HK1107641A1 - 用於治療焦慮、疼痛及其它疾病的作為脂肪酸酰胺水解酶 調節劑的哌啶和哌嗪- -甲酰胺衍生物及相關化合物 - Google Patents
用於治療焦慮、疼痛及其它疾病的作為脂肪酸酰胺水解酶 調節劑的哌啶和哌嗪- -甲酰胺衍生物及相關化合物Info
- Publication number
- HK1107641A1 HK1107641A1 HK07113211.9A HK07113211A HK1107641A1 HK 1107641 A1 HK1107641 A1 HK 1107641A1 HK 07113211 A HK07113211 A HK 07113211A HK 1107641 A1 HK1107641 A1 HK 1107641A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- faah
- acid amide
- anxiety
- modulators
- piperazine
- Prior art date
Links
- 101150042613 FA2H gene Proteins 0.000 title 2
- 101150008770 FAAH gene Proteins 0.000 title 2
- 208000019901 Anxiety disease Diseases 0.000 title 1
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 title 1
- 230000036506 anxiety Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 title 1
- YFTCCMMHBOHKKF-UHFFFAOYSA-N piperazine-1-carboxamide;piperidine Chemical class C1CCNCC1.NC(=O)N1CCNCC1 YFTCCMMHBOHKKF-UHFFFAOYSA-N 0.000 title 1
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TW200633990A (en) * | 2004-11-18 | 2006-10-01 | Takeda Pharmaceuticals Co | Amide compound |
ME02222B (me) | 2004-12-30 | 2016-02-20 | Janssen Pharmaceutica Nv | Amid derivati piperidin-i piperazin-1-karboksilne kiseline te povezani spojevi kao modulatori amid hidrolaze masnih kiselina (faah) za liječenje tjeskobe, boli i drugih stanja |
GB0503056D0 (en) * | 2005-02-14 | 2005-03-23 | Smithkline Beecham Corp | Chemical compounds |
WO2007005510A1 (en) * | 2005-06-30 | 2007-01-11 | Janssen Pharmaceutica N.V. | N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase |
CA2618653A1 (en) * | 2005-08-12 | 2007-02-22 | Takeda Pharmaceutical Company Limited | Brain/neuronal cell-protecting agent and therapeutic agent for sleep disorder |
WO2007086584A1 (ja) * | 2006-01-30 | 2007-08-02 | Meiji Seika Kaisha, Ltd. | 新規FabKおよびFabI/K阻害剤 |
ITRM20060090A1 (it) * | 2006-02-22 | 2007-08-23 | Sigma Tau Ind Farmaceuti | Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita |
EP2023728A4 (en) * | 2006-05-26 | 2010-11-24 | Janssen Pharmaceutica Nv | OXAZOLYLPIPERIDINES AS MODULATORS OF FATTY ACID AMIDHYDROLASE |
CA2665804A1 (en) * | 2006-08-23 | 2008-02-28 | Astellas Pharma Inc. | Urea compound or salt thereof |
MX2009004233A (es) * | 2006-10-18 | 2009-08-12 | Pfizer Prod Inc | Compuestos de biaril eter urea. |
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CA2714743C (en) * | 2008-02-19 | 2017-01-17 | Janssen Pharmaceutica N.V. | Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase |
JP2011518146A (ja) * | 2008-04-17 | 2011-06-23 | ファイザー・インク | Faah阻害剤として有用な4−[3−(アリールオキシ)ベンジリデン]−3−メチルピペリジンアリールカルボキサミド化合物 |
WO2009127946A1 (en) * | 2008-04-17 | 2009-10-22 | Pfizer Inc. | 4-benzylidene-3-methylpiperidine aryl carboxamide compounds useful as faah inhibitors |
US20110060012A1 (en) * | 2008-04-17 | 2011-03-10 | Pfizer Inc. | 4-[3-(aryloxy)benzylidene]-3-methyl piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors |
EP2276738A1 (en) * | 2008-04-17 | 2011-01-26 | Pfizer Inc. | Ether benzylidene piperidine 5-membered aryl carboxamide compounds useful as faah inhibitors |
WO2009127944A1 (en) * | 2008-04-17 | 2009-10-22 | Pfizer Inc. | Ether benzylidene piperidine aryl carboxamide compounds useful as faah inhibitors |
US8080566B1 (en) | 2008-06-11 | 2011-12-20 | Kalypsys, Inc | Carbazole inhibitors of histamine receptors for the treatment of disease |
US20100113465A1 (en) * | 2008-10-30 | 2010-05-06 | Pfizer Inc. | 7-azaspiro[3.5]nonane-7-carboxamide compounds |
CA2741839A1 (en) * | 2008-11-21 | 2010-05-27 | Pfizer Inc. | 1-oxa-8-azaspiro [4,5] decane-8-carboxamide compounds as faah inhibitors |
US8598356B2 (en) | 2008-11-25 | 2013-12-03 | Janssen Pharmaceutica Nv | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
US8461159B2 (en) | 2008-11-25 | 2013-06-11 | Jannsen Pharmaceutica BV | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase |
CN102333568B (zh) * | 2008-12-24 | 2016-01-20 | 比亚尔-珀特拉和Ca股份公司 | 药物化合物 |
WO2010141817A1 (en) | 2009-06-05 | 2010-12-09 | Janssen Pharmaceutica Nv | Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase |
US8901111B2 (en) | 2009-06-05 | 2014-12-02 | Janssen Pharmaceutica Nv | Aryl-substituted heterocyclic urea modulators of fatty acid amide hydrolase |
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