HK1117164A1 - Dicyclic azaalkane derivatives, preparing method and pharmaceutical use thereof - Google Patents

Dicyclic azaalkane derivatives, preparing method and pharmaceutical use thereof

Info

Publication number
HK1117164A1
HK1117164A1 HK08112175.4A HK08112175A HK1117164A1 HK 1117164 A1 HK1117164 A1 HK 1117164A1 HK 08112175 A HK08112175 A HK 08112175A HK 1117164 A1 HK1117164 A1 HK 1117164A1
Authority
HK
Hong Kong
Prior art keywords
dicyclic
pharmaceutical use
preparing method
azaalkane
derivatives
Prior art date
Application number
HK08112175.4A
Other languages
English (en)
Inventor
Peng Cho Tang
Zhigang Lin
Hejun Lue
Fuqiang Zhao
Li Li
Fanglong Yang
Jianhong Fu
Lin Wang
Guangyuan Shen
Dongliang Guan
Original Assignee
Shanghai Hengrui Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Hengrui Pharm Co Ltd filed Critical Shanghai Hengrui Pharm Co Ltd
Publication of HK1117164A1 publication Critical patent/HK1117164A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK08112175.4A 2007-01-23 2008-11-06 Dicyclic azaalkane derivatives, preparing method and pharmaceutical use thereof HK1117164A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA2007100043308A CN101230058A (zh) 2007-01-23 2007-01-23 双环氮杂烷类衍生物、其制备方法及其在医药上的用途

Publications (1)

Publication Number Publication Date
HK1117164A1 true HK1117164A1 (en) 2009-01-09

Family

ID=39644101

Family Applications (1)

Application Number Title Priority Date Filing Date
HK08112175.4A HK1117164A1 (en) 2007-01-23 2008-11-06 Dicyclic azaalkane derivatives, preparing method and pharmaceutical use thereof

Country Status (12)

Country Link
US (1) US8178575B2 (ja)
EP (1) EP2133077B1 (ja)
JP (1) JP5424256B2 (ja)
KR (1) KR101482159B1 (ja)
CN (2) CN101230058A (ja)
AU (1) AU2007345133B8 (ja)
BR (1) BRPI0719650A2 (ja)
CA (1) CA2673164C (ja)
HK (1) HK1117164A1 (ja)
MX (1) MX2009007765A (ja)
RU (1) RU2447063C2 (ja)
WO (1) WO2008089636A1 (ja)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2246347B1 (en) * 2008-01-23 2016-09-28 Shanghai Hengrui Pharmaceutical Co. Ltd. Dicycloazaalkane derivates, preparation processes and medical uses thereof
CN101919851B (zh) * 2009-06-09 2012-02-08 江苏恒瑞医药股份有限公司 治疗哺乳动物包括人2型糖尿病的药物组合物
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
ES2682755T3 (es) * 2011-12-21 2018-09-21 Jiangsu Hengrui Medicine Co. Ltd. Derivado del anillo heteroarilo de seis miembros de pirrol, método de preparación del mismo y sus usos medicinales
CN102827064B (zh) * 2012-08-14 2014-01-29 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
CN102827063B (zh) * 2012-08-14 2014-06-25 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
CN103709150B (zh) * 2012-10-09 2017-06-30 江苏豪森药业集团有限公司 托西酸贝格列汀晶型及其制备方法和用途
CN105142621A (zh) 2012-10-24 2015-12-09 国家健康科学研究所 用于预防或治疗糖尿病和促进β-细胞存活的TPL2激酶抑制剂
TW201605791A (zh) 2013-09-26 2016-02-16 美涅莫辛製藥公司 Ｎｒ２ｂ之選擇性八氫-環戊二烯并［ｃ］吡咯負向調節劑
ES2805743T3 (es) 2015-03-24 2021-02-15 Inst Nat Sante Rech Med Método y composición farmacéutica para uso en el tratamiento de la diabetes
AU2017366400B2 (en) 2016-11-23 2021-08-26 Jiangsu Hengrui Medicine Co., Ltd. Preparation method for and intermediate of pyrrolo six-membered heteroaromatic ring derivative
IL273924B2 (en) 2017-10-20 2024-07-01 Univ Vanderbilt Muscarinic acetylcholine M4 receptor antagonists
US11352344B2 (en) 2017-10-31 2022-06-07 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor M4
AU2018386298B2 (en) 2017-12-15 2023-09-07 Praxis Biotech LLC Inhibitors of fibroblast activation protein
WO2019152809A1 (en) 2018-02-02 2019-08-08 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
US11504364B2 (en) 2018-12-21 2022-11-22 Praxis Biotech LLC Inhibitors of fibroblast activation protein
CN111620816B (zh) * 2020-05-27 2023-06-02 上海赛默罗生物科技有限公司 螺桨烷类衍生物、其制备方法、药物组合物和用途

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US5280028A (en) * 1992-06-24 1994-01-18 G. D. Searle & Co. Benzimidazole compounds
KR970703324A (ko) 1994-05-18 1997-07-03 쇼오다 오사무 신규한 피리미딘 유도체(novel pyrimidine derivative)
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
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US6395767B2 (en) * 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
HUP0200849A2 (hu) * 2002-03-06 2004-08-30 Sanofi-Synthelabo N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
TW200401635A (en) * 2002-07-23 2004-02-01 Yamanouchi Pharma Co Ltd 2-Cyano-4-fluoropyrrolidine derivative or salt thereof
CN101928284A (zh) * 2003-03-14 2010-12-29 小野药品工业株式会社 含氮杂环衍生物以及包含所述化合物作为活性成分的药物
ATE421322T1 (de) * 2003-04-04 2009-02-15 Novartis Pharma Gmbh Chinolin-2-on-derivate zur behandlung von erkankungen der atemwege
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US7381738B2 (en) * 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
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WO2006028961A2 (en) * 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators
CN101050194B (zh) * 2006-04-05 2013-08-21 上海恒瑞医药有限公司 双环辛烷类衍生物、其制备方法及其在医药上的用途

Also Published As

Publication number Publication date
CN101914092B (zh) 2012-12-26
US8178575B2 (en) 2012-05-15
KR20090108093A (ko) 2009-10-14
RU2009124304A (ru) 2011-02-27
CA2673164C (en) 2016-05-10
CN101914092A (zh) 2010-12-15
MX2009007765A (es) 2009-07-30
JP5424256B2 (ja) 2014-02-26
RU2447063C2 (ru) 2012-04-10
EP2133077A4 (en) 2010-12-22
CA2673164A1 (en) 2008-07-31
EP2133077A1 (en) 2009-12-16
WO2008089636A1 (fr) 2008-07-31
EP2133077B1 (en) 2014-08-13
US20100016314A1 (en) 2010-01-21
JP2010516635A (ja) 2010-05-20
CN101230058A (zh) 2008-07-30
BRPI0719650A2 (pt) 2013-12-10
AU2007345133A1 (en) 2008-07-31
AU2007345133B8 (en) 2013-05-02
KR101482159B1 (ko) 2015-01-13
AU2007345133B2 (en) 2013-02-21

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20180123