HK1121054A1 - Molecular conjugate - Google Patents
Molecular conjugateInfo
- Publication number
- HK1121054A1 HK1121054A1 HK09100357.8A HK09100357A HK1121054A1 HK 1121054 A1 HK1121054 A1 HK 1121054A1 HK 09100357 A HK09100357 A HK 09100357A HK 1121054 A1 HK1121054 A1 HK 1121054A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- molecular conjugate
- conjugate
- molecular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/28—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6815—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03001—Alkaline phosphatase (3.1.3.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73979405P | 2005-11-23 | 2005-11-23 | |
PCT/US2006/045302 WO2007062177A2 (en) | 2005-11-23 | 2006-11-21 | Molecular conjugate |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1121054A1 true HK1121054A1 (en) | 2009-04-17 |
Family
ID=37793952
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK09100357.8A HK1121054A1 (en) | 2005-11-23 | 2009-01-14 | Molecular conjugate |
HK14111958.1A HK1198485A1 (en) | 2005-11-23 | 2014-11-27 | Molecular conjugate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14111958.1A HK1198485A1 (en) | 2005-11-23 | 2014-11-27 | Molecular conjugate |
Country Status (10)
Country | Link |
---|---|
US (4) | US20070117153A1 (xx) |
EP (3) | EP2963011B1 (xx) |
JP (1) | JP5199880B2 (xx) |
CN (2) | CN104090095B (xx) |
AU (1) | AU2006318438B2 (xx) |
CA (1) | CA2631005C (xx) |
DK (2) | DK2963011T3 (xx) |
ES (3) | ES2548518T3 (xx) |
HK (2) | HK1121054A1 (xx) |
WO (1) | WO2007062177A2 (xx) |
Families Citing this family (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060246524A1 (en) * | 2005-04-28 | 2006-11-02 | Christina Bauer | Nanoparticle conjugates |
ES2609919T3 (es) * | 2005-04-28 | 2017-04-25 | Ventana Medical Systems, Inc. | Enzimas conjugados con anticuerpos mediante un conector de PEG heterobifuncional |
ES2548518T3 (es) * | 2005-11-23 | 2015-10-19 | Ventana Medical Systems, Inc. | Conjugado molecular |
JP5380074B2 (ja) * | 2005-12-12 | 2014-01-08 | イノーバ・バイオサイエンシズ・リミテッド | 複合体の生成 |
CA2858359C (en) * | 2006-11-01 | 2018-04-03 | Ventana Medical Systems, Inc. | Haptens, hapten conjugates, compositions thereof and method for their preparation and use |
US7682789B2 (en) * | 2007-05-04 | 2010-03-23 | Ventana Medical Systems, Inc. | Method for quantifying biomolecules conjugated to a nanoparticle |
CA2687178C (en) | 2007-05-23 | 2014-02-04 | Ventana Medical Systems, Inc. | Polymeric carriers for immunohistochemistry and in situ hybridization |
EP3858347A3 (en) | 2007-08-17 | 2021-12-01 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
US8007998B2 (en) * | 2007-10-22 | 2011-08-30 | Pierce Biotechnology, Inc. | Polymerized conjugates for biological applications |
CA2720728C (en) | 2008-06-05 | 2018-04-03 | Ventana Medical Systems, Inc. | Compositions comprising nanomaterials and method for using such compositions for histochemical processes |
MX2011000861A (es) | 2008-07-23 | 2011-06-21 | Hanmi Holdings Co Ltd | Un complejo polipeptidico que consiste en un polimero no-peptidil que posee tres terminaciones funcionales. |
WO2010078376A2 (en) | 2008-12-30 | 2010-07-08 | Ventana Medical Systems, Inc. | Fc-specific polymer-conjugated antibodies and their diagnostic use |
AU2010339464B2 (en) | 2009-12-31 | 2014-10-09 | Ventana Medical Systems, Inc. | Methods for producing uniquely specific nucleic acid probes |
USPP22463P3 (en) * | 2010-02-16 | 2012-01-17 | Menachem Bornstein | Gypsophila plant named ‘Pearl Blossom’ |
US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
AU2011222501B2 (en) | 2010-03-04 | 2014-05-01 | Ventana Medical Systems, Inc. | Processing system for processing specimens using acoustic energy |
US10539487B2 (en) | 2010-03-04 | 2020-01-21 | Ventana Medical Systems, Inc. | Systems and methods for monitoring tissue sample processing |
US10126216B2 (en) | 2011-02-17 | 2018-11-13 | Ventana Medical Systems, Inc. | Method for tissue sample fixation |
DK2588144T3 (en) | 2010-07-02 | 2018-07-23 | Ventana Med Syst Inc | Detection of targets using mass markers and mass spectrometry |
JP2013531801A (ja) | 2010-07-02 | 2013-08-08 | ヴェンタナ メディカル システムズ, インク. | 標的検出のためのハプテンコンジュゲート |
DK2606055T3 (en) | 2010-08-16 | 2015-09-07 | Ventana Med Syst Inc | Chromogenic detection substrates and methods for use in detection assays and kits |
WO2012085064A1 (en) | 2010-12-23 | 2012-06-28 | Roche Diagnostics Gmbh | Detection of a posttranslationally modified polypeptide by a bi-valent binding agent |
JP6162044B2 (ja) | 2010-12-23 | 2017-07-12 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 結合剤 |
US9448231B2 (en) | 2011-02-28 | 2016-09-20 | Ventana Medical Systems, Inc. | Application of quantum dots for nuclear staining |
AU2012228424B2 (en) | 2011-03-14 | 2015-05-07 | Ventana Medical Systems, Inc. | A method of analyzing chromosomal translocations and a system therefore |
WO2013167387A1 (en) | 2012-05-10 | 2013-11-14 | Ventana Medical Systems, Inc. | Uniquely specific probes for pten, pik3ca, met, top2a, and mdm2 |
EP2872646B1 (en) | 2012-07-12 | 2017-08-30 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods for predicting the survival time and treatment responsiveness of a patient suffering from a solid cancer with a signature of at least 7 genes |
PT2880180T (pt) | 2012-08-06 | 2018-12-27 | Hopitaux Paris Assist Publique | Métodos e kits para o rastreio de doentes com um cancro |
WO2014048942A1 (en) | 2012-09-25 | 2014-04-03 | Ventana Medical Systems, Inc. | Probes for pten, pik3ca, met, and top2a, and method for using the probes |
MX2015006109A (es) | 2012-11-15 | 2016-02-05 | Endocyte Inc | Conjugados para el tratamiento de enfermedades causadas por celulas que expresan psma. |
AU2012395148B2 (en) | 2012-11-24 | 2016-10-27 | Hangzhou Dac Biotech Co., Ltd. | Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules |
CN103901187A (zh) * | 2012-12-25 | 2014-07-02 | 深圳先进技术研究院 | 纳米金靶向标记抗体复合物及其制备方法 |
CN103901191A (zh) * | 2012-12-25 | 2014-07-02 | 深圳先进技术研究院 | 纳米金靶向标记抗体的造影剂及其制备方法 |
EP2971064B1 (en) | 2013-03-12 | 2019-10-16 | Ventana Medical Systems, Inc. | Proximity assay for in situ detection of targets |
EP2999494B1 (en) * | 2013-05-20 | 2020-09-16 | Yale University | Anti-thrombogenic grafts |
WO2015001082A1 (en) | 2013-07-05 | 2015-01-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Novel alternative splice transcripts for mhc class i related chain alpha (mica) and uses thereof |
CN103439493A (zh) * | 2013-08-08 | 2013-12-11 | 南京大渊生物技术工程有限责任公司 | 适配子渗滤式生物芯片及制备方法 |
WO2015036405A1 (en) | 2013-09-10 | 2015-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating basal cell carcinoma |
RS65324B1 (sr) | 2013-10-18 | 2024-04-30 | Novartis Ag | Obeleženi inhibitori membranskog antigena specifičnog za prostatu (psma), njihova upotreba kao agenasa za snimanje i farmaceutskih agenasa za lečenje karcinoma prostate |
WO2015127685A1 (en) | 2014-02-28 | 2015-09-03 | Hangzhou Dac Biotech Co., Ltd | Charged linkers and their uses for conjugation |
JP6875129B2 (ja) | 2014-05-08 | 2021-05-19 | ノボダイアックス, インコーポレイテッド | 直接的な免疫組織化学アッセイ |
WO2016019166A1 (en) | 2014-07-30 | 2016-02-04 | Novilytic, LLC | Method for Analyzing Samples of Biological Fluid and Apparatus for Performing the Same |
EP3009147A1 (en) | 2014-10-16 | 2016-04-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating resistant glioblastoma |
WO2016083364A1 (en) | 2014-11-25 | 2016-06-02 | Ventana Medical Systems, Inc. | Proximity assays using chemical ligation and hapten transfer |
US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
JP6908531B2 (ja) | 2015-01-27 | 2021-07-28 | ベンタナ メディカル システムズ, インコーポレイテッド | アルデヒドに基づく固定溶液における長時間浸漬を用いる、組織試料固定法 |
WO2016146616A1 (en) | 2015-03-16 | 2016-09-22 | Ventana Medical Systems, Inc. | Control slides for immunohistochemistry generated from three-dimensional cell line cultures |
WO2017029391A1 (en) | 2015-08-20 | 2017-02-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating cancer |
JP6880001B2 (ja) | 2015-08-28 | 2021-06-02 | ヴェンタナ メディカル システムズ, インク. | ケージドハプテンを使用するホルマリン固定パラフィン包埋組織におけるタンパク質近接アッセイ |
WO2017055326A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of myeloid dendritic cells in a tissue sample |
WO2017055319A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of b cells in a tissue sample |
WO2017055327A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of endothelial cells in a tissue sample |
WO2017055325A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of nk cells in a tissue sample |
WO2017055324A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of cells of monocytic origin in a tissue sample |
WO2017055321A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of fibroblasts in a tissue sample |
WO2017055320A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample |
WO2017055322A1 (en) | 2015-09-29 | 2017-04-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of neutrophils in a tissue sample |
WO2017060397A1 (en) | 2015-10-09 | 2017-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of subjects suffering from melanoma metastases |
WO2017067944A1 (en) | 2015-10-19 | 2017-04-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of subjects suffering from triple negative breast cancer |
AU2017229370B2 (en) | 2016-03-08 | 2021-03-11 | Ventana Medical Systems, Inc. | Multiplexed immunohistochemistry using recombinant antibodies with epitope tags |
WO2017182834A1 (en) | 2016-04-19 | 2017-10-26 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method for treating resistant glioblastoma |
EP3463452A1 (en) | 2016-05-24 | 2019-04-10 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods and pharmaceutical compositions for the treatment of non small cell lung cancer (nsclc) that coexists with chronic obstructive pulmonary disease (copd) |
EP3475701B1 (en) | 2016-06-28 | 2023-02-22 | Ventana Medical Systems, Inc. | New colors for chromogenic ihc and ish staining with multi-dye quinone methide and tyramide conjugates |
EP3475291A1 (en) | 2016-06-28 | 2019-05-01 | Ventana Medical Systems, Inc. | Application of click chemistry for signal amplification in ihc and ish assays |
WO2018011107A1 (en) | 2016-07-11 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of er-alpha 46 in methods and kits for assessing the status of breast cancer |
WO2018011166A2 (en) | 2016-07-12 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for quantifying the population of myeloid dendritic cells in a tissue sample |
WO2018046736A1 (en) | 2016-09-12 | 2018-03-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from cancer |
WO2018055080A1 (en) | 2016-09-22 | 2018-03-29 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for reprograming immune environment in a subject in need thereof |
ES2873377T3 (es) | 2016-09-22 | 2021-11-03 | Inst Nat Sante Rech Med | Procedimientos y composiciones farmacéuticas para el tratamiento de cáncer de pulmón |
WO2018122245A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting the survival time of patients suffering from cms3 colorectal cancer |
WO2018122249A1 (en) | 2016-12-28 | 2018-07-05 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the survival time of patients suffering from a microsatellite stable colorectal cancer |
WO2018146239A1 (en) | 2017-02-10 | 2018-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Biomarker for outcome in aml patients |
WO2018162404A1 (en) | 2017-03-06 | 2018-09-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Biomarker for outcome in aml patients |
WO2018172540A1 (en) | 2017-03-24 | 2018-09-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method to predict the progression of alzheimer's disease |
WO2018189215A1 (en) | 2017-04-12 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the survival time of a patient suffering from hepatocellular carcinoma |
WO2019038219A1 (en) | 2017-08-21 | 2019-02-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | NEW PROGNOSTIC METHOD OF PANCREATIC CANCER |
WO2019043138A1 (en) | 2017-09-01 | 2019-03-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHOD FOR PREDICTING OUTCOME OF CANCER |
JP7038209B2 (ja) | 2017-11-13 | 2022-03-17 | エフ.ホフマン-ラ ロシュ アーゲー | エピタコ電気泳動を使用する試料分析のための装置 |
WO2019207030A1 (en) | 2018-04-26 | 2019-10-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting a response with an immune checkpoint inhibitor in a patient suffering from a lung cancer |
WO2020074742A1 (en) | 2018-10-12 | 2020-04-16 | F. Hoffmann-La Roche Ag | Detection methods for epitachophoresis workflow automation |
CN109205774A (zh) * | 2018-10-19 | 2019-01-15 | 佛山科学技术学院 | 一种基于a2o2创新工艺的mbr膜生物反应器 |
WO2020089428A1 (en) | 2018-11-02 | 2020-05-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New prognostic method of pancreatic cancer |
WO2020089432A1 (en) | 2018-11-02 | 2020-05-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New prognostic method of pancreatic cancer |
CA3125476A1 (en) | 2019-01-03 | 2020-07-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer |
JP2022522265A (ja) | 2019-01-16 | 2022-04-15 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | エリスロフェロンの変異体及びその使用 |
EP3924520A1 (en) | 2019-02-13 | 2021-12-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for selecting a cancer treatment in a subject suffering from cancer |
WO2020182932A1 (en) | 2019-03-13 | 2020-09-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New gene signatures for predicting survival time in patients suffering from renal cell carcinoma |
WO2020193740A1 (en) | 2019-03-28 | 2020-10-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy for treating pancreatic cancer |
JP2022527972A (ja) | 2019-04-02 | 2022-06-07 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 前悪性病変を有する患者において癌を予測及び予防する方法 |
US20220290237A1 (en) | 2019-04-24 | 2022-09-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the response of antipsychotic drugs |
WO2020229578A1 (en) | 2019-05-14 | 2020-11-19 | Ventana Medical Systems, Inc. | System including a biological sample treatment chamber |
US20220325268A1 (en) | 2019-05-14 | 2022-10-13 | Roche Sequencing Solutions, Inc | Devices and methods for sample analysis |
WO2020229521A1 (en) | 2019-05-14 | 2020-11-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for inhibiting or reducing bacterial biofilms on a surface |
US20220236276A1 (en) | 2019-06-03 | 2022-07-28 | Inserm (Institut National De La Santé Et De La Recherch Médicale | Methods for modulating a treatment regimen |
WO2021001539A1 (en) | 2019-07-04 | 2021-01-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy to detect and treat eosinophilic fasciitis |
US20220340975A1 (en) | 2019-09-05 | 2022-10-27 | INSERM (Institute National de la Santé et de la Recherche Médicale) | Method of treatment and pronostic of acute myeloid leukemia |
EP4045686A1 (en) | 2019-10-17 | 2022-08-24 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods for diagnosing nasal intestinal type adenocarcinomas |
US20230113705A1 (en) | 2020-02-28 | 2023-04-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, prognosing and managing treatment of breast cancer |
WO2021186014A1 (en) | 2020-03-20 | 2021-09-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting the survival time of a patient suffering from a cancer |
WO2021250106A1 (en) | 2020-06-10 | 2021-12-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating and prognosing cancer like glioblastoma |
WO2021255204A1 (en) | 2020-06-18 | 2021-12-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy for treating pancreatic cancer |
EP4172621A1 (en) | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
US20230266322A1 (en) | 2020-06-30 | 2023-08-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapy and radical surgery |
WO2022018163A1 (en) | 2020-07-22 | 2022-01-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for predicting survival time in patients suffering from cancer |
WO2022064049A1 (en) | 2020-09-28 | 2022-03-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for diagnosing brucella infection |
US20230383350A1 (en) | 2020-10-20 | 2023-11-30 | Institut National De La Sante Et De La Recherche Medicale | Method for predicting the response to tnf inhibitors |
JP2023548421A (ja) | 2020-11-06 | 2023-11-16 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | 多のう胞性卵巣症候群(pcos)を診断および処置するための方法 |
WO2022136252A1 (en) | 2020-12-21 | 2022-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for prognosis the humoral response of a subject prior to vaccination |
WO2022135753A1 (en) | 2020-12-21 | 2022-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for prognosis the humoral response of a subject prior to vaccination |
WO2022152698A1 (en) | 2021-01-12 | 2022-07-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of npdk-d to evaluate cancer prognosis |
EP4278181A1 (en) | 2021-01-15 | 2023-11-22 | Ventana Medical Systems, Inc. | Storage stable caged haptens |
EP4281779A1 (en) | 2021-01-25 | 2023-11-29 | Ventana Medical Systems, Inc. | Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties |
US20240044901A1 (en) | 2021-02-09 | 2024-02-08 | Institut National de la Santé et de la Recherche Médicale | New method to pronostic lung cancer |
US20240159760A1 (en) | 2021-03-17 | 2024-05-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for diagnosing pancreatic cancer |
WO2022207566A1 (en) | 2021-03-29 | 2022-10-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New method to evaluate pancreatic cancer prognosis |
WO2022223791A1 (en) | 2021-04-23 | 2022-10-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating cell senescence accumulation related disease |
WO2023280790A1 (en) | 2021-07-05 | 2023-01-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Gene signatures for predicting survival time in patients suffering from renal cell carcinoma |
WO2023089159A1 (en) | 2021-11-22 | 2023-05-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New strategy targeting stroma/tumor cell crosstalk to treat a cancer |
WO2023144303A1 (en) | 2022-01-31 | 2023-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cd38 as a biomarker and biotarget in t-cell lymphomas |
WO2024061930A1 (en) | 2022-09-22 | 2024-03-28 | Institut National de la Santé et de la Recherche Médicale | New method to treat and diagnose peripheral t-cell lymphoma (ptcl) |
Family Cites Families (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1564604A (en) | 1925-06-12 | 1925-12-08 | Chas S Hodges | Water wheel |
GB782420A (en) * | 1954-08-23 | 1957-09-04 | Ici Ltd | New hydrazides |
US3654090A (en) * | 1968-09-24 | 1972-04-04 | Organon | Method for the determination of antigens and antibodies |
NL154599B (nl) * | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US4002532A (en) * | 1974-10-21 | 1977-01-11 | Weltman Joel K | Enzyme conjugates |
IL47468A (en) * | 1975-06-12 | 1979-05-31 | Rehovot Res Prod | Process for the cross-linking of proteins using water soluble cross-linking agents |
US4016043A (en) * | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
JPS5344622A (en) * | 1976-09-30 | 1978-04-21 | Mochida Pharm Co Ltd | Immunologically measuring method |
DE2708018A1 (de) * | 1977-02-24 | 1978-09-07 | Boehringer Mannheim Gmbh | An polyamid fixiertes biologisch aktives protein und verfahren zu seiner herstellung |
SE427505B (sv) * | 1977-03-04 | 1983-04-11 | Pharmacia Diagnostics Ab | Reagens till anvendning vid immunkemiska bestemningsmetoder |
US4235960A (en) * | 1977-07-29 | 1980-11-25 | The Medical College Of Wisconsin, Inc. | Competitive enzyme-linked immunoassay |
US4218539A (en) * | 1978-03-24 | 1980-08-19 | Weltman Joel K | Enzyme conjugates and method of preparation and use |
US4433059A (en) * | 1981-09-08 | 1984-02-21 | Ortho Diagnostic Systems Inc. | Double antibody conjugate |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4454226A (en) * | 1982-03-17 | 1984-06-12 | Majid Ali | Enzymatic immunoassay |
IL71947A (en) * | 1984-05-29 | 1987-10-30 | Yeda Research And Dev Comp Ltd | Enzyme hydrazides and method for detection and determination of glycoconjugates |
US4657853A (en) * | 1984-09-14 | 1987-04-14 | E. I. Du Pont De Nemours And Company | Immunoassays utilizing covalent conjugates of polymerized enzyme and antibody |
US4732863A (en) | 1984-12-31 | 1988-03-22 | University Of New Mexico | PEG-modified antibody with reduced affinity for cell surface Fc receptors |
US5057313A (en) * | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
US4810638A (en) * | 1986-07-24 | 1989-03-07 | Miles Inc. | Enzyme-labeled antibody reagent with polyalkyleneglycol linking group |
WO1988007200A1 (en) * | 1987-03-19 | 1988-09-22 | Perry, Robert, Edward | Monoclonal antibody conjugation |
US5002883A (en) * | 1987-10-30 | 1991-03-26 | Abbott Laboratories | Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents |
US4994385A (en) * | 1987-10-30 | 1991-02-19 | Abbott Laboratories | Heterobifunctional coupling agents |
US6326136B1 (en) * | 1988-04-01 | 2001-12-04 | Digene Corporation | Macromolecular conjugate made using unsaturated aldehydes |
US5053520A (en) * | 1988-09-22 | 1991-10-01 | Abbott Laboratories | Heterobifunctional maleimido containing coupling agents |
US5063109A (en) * | 1988-10-11 | 1991-11-05 | Abbott Laboratories | Covalent attachment of antibodies and antigens to solid phases using extended length heterobifunctional coupling agents |
US5157123A (en) | 1989-03-13 | 1992-10-20 | Georgetown University | S-(2-thiopyridyl)-l-cysteine, a heterobifunctional crosslinking reagent |
AU657284B2 (en) | 1990-10-22 | 1995-03-09 | Abbott Laboratories | Homobifunctional agents for coupling enzymes and the like to antibodies and the like |
US5191066A (en) * | 1990-12-07 | 1993-03-02 | Abbott Laboratories | Site-specific conjugation of immunoglobulins and detectable labels |
JP3236667B2 (ja) | 1991-06-28 | 2001-12-10 | 三菱化学株式会社 | ヒト型モノクローナル抗体およびそれをコードする遺伝子、ハイブリドーマ並びに抗腫瘍剤 |
US5329028A (en) * | 1992-08-05 | 1994-07-12 | Genentech, Inc. | Carbohydrate-directed cross-linking reagents |
DK0656946T4 (da) * | 1992-08-21 | 2010-07-26 | Univ Bruxelles | Immunoglobuliner uden lette kæder |
US6005079A (en) * | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
US5648218A (en) * | 1993-02-12 | 1997-07-15 | Sealite Sciences, Inc. | Preparation of photoprotein conjugates and methods of use thereof |
US5736624A (en) * | 1994-12-02 | 1998-04-07 | Abbott Laboratories | Phosphatase activated crosslinking, conjugating and reducing agents; methods of using such agents; and reagents comprising phosphatase activated crosslinking and conjugating agents |
DE59607898D1 (de) * | 1995-12-29 | 2001-11-15 | Biotez Berlin Buch Gmbh Bioche | Verfahren zur markierung von biomolekülen mit meerrettichperoxidase |
DE19649390A1 (de) | 1996-11-29 | 1998-06-04 | Boehringer Mannheim Gmbh | Antigenspezifischer IgG-Nachweis |
KR19990029749A (ko) | 1997-09-17 | 1999-04-26 | 미우라 아끼라 | 2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체 |
US6218160B1 (en) * | 1997-10-31 | 2001-04-17 | Roche Diagnostics Corporation | Site-specific conjugation of glycoproteins |
DE19816550A1 (de) | 1997-12-24 | 1999-06-24 | Roche Diagnostics Gmbh | Universell verwendbarer Aufbau eines Analysenelements und dessen Einsatz zur Analytbestimmung |
JP3524401B2 (ja) * | 1998-09-16 | 2004-05-10 | 株式会社ニチレイ | 酵素抗体複合体およびその製造方法 |
DE69905832T2 (de) | 1998-09-18 | 2004-02-05 | Massachusetts Institute Of Technology, Cambridge | Biologische Verwendungen von halbleitenden Nanokristallen |
US6576746B2 (en) * | 1998-10-13 | 2003-06-10 | Immunomedics, Inc. | Site-specific labeling of disulfide-containing targeting vectors |
US20020102208A1 (en) * | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
US20050074499A1 (en) | 1999-03-17 | 2005-04-07 | Mitsubishi Chemical Corporation | Ligand-bonded complex |
AU3191100A (en) | 1999-03-17 | 2000-10-04 | Mitsubishi Chemical Corporation | Ligand-bonded complex |
CA2373146A1 (en) * | 1999-05-07 | 2000-11-16 | Quantum Dot Corporation | A method of detecting an analyte using semiconductor nanocrystals |
GB9919338D0 (en) | 1999-08-16 | 1999-10-20 | Celltech Therapeutics Ltd | Biological products |
JP3781934B2 (ja) * | 1999-12-22 | 2006-06-07 | 株式会社ニチレイバイオサイエンス | 酵素−タンパク質複合体 |
EP1118334A1 (en) * | 2000-01-11 | 2001-07-25 | Aventis Behring Gesellschaft mit beschränkter Haftung | Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases |
EP1118335A1 (en) * | 2000-01-11 | 2001-07-25 | Aventis Behring GmbH | Method for the production of conjugates for the treatment of allergic reactions and autoimmune diseases |
WO2001070685A2 (en) * | 2000-03-22 | 2001-09-27 | Solulink, Incorporated | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents |
US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
US20020083888A1 (en) * | 2000-12-28 | 2002-07-04 | Zehnder Donald A. | Flow synthesis of quantum dot nanocrystals |
US6670113B2 (en) | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
CA2453450A1 (en) * | 2001-07-20 | 2003-11-06 | Quantum Dot Corporation | Luminescent nanoparticles and methods for their preparation |
EP2279755B1 (en) * | 2001-10-10 | 2014-02-26 | ratiopharm GmbH | Remodelling and glycoconjugation of Fibroblast Growth Factor (FGF) |
US20030149246A1 (en) | 2002-02-01 | 2003-08-07 | Russell John C. | Macromolecular conjugates and processes for preparing the same |
JP2005539067A (ja) * | 2002-09-16 | 2005-12-22 | エリューシス セラピューティクス,インコーポレーテッド | ポリエチレングリコールリンカーを用いる二重特異性分子の産生 |
US7217845B2 (en) * | 2002-11-25 | 2007-05-15 | Sun Bio, Inc. | Bifunctional polyethylene glycol derivatives |
US7888536B2 (en) | 2004-02-13 | 2011-02-15 | Quanta Biodesign, Ltd. | Selective and specific preparation of discrete PEG compounds |
US20050176108A1 (en) | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
US7981667B2 (en) | 2003-05-07 | 2011-07-19 | Indiana University Research And Technology Corporation | Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto |
US7642064B2 (en) | 2003-06-24 | 2010-01-05 | Ventana Medical Systems, Inc. | Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest |
DK1636586T3 (da) | 2003-06-24 | 2009-11-23 | Ventana Med Syst Inc | Enzymkatalyseret metaldeponering til foröget in situ-detektion af immunhistokemisker epitoper og nucleinsyresekvenser |
KR100657891B1 (ko) * | 2003-07-19 | 2006-12-14 | 삼성전자주식회사 | 반도체 나노결정 및 그 제조방법 |
WO2005064018A2 (en) | 2003-12-22 | 2005-07-14 | Ventana Medical Systems, Inc. | Microwave mediated synthesis of nucleic acid probes |
US20050186642A1 (en) * | 2004-02-24 | 2005-08-25 | Biocare Medical, Inc. | Immunoassay reagents and methods of use thereof |
US7361516B2 (en) | 2004-09-24 | 2008-04-22 | The United States Of America As Represented By The Secretary Of The Navy | Field of modular multifunctional ligands |
US20060100976A1 (en) * | 2004-10-26 | 2006-05-11 | Ulead Systems, Inc. | Method for searching image files |
US20060246524A1 (en) * | 2005-04-28 | 2006-11-02 | Christina Bauer | Nanoparticle conjugates |
ES2609919T3 (es) * | 2005-04-28 | 2017-04-25 | Ventana Medical Systems, Inc. | Enzimas conjugados con anticuerpos mediante un conector de PEG heterobifuncional |
US20070122408A1 (en) | 2005-10-20 | 2007-05-31 | The Scripps Research Institute | Fc Labeling for Immunostaining and Immunotargeting |
ES2548518T3 (es) | 2005-11-23 | 2015-10-19 | Ventana Medical Systems, Inc. | Conjugado molecular |
-
2006
- 2006-11-21 ES ES06838327.2T patent/ES2548518T3/es active Active
- 2006-11-21 JP JP2008542455A patent/JP5199880B2/ja active Active
- 2006-11-21 DK DK15001958.6T patent/DK2963011T3/en active
- 2006-11-21 EP EP15001958.6A patent/EP2963011B1/en active Active
- 2006-11-21 DK DK06838327.2T patent/DK1951316T3/en active
- 2006-11-21 CN CN201410234039.XA patent/CN104090095B/zh active Active
- 2006-11-21 CA CA2631005A patent/CA2631005C/en active Active
- 2006-11-21 AU AU2006318438A patent/AU2006318438B2/en active Active
- 2006-11-21 EP EP16001225.8A patent/EP3095467B1/en active Active
- 2006-11-21 EP EP06838327.2A patent/EP1951316B1/en active Active
- 2006-11-21 ES ES15001958.6T patent/ES2677555T3/es active Active
- 2006-11-21 WO PCT/US2006/045302 patent/WO2007062177A2/en active Application Filing
- 2006-11-21 ES ES16001225T patent/ES2804129T3/es active Active
- 2006-11-21 CN CN200680043958.2A patent/CN101535244B/zh active Active
- 2006-11-21 US US11/603,425 patent/US20070117153A1/en not_active Abandoned
-
2009
- 2009-01-14 HK HK09100357.8A patent/HK1121054A1/xx unknown
-
2010
- 2010-01-14 US US12/687,564 patent/US8686122B2/en active Active
-
2014
- 2014-02-14 US US14/181,391 patent/US9310373B2/en active Active
- 2014-11-27 HK HK14111958.1A patent/HK1198485A1/xx unknown
-
2016
- 2016-02-24 US US15/052,768 patent/US20160195540A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN101535244B (zh) | 2014-07-23 |
US20140205995A1 (en) | 2014-07-24 |
EP2963011A1 (en) | 2016-01-06 |
AU2006318438B2 (en) | 2011-09-22 |
EP1951316B1 (en) | 2015-08-19 |
CN104090095A (zh) | 2014-10-08 |
EP1951316A2 (en) | 2008-08-06 |
EP3095467B1 (en) | 2020-05-06 |
JP5199880B2 (ja) | 2013-05-15 |
WO2007062177A3 (en) | 2009-05-28 |
WO2007062177A2 (en) | 2007-05-31 |
CN104090095B (zh) | 2016-06-01 |
DK1951316T3 (en) | 2015-08-31 |
US8686122B2 (en) | 2014-04-01 |
ES2804129T3 (es) | 2021-02-03 |
ES2548518T3 (es) | 2015-10-19 |
US20160195540A1 (en) | 2016-07-07 |
US20100136652A1 (en) | 2010-06-03 |
CN101535244A (zh) | 2009-09-16 |
EP2963011B1 (en) | 2018-05-09 |
DK2963011T3 (en) | 2018-08-06 |
ES2677555T3 (es) | 2018-08-03 |
HK1198485A1 (en) | 2015-05-08 |
JP2009521405A (ja) | 2009-06-04 |
CA2631005C (en) | 2017-02-28 |
US9310373B2 (en) | 2016-04-12 |
US20070117153A1 (en) | 2007-05-24 |
EP3095467A1 (en) | 2016-11-23 |
AU2006318438A1 (en) | 2007-05-31 |
CA2631005A1 (en) | 2007-05-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1198485A1 (en) | Molecular conjugate | |
PL1912671T3 (pl) | Koniugaty beta-glukuronid-linker-lek | |
IL191941A0 (en) | Conjugate vaccines | |
IL186521A0 (en) | Nanoparticle-active ingredient conjugates | |
IL185917A0 (en) | Immunogenic molecules | |
GB2440699B (en) | Combination dolly-pallet | |
IL176918A0 (en) | Ghrelin-carrier conjugates | |
GB0525970D0 (en) | Supramolecular polymers | |
GB0526186D0 (en) | Arylamine polymer | |
GB0619508D0 (en) | Molecular detector arrangement | |
EP1838317A4 (en) | ANALGESIC CONJUGATES | |
GB0523041D0 (en) | Combination | |
EP1715530A4 (en) | FUNCTIONAL MOLECULAR ELEMENT | |
GB2448098B (en) | Block copolymer | |
GB0423212D0 (en) | Polymer | |
GB0523040D0 (en) | Combination | |
EP2092343A4 (en) | DETECTION CONJUGATE | |
ZA200806230B (en) | Molecular Sieve SSZ-73 | |
TWI372053B (en) | Combination drug | |
GB0508636D0 (en) | Molecular sieves | |
GB0511841D0 (en) | Polymer formulations | |
GB0510207D0 (en) | Novel combination | |
ZA200805298B (en) | Conjugate vaccines | |
GB0524433D0 (en) | Contents-relating arrangements | |
GB0411526D0 (en) | Conjugate |