HK1117525A1 - Crystalline base of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3- dimethylpiperazine -1-((1r3s)-6--3--1-)-33- - Google Patents

Crystalline base of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3- dimethylpiperazine -1-((1r3s)-6--3--1-)-33-

Info

Publication number
HK1117525A1
HK1117525A1 HK08108318.0A HK08108318A HK1117525A1 HK 1117525 A1 HK1117525 A1 HK 1117525A1 HK 08108318 A HK08108318 A HK 08108318A HK 1117525 A1 HK1117525 A1 HK 1117525A1
Authority
HK
Hong Kong
Prior art keywords
phenylindan
dimethylpiperazine
trans
chloro
crystalline base
Prior art date
Application number
HK08108318.0A
Other languages
English (en)
Chinese (zh)
Inventor
Benny Bang-Andersen
De Diego Heidi Lopez
Original Assignee
．隆德貝克有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37908539&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1117525(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by ．隆德貝克有限公司 filed Critical ．隆德貝克有限公司
Publication of HK1117525A1 publication Critical patent/HK1117525A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK08108318.0A 2005-02-16 2008-07-28 Crystalline base of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3- dimethylpiperazine -1-((1r3s)-6--3--1-)-33- HK1117525A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200500239 2005-02-16
PCT/DK2006/000088 WO2006086986A1 (en) 2005-02-16 2006-02-14 Crystalline base of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine

Publications (1)

Publication Number Publication Date
HK1117525A1 true HK1117525A1 (en) 2009-01-16

Family

ID=37908539

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08108318.0A HK1117525A1 (en) 2005-02-16 2008-07-28 Crystalline base of trans-1-((1r,3s)-6-chloro-3-phenylindan-1-yl)-3,3- dimethylpiperazine -1-((1r3s)-6--3--1-)-33-

Country Status (29)

Country Link
US (2) US7648991B2 (ja)
EP (1) EP1853576B1 (ja)
JP (1) JP5055135B2 (ja)
KR (1) KR101386387B1 (ja)
CN (1) CN101119983B (ja)
AR (1) AR052909A1 (ja)
AT (1) ATE515501T1 (ja)
AU (1) AU2006215957B9 (ja)
BR (1) BRPI0607436B8 (ja)
CA (1) CA2597622C (ja)
CY (1) CY1111857T1 (ja)
DK (1) DK1853576T3 (ja)
EA (1) EA017631B1 (ja)
ES (1) ES2368786T3 (ja)
HK (1) HK1117525A1 (ja)
HR (1) HRP20110645T1 (ja)
IL (1) IL184551A (ja)
MX (1) MX2007009980A (ja)
MY (1) MY148683A (ja)
NO (1) NO339863B1 (ja)
NZ (1) NZ556397A (ja)
PL (1) PL1853576T3 (ja)
PT (1) PT1853576E (ja)
RS (1) RS51944B (ja)
SI (1) SI1853576T1 (ja)
TW (1) TWI376373B (ja)
UA (1) UA95901C2 (ja)
WO (1) WO2006086986A1 (ja)
ZA (1) ZA200705982B (ja)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010037398A1 (en) * 2008-10-03 2010-04-08 H. Lundbeck A/S Oral formulation
BRPI0413595B8 (pt) * 2003-08-18 2021-05-25 H Lundbeck As sal de malonato, composição farmacêutica, uso de um sal de malonato, e, método de fabricação de um composto
TWI376373B (en) 2005-02-16 2012-11-11 Lundbeck & Co As H Crystalline base of a pharmaceutical compound
TWI453198B (zh) * 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
BRPI0912223A2 (pt) * 2008-05-07 2015-10-06 Lundbeck & Co As H métodos para melhorar funcionamento cognitivo e para tratar uma doença, composto, uso do mesmo, e, composição farmacêutica.
JP5668177B2 (ja) 2011-06-20 2015-02-12 ハー・ルンドベック・アクチエゼルスカベット 統合失調症の治療のための重水素化１−ピペラジノ−３−フェニルインダン
CN112930341A (zh) 2018-10-29 2021-06-08 H.隆德贝克有限公司 无定形的具有式(i)的化合物和无定形的具有式(i)的化合物的盐
WO2020114853A1 (en) 2018-12-03 2020-06-11 H. Lundbeck A/S Prodrugs of 4-((1r,3s)-6-chloro-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1/r,3s)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazine

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NZ196284A (en) 1980-02-29 1983-12-16 Kefalas As 1-piperazino-3-phenylindane derivatives:pharmaceutical compositions
DE3139970A1 (de) * 1981-10-08 1983-04-28 Boehringer Mannheim Gmbh, 6800 Mannheim Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel
US5026853A (en) * 1987-04-01 1991-06-25 Janssen Pharmaceutica N.V. 4-substituted-2(or 3)aminocarbonyl-1-piperazineacetamide
US5466806A (en) * 1989-02-08 1995-11-14 Biochem Pharma Inc. Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
RU2125980C1 (ru) 1991-11-05 1999-02-10 Смитклайн Бичам Корпорейшн Антагонисты эндотелиновых рецепторов, фармкомпозиция, способ их получения, способ подавления эндотелиновых рецепторов
CA2091204C (en) * 1992-03-11 1997-04-08 Ronald J. Mattson Antiischemic-piperazinyl and piperidinyl-cyclohexanes
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JPH06184132A (ja) 1992-12-22 1994-07-05 Kotobuki Seiyaku Kk ベンゾフラン誘導体及びその製造方法並びに尿酸排泄剤
ES2108484T3 (es) 1993-11-30 1997-12-16 Pfizer Procedimiento para la preparacion de una tetralona asimetrica.
CA2132411A1 (en) * 1994-09-19 1996-03-20 Michael Trani Enzymatic esterification of long-chain racemic acids and alcohols
US6410794B1 (en) * 1994-12-16 2002-06-25 Uop Llc Process for preparation of pharmaceutically desired chiral tetralone from tetralones
US6455736B1 (en) * 1994-12-16 2002-09-24 Uop Llc Process for preparation of pharmaceutically desired sertraline and sertraline analogs
US5807897A (en) * 1996-03-01 1998-09-15 Zeneca Limited Aminotetralin derivative and compositions and method of use thereof
US6268367B1 (en) 1998-02-23 2001-07-31 Zymogenetics, Inc. Piperazine derivatives for treating bone deficit conditions
DE69913332T2 (de) * 1998-05-01 2004-05-27 Pfizer Products Inc., Groton Verfahren zur herstellung von enantiomeren reinem oder optisch angereicherter sertraline-tetralon durch kontinuierliche chromatographie
JP2002516314A (ja) 1998-05-22 2002-06-04 サイオス インコーポレイテッド 複素環式化合物ならびに心不全および他の疾患の処置方法
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IN187170B (ja) * 2000-01-04 2002-02-23 Sun Pharmaceutical Ind Ltd
BRPI0413595B8 (pt) * 2003-08-18 2021-05-25 H Lundbeck As sal de malonato, composição farmacêutica, uso de um sal de malonato, e, método de fabricação de um composto
MX2007009816A (es) 2005-02-16 2007-09-07 Lundbeck & Co As H Sales de tartrato y de malato de trans-1-((1r,3s)-6-cloro-3- fenilindan-1-i1)-3,3-dimetilpiperazina.
TWI376373B (en) * 2005-02-16 2012-11-11 Lundbeck & Co As H Crystalline base of a pharmaceutical compound
TWI453198B (zh) 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法

Also Published As

Publication number Publication date
TWI376373B (en) 2012-11-11
DK1853576T3 (da) 2011-09-26
BRPI0607436B8 (pt) 2021-05-25
US20080153848A1 (en) 2008-06-26
ES2368786T3 (es) 2011-11-22
US7648991B2 (en) 2010-01-19
CN101119983A (zh) 2008-02-06
ZA200705982B (en) 2009-06-24
JP2008530040A (ja) 2008-08-07
CN101119983B (zh) 2014-11-12
NZ556397A (en) 2010-06-25
EA200701740A1 (ru) 2007-12-28
EP1853576B1 (en) 2011-07-06
AU2006215957B2 (en) 2011-09-29
BRPI0607436B1 (pt) 2020-10-06
IL184551A (en) 2014-05-28
SI1853576T1 (sl) 2011-11-30
ATE515501T1 (de) 2011-07-15
NO20074639L (no) 2007-09-12
AU2006215957A1 (en) 2006-08-24
RS51944B (en) 2012-02-29
CA2597622A1 (en) 2006-08-24
KR20070103414A (ko) 2007-10-23
UA95901C2 (en) 2011-09-26
IL184551A0 (en) 2007-10-31
US8450324B2 (en) 2013-05-28
TW200640890A (en) 2006-12-01
CA2597622C (en) 2013-11-12
BRPI0607436A2 (pt) 2010-04-06
EA017631B1 (ru) 2013-02-28
WO2006086986A1 (en) 2006-08-24
US20100105699A1 (en) 2010-04-29
EP1853576A1 (en) 2007-11-14
CY1111857T1 (el) 2015-11-04
AR052909A1 (es) 2007-04-11
KR101386387B1 (ko) 2014-04-25
PT1853576E (pt) 2011-09-28
MX2007009980A (es) 2007-09-26
NO339863B1 (no) 2017-02-13
JP5055135B2 (ja) 2012-10-24
AU2006215957B9 (en) 2012-02-16
MY148683A (en) 2013-05-31
HRP20110645T1 (hr) 2011-10-31
PL1853576T3 (pl) 2011-12-30

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Legal Events

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20220214