DE69737217D1 - Radiomarkierte Alkylamino-benzothiazole und -benzothiazole sowie ihre Verwendung als D4-Liganden - Google Patents
Radiomarkierte Alkylamino-benzothiazole und -benzothiazole sowie ihre Verwendung als D4-LigandenInfo
- Publication number
- DE69737217D1 DE69737217D1 DE69737217T DE69737217T DE69737217D1 DE 69737217 D1 DE69737217 D1 DE 69737217D1 DE 69737217 T DE69737217 T DE 69737217T DE 69737217 T DE69737217 T DE 69737217T DE 69737217 D1 DE69737217 D1 DE 69737217D1
- Authority
- DE
- Germany
- Prior art keywords
- alkylaminobenzothiazoles
- benzothiazoles
- radiolabelled
- ligands
- radiolabelled alkylaminobenzothiazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96201282 | 1996-05-10 | ||
EP96201282 | 1996-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69737217D1 true DE69737217D1 (de) | 2007-02-15 |
DE69737217T2 DE69737217T2 (de) | 2007-11-08 |
Family
ID=8223970
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69737217T Expired - Lifetime DE69737217T2 (de) | 1996-05-10 | 1997-05-02 | Radiomarkierte Alkylamino-benzothiazole und -benzothiazole sowie ihre Verwendung als D4-Liganden |
DE69730962T Expired - Lifetime DE69730962T2 (de) | 1996-05-10 | 1997-05-02 | Alkylaminobenzothiazole und -benzoxazole derivate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69730962T Expired - Lifetime DE69730962T2 (de) | 1996-05-10 | 1997-05-02 | Alkylaminobenzothiazole und -benzoxazole derivate |
Country Status (29)
Country | Link |
---|---|
US (2) | US6103725A (de) |
EP (2) | EP0912533B1 (de) |
JP (1) | JP3237759B2 (de) |
KR (1) | KR100330699B1 (de) |
CN (1) | CN1074766C (de) |
AR (1) | AR007079A1 (de) |
AT (2) | ATE277917T1 (de) |
AU (1) | AU710175B2 (de) |
BG (1) | BG64097B1 (de) |
BR (1) | BR9709065A (de) |
CA (1) | CA2253453C (de) |
CZ (1) | CZ295639B6 (de) |
DE (2) | DE69737217T2 (de) |
EA (1) | EA001360B1 (de) |
EE (1) | EE03563B1 (de) |
ES (2) | ES2230605T3 (de) |
HK (2) | HK1057044A1 (de) |
HU (1) | HUP9902993A3 (de) |
ID (1) | ID16889A (de) |
IL (1) | IL126968A0 (de) |
MY (1) | MY117852A (de) |
NO (1) | NO311027B1 (de) |
NZ (1) | NZ332309A (de) |
PL (1) | PL190721B1 (de) |
SK (1) | SK282919B6 (de) |
TR (1) | TR199802253T2 (de) |
TW (1) | TW593290B (de) |
WO (1) | WO1997043271A1 (de) |
ZA (1) | ZA974053B (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1293804B1 (it) | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Diarilalchilpiperazine attive sulle basse vie urinarie |
US6281216B1 (en) * | 1998-02-09 | 2001-08-28 | Duphar International Research B.V. | 2-aminoquinoline derivatives having d4-agonistic activity |
EP0982030A3 (de) | 1998-08-17 | 2000-05-10 | Pfizer Products Inc. | 2,7-substituierte Octahydropyrrolo(1,2-a)pyrazinderivate als 5ht 1a Liganden |
EP1117663A2 (de) * | 1998-09-30 | 2001-07-25 | Neurogen Corporation | 2-piperazinoalkylaminobenzoazol derivate: dopamin rezeptor subtyp spezifische liganden |
US6284759B1 (en) * | 1998-09-30 | 2001-09-04 | Neurogen Corporation | 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands |
US6107313A (en) * | 1998-10-02 | 2000-08-22 | Combichem, Inc. | Dopamine receptor antagonists |
AU5569800A (en) * | 1999-06-30 | 2001-01-31 | Santen Pharmaceutical Co. Ltd. | Brain sigma-1 receptor-binding ligand |
AU2001249679A1 (en) | 2000-03-31 | 2001-10-15 | Ortho-Mcneil Pharmaceutical, Inc. | Phenyl-substituted imidazopyridines |
US6436939B2 (en) | 2000-03-31 | 2002-08-20 | Ortho-Mcneil Pharmaceutical, Inc. | Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists |
GB0203299D0 (en) * | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel compounds |
CA2497827A1 (en) * | 2002-09-06 | 2004-03-18 | Janssen Pharmaceutica, N.V. | (1h-benzoimidazol-2-yl)-(piperazinyl)-methanone derivatives and related compounds as histamine h4-receptor antagonists for the treatment of inflammatory and allergic disorders |
EP2610234A1 (de) * | 2004-02-24 | 2013-07-03 | The General Hospital Corporation | Katalytische Radiofluorierung |
US8257680B1 (en) | 2004-02-24 | 2012-09-04 | The General Hospital Corporation | Catalytic radiofluorination |
US9017724B2 (en) | 2004-02-24 | 2015-04-28 | The General Hospital Corporation | Catalytic radiofluorination |
FR2877005A1 (fr) * | 2004-10-22 | 2006-04-28 | Bioprojet Soc Civ Ile | Nouveaux derives d'arylpiperazine |
US7731940B2 (en) | 2006-01-25 | 2010-06-08 | The Regents Of The University Of California | Compositions and methods related to serotonin 5-HT1A receptors |
EP2268647B1 (de) | 2008-03-21 | 2017-01-25 | The General Hospital Corporation | Verbindungen und zusammensetzungen für den nachweis und die behandlung von morbus alzheimer und verwandten erkrankungen |
CN109843293A (zh) * | 2016-08-26 | 2019-06-04 | 百时美施贵宝公司 | 吲哚胺2,3-双加氧酶的抑制剂及其使用方法 |
PT109740B (pt) | 2016-11-14 | 2020-07-30 | Hovione Farmaciencia Sa | Processo para a preparação de brometo de umeclidínio |
KR20210091865A (ko) * | 2020-01-14 | 2021-07-23 | 서울대학교산학협력단 | 혈관생성 저해 효과를 가지는 n-페닐벤조티아졸-2-아민 화합물 및 그를 포함하는 약제학적 조성물 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0187162B1 (de) * | 1984-05-22 | 1989-11-02 | Sumitomo Chemical Company, Limited | Radioaktives iodospiroperidol und herstellung |
EP0287909B1 (de) * | 1987-04-08 | 1992-09-02 | Salutar, Inc. | Nachweis für Amyloidose und Alzheimer'sche Krankheit sowie Reagens hierfür |
US4929618A (en) * | 1988-03-25 | 1990-05-29 | Ube Industries, Ltd. | Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same |
FR2656609B1 (fr) * | 1989-12-28 | 1992-03-27 | Synthelabo | Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
US5731438A (en) * | 1996-08-01 | 1998-03-24 | Isis Pharmaceuticals, Inc. | N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles |
-
1997
- 1997-05-01 TW TW086105767A patent/TW593290B/zh not_active IP Right Cessation
- 1997-05-02 DE DE69737217T patent/DE69737217T2/de not_active Expired - Lifetime
- 1997-05-02 KR KR1019980707914A patent/KR100330699B1/ko not_active IP Right Cessation
- 1997-05-02 PL PL97329849A patent/PL190721B1/pl not_active IP Right Cessation
- 1997-05-02 CA CA002253453A patent/CA2253453C/en not_active Expired - Fee Related
- 1997-05-02 DE DE69730962T patent/DE69730962T2/de not_active Expired - Lifetime
- 1997-05-02 BR BR9709065A patent/BR9709065A/pt not_active IP Right Cessation
- 1997-05-02 TR TR1998/02253T patent/TR199802253T2/xx unknown
- 1997-05-02 WO PCT/EP1997/002505 patent/WO1997043271A1/en active IP Right Grant
- 1997-05-02 ES ES97923913T patent/ES2230605T3/es not_active Expired - Lifetime
- 1997-05-02 ES ES03075959T patent/ES2279923T3/es not_active Expired - Lifetime
- 1997-05-02 AU AU29560/97A patent/AU710175B2/en not_active Ceased
- 1997-05-02 EP EP97923913A patent/EP0912533B1/de not_active Expired - Lifetime
- 1997-05-02 US US09/180,369 patent/US6103725A/en not_active Expired - Lifetime
- 1997-05-02 EA EA199801000A patent/EA001360B1/ru not_active IP Right Cessation
- 1997-05-02 CZ CZ19983553A patent/CZ295639B6/cs not_active IP Right Cessation
- 1997-05-02 AT AT97923913T patent/ATE277917T1/de not_active IP Right Cessation
- 1997-05-02 AT AT03075959T patent/ATE350373T1/de not_active IP Right Cessation
- 1997-05-02 HU HU9902993A patent/HUP9902993A3/hu unknown
- 1997-05-02 IL IL12696897A patent/IL126968A0/xx not_active IP Right Cessation
- 1997-05-02 NZ NZ332309A patent/NZ332309A/xx unknown
- 1997-05-02 SK SK1532-98A patent/SK282919B6/sk not_active IP Right Cessation
- 1997-05-02 EE EE9800378A patent/EE03563B1/xx not_active IP Right Cessation
- 1997-05-02 JP JP54053597A patent/JP3237759B2/ja not_active Expired - Lifetime
- 1997-05-02 CN CN97194515A patent/CN1074766C/zh not_active Expired - Lifetime
- 1997-05-02 EP EP03075959A patent/EP1325917B1/de not_active Expired - Lifetime
- 1997-05-07 MY MYPI97002022A patent/MY117852A/en unknown
- 1997-05-09 AR ARP970101955A patent/AR007079A1/es active IP Right Grant
- 1997-05-09 ZA ZA974053A patent/ZA974053B/xx unknown
- 1997-05-09 ID IDP971546A patent/ID16889A/id unknown
-
1998
- 1998-10-07 BG BG102819A patent/BG64097B1/bg unknown
- 1998-11-09 NO NO19985227A patent/NO311027B1/no unknown
-
1999
- 1999-08-16 HK HK03109371A patent/HK1057044A1/xx not_active IP Right Cessation
- 1999-08-16 HK HK99103545A patent/HK1018457A1/xx not_active IP Right Cessation
-
2000
- 2000-06-27 US US09/604,427 patent/US6224849B1/en not_active Expired - Lifetime
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8381 | Inventor (new situation) |
Inventor name: KENNIS, LUDO E. J., BEERSE, BE Inventor name: MERTENS, JOSEPHUS C., BEERSE, BE Inventor name: PIETERS, SERGE M. A., BEERSE, BE |
|
8364 | No opposition during term of opposition |