HK1056876A1 - Ethylenedianme derivatives - Google Patents
Ethylenedianme derivativesInfo
- Publication number
- HK1056876A1 HK1056876A1 HK03109029A HK03109029A HK1056876A1 HK 1056876 A1 HK1056876 A1 HK 1056876A1 HK 03109029 A HK03109029 A HK 03109029A HK 03109029 A HK03109029 A HK 03109029A HK 1056876 A1 HK1056876 A1 HK 1056876A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- ethylenedianme
- derivatives
- aromatic ring
- heterocyclic ring
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000108047 | 2000-04-05 | ||
PCT/JP2001/002945 WO2001074774A1 (fr) | 2000-04-05 | 2001-04-05 | Derives ethylenediamine |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1056876A1 true HK1056876A1 (en) | 2004-03-05 |
Family
ID=18620961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK03109029A HK1056876A1 (en) | 2000-04-05 | 2003-12-11 | Ethylenedianme derivatives |
Country Status (18)
Country | Link |
---|---|
US (3) | US7192968B2 (de) |
EP (2) | EP1270557B1 (de) |
JP (2) | JP4495896B2 (de) |
KR (1) | KR100769592B1 (de) |
CN (1) | CN1293057C (de) |
AR (1) | AR027998A1 (de) |
AU (2) | AU4683501A (de) |
BR (1) | BR0110052A (de) |
CA (1) | CA2405144A1 (de) |
ES (2) | ES2389021T3 (de) |
HK (1) | HK1056876A1 (de) |
IL (1) | IL151710A0 (de) |
MX (1) | MXPA02009805A (de) |
NO (1) | NO324003B1 (de) |
RU (1) | RU2268259C2 (de) |
TW (2) | TWI288745B (de) |
WO (1) | WO2001074774A1 (de) |
ZA (1) | ZA200207331B (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI288745B (en) * | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
WO2002072548A2 (en) | 2001-03-09 | 2002-09-19 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds and their use as histamine h4 ligands. |
GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
US7365205B2 (en) * | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
EP1405852B9 (de) * | 2001-06-20 | 2013-03-27 | Daiichi Sankyo Company, Limited | Diaminderivate |
BR0211565A (pt) * | 2001-08-09 | 2004-06-29 | Daiichi Seiyaku Co | Derivados de diamina |
AR037097A1 (es) | 2001-10-05 | 2004-10-20 | Novartis Ag | Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento |
DE60332717D1 (de) * | 2002-04-11 | 2010-07-08 | Boehringer Ingelheim Pharma | Heterocyclische amid-derivate als cytokin-inhibitoren |
KR20050033662A (ko) | 2002-09-06 | 2005-04-12 | 얀센 파마슈티카 엔.브이. | 헤테로사이클릭 화합물 |
PE20040804A1 (es) * | 2002-12-19 | 2004-12-31 | Boehringer Ingelheim Pharma | DERIVADOS DE CARBOXAMIDAS COMO INHIBIDORES DEL FACTOR Xa |
MXPA05007012A (es) * | 2002-12-24 | 2005-08-18 | Daiichi Seiyaku Co | Derivados novedosos de etilendiamina. |
CN1751025B (zh) * | 2002-12-25 | 2010-05-12 | 第一制药株式会社 | 二胺衍生物 |
RU2333203C2 (ru) * | 2002-12-25 | 2008-09-10 | Дайити Фармасьютикал Ко., Лтд. | Диаминовые производные |
JP4630267B2 (ja) * | 2002-12-25 | 2011-02-09 | 第一三共株式会社 | ジアミン誘導体 |
US7205318B2 (en) | 2003-03-18 | 2007-04-17 | Bristol-Myers Squibb Company | Lactam-containing cyclic diamines and derivatives as a factor Xa inhibitors |
US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
US7115646B2 (en) * | 2003-10-08 | 2006-10-03 | Bristol Myers Squibb, Co. | Cyclic diamines and derivatives as factor Xa inhibitors |
EP2266992A3 (de) | 2003-11-12 | 2011-05-18 | Daiichi Sankyo Company, Limited | Verfahren zur Herstellung von Thiazolderivaten |
US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
JP4510088B2 (ja) * | 2005-09-16 | 2010-07-21 | 第一三共株式会社 | 光学活性なジアミン誘導体およびその製造方法 |
EP2044055A4 (de) * | 2006-07-21 | 2011-03-23 | Takeda Pharmaceutical | Amidverbindungen |
EP2062878A4 (de) | 2006-08-30 | 2010-09-08 | Shionogi & Co | Hydrazinamidderivat |
BRPI0809205B8 (pt) | 2007-03-29 | 2021-05-25 | Daiichi Sankyo Co Ltd | composição farmacêutica |
TW200909437A (en) * | 2007-06-21 | 2009-03-01 | Daiichi Sankyo Co Ltd | Process for the preparation of diamine-derivatives |
US20100015306A1 (en) * | 2008-07-15 | 2010-01-21 | Pepsico, Inc. | Method for Preparing a Low Viscosity Whole Grain Flour Slurry |
CA2747427C (en) | 2008-12-17 | 2015-10-13 | Daiichi Sankyo Company, Limited | Method for producing diamine derivative |
EP2383272A4 (de) | 2009-01-13 | 2012-07-25 | Daiichi Sankyo Co Ltd | Aktiver blutgerinnungsfaktor-hemmer |
US20100178400A1 (en) * | 2009-01-13 | 2010-07-15 | Pepsico, Inc. | Method of Preparing a Whole Grain Beverage |
EP2407457B1 (de) | 2009-03-10 | 2015-04-22 | Daiichi Sankyo Company, Limited | Verfahren zur herstellung eines diaminderivats |
ES2542237T3 (es) | 2009-03-13 | 2015-08-03 | Daiichi Sankyo Company, Limited | Procedimiento de producción de un derivado de diamina ópticamente activo |
KR20120037396A (ko) | 2009-06-18 | 2012-04-19 | 다이이찌 산쿄 가부시키가이샤 | 용출성이 개선된 의약 조성물 |
ES2601884T3 (es) | 2010-03-19 | 2017-02-16 | Daiichi Sankyo Company, Limited | Procedimiento para mejorar la capacidad de disolución de un anticoagulante |
WO2011115066A1 (ja) | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | ジアミン誘導体の結晶およびその製造方法 |
JP5780657B2 (ja) * | 2010-07-02 | 2015-09-16 | 第一三共株式会社 | 光学活性ジアミン誘導体の塩の製造方法 |
CN103732227B (zh) | 2011-08-10 | 2017-04-12 | 第一三共株式会社 | 含有二胺衍生物的药物组合物 |
CN102516249A (zh) * | 2011-12-08 | 2012-06-27 | 成都苑东药业有限公司 | 一种抗凝血的二胺衍生物 |
CN102731316B (zh) * | 2012-05-21 | 2014-04-16 | 南通市华峰化工有限责任公司 | 一种1,2-n,n`二甲基环己二胺的生产方法 |
CA2896338A1 (en) | 2013-03-29 | 2014-10-02 | Daiichi Sankyo Company, Limited | Method for producing (1s,4s,5s)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one |
TWI602803B (zh) * | 2013-03-29 | 2017-10-21 | 第一三共股份有限公司 | 光學活性二胺衍生物之製造方法 |
CN106459087B (zh) * | 2014-02-18 | 2019-04-09 | 第一三共株式会社 | 活化的凝血因子X (FXa)抑制剂的制备方法 |
PT3125883T (pt) | 2014-04-04 | 2020-10-12 | Iomet Pharma Ltd | Derivados de indol para utilização na medicina |
CN104163802B (zh) * | 2014-07-08 | 2016-04-27 | 浙江大学 | 2-氨基噻唑-4-甲酸乙酯的制备方法 |
JP2017538659A (ja) * | 2014-09-10 | 2017-12-28 | エピザイム インコーポレイテッド | Smyd阻害剤 |
US10858319B2 (en) | 2016-10-03 | 2020-12-08 | Iomet Pharma Ltd. | Indole derivatives for use in medicine |
CN108689878B (zh) * | 2017-04-10 | 2023-05-09 | 浙江九洲药业股份有限公司 | 光学活性二氨基衍生物的制备方法 |
CN108840816A (zh) * | 2018-05-25 | 2018-11-20 | 郑州依米花手性药物研究有限公司 | 酰亚胺类中间体化合物及其制备方法和应用 |
Family Cites Families (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4707440A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
IL100576A (en) | 1991-01-18 | 1995-11-27 | Eli Lilley And Company | Cephalosporin antibiotics |
WO1993010022A1 (en) | 1991-11-14 | 1993-05-27 | Frutin Bernard D | A pressurised container |
US5264457A (en) * | 1992-02-14 | 1993-11-23 | G. D. Searle & Co. | Phenyl amidines sulfonamides useful as platelet aggregation inhibitors |
JP2875930B2 (ja) * | 1992-12-02 | 1999-03-31 | 富士写真フイルム株式会社 | 旋光フイルムおよびそれを用いた液晶表示装置 |
US5430150A (en) * | 1992-12-16 | 1995-07-04 | American Cyanamid Company | Retroviral protease inhibitors |
AU6252794A (en) | 1993-03-03 | 1994-09-26 | Eli Lilly And Company | Balanoids |
ES2117264T3 (es) | 1993-03-17 | 1998-08-01 | Meiji Seika Co | Nuevo compuesto con actividad inhibitoria de la agregacion plaquetaria. |
US5707994A (en) | 1993-10-19 | 1998-01-13 | Sumitomo Pharmaceuticals Company, Limited | 2,3-diaminopropionic acid derivative |
TW270114B (de) | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5563158A (en) | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
AU6856094A (en) | 1994-06-01 | 1995-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Oxadiazole derivative and medicinal composition thereof |
IL115420A0 (en) | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
US5719144A (en) | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0820452B1 (de) | 1995-04-07 | 2003-06-04 | Schering Corporation | Carbonyl-piperaznyl und piperidinyl derivate zur hemmung farnesyl protein transferase |
DE19516954C1 (de) | 1995-05-12 | 1996-12-19 | Max Planck Gesellschaft | Verfahren zum ortsaufgelösten immunhistochemischen Nachweis von Steroidrezeptoren |
IL118007A0 (en) * | 1995-05-24 | 1996-08-04 | Du Pont Merck Pharma | Isoxazoline compounds pharmaceutical compositions containing them and their use |
ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
US5726126A (en) | 1995-06-02 | 1998-03-10 | American Cyanamid Company | 1-(3-heterocyclyphenyl)-S-triazine-2,6,6-oxo or thiotrione herbicidal agents |
US5741819A (en) | 1995-06-07 | 1998-04-21 | 3-Dimensional Pharmaceuticals, Inc. | Arylsulfonylaminobenzene derivatives and the use thereof as factor Xa inhibitors |
GB9516709D0 (en) | 1995-08-15 | 1995-10-18 | Zeneca Ltd | Medicament |
AU713247B2 (en) | 1995-10-19 | 1999-11-25 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5852045A (en) * | 1995-10-19 | 1998-12-22 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US6274715B1 (en) | 1995-11-08 | 2001-08-14 | Abbott Laboratories | Tricyclic erythromycin derivatives |
GB9602294D0 (en) | 1996-02-05 | 1996-04-03 | Zeneca Ltd | Heterocyclic compounds |
ES2218677T3 (es) | 1996-04-17 | 2004-11-16 | Bristol-Myers Squibb Pharma Company | Derivados de n-(amidinofenil)-n'-(subst.)-3h-2,4-benzodiazepin-3-ona como inhibidores del factor xa. |
US5668159A (en) | 1996-05-08 | 1997-09-16 | The Dupont Merck Pharmaceutical Company | 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists |
US6185453B1 (en) * | 1996-06-19 | 2001-02-06 | Dupont Pharmaceuticals Company | Iontophoretic delivery of integrin inhibitors |
AU3784997A (en) | 1996-08-09 | 1998-03-06 | Eisai Co. Ltd. | Benzopiperidine derivatives |
TR199900303T2 (xx) | 1996-08-14 | 1999-06-21 | Zeneca Limited | �kame edilmi� pirimidin t�revleri ve bunlar�n farmas�tik kullan�m�. |
EP0922039A1 (de) * | 1996-08-15 | 1999-06-16 | Du Pont Pharmaceuticals Company | Cyclische carbamate und isoxazolidine als iib/iiia antagonisten |
US6004955A (en) * | 1996-08-15 | 1999-12-21 | Dupont Pharmaceuticals Company | Cyclic carbamates and isoxazolidines as IIb/IIIa antagonists |
US5871762A (en) * | 1996-10-07 | 1999-02-16 | The Procter & Gamble Company | Cosmetic applicators which contain stable oil-in-water emulsions |
UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
JP2001511798A (ja) | 1997-02-13 | 2001-08-14 | ゼネカ・リミテッド | オキシド−スクアレンシクラーゼ抑制剤として有用な複素環化合物 |
IT1291823B1 (it) * | 1997-04-08 | 1999-01-21 | Menarini Ricerche Spa | Composti pseudo-peptidici, loro preparazione ed uso in formulazioni farmaceutiche |
AR012443A1 (es) | 1997-04-16 | 2000-10-18 | Uriach & Cia Sa J | Nuevas carboxamidas como inhibidores de la agregacion plaquetaria, procedimiento para su preparacion, composiciones farmaceuticas que loscontienen y uso de los mismos en la manufactura de medicamentos |
CA2287292A1 (en) | 1997-05-30 | 1998-12-03 | Takeda Chemical Industries, Ltd. | Sulfonamide derivatives, their production and use |
EP0991623A2 (de) * | 1997-06-19 | 2000-04-12 | Sepracor, Inc. | Chinolin-indol verbindungen mit antimikrobieller wirkung |
US6207679B1 (en) | 1997-06-19 | 2001-03-27 | Sepracor, Inc. | Antimicrobial agents uses and compositions related thereto |
WO1999000121A1 (en) | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Antithrombotic agents |
ATE306261T1 (de) | 1997-06-26 | 2005-10-15 | Lilly Co Eli | Antithrombosemittel |
US6417200B1 (en) | 1997-06-26 | 2002-07-09 | Eli Lilly And Company | Antithrombotic agents |
GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
GB9715894D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic derivatives |
BR9815377A (pt) | 1997-09-30 | 2001-01-16 | Daiichi Pharmaceutical Co Ltda | Derivados de sulfonil |
AR013693A1 (es) * | 1997-10-23 | 2001-01-10 | Uriach & Cia Sa J | Nuevas piperidinas y piperazinas como inhibidores de la agregacion plaquetaria |
EP0937711A1 (de) | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Neue Thiobenzamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
EP0937723A1 (de) | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Neue Sulfonamide, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
WO1999045939A1 (en) * | 1998-03-09 | 1999-09-16 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
GB9809350D0 (en) | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Novel salt |
PT1082321E (pt) | 1998-05-02 | 2005-03-31 | Astrazeneca Ab | Derivados heterociclicos que inibem o factor xa |
GB9809349D0 (en) | 1998-05-02 | 1998-07-01 | Zeneca Ltd | Heterocyclic derivatives |
JP2000086659A (ja) * | 1998-07-14 | 2000-03-28 | Takeda Chem Ind Ltd | オクタヒドロピリド[1,2―a]ピラジン誘導体 |
FR2781221B1 (fr) * | 1998-07-17 | 2000-10-13 | Lafon Labor | Piperazinones substituees en alpha |
US6303625B1 (en) * | 1998-07-27 | 2001-10-16 | Ortho-Mcneil Pharmaceutical, Inc. | Triazolopyridines for the treatment of thrombosis disorders |
JP2000119253A (ja) | 1998-08-11 | 2000-04-25 | Dai Ichi Seiyaku Co Ltd | 新規なスルホニル誘導体 |
AU5196399A (en) | 1998-08-11 | 2000-03-06 | Daiichi Pharmaceutical Co., Ltd. | Novel sulfonyl derivatives |
ATE240310T1 (de) * | 1998-12-14 | 2003-05-15 | Vertex Pharma San Diego Llc | Optische molekularsensoren für cytochrome p-450 aktivität |
CA2361149A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | Aromatic amides |
DE69931393T2 (de) | 1998-12-23 | 2007-03-29 | Eli Lilly And Co., Indianapolis | Antithrombotische amide |
EP1140905B1 (de) | 1998-12-23 | 2003-05-14 | Eli Lilly And Company | Heteroaromatische amide als inhibitoren von faktor xa |
EP1140839B1 (de) | 1998-12-24 | 2004-03-17 | Eli Lilly And Company | Heterocyclische amide als inhibitoren von faktor xa |
GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
WO2000053264A1 (en) | 1999-03-11 | 2000-09-14 | Du Pont Pharmaceuticals Company | Treatment of thrombosis by combined use of a factor xa inhibitor and aspirin, tissue plasminogen activator (tpa), a gpiib/iiia antagonist, low molecular weight heparin or heparin |
AU2241400A (en) | 1999-04-06 | 2000-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | Novel thiazolobenzoimidazole derivative |
JP4390024B2 (ja) | 1999-04-23 | 2009-12-24 | アステラス製薬株式会社 | 新規なジアゼパン誘導体又はその塩 |
EP1185512A2 (de) | 1999-05-24 | 2002-03-13 | Cor Therapeutics, Inc. | Faktor xa inhibitoren |
EP1192132B1 (de) | 1999-06-14 | 2005-09-07 | Eli Lilly And Company | Inhibitoren von serin proteasen |
GB9914342D0 (en) | 1999-06-19 | 1999-08-18 | Zeneca Ltd | Compound |
JP2001011071A (ja) * | 1999-06-25 | 2001-01-16 | Mochida Pharmaceut Co Ltd | アミノアルキルスルホンアミド誘導体 |
GB9917344D0 (en) | 1999-07-24 | 1999-09-22 | Zeneca Ltd | Novel salt |
CN1373755A (zh) | 1999-09-13 | 2002-10-09 | 三维药物公司 | 氮杂环烷酮丝氨酸蛋白酶抑制剂 |
RU2002110295A (ru) | 1999-09-17 | 2003-12-10 | Милленниум Фармасьютикалс, Инк. (Us) | Ингибиторы фактора Ха |
KR20020047175A (ko) | 1999-09-17 | 2002-06-21 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Xa 인자의 억제제 |
EP1229024A1 (de) * | 1999-10-08 | 2002-08-07 | Meiji Seika Kaisha Ltd. | M-substituierte benzoesäurederivate die alpha-v beta-3 integrin antagonismus zeigen |
CA2392576A1 (en) | 1999-11-24 | 2001-05-31 | Lingyan Wang | .beta.-amino acid-, aspartic acid- and diaminopropionic-based inhibitors of factor xa |
DK1259485T3 (da) | 2000-02-29 | 2006-04-10 | Millennium Pharm Inc | Benzamider og beslægtede inhibitorer for faktor Xa |
TWI288745B (en) * | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
AU2001275857A1 (en) | 2000-06-29 | 2002-01-14 | Bristol-Myers Squibb Pharma Company | Thrombin or factor xa inhibitors |
EP1322643A1 (de) | 2000-09-29 | 2003-07-02 | Millennium Pharmaceuticals, Inc. | Piperazin-2-onamide als faktor-xa-hemmer |
WO2002026720A2 (en) | 2000-09-29 | 2002-04-04 | Millennium Pharmaceuticals, Inc. | PIPERAZINE BASED INHIBITORS OF FACTOR Xa |
WO2002026712A2 (en) | 2000-09-29 | 2002-04-04 | Millennium Pharmaceuticals, Inc. | Quaternary amines and related inhibitors of factor xa |
US6710058B2 (en) | 2000-11-06 | 2004-03-23 | Bristol-Myers Squibb Pharma Company | Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors |
AU2002224064B2 (en) | 2000-11-22 | 2005-12-08 | Astellas Pharma Inc. | Substituted benzene derivatives or salts thereof |
AR035773A1 (es) | 2000-12-20 | 2004-07-14 | Bristol Myers Squibb Pharma Co | Compuestos diamino ciclico, composicion farmaceutica y su uso en la fabricacion de un medicamento util para modular la actividad de una quimioquina |
DE60221505D1 (de) | 2001-03-30 | 2007-09-13 | Millennium Pharm Inc | FAKTOR Xa BENZAMIDIN INHIBITOREN |
EP1405852B9 (de) | 2001-06-20 | 2013-03-27 | Daiichi Sankyo Company, Limited | Diaminderivate |
US7365205B2 (en) | 2001-06-20 | 2008-04-29 | Daiichi Sankyo Company, Limited | Diamine derivatives |
BR0211565A (pt) | 2001-08-09 | 2004-06-29 | Daiichi Seiyaku Co | Derivados de diamina |
RS20080517A (en) | 2001-09-21 | 2009-07-15 | Bristol-Myers Squibb Company, | Lactam containing compounds and derivatives thereof as factor xa inhibitors |
US7030141B2 (en) | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
WO2003048081A2 (en) | 2001-12-04 | 2003-06-12 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
MXPA05007012A (es) * | 2002-12-24 | 2005-08-18 | Daiichi Seiyaku Co | Derivados novedosos de etilendiamina. |
RU2333203C2 (ru) * | 2002-12-25 | 2008-09-10 | Дайити Фармасьютикал Ко., Лтд. | Диаминовые производные |
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2001
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- 2001-04-03 TW TW090107988A patent/TWI290136B/zh not_active IP Right Cessation
- 2001-04-04 AR ARP010101613A patent/AR027998A1/es not_active Application Discontinuation
- 2001-04-05 JP JP2001572469A patent/JP4495896B2/ja not_active Expired - Fee Related
- 2001-04-05 ES ES01919784T patent/ES2389021T3/es not_active Expired - Lifetime
- 2001-04-05 CA CA002405144A patent/CA2405144A1/en not_active Abandoned
- 2001-04-05 KR KR1020027013005A patent/KR100769592B1/ko not_active IP Right Cessation
- 2001-04-05 US US10/240,725 patent/US7192968B2/en not_active Expired - Fee Related
- 2001-04-05 ES ES11009091T patent/ES2417860T3/es not_active Expired - Lifetime
- 2001-04-05 EP EP01919784A patent/EP1270557B1/de not_active Expired - Lifetime
- 2001-04-05 MX MXPA02009805A patent/MXPA02009805A/es active IP Right Grant
- 2001-04-05 IL IL15171001A patent/IL151710A0/xx unknown
- 2001-04-05 RU RU2002129354/04A patent/RU2268259C2/ru not_active IP Right Cessation
- 2001-04-05 BR BR0110052-1A patent/BR0110052A/pt not_active IP Right Cessation
- 2001-04-05 CN CNB018086187A patent/CN1293057C/zh not_active Expired - Fee Related
- 2001-04-05 WO PCT/JP2001/002945 patent/WO2001074774A1/ja active Application Filing
- 2001-04-05 AU AU4683501A patent/AU4683501A/xx active Pending
- 2001-04-05 AU AU2001246835A patent/AU2001246835B2/en not_active Ceased
- 2001-04-05 EP EP11009091.7A patent/EP2431370B1/de not_active Expired - Lifetime
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2002
- 2002-09-12 ZA ZA200207331A patent/ZA200207331B/xx unknown
- 2002-10-03 NO NO20024766A patent/NO324003B1/no unknown
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2005
- 2005-09-02 US US11/217,837 patent/US20060004009A1/en not_active Abandoned
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2009
- 2009-05-13 US US12/465,329 patent/US7935824B2/en not_active Expired - Fee Related
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2010
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