HK1121403A1 - Molecules that are able to inhibit the binding between ngf and the trka receptor as analgesics with prolonged effect - Google Patents
Molecules that are able to inhibit the binding between ngf and the trka receptor as analgesics with prolonged effectInfo
- Publication number
- HK1121403A1 HK1121403A1 HK09101888.4A HK09101888A HK1121403A1 HK 1121403 A1 HK1121403 A1 HK 1121403A1 HK 09101888 A HK09101888 A HK 09101888A HK 1121403 A1 HK1121403 A1 HK 1121403A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ngf
- analgesics
- inhibit
- molecules
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000290A ITRM20050290A1 (it) | 2005-06-07 | 2005-06-07 | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
PCT/IT2006/000426 WO2006131951A2 (fr) | 2005-06-07 | 2006-06-07 | Molecules capables d'inhiber la liaison entre ngf et le recepteur trka en tant qu'analgesiques a effet prolonge |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1121403A1 true HK1121403A1 (en) | 2009-04-24 |
Family
ID=37056613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09101888.4A HK1121403A1 (en) | 2005-06-07 | 2009-02-27 | Molecules that are able to inhibit the binding between ngf and the trka receptor as analgesics with prolonged effect |
Country Status (15)
Country | Link |
---|---|
US (2) | US9688749B2 (fr) |
EP (3) | EP1890726B1 (fr) |
JP (5) | JP5730464B2 (fr) |
KR (1) | KR101486085B1 (fr) |
CN (1) | CN101277718B (fr) |
AU (1) | AU2006256387B2 (fr) |
CA (2) | CA2611433C (fr) |
DK (1) | DK1890726T3 (fr) |
HK (1) | HK1121403A1 (fr) |
IT (1) | ITRM20050290A1 (fr) |
MX (1) | MX2007015487A (fr) |
NO (1) | NO20080084L (fr) |
NZ (1) | NZ564071A (fr) |
RU (1) | RU2427387C2 (fr) |
WO (2) | WO2006131952A1 (fr) |
Families Citing this family (101)
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ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
CA2672902C (fr) * | 2006-12-21 | 2012-11-27 | Amgen Inc. | Formulations |
US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
RU2473564C2 (ru) | 2007-08-10 | 2013-01-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека с высокой аффинностью к фактору роста нервов человека |
JP5737944B2 (ja) | 2007-12-17 | 2015-06-17 | ファイザー・リミテッドPfizer Limited | 間質性膀胱炎の治療 |
EA021284B1 (ru) * | 2008-02-04 | 2015-05-29 | Лей Лайн Дженомикс С.П.А. | Антитела и их производные |
CA2722466A1 (fr) | 2008-04-29 | 2009-11-05 | Tariq Ghayur | Immunoglobulines a double domaine variable et utilisations |
UY31861A (es) | 2008-06-03 | 2010-01-05 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
EP2297209A4 (fr) | 2008-06-03 | 2012-08-01 | Abbott Lab | Immunoglobulines à deux domaines variables et leurs utilisations |
WO2009150623A1 (fr) | 2008-06-13 | 2009-12-17 | Pfizer Inc | Traitement de la prostatite chronique |
WO2010006060A2 (fr) | 2008-07-08 | 2010-01-14 | Abbott Laboratories | Immunoglobulines à double domaine variable de prostaglandine e2 et leurs utilisations |
EP2331090B1 (fr) | 2008-09-19 | 2018-01-03 | Pfizer Inc. | Composition, liquide et stable, à base d'anticorps |
PL2350075T3 (pl) | 2008-09-22 | 2014-07-31 | Array Biopharma Inc | Podstawione związki imidazo[1,2b]pirydazynowe jako inhibitory kinaz Trk |
BRPI0919873B8 (pt) | 2008-10-22 | 2021-05-25 | Array Biopharma Inc | compostos de pirazol[1,5-a]pirimidina substituídos como inibidores da trk quinase, seus processos de preparação e composições farmacêuticas |
WO2010077680A2 (fr) * | 2008-12-08 | 2010-07-08 | Vm Discovery Inc. | Compositions d'inhibiteurs de tyrosine kinase de récepteur protéique |
BRPI1008692B8 (pt) | 2009-02-17 | 2021-05-25 | Ucb Biopharma Sprl | anticorpo antagonista tendo especificidade para ox40 humano, sequência de dna isolado, vetor de clonagem ou de expressão, célula hospedeira, processo para a produção do referido anticorpo, composição farmacêutica, uso do 5 referido anticorpo e proteína de fusão |
US8435523B2 (en) * | 2009-05-04 | 2013-05-07 | Abbott Research B.V. | Antibodies against nerve growth factor (NGF) with enhanced in vivo stability |
WO2010146511A1 (fr) | 2009-06-17 | 2010-12-23 | Pfizer Limited | Traitement d'une vessie hyperactive |
AR077468A1 (es) | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa |
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UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
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US9783602B2 (en) | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
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HUE057288T2 (hu) | 2011-05-06 | 2022-04-28 | Zoetis Services Llc | Idegi növekedési faktor elleni ellenanyagok és eljárások elõállításukra és alkalmazásukra |
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US9855332B2 (en) | 2011-05-20 | 2018-01-02 | Alderbio Holdings Llc | Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels |
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TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
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TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
TW202410896A (zh) | 2017-10-10 | 2024-03-16 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
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TWI802635B (zh) | 2018-01-18 | 2023-05-21 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物 |
WO2019143991A1 (fr) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Composés de pyrazolo[3,4-d]pyrimidine substitués utilisés en tant qu'inhibiteurs de la kinase ret |
CA3087972C (fr) | 2018-01-18 | 2023-01-10 | Array Biopharma Inc. | Composes de pyrazolyl[4,3-c]pyridine substitues utilises en tant qu'inhibiteurs de la kinase ret |
AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
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-
2005
- 2005-06-07 IT IT000290A patent/ITRM20050290A1/it unknown
-
2006
- 2006-06-07 US US11/921,826 patent/US9688749B2/en not_active Expired - Fee Related
- 2006-06-07 US US11/921,398 patent/US8691221B2/en active Active
- 2006-06-07 EP EP06756318.9A patent/EP1890726B1/fr active Active
- 2006-06-07 JP JP2008515384A patent/JP5730464B2/ja not_active Expired - Fee Related
- 2006-06-07 WO PCT/IT2006/000427 patent/WO2006131952A1/fr active Application Filing
- 2006-06-07 MX MX2007015487A patent/MX2007015487A/es active IP Right Grant
- 2006-06-07 NZ NZ564071A patent/NZ564071A/en not_active IP Right Cessation
- 2006-06-07 CN CN2006800288760A patent/CN101277718B/zh not_active Expired - Fee Related
- 2006-06-07 AU AU2006256387A patent/AU2006256387B2/en not_active Ceased
- 2006-06-07 JP JP2008515383A patent/JP5133879B2/ja not_active Expired - Fee Related
- 2006-06-07 EP EP06756317A patent/EP1893234A2/fr not_active Withdrawn
- 2006-06-07 CA CA2611433A patent/CA2611433C/fr active Active
- 2006-06-07 DK DK06756318.9T patent/DK1890726T3/en active
- 2006-06-07 WO PCT/IT2006/000426 patent/WO2006131951A2/fr active Application Filing
- 2006-06-07 CA CA002610596A patent/CA2610596A1/fr not_active Abandoned
- 2006-06-07 RU RU2007147625/15A patent/RU2427387C2/ru not_active IP Right Cessation
- 2006-06-07 KR KR1020087000315A patent/KR101486085B1/ko not_active IP Right Cessation
- 2006-06-07 EP EP11188102A patent/EP2484380A1/fr not_active Withdrawn
-
2008
- 2008-01-07 NO NO20080084A patent/NO20080084L/no unknown
-
2009
- 2009-02-27 HK HK09101888.4A patent/HK1121403A1/xx not_active IP Right Cessation
-
2012
- 2012-05-07 JP JP2012106277A patent/JP2012158604A/ja not_active Withdrawn
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2013
- 2013-02-27 JP JP2013037304A patent/JP2013151509A/ja active Pending
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2014
- 2014-08-11 JP JP2014163809A patent/JP2014218513A/ja active Pending
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