HK1094210A1 - Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity - Google Patents

Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity

Info

Publication number
HK1094210A1
HK1094210A1 HK06114147.7A HK06114147A HK1094210A1 HK 1094210 A1 HK1094210 A1 HK 1094210A1 HK 06114147 A HK06114147 A HK 06114147A HK 1094210 A1 HK1094210 A1 HK 1094210A1
Authority
HK
Hong Kong
Prior art keywords
template
hairpin peptidomimetics
antagonizing activity
fixed beta
cxcr4 antagonizing
Prior art date
Application number
HK06114147.7A
Other languages
English (en)
Inventor
Jurg Zumbrunn
Steven J Demarco
Reshmi Mukherjee
Kerstin Moehle
John Anthony Robinson
Heiko Henze
Barbara Romagnoli
Sergio Lociuro
Jan Wim Vrijbloed
Frank Gombert
Daniel Obrecht
Christian Ludin
Original Assignee
Polyphor Ag
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ag, Univ Zuerich filed Critical Polyphor Ag
Publication of HK1094210A1 publication Critical patent/HK1094210A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Detergent Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Cosmetics (AREA)
HK06114147.7A 2003-05-02 2006-12-22 Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity HK1094210A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2003/004640 WO2004096839A1 (en) 2003-05-02 2003-05-02 Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
PCT/EP2004/004535 WO2004096840A1 (en) 2003-05-02 2004-04-29 Template- fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity

Publications (1)

Publication Number Publication Date
HK1094210A1 true HK1094210A1 (en) 2007-03-23

Family

ID=33395700

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06114147.7A HK1094210A1 (en) 2003-05-02 2006-12-22 Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity

Country Status (17)

Country Link
US (3) US7786078B2 (pt)
EP (3) EP1622931B1 (pt)
JP (3) JP4846564B2 (pt)
KR (5) KR101330239B1 (pt)
CN (1) CN1802385B (pt)
AU (2) AU2003232253A1 (pt)
BR (3) BR122019016210B8 (pt)
CA (3) CA2524253C (pt)
EA (1) EA010163B1 (pt)
ES (3) ES2563094T3 (pt)
HK (1) HK1094210A1 (pt)
IL (3) IL171530A (pt)
MX (1) MXPA05011550A (pt)
NO (2) NO333793B1 (pt)
NZ (1) NZ543806A (pt)
WO (2) WO2004096839A1 (pt)
ZA (1) ZA200508863B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3035941C (en) 2005-02-17 2021-11-16 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
CN105111280B (zh) * 2005-02-17 2020-01-24 波利弗尔有限公司 具有蛋白酶抑制活性的模板固定的β-发夹肽模拟物
WO2006117011A1 (en) * 2005-05-02 2006-11-09 Polyphor Ltd. Dye conjugates of template-fixed peptidomimetics
JP5251127B2 (ja) 2005-10-28 2013-07-31 小野薬品工業株式会社 塩基性基を含有する化合物およびその用途
ES2407115T3 (es) 2005-11-18 2013-06-11 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
WO2007079597A1 (en) * 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
EP2114986B1 (en) 2007-01-29 2013-05-22 Polyphor Ltd. Template-fixed peptidomimetics
PL2132221T3 (pl) 2007-02-28 2011-04-29 Polyphor Ltd Przyłączone do matrycy peptydomimetyki
US8440199B2 (en) 2007-12-12 2013-05-14 Imperial Innovations Limited Methods for mobilizing mesenchymal stem cells in a patient
ES2537634T3 (es) * 2008-08-08 2015-06-10 Polyphor Ag Peptidomiméticos fijados por plantilla
US8883720B2 (en) 2008-11-26 2014-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
US8865656B2 (en) 2009-05-07 2014-10-21 Polyphor Ag Beta-hairpin peptidomimetics having CXCR4 antagonizing activity
AU2012266355B2 (en) * 2011-06-07 2016-06-09 Polyphor Ag Beta - hairpin peptidomimetics as CXC4 antagonists
AR087363A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
JP6294227B2 (ja) 2011-10-07 2018-03-14 ポリフォー・アクチェンゲゼルシャフトＰｏｌｙｐｈｏｒ Ａｇ Ｆｐｒ１の阻害剤としてのテンプレート固定ペプチド模倣薬
MX355396B (es) * 2012-06-06 2018-04-18 Polyphor Ag Peptido - mimeticos de la horquilla beta.
LT2882771T (lt) * 2012-08-08 2017-09-25 Polyphor Ag Deriniai su per šoninę grandinę ciklizuotu peptidu
JP6819573B2 (ja) * 2015-03-24 2021-01-27 東レ株式会社 布帛および衣料
JP7011830B2 (ja) 2015-10-14 2022-01-27 エックス－サーマ インコーポレイテッド 氷晶形成を低減するための組成物および方法
US11858974B2 (en) * 2017-05-22 2024-01-02 Resq Biotech Macrocyclic modulators of disease associated protein misfolding and aggregation
WO2023227771A1 (en) 2022-05-27 2023-11-30 Fundación Privada Instituto De Salud Global Barcelona Cyclic peptides with antibacterial activity against multidrug resistant (mdr) pathogens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU217442B (hu) 1993-10-14 2000-01-28 Seikagaku Corp. Polipeptidek és ezeket tartalmazó HIV-ellenes hatású gyógyászati készítmények
JP4625603B2 (ja) * 1999-08-30 2011-02-02 ポリファー アーゲー テンプレートを固定したβヘアピンループ類似物の合成
ES2527339T3 (es) * 2001-02-23 2015-01-23 Polyphor Ltd. Peptidomiméticos fijados a patrón con actividad antimicrobiana
CN101157924A (zh) * 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
CN1688600B (zh) * 2002-08-20 2010-04-28 波利弗尔有限公司 具有抗菌活性的模板固定的肽模拟物
WO2004033489A1 (en) * 2002-10-02 2004-04-22 Polyphor Ltd. Template-fixed peptidomimetics with antimicrobial activity

Also Published As

Publication number Publication date
EP2540735A3 (en) 2013-02-27
IL227932B (en) 2019-01-31
KR20060034217A (ko) 2006-04-21
BR122019016211B1 (pt) 2020-05-12
AU2004234062B2 (en) 2010-07-15
BR122019016210B8 (pt) 2021-07-27
EP2540735A2 (en) 2013-01-02
CA2847490A1 (en) 2004-11-11
CN1802385A (zh) 2006-07-12
KR20110089174A (ko) 2011-08-04
CA2524253A1 (en) 2004-11-11
CA2524253C (en) 2016-03-29
EP2540736A2 (en) 2013-01-02
IL227933B (en) 2019-01-31
EA200501550A1 (ru) 2006-06-30
IL171530A (en) 2013-08-29
JP2011140496A (ja) 2011-07-21
US20070078079A1 (en) 2007-04-05
KR101330238B1 (ko) 2013-11-15
BRPI0409928A (pt) 2006-04-25
WO2004096840A1 (en) 2004-11-11
BR122019016211B8 (pt) 2021-07-27
NZ543806A (en) 2008-03-28
CA2847486A1 (en) 2004-11-11
BRPI0409928A8 (pt) 2019-09-10
EP2540736A3 (en) 2013-02-27
IL227933A0 (en) 2013-09-30
EP2540735B1 (en) 2015-07-22
EP1622931A1 (en) 2006-02-08
EA010163B1 (ru) 2008-06-30
KR20130059462A (ko) 2013-06-05
BRPI0409928B8 (pt) 2021-05-25
AU2004234062A1 (en) 2004-11-11
NO333793B1 (no) 2013-09-16
WO2004096839A1 (en) 2004-11-11
KR101330239B1 (ko) 2013-11-15
ES2563094T3 (es) 2016-03-10
BR122019016210B1 (pt) 2020-09-08
NO20131086A1 (no) 2005-11-25
EP2540736B1 (en) 2015-11-18
KR20130059463A (ko) 2013-06-05
JP2007523847A (ja) 2007-08-23
CA2847486C (en) 2016-03-15
KR20110089173A (ko) 2011-08-04
JP5770781B2 (ja) 2015-08-26
JP2013227317A (ja) 2013-11-07
IL227932A0 (en) 2013-09-30
US9518092B2 (en) 2016-12-13
NO340835B1 (no) 2017-06-26
ZA200508863B (en) 2007-03-28
AU2003232253A1 (en) 2004-11-23
CA2847490C (en) 2015-11-17
NO20055585L (no) 2005-11-25
KR101230453B1 (ko) 2013-02-06
JP4846564B2 (ja) 2011-12-28
US8895695B2 (en) 2014-11-25
ES2550241T3 (es) 2015-11-05
US7786078B2 (en) 2010-08-31
US20150087577A1 (en) 2015-03-26
BRPI0409928B1 (pt) 2020-05-12
ES2550856T3 (es) 2015-11-12
CN1802385B (zh) 2011-11-09
EP1622931B1 (en) 2015-07-15
US20110245155A1 (en) 2011-10-06
MXPA05011550A (es) 2006-07-06
JP5307169B2 (ja) 2013-10-02
AU2003232253A8 (en) 2004-11-23

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Legal Events

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PE Patent expired

Effective date: 20240428