsalzen von reduzierten Folaten.
|
US5422116A
(en)
|
1994-02-18 |
1995-06-06 |
Ciba-Geigy Corporation |
Liquid ophthalmic sustained release delivery system
|
US5773021A
(en)
|
1994-03-14 |
1998-06-30 |
Vetoquinol S.A. |
Bioadhesive ophthalmic insert
|
US5466233A
(en)
|
1994-04-25 |
1995-11-14 |
Escalon Ophthalmics, Inc. |
Tack for intraocular drug delivery and method for inserting and removing same
|
US5474979A
(en)
*
|
1994-05-17 |
1995-12-12 |
Allergan, Inc. |
Nonirritating emulsions for sensitive tissue
|
IL114193A
(en)
|
1994-06-20 |
2000-02-29 |
Teva Pharma |
Ophthalmic pharmaceutical compositions based on sodium alginate
|
US5877180A
(en)
|
1994-07-11 |
1999-03-02 |
University Of Virginia Patent Foundation |
Method for treating inflammatory diseases with A2a adenosine receptor agonists
|
EP0775134A4
(en)
|
1994-08-04 |
1997-08-13 |
Synaptic Pharma Corp |
NEW BENZIMIDAZOLE DERIVATIVES
|
ATE267174T1
(de)
|
1994-08-09 |
2004-06-15 |
Eisai Co Ltd |
Kondensierte pyridazinverbindungen
|
US5693648A
(en)
|
1994-09-30 |
1997-12-02 |
Merck & Co., Inc. |
O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
|
US5545504A
(en)
|
1994-10-03 |
1996-08-13 |
Xerox Corporation |
Ink jettable toner compositions and processes for making and using
|
US6294563B1
(en)
|
1994-10-27 |
2001-09-25 |
Allergan Sales, Inc. |
Combinations of prostaglandins and brimonidine or derivatives thereof
|
WO1996015117A1
(fr)
|
1994-11-11 |
1996-05-23 |
Nippon Soda Co., Ltd. |
Compose optiquement actif
|
GB9423910D0
(en)
|
1994-11-26 |
1995-01-11 |
Pfizer Ltd |
Therapeutic agents
|
US5725493A
(en)
|
1994-12-12 |
1998-03-10 |
Avery; Robert Logan |
Intravitreal medicine delivery
|
US5696133A
(en)
|
1994-12-22 |
1997-12-09 |
Ligand Pharmaceuticals Incorporated |
Steroid receptor modulator compounds and methods
|
WO1996026940A1
(fr)
|
1995-03-01 |
1996-09-06 |
Kyowa Hakko Kogyo Co., Ltd. |
Derives d'imidazoquinazoline
|
DE19518082A1
(de)
|
1995-05-17 |
1996-11-21 |
Merck Patent Gmbh |
4(-Arylaminomethylen)-2,4-dihydropyrazol-3-one
|
US6369116B1
(en)
*
|
1995-06-02 |
2002-04-09 |
Oculex Pharmaceuticals, Inc. |
Composition and method for treating glaucoma
|
US5914342A
(en)
|
1995-06-07 |
1999-06-22 |
The Procter & Gamble Company |
2-imidazolinylamino heterocyclic compounds useful as alpha-2 adrenoceptor agonists
|
AU5938996A
(en)
|
1995-06-07 |
1996-12-30 |
Nexstar Pharmaceuticals, Inc. |
Method for encapsulating pharmaceutical materials
|
US6194415B1
(en)
|
1995-06-28 |
2001-02-27 |
Allergan Sales, Inc. |
Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury
|
US5856329A
(en)
|
1995-06-28 |
1999-01-05 |
Allergan |
Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury
|
US5916900A
(en)
|
1995-06-29 |
1999-06-29 |
The Procter & Gamble Company |
7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
|
US5804587A
(en)
|
1995-06-29 |
1998-09-08 |
The Procter & Gamble Company |
6-(2-imidazolinylamino) quinolines useful as alpha-2 adrenoceptor agonists
|
GB9514464D0
(en)
|
1995-07-14 |
1995-09-13 |
Glaxo Lab Sa |
Medicaments
|
US5773019A
(en)
|
1995-09-27 |
1998-06-30 |
The University Of Kentucky Research Foundation |
Implantable controlled release device to deliver drugs directly to an internal portion of the body
|
DE19537012A1
(de)
|
1995-10-04 |
1997-04-10 |
Dietl Hans |
Cyclosporin(e) enhaltende pharmazeutische Zubereitung zur oralen Applikation und Verfahren zu ihrer Herstellung
|
US6153754A
(en)
|
1995-12-21 |
2000-11-28 |
Albany Molecular Research, Inc. |
Process for production of piperidine derivatives
|
US6201124B1
(en)
|
1995-12-21 |
2001-03-13 |
Albany Molecular Research, Inc. |
Process for production of piperidine derivatives
|
HUP9901478A3
(en)
|
1996-05-10 |
1999-11-29 |
Icos Corp Bothell |
Carboline derivatives, their use, production thereof and medicaments containing the same
|
US5709797A
(en)
|
1996-06-05 |
1998-01-20 |
Poli Industria Chimica S.P.A. |
Method of isolating cyclosporins
|
US5789416B1
(en)
|
1996-08-27 |
1999-10-05 |
Cv Therapeutics Inc |
N6 mono heterocyclic substituted adenosine derivatives
|
BR9712196A
(pt)
|
1996-10-04 |
1999-08-31 |
Novo Nordisk As |
Composto, uso do mesmo, processo para sua preparação e para tratar inflamação neurogênica, e, composições farmacêuticas para tratar inflamação neurogênica, para tratar neuropatia, para tratar artrite reumatóide, para reduzir glicose no sangue e/ou para inibir a atividade de cgrp, para tratar enxaqueca e para tratar coceira
|
DE19644228A1
(de)
|
1996-10-24 |
1998-04-30 |
Merck Patent Gmbh |
Thienopyrimidine
|
US6172095B1
(en)
|
1996-11-25 |
2001-01-09 |
The Procter & Gamble Company |
Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
|
TR199901885T2
(xx)
|
1996-11-25 |
1999-10-21 |
The Procter & Gamble Company |
Alfa-2 adrenosept�r agonistleri olarak yararl� 2-imidazolinilaminoindol bile�ikleri.
|
AU736992B2
(en)
|
1996-11-25 |
2001-08-09 |
Procter & Gamble Company, The |
2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists
|
US6306877B1
(en)
|
1999-08-09 |
2001-10-23 |
The Procter & Gamble Co. |
Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
|
JP2001506600A
(ja)
|
1996-11-25 |
2001-05-22 |
ザ プロクター アンド ギャンブル カンパニー |
α―2アドレナリン受容体作動薬として有用なグアニジニル複素環式化合物
|
US5888493A
(en)
|
1996-12-05 |
1999-03-30 |
Sawaya; Assad S. |
Ophthalmic aqueous gel formulation and related methods
|
US5837713A
(en)
*
|
1997-02-26 |
1998-11-17 |
Mayo Foundation For Medical Education And Research |
Treatment of eosinophil-associated pathologies by administration of topical anesthetics and glucocorticoids
|
US6495583B1
(en)
|
1997-03-25 |
2002-12-17 |
Synaptic Pharmaceutical Corporation |
Benzimidazole derivatives
|
NZ338075A
(en)
|
1997-04-25 |
2000-10-27 |
Pfizer Ltd |
Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP PED5) for the treatment of sexual dysfunction
|
US6342507B1
(en)
|
1997-09-05 |
2002-01-29 |
Isotechnika, Inc. |
Deuterated rapamycin compounds, method and uses thereof
|
NZ502362A
(en)
|
1997-10-08 |
2001-05-25 |
Isotechnika Inc |
Deuterated cyclosporine A derivatives and their use as immunomodulating agents
|
US6156753A
(en)
|
1997-10-28 |
2000-12-05 |
Vivus, Inc. |
Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
|
EP1027057A4
(en)
|
1997-10-28 |
2003-01-02 |
Vivus Inc |
TREATMENT OF FEMALE SEXUAL DISORDERS
|
KR20010032435A
(ko)
|
1997-11-24 |
2001-04-25 |
데이비드 엠 모이어 |
5-(2-이미다졸리닐아미노)벤즈이미다졸 유도체, 그의 제조및 대사 안정성이 개선된 알파-아드레날린수용체아고니스트로서의 그의 용도
|
US6066740A
(en)
|
1997-11-25 |
2000-05-23 |
The Procter & Gamble Company |
Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives
|
BR9813699A
(pt)
|
1997-12-16 |
2000-10-10 |
Pfizer Prod Inc |
Combinação eficaz para o tratamento da impotência
|
ZA9811898B
(en)
|
1997-12-29 |
2000-06-28 |
Ortho Mcneil Pharm Inc |
Anti-Inflammatory Compounds.
|
US5981607A
(en)
*
|
1998-01-20 |
1999-11-09 |
Allergan |
Emulsion eye drop for alleviation of dry eye related symptoms in dry eye patients and/or contact lens wearers
|
US6380207B2
(en)
|
1998-02-13 |
2002-04-30 |
Abbott Laboratories |
Glucocortiocoid-selective antiinflammatory agents
|
US6506766B1
(en)
|
1998-02-13 |
2003-01-14 |
Abbott Laboratories |
Glucocortiocoid-selective antinflammatory agents
|
WO1999042104A1
(en)
|
1998-02-23 |
1999-08-26 |
Fujisawa Pharmaceutical Co., Ltd. |
Use of macrolide compounds for treating glaucoma
|
TR200003130T2
(tr)
|
1998-04-28 |
2001-01-22 |
Arzneimittelwerk Dresden Gmbh |
Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
|
US6235781B1
(en)
|
1998-07-14 |
2001-05-22 |
Alcon Laboratories, Inc. |
Prostaglandin product
|
US20040152664A1
(en)
*
|
1998-09-02 |
2004-08-05 |
Allergan, Inc. |
Prednisolone compositions
|
WO2004073708A1
(en)
|
1998-12-17 |
2004-09-02 |
Dean Thomas R |
Brinzolamide and brimonidine for treating ocular conditions
|
WO2000039099A1
(fr)
|
1998-12-24 |
2000-07-06 |
Fujisawa Pharmaceutical Co., Ltd. |
Derives de benzimidazole
|
US6232297B1
(en)
|
1999-02-01 |
2001-05-15 |
University Of Virginia Patent Foundation |
Methods and compositions for treating inflammatory response
|
US6254860B1
(en)
*
|
1999-04-13 |
2001-07-03 |
Allergan Sales, Inc. |
Ocular treatment using cyclosporin-A derivatives
|
US6943166B1
(en)
|
1999-04-30 |
2005-09-13 |
Lilly Icos Llc. |
Compositions comprising phosphodiesterase inhabitors for the treatment of sexual disfunction
|
EA004886B1
(ru)
|
1999-04-30 |
2004-08-26 |
Пфайзер Продактс Инк. |
Модуляторы рецепторов глюкокортикоидов
|
US20010053780A1
(en)
|
1999-04-30 |
2001-12-20 |
Whitaker John S. |
Daily treatment for erectile dysfunction using a PDE5 inhibitor
|
ES2228512T3
(es)
|
1999-05-04 |
2005-04-16 |
Altana Pharma Ag |
Combinacion sinergica que comprende roflumilast y un inhibidor de pde-3.
|
AU4589800A
(en)
|
1999-05-05 |
2000-11-21 |
Darwin Discovery Limited |
9-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,9-dihydropurin-6-one derivatives as pde7inhibitors
|
IT1313583B1
(it)
|
1999-07-30 |
2002-09-09 |
Chiesi Farma Spa |
Derivati 2-amminotetralinici per la terapia del glaucoma.
|
US6593480B2
(en)
|
1999-09-01 |
2003-07-15 |
Abbott Laboratories |
Glucocorticoid receptor antagonists for treatment of diabetes
|
US6331313B1
(en)
*
|
1999-10-22 |
2001-12-18 |
Oculex Pharmaceticals, Inc. |
Controlled-release biocompatible ocular drug delivery implant devices and methods
|
US7323496B2
(en)
|
1999-11-08 |
2008-01-29 |
Theracos, Inc. |
Compounds for treatment of inflammation, diabetes and related disorders
|
ES2257336T3
(es)
|
1999-11-12 |
2006-08-01 |
MERCK & CO., INC. |
Derivados de diaril piperidil pirrol como agentes antiprotozoarios.
|
WO2001034632A2
(en)
|
1999-11-12 |
2001-05-17 |
Merck & Co., Inc. |
Aliphatic hydroxy substituted piperidyl diaryl pyrrole derivatives as antiprotozoal agents
|
TWI227143B
(en)
|
1999-12-15 |
2005-02-01 |
Guo-Jiun Sung |
In situ gel formation for ophthalmic delivery by combining Pluronic/Carbopol medic composition and its preparing method
|
US6258833B1
(en)
|
1999-12-23 |
2001-07-10 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
US6372777B1
(en)
|
1999-12-23 |
2002-04-16 |
Icos Corporation |
Cyclic AMP-specific phosphodiesterase inhibitors
|
DK1252157T3
(da)
|
2000-01-31 |
2004-10-25 |
Pfizer Prod Inc |
Pyrimidin-carboxamider anvendelige som inhibitorer af PDE4 isozymer
|
WO2001068600A2
(en)
|
2000-03-16 |
2001-09-20 |
Inflazyme Pharmaceuticals Limited |
Benzylated pde4 inhibitors
|
GB0008694D0
(en)
|
2000-04-07 |
2000-05-31 |
Novartis Ag |
Organic compounds
|
US7019136B2
(en)
|
2000-04-07 |
2006-03-28 |
Novartis, Ag |
8-quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors
|
TR200302105T4
(tr)
*
|
2000-04-07 |
2004-02-23 |
Laboratoire Medidom S. A. |
Siklosporin, hiyalüronik asit ve polisorbat içeren göz formülasyonları.
|
US6919337B2
(en)
|
2000-04-07 |
2005-07-19 |
Novartis, Ag |
8-Quinolinxanthine and 8-isoquinolinxanthine derivatives as PDE 5 inhibitors
|
EA005824B1
(ru)
|
2000-06-05 |
2005-06-30 |
Алтана Фарма Аг |
СОЕДИНЕНИЯ, ЭФФЕКТИВНЫЕ В КАЧЕСТВЕ АГОНИСТОВ β-2-АДРЕНОРЕЦЕПТОРА И ИНГИБИТОРОВ ФОСФОДИЭСТЕРАЗЫ PDE4
|
IL151530A0
(en)
|
2000-07-14 |
2003-04-10 |
Allergan Sales Inc |
Compositions containing alpha-2-adrenergic agonist components
|
JP2004503593A
(ja)
|
2000-07-14 |
2004-02-05 |
アラーガン、インコーポレイテッド |
増大した溶解度を持つ治療活性成分を含む組成物
|
BR0113167A
(pt)
|
2000-08-11 |
2003-06-24 |
Ono Pharmaceutical Co |
Derivados de piperidina e agente que compreende o derivado como ingrediente ativo
|
PT1313415E
(pt)
|
2000-08-30 |
2008-11-25 |
Univ Johns Hopkins |
Dispositivos para entrega intra-ocular de fármacos
|
US6579519B2
(en)
|
2000-09-18 |
2003-06-17 |
Registrar, University Of Delhi |
Sustained release and long residing ophthalmic formulation and the process of preparing the same
|
US6545057B2
(en)
|
2000-09-26 |
2003-04-08 |
The Brigham And Women's Hospital Inc. |
Tricyclic antidepressants and their analogues as long-acting local anesthetics and analgesics
|
TWI262920B
(en)
|
2000-10-27 |
2006-10-01 |
Elbion Ag |
New 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
|
IL146057A
(he)
|
2000-10-27 |
2007-09-20 |
Pfizer Prod Inc |
תהליך להכנת מודולטורים של רצפטור לא–סטרואידלי של גלוקוקורטיקואיד
|
ES2262612T3
(es)
|
2000-10-28 |
2006-12-01 |
Pfizer Products Inc. |
Moduladpres del receptor de glucocorticoides.
|
ES2271080T3
(es)
|
2000-11-06 |
2007-04-16 |
Lilly Icos Llc |
Derivados de indol como inhibidores de pde5.
|
US6960587B2
(en)
|
2000-11-08 |
2005-11-01 |
Lilly Icos Llc |
Condensed pyrazindione derivatives as PDE inhibitors
|
PL362980A1
(en)
|
2000-11-17 |
2004-11-02 |
Warner-Lambert Company Llc |
Treatment of sexual dysfunction
|
PL364910A1
(en)
|
2001-01-31 |
2004-12-27 |
Pfizer Products Inc. |
Ether derivatives useful as inhibitors of pde4 isozymes
|
US7250518B2
(en)
|
2001-01-31 |
2007-07-31 |
Pfizer Inc. |
Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
|
EE200300362A
(et)
|
2001-01-31 |
2003-12-15 |
Pfizer Products Inc. |
PDE4 isosüümide inhibiitoritena kasutatavad tiasolüül-, oksasolüül-, pürrolüül- ja imidasolüülhappeamiidi derivaadid
|
IL156413A0
(en)
|
2001-01-31 |
2004-01-04 |
Pfizer Prod Inc |
Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
|
US6583180B2
(en)
|
2001-02-14 |
2003-06-24 |
Abbott Laboratories |
Glucocorticoid receptor modulators
|
EE05386B1
(et)
|
2001-02-15 |
2011-02-15 |
ALTANA�Pharma�AG |
Ftalasinoon-piperidinoderivaadid,ÁnendeÁkasutamineÁjaÁravim
|
US6617357B2
(en)
|
2001-03-06 |
2003-09-09 |
Smithkline Beecham Corporation |
Compounds and their use as PDE inhibitors
|
US6713081B2
(en)
|
2001-03-15 |
2004-03-30 |
The United States Of America As Represented By The Department Of Health And Human Services |
Ocular therapeutic agent delivery devices and methods for making and using such devices
|
AP1699A
(en)
|
2001-03-21 |
2006-12-26 |
Warner Lambert Co |
New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
|
US6958328B2
(en)
|
2001-04-18 |
2005-10-25 |
Ortho-Mcneil Pharmaceutical, Inc |
Arylindenopyridines and related therapeutic and prophylactic methods
|
JP4510384B2
(ja)
|
2001-05-23 |
2010-07-21 |
田辺三菱製薬株式会社 |
骨折治癒促進用組成物
|
JP4510383B2
(ja)
|
2001-05-23 |
2010-07-21 |
田辺三菱製薬株式会社 |
軟骨疾患修復治療用組成物
|
JP2004536816A
(ja)
|
2001-06-05 |
2004-12-09 |
リリー アイコス リミテッド ライアビリティ カンパニー |
Pde5阻害剤としてのカルボリン誘導体
|
EP1396487B1
(en)
|
2001-06-15 |
2008-12-10 |
Astellas Pharma Inc. |
Phenylpyridine carbonyl piperazine derivative
|
PE20030008A1
(es)
|
2001-06-19 |
2003-01-22 |
Bristol Myers Squibb Co |
Inhibidores duales de pde 7 y pde 4
|
CA2450934A1
(en)
|
2001-06-19 |
2002-12-27 |
Marco Dodier |
Pyrimidine inhibitors of phosphodiesterase (pde) 7
|
GB0115181D0
(en)
*
|
2001-06-20 |
2001-08-15 |
Glaxo Group Ltd |
Novel use
|
ATE335742T1
(de)
|
2001-06-21 |
2006-09-15 |
Lilly Icos Llc |
Carbolinderivate als pdev inhibitoren
|
ATE296630T1
(de)
|
2001-06-27 |
2005-06-15 |
Merck Frosst Canada Inc |
Substituierte 8-arylchinoline als pde4-hemmer
|
US6872705B2
(en)
|
2001-07-13 |
2005-03-29 |
Allergan, Inc. |
Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions
|
JP2004536614A
(ja)
|
2001-08-01 |
2004-12-09 |
ユニバーシティ オブ ユタ |
Pde3環状ヌクレオチド・ホスホジエステラーゼのアイソフォーム選択的な阻害剤および活性化剤
|
DE10141212A1
(de)
|
2001-08-22 |
2003-03-06 |
Bayer Ag |
Neue 4-Aminofuropyrimidine und ihre Verwendung
|
US20030176316A1
(en)
|
2001-08-24 |
2003-09-18 |
Whitehead Clark M. |
Methods for treatment of rheumatoid arthritis
|
US6582422B2
(en)
|
2001-10-03 |
2003-06-24 |
Bausch & Lomb Incorporated |
Ophthalmic delivery device
|
US6809077B2
(en)
*
|
2001-10-12 |
2004-10-26 |
Enanta Pharmaceuticals, Inc. |
Cyclosporin analogs for the treatment of autoimmune diseases
|
EP1304321A3
(en)
|
2001-10-17 |
2003-07-30 |
Samsung Electronics Co., Ltd. |
Process for preparing 3-Hydroxyesters from epoxide derivatives
|
MXPA04003668A
(es)
*
|
2001-10-31 |
2004-07-22 |
Merck Patent Gmbh |
Inhibidores de fosfodiesteresa de tipo 4 y usos de los mismos.
|
FR2832711B1
(fr)
|
2001-11-26 |
2004-01-30 |
Warner Lambert Co |
Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
|
EP1467730A4
(en)
|
2002-01-22 |
2010-03-10 |
Univ California |
Non-steroid ligands for the glucocorticoid receptor, compositions and uses thereof
|
AU2003205926A1
(en)
|
2002-02-07 |
2003-09-02 |
Pfizer Limited |
Use of pde5 inhibitors such as sildenafil in the treatment of polycystic ovary syndrome
|
NZ534197A
(en)
|
2002-02-11 |
2007-01-26 |
Pfizer |
Nicotinamide derivatives useful as PDE4 inhibitors
|
AR038575A1
(es)
|
2002-02-22 |
2005-01-19 |
Pharmacia Corp |
Formulacion oftalmica con nueva composicion de goma
|
TWI347845B
(en)
*
|
2002-03-06 |
2011-09-01 |
Nycomed Gmbh |
Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
|
US6962940B2
(en)
|
2002-03-20 |
2005-11-08 |
Celgene Corporation |
(+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof
|
EP1348433A1
(en)
|
2002-03-28 |
2003-10-01 |
Warner-Lambert Company LLC |
Thiazol-2-yl-imine compounds as PDE-7 inhibitors
|
EP1348701A1
(en)
|
2002-03-28 |
2003-10-01 |
Warner-Lambert Company LLC |
(2,4-disubstituted-thiazol-5-yl) amine compounds as PDE7 inhibitors
|
US7084157B2
(en)
*
|
2002-05-17 |
2006-08-01 |
Rajeev Raut |
Ophthalmic pharmaceutical compositions and methods for treating ocular inflammation
|
DE60326585D1
(de)
|
2002-07-10 |
2009-04-23 |
Dynogen Pharmaceuticals Inc |
4-(2-fluorophenyl)-6-methyl-2(1-piperazinyl)thieno(2,3-d) pyrimidin bei der behandlung von funktionalen darmstörungen
|
JP4254263B2
(ja)
*
|
2002-08-22 |
2009-04-15 |
日産自動車株式会社 |
ガス流量測定装置及びガス流量測定方法
|
US20060019932A1
(en)
|
2002-09-06 |
2006-01-26 |
Mancini Joseph A |
Treatment of rheumatoid arthritis by inhibition of pde4
|
BR0314364A
(pt)
|
2002-09-16 |
2005-07-19 |
Alcon Mfg Ltd |
Uso de inibidores de pde iv para tratar angiogênese
|
AU2003294312A1
(en)
|
2002-11-18 |
2004-07-09 |
Celgene Corporation |
Methods of usig and compositions comprising (-)-3-(3,4-dimethoxy-phenyl)-3-(1-oxo-1,3-dihydro-isoindol-2-yl)-propionamide
|
US6909002B2
(en)
|
2002-11-22 |
2005-06-21 |
Merck & Co., Inc. |
Method of preparing inhibitors of phosphodiesterase-4
|
US20040151754A1
(en)
*
|
2002-12-20 |
2004-08-05 |
Control Delivery Systems, Inc. |
Steroid suspensions for intraocular use
|
WO2004069267A1
(en)
|
2003-02-10 |
2004-08-19 |
Novartis Ag |
Pharmaceutical combinations comprising corticoids and immunosuppressants for treating corticoid- and/or calcineurin inhibitors-resistant diseases
|
WO2004080414A2
(en)
*
|
2003-03-12 |
2004-09-23 |
Mullally John P |
Composition and method for treating inflammations by reducing c-reactive protein
|
US20040186046A1
(en)
|
2003-03-17 |
2004-09-23 |
Pfizer Inc |
Treatment of type 1 diabetes with PDE5 inhibitors
|
EP1613747A1
(en)
|
2003-03-31 |
2006-01-11 |
Pfizer Products Inc. |
Crystal structure of 3 ,5 -cyclic nucleotide phosphodiesterase 1b (pde1b) and uses thereof
|
EA200501548A1
(ru)
|
2003-04-01 |
2006-02-24 |
Апплайд Резеч Системз Арс Холдинг Н.В. |
Ингибиторы фосфодиэстераз при бесплодии
|
RU2379292C2
(ru)
|
2003-04-18 |
2010-01-20 |
Мемори Фармасьютиклз Корпорейшн |
Производные пиразола в качестве ингибиторов фосфодиэстеразы 4
|
DE10318610A1
(de)
|
2003-04-24 |
2004-11-11 |
Elbion Ag |
7-Azaindole und deren Verwendung als Therapeutika
|
DE10318611A1
(de)
|
2003-04-24 |
2004-11-11 |
Elbion Ag |
4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
|
SI1477166T1
(sl)
|
2003-04-28 |
2006-12-31 |
Biofrontera Bioscience Gmbh |
Uporaba riluzola, kombiniranega s primernimi pomoznimi in dodatnimi snovmi, za zdravljenje bolezni,za katere je znacilna hiperproliferacija keratinocitov, se zlasti nevrodermitisa in psoriaze
|
AU2004247023A1
(en)
|
2003-05-16 |
2004-12-23 |
Ambit Biosciences Corporation |
Heterocyclic compounds and uses thereof
|
US20050042177A1
(en)
|
2003-07-23 |
2005-02-24 |
Elan Pharma International Ltd. |
Novel compositions of sildenafil free base
|
US20050192261A1
(en)
*
|
2003-09-15 |
2005-09-01 |
Jost-Price Edward R. |
Methods and reagents for the treatment of immunoinflammatory disorders
|
US20050059583A1
(en)
*
|
2003-09-15 |
2005-03-17 |
Allergan, Inc. |
Methods of providing therapeutic effects using cyclosporin components
|
US20050112199A1
(en)
*
|
2003-09-24 |
2005-05-26 |
Mahesh Padval |
Therapeutic regimens for administering drug combinations
|
US7572799B2
(en)
|
2003-11-24 |
2009-08-11 |
Pfizer Inc |
Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
|
MY141255A
(en)
|
2003-12-11 |
2010-03-31 |
Memory Pharm Corp |
Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs
|
US20050256081A1
(en)
*
|
2004-02-26 |
2005-11-17 |
Peyman Gholam A |
Tetracycline derivatives for the treatment of ocular pathologies
|
US20060025463A1
(en)
|
2004-03-22 |
2006-02-02 |
Michael Bristow |
Enoximone sulfoxide enantiomers and their use in the treatment of PDE-III mediated diseases
|
CA2560538A1
(en)
|
2004-03-22 |
2005-10-06 |
Myogen, Inc. |
(r)-enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases
|
MXPA06011244A
(es)
*
|
2004-03-29 |
2007-04-13 |
Inotek Pharmaceuticals Corp |
Compuestos de porfirina sustituida por piridilo, y metodos de uso de los mismos.
|
US20050234018A1
(en)
|
2004-04-15 |
2005-10-20 |
Allergan, Inc. |
Drug delivery to the back of the eye
|
EP1746885A4
(en)
|
2004-05-03 |
2010-09-08 |
Univ Virginia |
ADENOSINE A2A RECEPTOR AGONISTS FOR THE TREATMENT OF DIABETIC NEPHROPATHY
|
US20050277584A1
(en)
*
|
2004-06-09 |
2005-12-15 |
Allergan, Inc. |
Pharmaceutical compositions comprising cyclosporins
|
EP1611879B1
(en)
*
|
2004-07-02 |
2009-08-12 |
Novagali Pharma SA |
Use of emulsions for intra- and periocular injection
|
MXPA06014699A
(es)
|
2004-07-05 |
2007-03-26 |
Astellas Pharma Inc |
Derivados de pirazolo-piridina.
|
EP1812113A1
(en)
|
2004-11-11 |
2007-08-01 |
Argenta Discovery Limited |
Pyrimidine compounds as histamine modulators
|
US20060122152A1
(en)
*
|
2004-12-03 |
2006-06-08 |
Peyman Gholam A |
Heparin for the treatment of ocular pathologies
|
WO2006073786A2
(en)
*
|
2004-12-30 |
2006-07-13 |
Bausch & Lomb Incorporated |
Ophthalmic compositions comprising steroid and cyclosporine for dry eye therapy
|
CN101355876B
(zh)
*
|
2005-11-09 |
2012-09-05 |
康宾纳特克斯公司 |
一种适用于眼部给药的组合物
|
EP2521721B1
(en)
|
2009-12-30 |
2014-10-01 |
Shanghai Fochon Pharmaceutical Co. Ltd |
3-(3-aminopiperidin-1-yl)-5-oxo-1,2,4-triazine derivates as dipeptidyl peptidase iv(dpp-iv) inhibitors
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