HK1057044A1 - Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as d4 ligands - Google Patents

Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as d4 ligands

Info

Publication number
HK1057044A1
HK1057044A1 HK03109371A HK03109371A HK1057044A1 HK 1057044 A1 HK1057044 A1 HK 1057044A1 HK 03109371 A HK03109371 A HK 03109371A HK 03109371 A HK03109371 A HK 03109371A HK 1057044 A1 HK1057044 A1 HK 1057044A1
Authority
HK
Hong Kong
Prior art keywords
radiolabelled
benzothiazole
alkylamino
ligands
benzoxazole derivatives
Prior art date
Application number
HK03109371A
Other languages
English (en)
Inventor
Ludo E J Kennis
Josephus C Mertens
Serge M A Pieters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1057044A1 publication Critical patent/HK1057044A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
HK03109371A 1996-05-10 1999-08-16 Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as d4 ligands HK1057044A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201282 1996-05-10
HK99103545A HK1018457A1 (en) 1996-05-10 1999-08-16 Alkylaminobenzothiazole and-benzoxazole derivatives.

Publications (1)

Publication Number Publication Date
HK1057044A1 true HK1057044A1 (en) 2004-03-12

Family

ID=8223970

Family Applications (2)

Application Number Title Priority Date Filing Date
HK99103545A HK1018457A1 (en) 1996-05-10 1999-08-16 Alkylaminobenzothiazole and-benzoxazole derivatives.
HK03109371A HK1057044A1 (en) 1996-05-10 1999-08-16 Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as d4 ligands

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK99103545A HK1018457A1 (en) 1996-05-10 1999-08-16 Alkylaminobenzothiazole and-benzoxazole derivatives.

Country Status (29)

Country Link
US (2) US6103725A (hu)
EP (2) EP1325917B1 (hu)
JP (1) JP3237759B2 (hu)
KR (1) KR100330699B1 (hu)
CN (1) CN1074766C (hu)
AR (1) AR007079A1 (hu)
AT (2) ATE277917T1 (hu)
AU (1) AU710175B2 (hu)
BG (1) BG64097B1 (hu)
BR (1) BR9709065A (hu)
CA (1) CA2253453C (hu)
CZ (1) CZ295639B6 (hu)
DE (2) DE69730962T2 (hu)
EA (1) EA001360B1 (hu)
EE (1) EE03563B1 (hu)
ES (2) ES2279923T3 (hu)
HK (2) HK1018457A1 (hu)
HU (1) HUP9902993A3 (hu)
ID (1) ID16889A (hu)
IL (1) IL126968A0 (hu)
MY (1) MY117852A (hu)
NO (1) NO311027B1 (hu)
NZ (1) NZ332309A (hu)
PL (1) PL190721B1 (hu)
SK (1) SK282919B6 (hu)
TR (1) TR199802253T2 (hu)
TW (1) TW593290B (hu)
WO (1) WO1997043271A1 (hu)
ZA (1) ZA974053B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (en) * 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
CN1325397A (zh) * 1998-09-30 2001-12-05 纽罗根公司 2－哌嗪烷基氨基苯并吡咯衍生物∶多巴胺受体亚型特异配体
US6284759B1 (en) * 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
AU5569800A (en) * 1999-06-30 2001-01-31 Santen Pharmaceutical Co. Ltd. Brain sigma-1 receptor-binding ligand
DE60128211T2 (de) 2000-03-31 2008-01-10 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituierte imidazopyridine
AU2001251083A1 (en) * 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
KR20050033662A (ko) * 2002-09-06 2005-04-12 얀센 파마슈티카 엔.브이. 헤테로사이클릭 화합물
JP5070038B2 (ja) * 2004-02-24 2012-11-07 ザ ジェネラル ホスピタル コーポレーション 触媒性放射性フッ素化
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
FR2877005A1 (fr) 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
CA2978149C (en) 2008-03-21 2019-02-12 The General Hospital Corporation Inositol derivatives for the detection and treatment of alzheimer's disease and related disorders
WO2018039512A1 (en) * 2016-08-26 2018-03-01 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
PT109740B (pt) 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
KR20210091865A (ko) * 2020-01-14 2021-07-23 서울대학교산학협력단 혈관생성 저해 효과를 가지는 n-페닐벤조티아졸-2-아민 화합물 및 그를 포함하는 약제학적 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0187162B1 (en) * 1984-05-22 1989-11-02 Sumitomo Chemical Company, Limited Novel radioactive iodospiroperidol and process for its preparation
CA1302403C (en) * 1987-04-08 1992-06-02 Steven C. Quay Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles

Also Published As

Publication number Publication date
CZ355398A3 (cs) 1999-02-17
MY117852A (en) 2004-08-30
TW593290B (en) 2004-06-21
DE69730962D1 (de) 2004-11-04
ATE350373T1 (de) 2007-01-15
DE69730962T2 (de) 2006-03-30
BR9709065A (pt) 1999-08-03
IL126968A0 (en) 1999-09-22
ATE277917T1 (de) 2004-10-15
AU710175B2 (en) 1999-09-16
BG102819A (en) 1999-08-31
US6224849B1 (en) 2001-05-01
TR199802253T2 (xx) 1999-02-22
CA2253453C (en) 2007-01-16
CN1074766C (zh) 2001-11-14
NO985227L (no) 1999-01-11
AU2956097A (en) 1997-12-05
CZ295639B6 (cs) 2005-09-14
HUP9902993A2 (hu) 2000-05-28
EA199801000A1 (ru) 1999-04-29
US6103725A (en) 2000-08-15
EP0912533B1 (en) 2004-09-29
JP3237759B2 (ja) 2001-12-10
WO1997043271A1 (en) 1997-11-20
EP1325917B1 (en) 2007-01-03
DE69737217D1 (de) 2007-02-15
SK153298A3 (en) 1999-03-12
HK1018457A1 (en) 1999-12-24
ID16889A (id) 1997-11-20
PL329849A1 (en) 1999-04-12
NO311027B1 (no) 2001-10-01
CA2253453A1 (en) 1997-11-20
KR100330699B1 (ko) 2002-08-27
BG64097B1 (bg) 2003-12-31
NZ332309A (en) 1999-08-30
DE69737217T2 (de) 2007-11-08
NO985227D0 (no) 1998-11-09
EP0912533A1 (en) 1999-05-06
EE03563B1 (et) 2001-12-17
ZA974053B (en) 1998-11-09
ES2230605T3 (es) 2005-05-01
EA001360B1 (ru) 2001-02-26
SK282919B6 (sk) 2003-01-09
ES2279923T3 (es) 2007-09-01
CN1218461A (zh) 1999-06-02
HUP9902993A3 (en) 2002-01-28
EP1325917A1 (en) 2003-07-09
EE9800378A (et) 1999-04-15
JP2000503667A (ja) 2000-03-28
KR20000005227A (ko) 2000-01-25
PL190721B1 (pl) 2005-12-30
AR007079A1 (es) 1999-10-13

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100502