HK1100774A1 - 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp- ribose) polymerase inhibitors - Google Patents
7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp- ribose) polymerase inhibitorsInfo
- Publication number
- HK1100774A1 HK1100774A1 HK07105886.9A HK07105886A HK1100774A1 HK 1100774 A1 HK1100774 A1 HK 1100774A1 HK 07105886 A HK07105886 A HK 07105886A HK 1100774 A1 HK1100774 A1 HK 1100774A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- quinoxalinones
- quinolinones
- adp
- ribose
- poly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Quinoline Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03078650 | 2003-11-20 | ||
PCT/EP2004/013162 WO2005054209A1 (en) | 2003-11-20 | 2004-11-18 | 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp-ribose) polymerase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1100774A1 true HK1100774A1 (en) | 2007-09-28 |
Family
ID=34639291
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK07105886.9A HK1100774A1 (en) | 2003-11-20 | 2007-06-04 | 7-phenylalkyl substituted 2-quinolinones and 2 quinoxalinones as poly(adp- ribose) polymerase inhibitors |
Country Status (19)
Country | Link |
---|---|
US (2) | US7928104B2 (xx) |
EP (1) | EP1709011B1 (xx) |
JP (1) | JP4864717B2 (xx) |
KR (1) | KR101118644B1 (xx) |
CN (1) | CN1882549B (xx) |
AU (1) | AU2004295057B2 (xx) |
BR (1) | BRPI0416817A (xx) |
CA (1) | CA2546002C (xx) |
EA (1) | EA011211B1 (xx) |
ES (1) | ES2551027T3 (xx) |
HK (1) | HK1100774A1 (xx) |
IL (1) | IL175756A (xx) |
MX (1) | MXPA06005686A (xx) |
NO (1) | NO337252B1 (xx) |
NZ (1) | NZ546990A (xx) |
SG (1) | SG150534A1 (xx) |
UA (1) | UA91002C2 (xx) |
WO (1) | WO2005054209A1 (xx) |
ZA (1) | ZA200604076B (xx) |
Families Citing this family (33)
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BRPI0416206A (pt) | 2003-11-20 | 2006-12-26 | Janssen Pharmaceutica Nv | 2-quinolinonas e 2-quinoxalinonas substituìdas por 6-alquenila e 6-fenilalquila como inibidores de polimerase de poli(adp-ribose) |
JP4864717B2 (ja) * | 2003-11-20 | 2012-02-01 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ポリ(adp−リボース)ポリメラーゼインヒビターとしての7−フェニルアルキル置換2−キノリノンおよび2−キノキサリノン |
NZ546991A (en) * | 2003-11-20 | 2010-01-29 | Janssen Pharmaceutica Nv | 6-Alkenyl and 6-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as PARP inhibitors |
CN1890224B (zh) * | 2003-12-05 | 2011-06-08 | 詹森药业有限公司 | 用作聚(adp-核糖)聚合酶抑制剂的6-取代的2-喹啉酮和2-喹喔啉酮 |
EA011277B1 (ru) * | 2004-01-23 | 2009-02-27 | Янссен Фармацевтика Н.В. | Производные хинолина и их применение в качестве ингибиторов микобактерий |
ES2563954T3 (es) | 2004-06-30 | 2016-03-16 | Janssen Pharmaceutica Nv | Derivados de ftalazina como inhibidores de PARP |
AU2005259190B2 (en) | 2004-06-30 | 2011-05-12 | Janssen Pharmaceutica N.V. | Quinazolinedione derivatives as PARP inhibitors |
EA012416B1 (ru) | 2004-06-30 | 2009-10-30 | Янссен Фармацевтика Н.В. | Производные замещенного 2-алкилхиназолинона как ингибиторы parp |
NZ587586A (en) | 2005-07-18 | 2012-04-27 | Bipar Sciences Inc | Treatment of cancer |
JO2952B1 (en) * | 2005-08-03 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Quinoline derivatives acting as antibacterial agents |
US8143447B2 (en) | 2006-09-05 | 2012-03-27 | Bipar Sciences, Inc. | Treatment of cancer |
CN101534836B (zh) | 2006-09-05 | 2011-09-28 | 彼帕科学公司 | Parp抑制剂在制备治疗肥胖症的药物中的用途 |
AU2008223793B2 (en) * | 2007-03-08 | 2012-08-23 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
ES2448870T3 (es) * | 2007-10-26 | 2014-03-17 | Janssen Pharmaceutica, N.V. | Derivados de quinolina como inhibidores de PARP |
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US20120156134A1 (en) | 2007-12-20 | 2012-06-21 | Shayne Squires | Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease |
RU2490260C2 (ru) | 2008-03-27 | 2013-08-20 | Янссен Фармацевтика Нв | Тетрагидрофенантридиноны и тетрагидроциклопентахинолиноны в качестве ингибиторов parp и ингибиторов полимеризации тубулина |
ATE513818T1 (de) * | 2008-03-27 | 2011-07-15 | Janssen Pharmaceutica Nv | Chinazolinonderivate als tubulinpolymerisationshemmer |
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WO2012177927A1 (en) | 2011-06-21 | 2012-12-27 | Mayo Foundation For Medical Education And Research | Transgenic animals capable of being induced to delete senescent cells |
CA2859385A1 (en) | 2011-12-13 | 2013-06-20 | Buck Institute For Research On Aging | Methods for improving medical therapies |
WO2013158664A2 (en) | 2012-04-17 | 2013-10-24 | Kythera Biopharmaceuticals, Inc. | Use of engineered viruses to specifically kill senescent cells |
US9901080B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells |
US9901081B2 (en) | 2012-08-23 | 2018-02-27 | Buck Institute For Research On Aging | Transgenic mouse for determining the role of senescent cells in cancer |
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WO2007087684A1 (en) | 2006-02-03 | 2007-08-09 | Bionomics Limited | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
ES2587827T3 (es) | 2006-02-15 | 2016-10-27 | Abbvie Inc. | Las pirazoloquinolonas son potentes inhibidores de PARP |
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WO2009002469A1 (en) | 2007-06-25 | 2008-12-31 | Amgen Inc. | Phthalazine compounds, compositions and methods of use |
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2004
- 2004-11-18 JP JP2006540337A patent/JP4864717B2/ja not_active Expired - Fee Related
- 2004-11-18 WO PCT/EP2004/013162 patent/WO2005054209A1/en active Application Filing
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- 2004-11-18 EA EA200601007A patent/EA011211B1/ru not_active IP Right Cessation
- 2004-11-18 UA UAA200603547A patent/UA91002C2/ru unknown
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- 2004-11-18 SG SG200901198-2A patent/SG150534A1/en unknown
- 2004-11-18 ES ES04819600.0T patent/ES2551027T3/es active Active
- 2004-11-18 BR BRPI0416817-8A patent/BRPI0416817A/pt not_active Application Discontinuation
- 2004-11-18 EP EP04819600.0A patent/EP1709011B1/en active Active
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2006
- 2006-05-18 IL IL175756A patent/IL175756A/en not_active IP Right Cessation
- 2006-05-19 ZA ZA200604076A patent/ZA200604076B/en unknown
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JP2007513087A (ja) | 2007-05-24 |
IL175756A0 (en) | 2006-09-05 |
KR101118644B1 (ko) | 2012-03-06 |
CA2546002C (en) | 2012-09-18 |
US8524714B2 (en) | 2013-09-03 |
EP1709011A1 (en) | 2006-10-11 |
NZ546990A (en) | 2010-03-26 |
NO20062892L (no) | 2006-08-09 |
US20080249099A1 (en) | 2008-10-09 |
CA2546002A1 (en) | 2005-06-16 |
MXPA06005686A (es) | 2006-08-17 |
SG150534A1 (en) | 2009-03-30 |
AU2004295057B2 (en) | 2010-11-25 |
AU2004295057A1 (en) | 2005-06-16 |
US7928104B2 (en) | 2011-04-19 |
US20110230492A1 (en) | 2011-09-22 |
KR20060111532A (ko) | 2006-10-27 |
JP4864717B2 (ja) | 2012-02-01 |
WO2005054209A1 (en) | 2005-06-16 |
EP1709011B1 (en) | 2015-07-29 |
BRPI0416817A (pt) | 2007-03-06 |
ZA200604076B (en) | 2007-09-26 |
EA011211B1 (ru) | 2009-02-27 |
NO337252B1 (no) | 2016-02-22 |
CN1882549A (zh) | 2006-12-20 |
EA200601007A1 (ru) | 2006-10-27 |
ES2551027T3 (es) | 2015-11-13 |
IL175756A (en) | 2013-03-24 |
UA91002C2 (ru) | 2010-06-25 |
CN1882549B (zh) | 2011-02-23 |
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