HK1120509A1 - 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofuran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors - Google Patents
3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofuran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitorsInfo
- Publication number
- HK1120509A1 HK1120509A1 HK08113800.5A HK08113800A HK1120509A1 HK 1120509 A1 HK1120509 A1 HK 1120509A1 HK 08113800 A HK08113800 A HK 08113800A HK 1120509 A1 HK1120509 A1 HK 1120509A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- alkyl
- synthesis
- renin inhibitors
- pyrrolidin
- intermediates
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title abstract 2
- 239000002461 renin inhibitor Substances 0.000 title abstract 2
- 229940086526 renin-inhibitors Drugs 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- HNJBEVLQSNELDL-YZRHJBSPSA-N pyrrolidin-2-one Chemical class O=C1CC[14CH2]N1 HNJBEVLQSNELDL-YZRHJBSPSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 238000000034 method Methods 0.000 abstract 4
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 abstract 2
- 229960004601 aliskiren Drugs 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 150000002894 organic compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002243 precursor Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0521083.6A GB0521083D0 (en) | 2005-10-17 | 2005-10-17 | Organic compounds |
| PCT/EP2006/009970 WO2007045420A2 (en) | 2005-10-17 | 2006-10-16 | 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofutran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1120509A1 true HK1120509A1 (en) | 2009-04-03 |
Family
ID=35451886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK08113800.5A HK1120509A1 (en) | 2005-10-17 | 2008-12-19 | 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofuran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7772405B2 (ru) |
| EP (1) | EP1948643B1 (ru) |
| JP (3) | JP5356031B2 (ru) |
| KR (1) | KR101294432B1 (ru) |
| CN (2) | CN103121995B (ru) |
| AR (1) | AR058089A1 (ru) |
| AU (1) | AU2006303489B2 (ru) |
| BR (1) | BRPI0617492A2 (ru) |
| CA (2) | CA2829487A1 (ru) |
| CY (1) | CY1114308T1 (ru) |
| DK (1) | DK1948643T3 (ru) |
| EC (1) | ECSP088368A (ru) |
| ES (1) | ES2427098T3 (ru) |
| GB (1) | GB0521083D0 (ru) |
| HK (1) | HK1120509A1 (ru) |
| HR (1) | HRP20130793T1 (ru) |
| IL (1) | IL190330A (ru) |
| JO (1) | JO2926B1 (ru) |
| MY (1) | MY145466A (ru) |
| NO (1) | NO342854B1 (ru) |
| NZ (1) | NZ567042A (ru) |
| PE (2) | PE20120581A1 (ru) |
| PL (1) | PL1948643T3 (ru) |
| PT (1) | PT1948643E (ru) |
| RU (1) | RU2432354C2 (ru) |
| SI (1) | SI1948643T1 (ru) |
| TN (1) | TNSN08170A1 (ru) |
| TW (1) | TWI395733B (ru) |
| WO (1) | WO2007045420A2 (ru) |
| ZA (1) | ZA200802632B (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
| DE102005052195A1 (de) * | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
| CN101679213A (zh) * | 2007-04-03 | 2010-03-24 | 诺瓦提斯公司 | 新方法 |
| RU2010101236A (ru) * | 2007-06-19 | 2011-07-27 | Новартис АГ (CH) | Органические соединения |
| DE102007049039A1 (de) * | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
| SI2189442T1 (sl) * | 2008-11-20 | 2015-03-31 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Postopek in intermediati za pripravo aliskirena |
| WO2011019789A1 (en) | 2009-08-11 | 2011-02-17 | Novartis Ag | The ring opening of lactones and lactams |
| WO2011051853A1 (en) * | 2009-10-29 | 2011-05-05 | CarboDesign LLC | Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren |
| US20110137047A1 (en) * | 2009-12-07 | 2011-06-09 | CarboDesign LLC | Process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren |
| CN101774986B (zh) * | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
| CN102241650B (zh) * | 2010-05-14 | 2014-05-07 | 浙江九洲药业股份有限公司 | 用于制备阿立克仑的中间体化合物及相关制备方法 |
| CN102485722B (zh) * | 2010-12-06 | 2014-05-07 | 博瑞生物医药技术(苏州)有限公司 | 阿利克仑、其中间体和药用盐及制备方法 |
| CN102775393B (zh) * | 2011-05-09 | 2014-08-27 | 上海现代制药股份有限公司 | 一种药物中间体的制备方法 |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| CN102746182B (zh) * | 2012-07-27 | 2014-09-03 | 浙江普洛医药科技有限公司 | 一种阿利克伦的制备方法 |
| CN103059012B (zh) * | 2013-01-30 | 2016-06-22 | 浙江海翔药业股份有限公司 | 1,8-二羰基-4,5-环氧化合物及其制备方法 |
| CN106220528B (zh) * | 2014-02-28 | 2018-05-08 | 华润双鹤药业股份有限公司 | 阿利吉仑的4-位差向异构体、其制备方法及用途 |
| CN105294612A (zh) * | 2014-06-05 | 2016-02-03 | 山东威智医药工业有限公司 | 阿利克仑中间体及其制备方法和应用 |
| US10087190B1 (en) * | 2017-04-24 | 2018-10-02 | Purdue Research Foundation | Lactones |
| CN114315749B (zh) * | 2021-12-13 | 2024-04-26 | 湖南华腾医药有限公司 | 一种连续流微反应器合成阿利克仑中间体的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5659065A (en) | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
| US5606078A (en) * | 1994-04-18 | 1997-02-25 | Ciba-Geigy Corporation | 3,5-Disubstituted tetrahydrofuran-2-ones |
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| EP1200390B1 (de) | 1999-07-29 | 2008-08-27 | Speedel Pharma AG | Herstellung von n-substituierten 2,7-dialkyl-4-hydroxy-5-amino-8-aryl-octanoylamiden |
| FR2801051B1 (fr) * | 1999-11-17 | 2001-12-14 | Adir | Nouveaux composes aminopyrroline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6310904B1 (en) | 2000-05-31 | 2001-10-30 | Honeywell International, Inc. | Measurement method to facilitate production of self-aligning laser gyroscope block |
| DE60123911T2 (de) | 2000-12-14 | 2007-05-31 | Speedel Pharma Ag | Verfahren zur Herstellung von Aryloctanoyl-amiden |
| KR100903228B1 (ko) * | 2001-09-07 | 2009-06-17 | 바스프 에스이 | 2-피롤리돈의 제조 방법 |
| GB0212410D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Organic compounds |
| EP1689702B1 (en) * | 2003-11-26 | 2013-01-30 | Novartis AG | Organic compounds |
| BRPI0417543A (pt) * | 2003-12-12 | 2007-03-27 | Wyeth Corp | quinolinas úteis no tratamento de doença cardiovascular |
| PT1717226E (pt) * | 2004-03-19 | 2009-04-03 | Novartis Ag | Derivados de 5-amino-4-hidroxi-8-(1h-indol-5-il)-octan amida 2,7-substituída como inibidores da renina para o tratamento da hipertensão |
| EP1582523A1 (en) * | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
| GB0419361D0 (en) * | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
| GB0511686D0 (en) | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
-
2005
- 2005-10-17 GB GBGB0521083.6A patent/GB0521083D0/en not_active Ceased
-
2006
- 2006-10-13 AR ARP060104497A patent/AR058089A1/es not_active Application Discontinuation
- 2006-10-15 JO JO2006369A patent/JO2926B1/en active
- 2006-10-16 CN CN201210566662.6A patent/CN103121995B/zh not_active Expired - Fee Related
- 2006-10-16 JP JP2008535948A patent/JP5356031B2/ja active Active
- 2006-10-16 CN CN2006800035979A patent/CN101111493B/zh not_active Expired - Fee Related
- 2006-10-16 EP EP06828821.6A patent/EP1948643B1/en active Active
- 2006-10-16 DK DK06828821.6T patent/DK1948643T3/da active
- 2006-10-16 BR BRPI0617492-2A patent/BRPI0617492A2/pt not_active Application Discontinuation
- 2006-10-16 PE PE2011001455A patent/PE20120581A1/es active IP Right Grant
- 2006-10-16 US US12/088,457 patent/US7772405B2/en active Active
- 2006-10-16 KR KR1020087009098A patent/KR101294432B1/ko active IP Right Grant
- 2006-10-16 ES ES06828821T patent/ES2427098T3/es active Active
- 2006-10-16 TW TW095138055A patent/TWI395733B/zh not_active IP Right Cessation
- 2006-10-16 NZ NZ567042A patent/NZ567042A/en not_active IP Right Cessation
- 2006-10-16 WO PCT/EP2006/009970 patent/WO2007045420A2/en active Application Filing
- 2006-10-16 CA CA2829487A patent/CA2829487A1/en not_active Abandoned
- 2006-10-16 RU RU2008119276/04A patent/RU2432354C2/ru not_active IP Right Cessation
- 2006-10-16 PE PE2006001252A patent/PE20070792A1/es active IP Right Grant
- 2006-10-16 AU AU2006303489A patent/AU2006303489B2/en not_active Ceased
- 2006-10-16 CA CA2625034A patent/CA2625034C/en not_active Expired - Fee Related
- 2006-10-16 PL PL06828821T patent/PL1948643T3/pl unknown
- 2006-10-16 SI SI200631641T patent/SI1948643T1/sl unknown
- 2006-10-16 PT PT68288216T patent/PT1948643E/pt unknown
-
2008
- 2008-03-20 IL IL190330A patent/IL190330A/en active IP Right Grant
- 2008-03-25 ZA ZA200802632A patent/ZA200802632B/xx unknown
- 2008-04-15 EC EC2008008368A patent/ECSP088368A/es unknown
- 2008-04-15 MY MYPI20081108A patent/MY145466A/en unknown
- 2008-04-16 TN TNP2008000170A patent/TNSN08170A1/en unknown
- 2008-05-16 NO NO20082263A patent/NO342854B1/no not_active IP Right Cessation
- 2008-12-19 HK HK08113800.5A patent/HK1120509A1/xx not_active IP Right Cessation
-
2010
- 2010-06-25 US US12/823,699 patent/US8198465B2/en active Active
-
2012
- 2012-09-26 JP JP2012213001A patent/JP5792139B2/ja active Active
-
2013
- 2013-08-22 HR HRP20130793TT patent/HRP20130793T1/hr unknown
- 2013-09-02 CY CY20131100754T patent/CY1114308T1/el unknown
-
2014
- 2014-05-21 JP JP2014105430A patent/JP2014196312A/ja not_active Withdrawn
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1120509A1 (en) | 3-alkyl-5- (4-alkyl-5-oxo-tetrahydrofuran-2-yl) pyrrolidin-2-one derivatives as intermediates in the synthesis of renin inhibitors | |
| TN2009000401A1 (en) | New methods | |
| WO2011015522A3 (en) | Process for the manufacture of pharmaceutically active compounds | |
| WO2007091009A3 (en) | Preparation of delmopinol | |
| TW200716544A (en) | Organic compounds | |
| TW200609215A (en) | Organic compounds | |
| WO2008155338A3 (en) | Process for the synthesis of intermediates of renin inhibitors such as aliskiren | |
| SG170794A1 (en) | Process for preparation of hiv protease inhibitors | |
| WO2009121033A3 (en) | Substituted nitrogen heterocycles and synthesis and uses thereof | |
| MY146084A (en) | Benzyl amines, a process for their production and their use as anti-inflammatory agents | |
| TNSN08142A1 (en) | Synthesis of renin inhibitors involving a cycloaddition reaction | |
| RS51144B (sr) | Postupak za izradu inhibitora triptaze | |
| WO2006136552A3 (en) | Process for the production of intermadiates for the preparation of tricyclic benzimidazoles | |
| WO2006122020A3 (en) | Process for production of 4-biphenylyazetidin-2-ones | |
| TW200624435A (en) | Process for preparing iridium(Ⅲ) ketoketonates | |
| WO2007044490A3 (en) | Process for making heteroaryl amine intermediate compounds | |
| WO2010122580A3 (en) | Piperidine derivatives as inhibitors of renin | |
| UA100843C2 (ru) | Полиморфные формы сульфатов зипразидона | |
| TH89325B (th) | สารประกอบอินทรีย์ | |
| WO2006133322A3 (en) | Synthesis of 3-amino-4-substituted pyrazole derivatives | |
| TH88107B (th) | สารประกอบอินทรีย์ | |
| TH88107A (th) | สารประกอบอินทรีย์ | |
| TH89325A (th) | อนุพันธ์ของ 3-อัลคิล-5-(4-อัลคิล-5-ออกโซ-เตตระไฮโดรฟิวราน-2-อิล)ไพรโรลิดิน-2-โอน (3-alkyl-5-(4-alkyl-5-oxo-tetrahydrifuran-2-yl)pyrrolidin-2-one) ในฐานะเป็นสารมัธยันต์ในการสังเคราะห์ของสารยับยั้งเรนิน | |
| TW200716559A (en) | Preparation of 3-amino-4,5-disubstituted-pyrazole derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20231014 |