HK1094210A1 - Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity - Google Patents

Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity

Info

Publication number
HK1094210A1
HK1094210A1 HK06114147.7A HK06114147A HK1094210A1 HK 1094210 A1 HK1094210 A1 HK 1094210A1 HK 06114147 A HK06114147 A HK 06114147A HK 1094210 A1 HK1094210 A1 HK 1094210A1
Authority
HK
Hong Kong
Prior art keywords
template
hairpin peptidomimetics
antagonizing activity
fixed beta
cxcr4 antagonizing
Prior art date
Application number
HK06114147.7A
Other languages
English (en)
Inventor
Jurg Zumbrunn
Steven J Demarco
Reshmi Mukherjee
Kerstin Moehle
John Anthony Robinson
Heiko Henze
Barbara Romagnoli
Sergio Lociuro
Jan Wim Vrijbloed
Frank Gombert
Daniel Obrecht
Christian Ludin
Original Assignee
Polyphor Ag
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polyphor Ag, Univ Zuerich filed Critical Polyphor Ag
Publication of HK1094210A1 publication Critical patent/HK1094210A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
HK06114147.7A 2003-05-02 2006-12-22 Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity HK1094210A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2003/004640 WO2004096839A1 (en) 2003-05-02 2003-05-02 Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity
PCT/EP2004/004535 WO2004096840A1 (en) 2003-05-02 2004-04-29 Template- fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity

Publications (1)

Publication Number Publication Date
HK1094210A1 true HK1094210A1 (en) 2007-03-23

Family

ID=33395700

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06114147.7A HK1094210A1 (en) 2003-05-02 2006-12-22 Template-fixed beta-hairpin peptidomimetics with cxcr4 antagonizing activity

Country Status (17)

Country Link
US (3) US7786078B2 (xx)
EP (3) EP1622931B1 (xx)
JP (3) JP4846564B2 (xx)
KR (5) KR20130059463A (xx)
CN (1) CN1802385B (xx)
AU (2) AU2003232253A1 (xx)
BR (3) BRPI0409928B8 (xx)
CA (3) CA2524253C (xx)
EA (1) EA010163B1 (xx)
ES (3) ES2550856T3 (xx)
HK (1) HK1094210A1 (xx)
IL (3) IL171530A (xx)
MX (1) MXPA05011550A (xx)
NO (2) NO333793B1 (xx)
NZ (1) NZ543806A (xx)
WO (2) WO2004096839A1 (xx)
ZA (1) ZA200508863B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105111280B (zh) * 2005-02-17 2020-01-24 波利弗尔有限公司 具有蛋白酶抑制活性的模板固定的β-发夹肽模拟物
EP1856140B1 (en) * 2005-02-17 2013-12-25 Polyphor Ltd. Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
WO2006117011A1 (en) * 2005-05-02 2006-11-09 Polyphor Ltd. Dye conjugates of template-fixed peptidomimetics
ES2427989T3 (es) 2005-10-28 2013-11-05 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
PL1961744T3 (pl) 2005-11-18 2013-09-30 Ono Pharmaceutical Co Związek zawierający grupę zasadową oraz jego zastosowanie
WO2007079597A1 (en) * 2006-01-16 2007-07-19 Polyphor Ltd. Template - fixed peptidomimetics with antimicrobial activity
AU2007345497B2 (en) * 2007-01-29 2013-01-17 Polyphor Ltd. Template-fixed peptidomimetics
PL2132221T3 (pl) 2007-02-28 2011-04-29 Polyphor Ltd Przyłączone do matrycy peptydomimetyki
WO2009074807A2 (en) 2007-12-12 2009-06-18 Imperial Innovations Limited Methods
US20110230426A1 (en) * 2008-08-08 2011-09-22 Polyphor Ag Template-fixed peptidomimetics
US8883720B2 (en) 2008-11-26 2014-11-11 Polyphor Ag Template-fixed beta-hairpin peptidomimetics with CXCR4 antagonizing activity
WO2010127704A1 (en) * 2009-05-07 2010-11-11 Polyphor Ag Beta-hairpin peptidomimetics having cxcr4 antagonizing activity
SG195055A1 (en) 2011-06-07 2013-12-30 Polyphor Ag Beta - hairpin peptidomimetics as cxc4 antagonists
AR087363A1 (es) * 2011-07-29 2014-03-19 Pf Medicament Uso del anticuerpo i-3859 para la deteccion y diagnostico de los canceres
WO2013050346A1 (en) 2011-10-07 2013-04-11 Polyphor Ag Template -fixed peptidomimetics as inhibitors of fpr1
ES2647076T3 (es) * 2012-06-06 2017-12-19 Polyphor Ag Peptidomiméticos de horquilla beta
AU2013301576B2 (en) * 2012-08-08 2017-10-19 Polyphor Ag Combinations with a backbone-cyclized peptide
US10544527B2 (en) * 2015-03-24 2020-01-28 Toray Industries, Inc. Fabric and clothing having flame retardancy and high visibility
WO2017066454A2 (en) 2015-10-14 2017-04-20 X-Therma, Inc. Compositions and methods for reducing ice crystal formation
EP3630153A2 (en) * 2017-05-22 2020-04-08 National Hellenic Research Foundation Macrocyclic modulators of disease associated protein misfolding and aggregation
WO2023227771A1 (en) 2022-05-27 2023-11-30 Fundación Privada Instituto De Salud Global Barcelona Cyclic peptides with antibacterial activity against multidrug resistant (mdr) pathogens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE177114T1 (de) 1993-10-14 1999-03-15 Seikagaku Kogyo Co Ltd Polypeptide und daraus hergestellte, gegen hiv wirksame substanzen
EP1214336A1 (en) * 1999-08-30 2002-06-19 Universität Zürich Synthesis of template-fixed beta-hairpin loop mimetics
US7253146B2 (en) * 2001-02-23 2007-08-07 Polyphor Ltd Template-fixed peptidomimetics with antimicrobial activity
CN101157924A (zh) * 2001-12-11 2008-04-09 人体基因组科学有限公司 嗜中性白细胞因子α
AU2002342618C1 (en) * 2002-08-20 2008-10-30 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
ATE393774T1 (de) * 2002-10-02 2008-05-15 Polyphor Ltd Matrizenfixierte peptidomimetika mit antimikrobieller wirkung

Also Published As

Publication number Publication date
BR122019016210B8 (pt) 2021-07-27
NZ543806A (en) 2008-03-28
EP2540735A3 (en) 2013-02-27
BRPI0409928A (pt) 2006-04-25
EA200501550A1 (ru) 2006-06-30
IL227933A0 (en) 2013-09-30
EP1622931B1 (en) 2015-07-15
EP2540735B1 (en) 2015-07-22
JP2013227317A (ja) 2013-11-07
CA2847490C (en) 2015-11-17
KR101330239B1 (ko) 2013-11-15
CA2847490A1 (en) 2004-11-11
BR122019016210B1 (pt) 2020-09-08
IL171530A (en) 2013-08-29
CA2524253A1 (en) 2004-11-11
MXPA05011550A (es) 2006-07-06
US7786078B2 (en) 2010-08-31
KR20060034217A (ko) 2006-04-21
KR20110089173A (ko) 2011-08-04
EP2540736A3 (en) 2013-02-27
NO20055585L (no) 2005-11-25
EP2540735A2 (en) 2013-01-02
ES2563094T3 (es) 2016-03-10
WO2004096840A1 (en) 2004-11-11
NO333793B1 (no) 2013-09-16
CN1802385B (zh) 2011-11-09
US20070078079A1 (en) 2007-04-05
EA010163B1 (ru) 2008-06-30
IL227932A0 (en) 2013-09-30
ES2550856T3 (es) 2015-11-12
ZA200508863B (en) 2007-03-28
BR122019016211B8 (pt) 2021-07-27
CA2524253C (en) 2016-03-29
JP2011140496A (ja) 2011-07-21
KR20110089174A (ko) 2011-08-04
ES2550241T3 (es) 2015-11-05
EP2540736B1 (en) 2015-11-18
US20150087577A1 (en) 2015-03-26
KR20130059463A (ko) 2013-06-05
AU2004234062A1 (en) 2004-11-11
BRPI0409928B8 (pt) 2021-05-25
US20110245155A1 (en) 2011-10-06
JP2007523847A (ja) 2007-08-23
EP2540736A2 (en) 2013-01-02
JP5307169B2 (ja) 2013-10-02
CA2847486A1 (en) 2004-11-11
AU2003232253A1 (en) 2004-11-23
KR20130059462A (ko) 2013-06-05
JP5770781B2 (ja) 2015-08-26
US9518092B2 (en) 2016-12-13
IL227932B (en) 2019-01-31
EP1622931A1 (en) 2006-02-08
NO20131086A1 (no) 2005-11-25
BRPI0409928A8 (pt) 2019-09-10
KR101330238B1 (ko) 2013-11-15
WO2004096839A1 (en) 2004-11-11
US8895695B2 (en) 2014-11-25
AU2004234062B2 (en) 2010-07-15
IL227933B (en) 2019-01-31
CN1802385A (zh) 2006-07-12
BR122019016211B1 (pt) 2020-05-12
JP4846564B2 (ja) 2011-12-28
NO340835B1 (no) 2017-06-26
BRPI0409928B1 (pt) 2020-05-12
CA2847486C (en) 2016-03-15
AU2003232253A8 (en) 2004-11-23
KR101230453B1 (ko) 2013-02-06

Similar Documents

Publication Publication Date Title
IL227932A0 (en) A constant pattern of beta-harpin peptidomimetics with antagonistic activity to 4cxcr
HK1081561A1 (en) Template-fixed peptidomimetics with antibacterial activity
GB0306731D0 (en) Activity monitor
IL163928A0 (en) Pyridinoylpiperidines as 5-htf agonists
HK1064391A1 (en) Template-fixed peptidomimetics with antimicrobial activity
EP1668755A4 (en) ORDER SYSTEM COMPRISING NON-NOBLE METAL ELECTRODE COMPOSITIONS
AU2003287187A8 (en) Novel compositions with chitinase activity
HK1129681A1 (en) Macrolide-conjugates with anti-inflammatory activity
HK1079199A1 (en) Indazolamides with analgesic activity
AU2003234432A8 (en) Voice activity detection
IL184804A0 (en) Template-fixed beta-hairpin peptidomimetics with protease inhibitory activity
AU2002951144A0 (en) Aquatic activity garment
IL156615A0 (en) Pharmaceutical compositions with antibiotic activity
DE60328040D1 (en) Skyhook auslösesystem für reservefallschirm
EP1495176A4 (en) WASHING MACHINE
GB0205347D0 (en) Biologically active complex
EP1717244A4 (en) POLYPEPTIDE SPECIFICALLY INHIBITING AKT ACTIVITY
GB0216121D0 (en) Washer
EP1642903A4 (en) PEPTIDES WITH APOPTOSIS-INHIBITING EFFECT
AU2002100221A4 (en) The lean pole
AU2003225764A8 (en) Aza-thioxanthenones with antitumor activity
AU2003224677A1 (en) Aza-benzothiopyranoindazoles with antitumor activity
TW587697U (en) Probe structure
AU3891P (en) Ever Bright Photinia glabra
TW549143U (en) Automatic swiveling sprinkler structure

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20240428