HK1066170A1 - 6-substitued pyrido-pyrimidines - Google Patents

6-substitued pyrido-pyrimidines

Info

Publication number
HK1066170A1
HK1066170A1 HK04109141A HK04109141A HK1066170A1 HK 1066170 A1 HK1066170 A1 HK 1066170A1 HK 04109141 A HK04109141 A HK 04109141A HK 04109141 A HK04109141 A HK 04109141A HK 1066170 A1 HK1066170 A1 HK 1066170A1
Authority
HK
Hong Kong
Prior art keywords
substitued
pyrido
pyrimidines
substitued pyrido
Prior art date
Application number
HK04109141A
Other languages
English (en)
Inventor
Jian Jeffrey Chen
James Patrick Dunn
David Michael Goldstein
Christoph Martin Stahl
Original Assignee
Hoffman La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffman La Roche Ag filed Critical Hoffman La Roche Ag
Publication of HK1066170A1 publication Critical patent/HK1066170A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK04109141A 2001-02-12 2004-11-19 6-substitued pyrido-pyrimidines HK1066170A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26837501P 2001-02-12 2001-02-12
US33465401P 2001-11-30 2001-11-30
PCT/EP2002/001106 WO2002064594A2 (fr) 2001-02-12 2002-02-04 Pyrido-pyrimidines substituees en position 6

Publications (1)

Publication Number Publication Date
HK1066170A1 true HK1066170A1 (en) 2005-03-18

Family

ID=26953040

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04109141A HK1066170A1 (en) 2001-02-12 2004-11-19 6-substitued pyrido-pyrimidines

Country Status (32)

Country Link
US (3) US6696566B2 (fr)
EP (1) EP1361880B1 (fr)
JP (1) JP4064818B2 (fr)
KR (1) KR100639772B1 (fr)
CN (1) CN100376571C (fr)
AR (1) AR035854A1 (fr)
AT (1) ATE305303T1 (fr)
AU (1) AU2002256615B2 (fr)
BR (1) BRPI0207172B8 (fr)
CA (1) CA2434834C (fr)
CZ (1) CZ20032416A3 (fr)
DE (1) DE60206363T2 (fr)
DK (1) DK1361880T3 (fr)
ES (1) ES2249574T3 (fr)
HK (1) HK1066170A1 (fr)
HR (1) HRP20030624B1 (fr)
HU (1) HU229604B1 (fr)
IL (2) IL156872A0 (fr)
JO (1) JO2410B1 (fr)
MA (1) MA26993A1 (fr)
MX (1) MXPA03007166A (fr)
MY (1) MY131518A (fr)
NO (1) NO326133B1 (fr)
NZ (1) NZ526961A (fr)
PA (1) PA8539201A1 (fr)
PE (1) PE20020976A1 (fr)
PL (1) PL366918A1 (fr)
RU (1) RU2269527C2 (fr)
SK (1) SK11322003A3 (fr)
WO (1) WO2002064594A2 (fr)
YU (1) YU63703A (fr)
ZA (1) ZA200305938B (fr)

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WO2002064594A2 (fr) 2001-02-12 2002-08-22 F. Hoffmann-La Roche Ag Pyrido-pyrimidines substituees en position 6
ME00230B (me) 2002-01-22 2011-02-10 2-(piridin -2-ilamino)-pirido(2,3-d) pirimidin-7-oni
KR100656205B1 (ko) 2002-04-03 2006-12-12 에프. 호프만-라 로슈 아게 이미다조 융합 화합물
MXPA05001332A (es) * 2002-08-06 2005-04-28 Hoffmann La Roche 6-alcoxi-pirido-pirimidinas como inhibidores de cinasa del map p-38.
EP1594459B1 (fr) 2002-12-30 2010-02-17 Angiotech International Ag Liberation de medicaments a partir d'une composition polymere a gelification rapide
DK2476667T3 (da) * 2003-02-26 2014-09-15 Sugen Inc Aminoheteroaryl-forbindelser som proteinkinase-inhibitorer
JP2006523640A (ja) * 2003-04-16 2006-10-19 エフ．ホフマン−ラ　ロシュ　アーゲー 置換７−アザ−キナゾリン化合物
NZ546634A (en) * 2003-11-13 2010-01-29 Hoffmann La Roche Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones
EP1831215A1 (fr) * 2004-11-23 2007-09-12 Ranbaxy Laboratories Limited Pyrido[2, 3-d]pyrimidines utilisees comme agents anti-inflammatoires
US20060142312A1 (en) * 2004-12-23 2006-06-29 Pfizer Inc C6-aryl and heteroaryl substituted pyrido[2,3-D] pyrimidin-7-ones
US20090036472A1 (en) * 2005-02-02 2009-02-05 Palle Venkata P Azabicyclo derivatives as anti-inflammatory agents
MX2007013595A (es) * 2005-05-04 2008-01-24 Renovis Inc Compuestos heterociclicos fusionados y composiciones y usos de estos.
ATE449097T1 (de) * 2005-07-21 2009-12-15 Hoffmann La Roche Pyridoä2,3-düpyrimidin-2,4-diamin-verbindungen als ptpib-hemmer
PL2099797T3 (pl) * 2005-08-09 2011-03-31 Irm Llc Związki i kompozycje jako inhibitory kinaz białkowych
WO2007022946A1 (fr) 2005-08-21 2007-03-01 Abbott Gmbh & Co. Kg Composes heterocycliques et leur utilisation en tant que partenaires de liaison des recepteurs 5-ht5
JO2783B1 (en) * 2005-09-30 2014-03-15 نوفارتيس ايه جي Compounds 2-Amino-7, 8-dihydro-6H-Bayredo (3,4-D) Pyrimidine-5-Ones
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WO2008078249A1 (fr) * 2006-12-21 2008-07-03 Ranbaxy Laboratories Limited Agents anti-inflammatoires
US8022085B2 (en) 2007-05-07 2011-09-20 Amgen Inc. Pyrazolo-pyridinone and pyrazolo-pyrazinone compounds as P38 modulators and methods of use thereof
CN101679211A (zh) 2007-06-15 2010-03-24 霍夫曼-拉罗奇有限公司 用于制备3-氨基-戊-1,5-二醇的新方法
US8367671B2 (en) 2008-03-21 2013-02-05 Amgen Inc. Pyrazolo[3.4-B]pyrazine compounds as p38 modulators and methods of use as anti-inflamatory agents
EP2112150B1 (fr) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Inhibiteurs Raf améliorés
WO2010046273A2 (fr) * 2008-10-22 2010-04-29 F. Hoffmann-La Roche Ag Inhibiteurs pyrimidinylpyridone de jnk
WO2010071846A2 (fr) 2008-12-19 2010-06-24 Afraxis, Inc. Composés pour traiter des états neuropsychiatriques
EA201270498A1 (ru) * 2009-10-09 2012-11-30 Афраксис, Инк. 8-этил-6-(арил)пиридо[2,3-d]пиримидин-7(8h)-оны для лечения заболеваний цнс
CA2784749C (fr) * 2009-12-18 2017-12-12 E. Premkumar Reddy Pyrido[2,3-d]pyrimidin-7(8h)-ones substitues et leurs utilisations therapeuthiques
CN105294682B (zh) 2014-07-26 2017-07-07 广东东阳光药业有限公司 Cdk类小分子抑制剂的化合物及其用途
CN115105601A (zh) * 2016-06-08 2022-09-27 投资支持有限公司 用于治疗癌症的药物组合
PL3497103T3 (pl) 2016-08-15 2021-10-25 Pfizer Inc. Pirydopirymidynonowe inhibitory CDK2/4/6
CN109562105A (zh) * 2016-08-17 2019-04-02 企业支持有限责任公司 预防或治疗听力损失的方法
WO2018132550A1 (fr) 2017-01-11 2018-07-19 The General Hospital Corporation Agents d'imagerie à canaux sodiques dépendant de la tension
UA127245C2 (uk) 2017-04-04 2023-06-21 Кінарус Аг Способи запобігання або лікування офтальмологічних захворювань
KR20200037876A (ko) * 2017-08-31 2020-04-09 다나-파버 캔서 인스티튜트 인크. Egfr 및/또는 her2의 저해제 및 사용 방법
CA3128468A1 (fr) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Inhibiteurs de la kinase p38 reduisant l'expression du gene dux4 et des genes aval pour le traitement de la fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
US20210261547A1 (en) * 2018-06-27 2021-08-26 Tufts Medical Center, Inc. Pyridopyrimidine compounds and methods of their use
AU2019300135A1 (en) 2018-07-13 2021-01-28 Kinarus Ag Combinations of PPAR agonists and p38 kinase inhibitors for preventing or treating fibrotic diseases
TW202112368A (zh) 2019-06-13 2021-04-01 荷蘭商法西歐知識產權股份有限公司 用於治療有關dux4表現之疾病的抑制劑組合
EP4196120A1 (fr) 2020-08-11 2023-06-21 Kinarus AG Procédés de prévention ou de traitement de covid-19 et de maladies ou troubles viraux associés

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US6518276B2 (en) * 2000-08-31 2003-02-11 Syntex (U.S.A.) Llc 7-oxo-pyridopyrimidines (II)
WO2002064594A2 (fr) * 2001-02-12 2002-08-22 F. Hoffmann-La Roche Ag Pyrido-pyrimidines substituees en position 6
ME00230B (me) * 2002-01-22 2011-02-10 2-(piridin -2-ilamino)-pirido(2,3-d) pirimidin-7-oni

Also Published As

Publication number Publication date
RU2003125887A (ru) 2005-03-20
MY131518A (en) 2007-08-30
JO2410B1 (en) 2007-06-17
WO2002064594A3 (fr) 2003-01-09
RU2269527C2 (ru) 2006-02-10
PA8539201A1 (es) 2004-08-31
NO20033540L (no) 2003-08-11
US6696566B2 (en) 2004-02-24
IL156872A (en) 2009-07-20
DE60206363D1 (de) 2006-02-09
AU2002256615B2 (en) 2007-09-13
HU229604B1 (en) 2014-02-28
YU63703A (sh) 2006-05-25
MA26993A1 (fr) 2004-12-20
PE20020976A1 (es) 2002-10-29
WO2002064594A2 (fr) 2002-08-22
EP1361880B1 (fr) 2005-09-28
MXPA03007166A (es) 2003-11-18
DK1361880T3 (da) 2006-01-23
HUP0303458A3 (en) 2012-12-28
EP1361880A2 (fr) 2003-11-19
KR20040018254A (ko) 2004-03-02
KR100639772B1 (ko) 2006-10-30
BRPI0207172B1 (pt) 2019-04-09
ZA200305938B (en) 2005-01-26
HRP20030624A2 (en) 2005-06-30
US20040116698A1 (en) 2004-06-17
US7169794B2 (en) 2007-01-30
DE60206363T2 (de) 2006-07-06
CZ20032416A3 (cs) 2004-07-14
CN100376571C (zh) 2008-03-26
PL366918A1 (en) 2005-02-07
JP4064818B2 (ja) 2008-03-19
NO326133B1 (no) 2008-10-06
US20070135458A1 (en) 2007-06-14
BRPI0207172B8 (pt) 2021-05-25
ES2249574T3 (es) 2006-04-01
BR0207172A (pt) 2004-03-30
NO20033540D0 (no) 2003-08-11
IL156872A0 (en) 2004-02-08
AR035854A1 (es) 2004-07-21
CA2434834C (fr) 2010-09-14
CA2434834A1 (fr) 2002-08-22
ATE305303T1 (de) 2005-10-15
CN1503672A (zh) 2004-06-09
NZ526961A (en) 2005-03-24
SK11322003A3 (en) 2004-10-05
US7449581B2 (en) 2008-11-11
HRP20030624B1 (en) 2007-03-31
US20030171584A1 (en) 2003-09-11
JP2004525896A (ja) 2004-08-26
HUP0303458A2 (hu) 2004-01-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20120204