HK1126493A1 - Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase 1 11-- 1- - Google Patents

Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase 1 11-- 1-

Info

Publication number
HK1126493A1
HK1126493A1 HK09105407.7A HK09105407A HK1126493A1 HK 1126493 A1 HK1126493 A1 HK 1126493A1 HK 09105407 A HK09105407 A HK 09105407A HK 1126493 A1 HK1126493 A1 HK 1126493A1
Authority
HK
Hong Kong
Prior art keywords
cyclohexylpyrazole
inhibitors
beta
hydroxysteroid dehydrogenase
lactam derivatives
Prior art date
Application number
HK09105407.7A
Other languages
English (en)
Chinese (zh)
Inventor
Thomas Daniel Aicher
Peter Biagio Anzeveno
Renhua Li
Alexei Pavlovych Krasutsky
Thomas Edward Mabry
Ashraf Saeed
Nancy June Snyder
Gregory Alan Stephenson
Hongqi Tian
Owen Brendan Wallace
Leonard Larry Junior Winneroski
Yanping Xu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1126493A1 publication Critical patent/HK1126493A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK09105407.7A 2006-04-21 2009-06-17 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase 1 11-- 1- HK1126493A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21
PCT/US2007/066069 WO2007124254A2 (en) 2006-04-21 2007-04-05 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (1)

Publication Number Publication Date
HK1126493A1 true HK1126493A1 (en) 2009-09-04

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09105407.7A HK1126493A1 (en) 2006-04-21 2009-06-17 Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta- hydroxysteroid dehydrogenase 1 11-- 1-

Country Status (30)

Country Link
US (1) US7981918B2 (bg)
EP (1) EP2029579B1 (bg)
JP (1) JP5161869B2 (bg)
KR (1) KR101055576B1 (bg)
CN (1) CN101426783B (bg)
AR (1) AR060618A1 (bg)
AU (1) AU2007240550B2 (bg)
BR (1) BRPI0710229A2 (bg)
CA (1) CA2647677C (bg)
CO (1) CO6140026A2 (bg)
CR (1) CR10400A (bg)
DO (1) DOP2007000078A (bg)
EA (1) EA015675B1 (bg)
EC (1) ECSP088839A (bg)
ES (1) ES2533263T3 (bg)
HK (1) HK1126493A1 (bg)
IL (1) IL194835A (bg)
JO (1) JO3042B1 (bg)
MA (1) MA30476B1 (bg)
MX (1) MX2008013484A (bg)
MY (1) MY148128A (bg)
NO (1) NO20084403L (bg)
NZ (1) NZ571175A (bg)
PE (1) PE20080362A1 (bg)
SV (1) SV2008003070A (bg)
TN (1) TNSN08405A1 (bg)
TW (1) TWI347321B (bg)
UA (1) UA95798C2 (bg)
WO (1) WO2007124254A2 (bg)
ZA (1) ZA200808686B (bg)

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MX2008013328A (es) 2006-04-21 2008-10-27 Lilly Co Eli Derivados de lactamas de ciclohexilimidazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
WO2007124337A1 (en) * 2006-04-21 2007-11-01 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
PL2029529T3 (pl) 2006-04-24 2010-11-30 Lilly Co Eli PODSTAWIONE PIROLIDYNONY JAKO INHIBITORY DEHYDROGENAZY 11-ß-HYDROKSYSTEROIDOWEJ TYPU 1
AU2007244971B2 (en) 2006-04-24 2012-01-19 Eli Lilly And Company Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PL2021336T3 (pl) * 2006-04-24 2010-11-30 Lilly Co Eli Inhibitory dehydrogenazy 11-ß- hydroksysteroidowej typu 1
CA2648236C (en) 2006-04-25 2013-05-28 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
MX2008013656A (es) * 2006-04-25 2008-11-10 Lilly Co Eli Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa.
WO2007127763A2 (en) 2006-04-25 2007-11-08 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA014719B1 (ru) 2006-04-28 2011-02-28 Эли Лилли Энд Компани Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1
WO2008106128A2 (en) 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1
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AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
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EP2300461B1 (en) 2008-05-01 2013-04-17 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
RU2539979C2 (ru) 2008-07-25 2015-01-27 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
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WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
WO2010091067A2 (en) * 2009-02-04 2010-08-12 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
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UA109255C2 (ru) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Циклические ингибиторы 11бета-гидроксистероиддегидрогеназы 1
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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
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WO2012120052A1 (de) 2011-03-08 2012-09-13 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
TWI545113B (zh) * 2011-10-18 2016-08-11 安斯泰來製藥股份有限公司 二環式雜環化合物
TW201625605A (zh) * 2014-04-04 2016-07-16 賽諾菲公司 用於治療糖尿病、肥胖、血脂異常及相關病症之作為gpr119調節劑的經取代之稠合雜環類
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MX2008013328A (es) 2006-04-21 2008-10-27 Lilly Co Eli Derivados de lactamas de ciclohexilimidazol como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1.
PL2021336T3 (pl) * 2006-04-24 2010-11-30 Lilly Co Eli Inhibitory dehydrogenazy 11-ß- hydroksysteroidowej typu 1
AU2007244971B2 (en) 2006-04-24 2012-01-19 Eli Lilly And Company Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
PL2029529T3 (pl) * 2006-04-24 2010-11-30 Lilly Co Eli PODSTAWIONE PIROLIDYNONY JAKO INHIBITORY DEHYDROGENAZY 11-ß-HYDROKSYSTEROIDOWEJ TYPU 1
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CA2648236C (en) 2006-04-25 2013-05-28 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
WO2007127763A2 (en) 2006-04-25 2007-11-08 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA014719B1 (ru) 2006-04-28 2011-02-28 Эли Лилли Энд Компани Пиперидинилзамещённые пирролидиноны в качестве ингибиторов 11-бета-гидроксистероид дегидрогеназы 1
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Also Published As

Publication number Publication date
MA30476B1 (fr) 2009-06-01
CR10400A (es) 2009-01-14
TW200811141A (en) 2008-03-01
EA200870460A1 (ru) 2009-04-28
JP2009534398A (ja) 2009-09-24
PE20080362A1 (es) 2008-04-25
EA015675B1 (ru) 2011-10-31
EP2029579A2 (en) 2009-03-04
IL194835A (en) 2015-04-30
NO20084403L (no) 2008-11-14
JO3042B1 (ar) 2016-09-05
TNSN08405A1 (en) 2010-04-14
AU2007240550A1 (en) 2007-11-01
AR060618A1 (es) 2008-07-02
WO2007124254A2 (en) 2007-11-01
DOP2007000078A (es) 2007-11-15
BRPI0710229A2 (pt) 2011-08-02
US7981918B2 (en) 2011-07-19
ZA200808686B (en) 2009-12-30
MX2008013484A (es) 2008-10-30
UA95798C2 (ru) 2011-09-12
US20090111800A1 (en) 2009-04-30
AU2007240550B2 (en) 2012-02-23
KR101055576B1 (ko) 2011-08-08
MY148128A (en) 2013-02-28
IL194835A0 (en) 2009-08-03
SV2008003070A (es) 2010-01-18
TWI347321B (en) 2011-08-21
ES2533263T3 (es) 2015-04-08
EP2029579B1 (en) 2014-12-31
CA2647677A1 (en) 2007-11-01
CN101426783B (zh) 2013-10-30
CA2647677C (en) 2014-03-18
JP5161869B2 (ja) 2013-03-13
CN101426783A (zh) 2009-05-06
WO2007124254A3 (en) 2007-12-27
ECSP088839A (es) 2008-11-27
KR20080109867A (ko) 2008-12-17
CO6140026A2 (es) 2010-03-19
NZ571175A (en) 2011-10-28

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190405