HK1092463A1 - Substituted dihydrochinazolines having antiviral properties - Google Patents

Substituted dihydrochinazolines having antiviral properties

Info

Publication number
HK1092463A1
HK1092463A1 HK06112993.6A HK06112993A HK1092463A1 HK 1092463 A1 HK1092463 A1 HK 1092463A1 HK 06112993 A HK06112993 A HK 06112993A HK 1092463 A1 HK1092463 A1 HK 1092463A1
Authority
HK
Hong Kong
Prior art keywords
dihydrochinazolines
substituted
antiviral properties
antiviral
properties
Prior art date
Application number
HK06112993.6A
Other languages
English (en)
Inventor
Tobias Wunberg
Judith Baumeister
Ulrich Betz
Mario Jeske
Thomas Lampe
Susanne Nikolic
Juergen Reefschlaeger
Rudolf Schohe-Loop
Frank Suessmeier
Holger Zimmermann
Rolf Grosser
Kerstin Henninger
Guy Hewlett
Joerg Keldenich
Dieter Lang
Peter Nell
Original Assignee
Aicuris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh filed Critical Aicuris Gmbh
Publication of HK1092463A1 publication Critical patent/HK1092463A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK06112993.6A 2003-05-02 2006-11-27 Substituted dihydrochinazolines having antiviral properties HK1092463A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10319612A DE10319612A1 (de) 2003-05-02 2003-05-02 Substituierte Dihydrochinazoline
PCT/EP2004/004103 WO2004096778A1 (de) 2003-05-02 2004-04-17 Substituierte dihydrochinazoline mit antiviralen eigenschaften

Publications (1)

Publication Number Publication Date
HK1092463A1 true HK1092463A1 (en) 2007-02-09

Family

ID=33305099

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06112993.6A HK1092463A1 (en) 2003-05-02 2006-11-27 Substituted dihydrochinazolines having antiviral properties

Country Status (39)

Country Link
US (4) US7196086B2 (no)
EP (1) EP1622880B3 (no)
JP (1) JP4733631B2 (no)
KR (1) KR100927063B1 (no)
CN (1) CN100393706C (no)
AR (1) AR044078A1 (no)
AT (1) ATE355280T1 (no)
AU (1) AU2004233978B2 (no)
BR (1) BRPI0410029B8 (no)
CA (1) CA2524069C (no)
CL (1) CL2004000930A1 (no)
CO (1) CO5700764A2 (no)
CY (2) CY1106476T1 (no)
DE (2) DE10319612A1 (no)
DK (1) DK1622880T6 (no)
EC (1) ECSP056138A (no)
EG (1) EG25273A (no)
ES (1) ES2284007T7 (no)
FR (1) FR18C1029I2 (no)
HK (1) HK1092463A1 (no)
HN (1) HN2004000146A (no)
HU (2) HUS1800018I1 (no)
IL (1) IL171513A (no)
MA (1) MA27794A1 (no)
MX (1) MXPA05011707A (no)
MY (1) MY144616A (no)
NL (1) NL300933I2 (no)
NO (2) NO333265B3 (no)
NZ (1) NZ543317A (no)
PE (1) PE20050145A1 (no)
PL (1) PL1622880T6 (no)
PT (1) PT1622880E (no)
RU (1) RU2360912C2 (no)
SI (1) SI1622880T1 (no)
TW (1) TWI335912B (no)
UA (1) UA82519C2 (no)
UY (1) UY28294A1 (no)
WO (1) WO2004096778A1 (no)
ZA (1) ZA200508710B (no)

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DE10319612A1 (de) 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) * 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
DE102011101446A1 (de) 2011-05-10 2012-11-15 Aicuris Gmbh & Co. Kg Herstellung von "Dense Bodies" (DB)
DE102012101680A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
ME03483B (me) * 2013-06-19 2020-01-20 Aicuris Anti Infective Cures Gmbh Amorfni letermovir i njegove čvrste farmaceutske formulacije za oralno davanje
US9890128B2 (en) 2013-12-12 2018-02-13 Merck Sharp & Dohme Corp. Process for making substituted quinazoline compounds
US10392353B2 (en) * 2015-11-24 2019-08-27 Merck Sharp & Dohme Corp. Processes for making substituted quinazoline compounds using hydrogen bonding catalysts
JP6951418B2 (ja) * 2016-08-08 2021-10-20 メッドシャイン ディスカバリー インコーポレイテッド 抗ｈｃｍｖウイルス化合物
AU2019218150B2 (en) * 2018-02-08 2021-05-13 Phaeno Therapeutics Co., Ltd. Crystal form of 3,4-dihydrothieno[3,2-d]pyrimidine compound and preparation method therefor
EP3527209A1 (en) * 2018-02-16 2019-08-21 UCB Biopharma SPRL Pharmaceutical 6,5 heterobicyclic ring derivatives
JP7273951B2 (ja) 2018-09-12 2023-05-15 ノバルティス アーゲー 抗ウイルス性ピリドピラジンジオン化合物
CN114667285A (zh) 2019-09-26 2022-06-24 诺华股份有限公司 抗病毒吡唑并吡啶酮化合物
AR121440A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método de preparación de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio monohidrato, dicho compuesto y el uso del mismo para el tratamiento de infecciones virales
AR121439A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Un método para producir una forma cristalina de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acetato de sodio trihidrato
AR121437A1 (es) * 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Sal de potasio del ácido 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il]acético
AR121438A1 (es) 2020-02-27 2022-06-08 Aic246 Gmbh & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de sodio
UY39099A (es) 2020-02-27 2021-08-31 Aic246 Gmbh & Co Kg 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] acetato de sodio y composiciones farmacéuticas del mismo
EP3906929A1 (en) 2020-05-08 2021-11-10 AiCuris GmbH & Co. KG Letermovir for use in the prevention and the treatment of coronavirus infections
CA3189271A1 (en) 2020-08-17 2022-02-24 Girij Pal Singh A precipitation process for amorphous letermovir
CN115403528A (zh) * 2021-05-27 2022-11-29 南京正大天晴制药有限公司 无定形3,4-二氢喹唑啉衍生物的制备方法
CN114031560B (zh) * 2021-11-16 2022-10-04 山东诚创蓝海医药科技有限公司 一种来特莫韦钠盐的制备方法
AR128035A1 (es) 2021-12-21 2024-03-20 Aic246 Ag & Co Kg Composiciones farmacéuticas que comprenden acetato de 2-[(4s)-8-fluoro-2-[4-(3-metoxifenil)piperazin-1-il]-3-[2-metoxi-5-(trifluorometil)fenil]-4h-quinazolin-4-il] e iones de potasio
WO2023185597A1 (zh) * 2022-04-01 2023-10-05 上海迪赛诺化学制药有限公司 莱特莫韦中间体及其制备方法
CN115322157B (zh) * 2022-06-02 2023-12-05 浙江车头制药股份有限公司 来特莫韦中间体化合物及其制备方法和应用
CN117229223A (zh) * 2022-06-08 2023-12-15 苏州远智医药科技有限公司 一种杂环衍生物及其药物组合物、应用

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US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
DE19802437A1 (de) 1998-01-23 1999-07-29 Bayer Ag Verwendung von substituierten Sulfonamiden als anitvirale Mittel und neue Stoffe
ATE245641T1 (de) 1998-02-17 2003-08-15 Tularik Inc Antivirale pyrimidinderivate
US6495578B1 (en) 1999-04-19 2002-12-17 Shionogi & Co., Ltd. Sulfonamide derivatives having oxadiazole rings
DE19930075A1 (de) 1999-06-30 2001-01-04 Bayer Ag Neue Amino- und Amidosulfonamide als antivirale Mittel
US6730682B2 (en) * 2000-07-12 2004-05-04 Pharmacia & Upjohn Company Heterocycle carboxamides as antiviral agents
MXPA03000906A (es) * 2000-07-31 2005-02-24 Hoffmann La Roche Derivados de piperazina.
EP1201765A3 (en) * 2000-10-16 2003-08-27 Axxima Pharmaceuticals Aktiengesellschaft Cellular kinases involved in cytomegalovirus infection and their inhibition
DE50204780D1 (de) 2001-04-19 2005-12-08 Bayer Healthcare Ag Arylsulfonamide als antivirale mittel
DE10138578A1 (de) 2001-08-06 2003-02-27 Bayer Ag Heterocyclylarylsulfonamide
DE10251914A1 (de) 2002-11-08 2004-05-19 Bayer Ag Substituierte Chinazoline
DE10319612A1 (de) * 2003-05-02 2004-11-18 Bayer Healthcare Ag Substituierte Dihydrochinazoline
DE10305785A1 (de) * 2003-02-12 2004-08-26 Bayer Healthcare Ag Dihydrochinazoline
DE10320780A1 (de) 2003-05-09 2005-01-20 Bayer Healthcare Ag Heterocyclyl-substituierte Dihydrochinazoline
DE10352499A1 (de) * 2003-11-11 2005-06-09 Bayer Healthcare Ag Substituierte Dihydrochinazoline II
KR100610731B1 (ko) * 2004-02-24 2006-08-09 한국과학기술연구원 Ｔ-형 칼슘 채널 차단제로서 유용한 ３,４-디히드로퀴나졸린유도체 및 그의 제조 방법
DE102004022672A1 (de) 2004-05-07 2005-11-24 Bayer Healthcare Ag Substituierte Azachinazoline
WO2006081331A2 (en) * 2005-01-25 2006-08-03 Prolexys Pharmaceuticals, Inc. Quinoxaline derivatives as antitumor agents
DE102005027517A1 (de) 2005-06-15 2006-12-21 Bayer Healthcare Ag Verfahren zur Herstellung von Dihydrochinazolinen
CA2614443C (en) * 2005-07-21 2011-03-22 F. Hoffmann-La Roche Ag Pyrido [2,3-d] pyrimidine-2,4-diamine compounds as ptp1b inhibitors
DE102006009928A1 (de) 2006-03-03 2007-09-06 Aicuris Gmbh & Co. Kg Substituierte Arylsulfonamide
DE102012101659A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101673A1 (de) 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Salze eines Dihydrochinazolinderivats
DE102012101680A1 (de) * 2012-02-29 2013-08-29 Aicuris Gmbh & Co. Kg Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat
ME03483B (me) * 2013-06-19 2020-01-20 Aicuris Anti Infective Cures Gmbh Amorfni letermovir i njegove čvrste farmaceutske formulacije za oralno davanje

Also Published As

Publication number Publication date
PE20050145A1 (es) 2005-05-22
KR20060009883A (ko) 2006-02-01
NO333265B3 (no) 2019-06-03
CA2524069A1 (en) 2004-11-11
DE502004003052D1 (de) 2007-04-12
RU2005137276A (ru) 2006-07-27
NL300933I2 (nl) 2018-04-26
PL1622880T3 (pl) 2007-08-31
US20070191387A1 (en) 2007-08-16
AU2004233978A1 (en) 2004-11-11
RU2360912C2 (ru) 2009-07-10
ATE355280T1 (de) 2006-03-15
JP2006525249A (ja) 2006-11-09
ES2284007T3 (es) 2007-11-01
TWI335912B (en) 2011-01-11
EP1622880B1 (de) 2007-02-28
US7196086B2 (en) 2007-03-27
MY144616A (en) 2011-10-14
MXPA05011707A (es) 2006-02-13
AU2004233978B2 (en) 2010-02-11
EG25273A (en) 2011-12-04
DK1622880T6 (da) 2018-06-18
SI1622880T1 (sl) 2007-08-31
FR18C1029I1 (no) 2018-08-17
IL171513A (en) 2011-11-30
PT1622880E (pt) 2007-06-04
ZA200508710B (en) 2006-12-27
HN2004000146A (es) 2008-06-24
AR044078A1 (es) 2005-08-24
CO5700764A2 (es) 2006-11-30
DK1622880T3 (da) 2007-06-25
CY2018019I2 (el) 2018-12-12
JP4733631B2 (ja) 2011-07-27
EP1622880A1 (de) 2006-02-08
USRE49698E1 (en) 2023-10-17
NO20055649L (no) 2006-01-31
BRPI0410029B8 (pt) 2021-06-15
KR100927063B1 (ko) 2009-11-13
HUS1800028I1 (hu) 2018-07-30
HUS1800018I1 (hu) 2018-05-28
NO333265B1 (no) 2013-04-22
BRPI0410029B1 (pt) 2019-12-31
CY2018019I1 (el) 2018-12-12
US8513255B2 (en) 2013-08-20
CL2004000930A1 (es) 2005-03-18
ES2284007T7 (es) 2018-06-20
UY28294A1 (es) 2004-11-30
NO2018022I1 (no) 2018-07-04
CN1784390A (zh) 2006-06-07
FR18C1029I2 (fr) 2020-07-17
CN100393706C (zh) 2008-06-11
PL1622880T6 (pl) 2018-08-31
TW200510343A (en) 2005-03-16
UA82519C2 (uk) 2008-04-25
WO2004096778A1 (de) 2004-11-11
ECSP056138A (es) 2006-04-19
CY1106476T1 (el) 2012-01-25
US20050065160A1 (en) 2005-03-24
NO20055649D0 (no) 2005-11-30
CA2524069C (en) 2011-11-08
BRPI0410029A (pt) 2006-04-25
DE10319612A1 (de) 2004-11-18
USRE46791E1 (en) 2018-04-17
MA27794A1 (fr) 2006-03-01
EP1622880B3 (de) 2018-05-23
NZ543317A (en) 2008-05-30

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Effective date: 20240416